| Identification |
|---|
| HMDB Protein ID
| CDBP05115 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase RNF138 |
| Description
| Not Available |
| Synonyms
|
- NLK-associated RING finger protein
- Nemo-like kinase-associated RING finger protein
- RING finger protein 138
- hNARF
|
| Gene Name
| RNF138 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase. Together with NLK, involved in the ubiquitination and degradation of TCF/LEF. Also exhibits auto-ubiquitination activity in combination with UBE2K. May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.1 |
| SNPs
| RNF138 |
| Gene Sequence
|
>738 bp
ATGGCCGAGGACCTCTCTGCGGCCACGTCCTACACCGAAGATGATTTCTACTGCCCCGTC
TGTCAGGAGGTGCTCAAAACGCCCGTGCGGACCACGGCCTGTCAGCACGTTTTCTGTAGA
AAATGTTTCCTGACTGCAATGAGGGAAAGCGGAGCACATTGTCCCCTATGTCGTGGAAAT
GTGACTAGAAGAGAGAGAGCATGTCCTGAACGGGCCTTAGACCTTGAAAATATAATGAGG
AAGTTTTCTGGTAGCTGCAGATGCTGTGCAAAACAGATTAAATTCTATCGCATGAGACAT
CATTACAAATCTTGTAAGAAGTATCAGGATGAATATGGTGTTTCTTCTATCGTTCCAAAC
TTTCAGATCTCTCAAGATTCAGTAGGGAACAGCAATAGGAGTGAAACATCCACATCTGAT
AACACAGAAACTTACCAAGAGAATACAAGTTCTTCTGGTCATCCTACTTTTAAGTGTCCC
CTGTGTCAAGAATCAAATTTTACCAGACAGCGTTTACTGGATCACTGTAACAGTAATCAC
CTATTTCAGATAGTTCCTGTGACATGTCCTATTTGTGTGTCTCTTCCTTGGGGAGATCCT
AGCCAGATTACCAGAAATTTCGTTAGTCATCTAAATCAGAGACGTCAATTTGATTATGGA
GAATTTGTGAATCTTCAGCTAGATGAAGAAACCCAATACCAAACTGCTGTTGAAGAATCT
TTTCAAGTAAACATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 245 |
| Molecular Weight
| 28192.4 |
| Theoretical pI
| 6.93 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase RNF138
MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLTAMRESGAHCPLCRGN
VTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSCKKYQDEYGVSSIIPN
FQISQDSVGNSNRSETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNH
LFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEES
FQVNI
|
| External Links |
|---|
| GenBank ID Protein
| 6468773 |
| UniProtKB/Swiss-Prot ID
| Q8WVD3 |
| UniProtKB/Swiss-Prot Entry Name
| RN138_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF162680 |
| GeneCard ID
| RNF138 |
| GenAtlas ID
| RNF138 |
| HGNC ID
| HGNC:17765 |
| References |
|---|
| General References
| Not Available |