Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 A (CDBP00531)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00531

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 A

Description

Not Available

Synonyms

HR6A
RAD6 homolog A
Ubiquitin carrier protein A
Ubiquitin-protein ligase A
hHR6A

Gene Name

UBE2A

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In association with the E3 enzyme BRE1 (RNF20 and/or RNF40), it plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. In vitro catalyzes 'Lys-11', as well as 'Lys-48'-linked polyubiquitination. Required for postreplication repair of UV-damaged DNA.

GO Classification

Biological Process
protein autoubiquitination
response to UV
postreplication repair
maternal process involved in female pregnancy
positive regulation of cell proliferation
in utero embryonic development
protein K48-linked ubiquitination
ubiquitin-dependent protein catabolic process
protein K11-linked ubiquitination
antigen processing and presentation of peptide antigen via MHC class I
histone H2A ubiquitination
Cellular Component
cytosol
HULC complex
XY body
nuclear chromatin
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available

Gene Properties

Chromosome Location

Locus

Xq24

SNPs

UBE2A

Gene Sequence

>459 bp
ATGTCCACCCCGGCTCGGCGGCGCCTCATGCGGGACTTCAAGAGGTTGCAGGAGGATCCT
CCAGCCGGAGTCAGCGGGGCTCCGTCCGAGAACAACATAATGGTGTGGAACGCGGTCATT
TTCGGGCCTGAAGGGACCCCGTTTGAGGATGGAACATTTAAACTTACAATAGAATTCACT
GAAGAATATCCAAATAAACCACCTACAGTTAGATTTGTCTCTAAGATGTTCCATCCAAAT
GTCTATGCAGATGGTAGTATATGTCTGGACATACTTCAGAACCGTTGGAGTCCAACCTAT
GATGTGTCTTCCATTCTAACATCCATACAGTCTCTGTTGGATGAACCCAATCCCAATAGT
CCAGCAAACAGCCAGGCTGCTCAGCTGTACCAGGAGAACAAACGGGAATATGAAAAGCGT
GTTTCTGCAATAGTAGAACAAAGCTGGCGTGATTGTTGA

Protein Properties

Number of Residues

152

Molecular Weight

17315.265

Theoretical pI

5.147

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 A
MSTPARRRLMRDFKRLQEDPPAGVSGAPSENNIMVWNAVIFGPEGTPFEDGTFKLTIEFT
EEYPNKPPTVRFVSKMFHPNVYADGSICLDILQNRWSPTYDVSSILTSIQSLLDEPNPNS
PANSQAAQLYQENKREYEKRVSAIVEQSWRDC

External Links

GenBank ID Protein

32967280

UniProtKB/Swiss-Prot ID

P49459

UniProtKB/Swiss-Prot Entry Name

UBE2A_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_003336.2

GeneCard ID