Identification
HMDB Protein ID CDBP04427
Secondary Accession Numbers Not Available
Name Ubiquitin-conjugating enzyme E2 W
Description Not Available
Synonyms
  1. SubName: Ubiquitin-conjugating enzyme E2W (Putative), isoform CRA_c
  2. Ubiquitin carrier protein W
  3. Ubiquitin-conjugating enzyme 16
  4. Ubiquitin-protein ligase W
  5. UBC-16
Gene Name UBE2W
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination.
GO Classification
Biological Process
DNA repair
protein K11-linked ubiquitination
protein monoubiquitination
cellular response to misfolded protein
misfolded or incompletely synthesized protein catabolic process
proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
nucleus
Function
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
catalytic activity
small conjugating protein ligase activity
ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 8
Locus 8q21.11
SNPs UBE2W
Gene Sequence
>489 bp
ATGGCGTCAATGCAGACCACAGGAAGGAGGGTGGAAGTATGGTTTCCAAAACGACTACAG
AAAGAACTGTTGGCTTTGCAAAATGACCCACCTCCTGGAATGACCTTAAATGAGAAGAGT
GTTCAAAATTCAATTACACAGTGGATTGTAGACATGGAAGGTGCACCAGGTACCTTATAT
GAAGGGGAAAAATTTCAACTTCTATTTAAATTTAGTAGTCGATATCCTTTTGACTCTCCT
CAGGTCATGTTTACTGGTGAAAATATTCCTGTTCATCCTCATGTTTATAGCAATGGTCAT
ATCTGTTTATCCATTCTAACAGAAGACTGGTCCCCAGCGCTCTCAGTCCAATCAGTTTGT
CTTAGCATTATTAGCATGCTTTCCAGCTGCAAGGAAAAGAGACGACCACCGGATAATTCT
TTTTATGTGCGAACATGTAACAAGAATCCAAAGAAAACAAAATGGTGGTATCATGATGAT
ACTTGTTGA
Protein Properties
Number of Residues 162
Molecular Weight 22018.2
Theoretical pI 9.148
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ubiquitin-conjugating enzyme 16
MASMQTTGRRVEVWFPKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGAPGTLY
EGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVC
LSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC
GenBank ID Protein 62997235
UniProtKB/Swiss-Prot ID Q96B02
UniProtKB/Swiss-Prot Entry Name Q1XBE0_HUMAN
PDB IDs
GenBank Gene ID AY948289
GeneCard ID UBE2W
GenAtlas ID UBE2W
HGNC ID HGNC:25616
References
General References Not Available