Identification
HMDB Protein ID CDBP04418
Secondary Accession Numbers Not Available
Name CCR4-NOT transcription complex subunit 4
Description Not Available
Synonyms
  1. CCR4-associated factor 4
  2. E3 ubiquitin-protein ligase CNOT4
  3. Potential transcriptional repressor NOT4Hp
Gene Name CNOT4
Protein Type Enzyme
Biological Properties
General Function Involved in nucleotide binding
Specific Function Has E3 ubiquitin ligase activity. The CCR4-NOT complex functions as general transcription regulation complex
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
nucleotide binding
transition metal ion binding
zinc ion binding
protein binding
nucleic acid binding
Cellular Location
  1. Cytoplasm (Probable)
  2. Nucleus (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:7
Locus 7q22-qter
SNPs CNOT4
Gene Sequence
>1728 bp
ATGTCTCGCAGTCCTGATGCGAAGGAAGACCCTGTGGAGTGCCCTCTTTGCATGGAGCCC
TTGGAGATAGATGATATCAACTTTTTCCCTTGCACCTGTGGCTACCAGATTTGCCGATTT
TGTTGGCATCGAATTCGCACTGATGAAAATGGGCTTTGTCCTGCATGTAGAAAGCCATAT
CCAGAAGACCCAGCAGTTTATAAACCACTCTCCCAGGAAGAGCTGCAAAGGATAAAGAAT
GAGAAAAAACAGAAACAAAATGAGAGAAAACAGAAAATATCAGAAAATCGCAAACATTTG
GCTAGTGTACGTGTCGTACAAAAAAACCTCGTCTTTGTTGTAGGTTTATCTCAGCGCCTA
GCAGACCCAGAGGTTTTAAAACGACCAGAATATTTTGGGAAGTTTGGTAAAATACATAAA
GTTGTCATCAATAATAGCACATCATATGCAGGCTCACAGGGTCCAAGTGCCAGTGCTTAT
GTAACCTATATCCGGTCAGAAGACGCTCTCAGAGCCATACAGTGTGTCAACAATGTGGTA
GTAGATGGCAGAACACTTAAGGCATCTCTAGGTACAACAAAATACTGCAGTTACTTCTTA
AAGAATATGCAGTGTCCAAAACCTGACTGCATGTATCTTCATGAATTGGGGGATGAGGCG
GCCAGCTTCACAAAAGAGGAAATGCAGGCGGGTAAACACCAAGAATATGAACAGAAGCTA
CTTCAAGAATTATATAAATTAAATCCCAATTTTCTTCAGCTATCTACGGGTTCAGTTGAT
AAAAATAAGAACAAAGTGACACCACTGCAGAGGTACGATACCCCCATTGACAAACCTTCA
GATTCTCTCAGTATAGGGAACGGTGATAATTCCCAGCAGATATCTAACAGTGATACGCCT
TCACCACCACCTGGTTTGTCAAAATCCAATCCAGTCATCCCCATCAGTTCATCCAATCAC
AGTGCACGGTCCCCTTTTGAAGGGGCAGTAACAGAGTCACAGTCGTTATTCTCAGACAAT
TTTCGCCATCCCAACCCTATCCCAAGTGGGCTTCCTCCTTTCCCCAGCTCCCCACAGACA
TCCAGTGACTGGCCTACAGCACCAGAACCACAGAGCCTCTTCACATCAGAAACAATCCCA
GTATCATCCTCTACAGACTGGCAAGCAGCTTTTGGCTTTGGTTCTTCTAAACAACCAGAG
GATGACTTGGGTTTTGATCCCTTCGATGTCACTCGAAAAGCCTTAGCAGACCTGATTGAG
AAGGAACTGTCCGTTCAAGACCAACCTTCCCTTTCGCCCACATCTCTTCAGAACTCCTCT
TCACACACTACAACCGCCAAAGGTCCAGGCTCTGGATTCCTGCATCCTGCTGCAGCTACA
AATGCCAATTCTCTCAATAGTACCTTTTCAGTCTTGCCCCAGAGGTTCCCTCAATTTCAG
CAGCACCGAGCGGTTTATAATTCATTCAGTTTTCCAGGCCAGGCAGCCCGCTATCCTTGG
ATGGCCTTTCCACGCAATAGCATCATGCACTTGAACCACACAGCAAACCCCACCTCAAAT
AGTAATTTCTTGGACTTGAATCTCCCGCCACAGCACAACACAGGTCTGGGAGGGATCCCT
GTAGCAGGGGAAGAAGAGGTGAAGGTTTCGACCATGCCACTGTCAACCTCTTCCCATTCA
TTACAACAAGGACAGCAGCCTACAAGTCTCCACACTACTGTGGCCTGA
Protein Properties
Number of Residues 575
Molecular Weight 63509.5
Theoretical pI 7.04
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>CCR4-NOT transcription complex subunit 4
MSRSPDAKEDPVECPLCMEPLEIDDINFFPCTCGYQICRFCWHRIRTDENGLCPACRKPY
PEDPAVYKPLSQEELQRIKNEKKQKQNERKQKISENRKHLASVRVVQKNLVFVVGLSQRL
ADPEVLKRPEYFGKFGKIHKVVINNSTSYAGSQGPSASAYVTYIRSEDALRAIQCVNNVV
VDGRTLKASLGTTKYCSYFLKNMQCPKPDCMYLHELGDEAASFTKEEMQAGKHQEYEQKL
LQELYKLNPNFLQLSTGSVDKNKNKVTPLQRYDTPIDKPSDSLSIGNGDNSQQISNSDTP
SPPPGLSKSNPVIPISSSNHSARSPFEGAVTESQSLFSDNFRHPNPIPSGLPPFPSSPQT
SSDWPTAPEPQSLFTSETIPVSSSTDWQAAFGFGSSKQPEDDLGFDPFDVTRKALADLIE
KELSVQDQPSLSPTSLQNSSSHTTTAKGPGSGFLHPAAATNANSLNSTFSVLPQRFPQFQ
QHRAVYNSFSFPGQAARYPWMAFPRNSIMHLNHTANPTSNSNFLDLNLPPQHNTGLGGIP
VAGEEEVKVSTMPLSTSSHSLQQGQQPTSLHTTVA
GenBank ID Protein 300069013
UniProtKB/Swiss-Prot ID O95628
UniProtKB/Swiss-Prot Entry Name CNOT4_HUMAN
PDB IDs
GenBank Gene ID NM_001190848.1
GeneCard ID CNOT4
GenAtlas ID CNOT4
HGNC ID HGNC:7880
References
General References Not Available