Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 W (CDBP04427)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP04427

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 W

Description

Not Available

Synonyms

SubName: Ubiquitin-conjugating enzyme E2W (Putative), isoform CRA_c
Ubiquitin carrier protein W
Ubiquitin-conjugating enzyme 16
Ubiquitin-protein ligase W
UBC-16

Gene Name

UBE2W

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination.

GO Classification

Biological Process
DNA repair
protein K11-linked ubiquitination
protein monoubiquitination
cellular response to misfolded protein
misfolded or incompletely synthesized protein catabolic process
proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
nucleus
Function
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
catalytic activity
small conjugating protein ligase activity
ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available

Gene Properties

Chromosome Location

Locus

8q21.11

SNPs

UBE2W

Gene Sequence

>489 bp
ATGGCGTCAATGCAGACCACAGGAAGGAGGGTGGAAGTATGGTTTCCAAAACGACTACAG
AAAGAACTGTTGGCTTTGCAAAATGACCCACCTCCTGGAATGACCTTAAATGAGAAGAGT
GTTCAAAATTCAATTACACAGTGGATTGTAGACATGGAAGGTGCACCAGGTACCTTATAT
GAAGGGGAAAAATTTCAACTTCTATTTAAATTTAGTAGTCGATATCCTTTTGACTCTCCT
CAGGTCATGTTTACTGGTGAAAATATTCCTGTTCATCCTCATGTTTATAGCAATGGTCAT
ATCTGTTTATCCATTCTAACAGAAGACTGGTCCCCAGCGCTCTCAGTCCAATCAGTTTGT
CTTAGCATTATTAGCATGCTTTCCAGCTGCAAGGAAAAGAGACGACCACCGGATAATTCT
TTTTATGTGCGAACATGTAACAAGAATCCAAAGAAAACAAAATGGTGGTATCATGATGAT
ACTTGTTGA

Protein Properties

Number of Residues

162

Molecular Weight

22018.2

Theoretical pI

9.148

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme 16
MASMQTTGRRVEVWFPKRLQKELLALQNDPPPGMTLNEKSVQNSITQWIVDMEGAPGTLY
EGEKFQLLFKFSSRYPFDSPQVMFTGENIPVHPHVYSNGHICLSILTEDWSPALSVQSVC
LSIISMLSSCKEKRRPPDNSFYVRTCNKNPKKTKWWYHDDTC

External Links

GenBank ID Protein

62997235

UniProtKB/Swiss-Prot ID

Q96B02

UniProtKB/Swiss-Prot Entry Name

Q1XBE0_HUMAN

PDB IDs