Identification |
HMDB Protein ID
| CDBP02385 |
Secondary Accession Numbers
| Not Available |
Name
| Methionine adenosyltransferase 2 subunit beta |
Description
| Not Available |
Synonyms
|
- DTDP-4-keto-6-deoxy-D-glucose 4-reductase
- MAT II beta
- Methionine adenosyltransferase II beta
- Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase
|
Gene Name
| MAT2B |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in dTDP-4-dehydrorhamnose reductase activity |
Specific Function
| Non-catalytic regulatory subunit of S-adenosylmethionine synthetase 2 (MAT2A), an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates the activity of S-adenosylmethionine synthetase 2 by changing its kinetic properties, rendering the enzyme more susceptible to S-adenosylmethionine inhibition.
|
GO Classification
|
Biological Process |
one-carbon metabolic process |
sulfur amino acid metabolic process |
xenobiotic metabolic process |
extracellular polysaccharide biosynthetic process |
S-adenosylmethionine biosynthetic process |
methylation |
Cellular Component |
cytosol |
mitochondrion |
nucleus |
methionine adenosyltransferase complex |
Function |
binding |
catalytic activity |
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor |
oxidoreductase activity, acting on ch-oh group of donors |
oxidoreductase activity |
dtdp-4-dehydrorhamnose reductase activity |
Molecular Function |
dTDP-4-dehydrorhamnose reductase activity |
methionine adenosyltransferase regulator activity |
nucleotide binding |
Process |
primary metabolic process |
carbohydrate metabolic process |
polysaccharide biosynthetic process |
cellular polysaccharide biosynthetic process |
extracellular polysaccharide biosynthetic process |
polysaccharide metabolic process |
metabolic process |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | S-adenosyl-L-methionine biosynthesis | Not Available | Not Available | Cysteine and methionine metabolism | Not Available | | Selenoamino Acid Metabolism | | | Spermidine and Spermine Biosynthesis | | Not Available | Methionine Metabolism | | |
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| MAT2B |
Gene Sequence
|
>1005 bp
ATGGTGGGGAGGGAGAAAGAACTGTCTATACACTTTGTTCCCGGGAGCTGTCGGCTGGTG
GAGGAGGAAGTTAACATCCCTAATAGGAGGGTTCTGGTTACTGGTGCCACTGGGCTTCTT
GGCAGAGCTGTACACAAAGAATTTCAGCAGAATAATTGGCATGCAGTTGGCTGTGGTTTC
AGAAGAGCAAGACCAAAATTTGAACAGGTTAATCTGTTGGATTCTAATGCAGTTCATCAC
ATCATTCATGATTTTCAGCCCCATGTTATAGTACATTGTGCAGCAGAGAGAAGACCAGAT
GTTGTAGAAAATCAGCCAGATGCTGCCTCTCAACTTAATGTGGATGCTTCTGGGAATTTA
GCAAAGGAAGCAGCTGCTGTTGGAGCATTTCTCATCTACATTAGCTCAGATTATGTATTT
GATGGAACAAATCCACCTTACAGAGAGGAAGACATACCAGCTCCCCTAAATTTGTATGGC
AAAACAAAATTAGATGGAGAAAAGGCTGTCCTGGAGAACAATCTAGGAGCTGCTGTTTTG
AGGATTCCTATTCTGTATGGGGAAGTTGAAAAGCTCGAAGAAAGTGCTGTGACTGTTATG
TTTGATAAAGTGCAGTTCAGCAACAAGTCAGCAAACATGGATCACTGGCAGCAGAGGTTC
CCCACACATGTCAAAGATGTGGCCACTGTGTGCCGGCAGCTAGCAGAGAAGAGAATGCTG
GATCCATCAATTAAGGGAACCTTTCACTGGTCTGGCAATGAACAGATGACTAAGTATGAA
ATGGCATGTGCAATTGCAGATGCCTTCAACCTCCCCAGCAGTCACTTAAGACCTATTACT
GACAGCCCTGTCCTAGGAGCACAACGTCCGAGAAATGCTCAGCTTGACTGCTCCAAATTG
GAGACCTTGGGCATTGGCCAACGAACACCATTTCGAATTGGAATCAAAGAATCACTTTGG
CCTTTCCTCATTGACAAGAGATGGAGACAAACGGTCTTTCATTAG
|
Protein Properties |
Number of Residues
| 334 |
Molecular Weight
| Not Available |
Theoretical pI
| Not Available |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Methionine adenosyltransferase 2 subunit beta
MVGREKELSIHFVPGSCRLVEEEVNIPNRRVLVTGATGLLGRAVHKEFQQNNWHAVGCGF
RRARPKFEQVNLLDSNAVHHIIHDFQPHVIVHCAAERRPDVVENQPDAASQLNVDASGNL
AKEAAAVGAFLIYISSDYVFDGTNPPYREEDIPAPLNLYGKTKLDGEKAVLENNLGAAVL
RIPILYGEVEKLEESAVTVMFDKVQFSNKSANMDHWQQRFPTHVKDVATVCRQLAEKRML
DPSIKGTFHWSGNEQMTKYEMACAIADAFNLPSSHLRPITDSPVLGAQRPRNAQLDCSKL
ETLGIGQRTPFRIGIKESLWPFLIDKRWRQTVFH
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9NZL9 |
UniProtKB/Swiss-Prot Entry Name
| MAT2B_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| AF182814 |
GeneCard ID
| MAT2B |
GenAtlas ID
| MAT2B |
HGNC ID
| HGNC:6905 |
References |
General References
| Not Available |