| Identification |
|---|
| HMDB Protein ID
| CDBP05465 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA-directed RNA polymerases I, II, and III subunit RPABC3 |
| Description
| Not Available |
| Synonyms
|
- RNA polymerases I, II, and III subunit ABC3
- DNA-directed RNA polymerase II subunit H
- DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide
- RPB17
- RPB8 homolog
- hRPB8
|
| Gene Name
| POLR2H |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.
|
| GO Classification
|
| Biological Process |
| transcription elongation from RNA polymerase II promoter |
| transcription initiation from RNA polymerase II promoter |
| termination of RNA polymerase III transcription |
| transcription elongation from RNA polymerase III promoter |
| transcription-coupled nucleotide-excision repair |
| 7-methylguanosine mRNA capping |
| mRNA splicing, via spliceosome |
| termination of RNA polymerase I transcription |
| transcription elongation from RNA polymerase I promoter |
| transcription initiation from RNA polymerase I promoter |
| viral reproduction |
| protein phosphorylation |
| positive regulation of viral transcription |
| Cellular Component |
| DNA-directed RNA polymerase II, core complex |
| cytoplasm |
| nucleolus |
| Molecular Function |
| zinc ion binding |
| DNA-directed RNA polymerase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | RNA polymerase | Not Available |  | | Cytosolic DNA-sensing pathway | Not Available |  | | Huntington's disease | Not Available |  | | Epstein-Barr virus infection | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q28 |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 17143.115 |
| Theoretical pI
| 4.678 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>gi|14589953|ref|NP_006223.2| DNA-directed RNA polymerases I, II, and III subunit RPABC3 [Homo sapiens]
MAGILFEDIFDVKDIDPEGKKFDRVSRLHCESESFKMDLILDVNIQIYPVDLGDKFRLVI
ASTLYEDGTL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P52434 |
| UniProtKB/Swiss-Prot Entry Name
| Not Available |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:9195 |
| References |
|---|
| General References
| Not Available |