| Identification |
|---|
| HMDB Protein ID
| CDBP00569 |
| Secondary Accession Numbers
| Not Available |
| Name
| RNA 3'-terminal phosphate cyclase |
| Description
| Not Available |
| Synonyms
|
- RNA cyclase
- RNA terminal phosphate cyclase domain-containing protein 1
- RNA-3'-phosphate cyclase
- RTC domain-containing protein 1
|
| Gene Name
| RTCA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ligase activity, forming phosphoric ester bonds |
| Specific Function
| Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.
|
| GO Classification
|
| Biological Process |
| RNA processing |
| Cellular Component |
| nucleoplasm |
| Function |
| catalytic activity |
| ligase activity |
| ligase activity, forming phosphoric ester bonds |
| cyclase activity |
| rna-3'-phosphate cyclase activity |
| Molecular Function |
| RNA-3'-phosphate cyclase activity |
| ATP binding |
| RNA binding |
| Process |
| rna metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| rna processing |
|
| Cellular Location
|
- Nucleus
- nucleoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p21.2 |
| SNPs
| RTCD1 |
| Gene Sequence
|
>1101 bp
ATGGCGGGGCCGCGGGTGGAGGTCGATGGCAGCATCATGGAAGGGGGCGGCCAGATCCTG
AGAGTCTCTACGGCCTTGAGCTGTCTCCTAGGCCTCCCCTTGCGGGTGCAGAAGATCCGA
GCCGGCCGGAGCACGCCAGGCCTGAGGCCTCAACATTTATCTGGACTGGAAATGATTCGA
GATTTGTGTGATGGGCAACTGGAGGGGGCAGAAATTGGCTCAACAGAAATAACCTTTACA
CCAGAGAAGATCAAAGGTGGAATCCACACAGCAGATACCAAGACAGCAGGGAGTGTGTGC
CTCTTGATGCAGGTCTCAATGCCGTGTGTTCTCTTTGCTGCTTCTCCATCAGAACTTCAT
TTGAAAGGTGGAACTAATGCTGAAATGGCACCACAGATCGATTATACAGTGATGGTCTTC
AAGCCAATTGTTGAAAAATTTGGTTTCATATTTAATTGTGACATTAAAACAAGGGGATAT
TACCCAAAAGGGGGTGGTGAAGTGATTGTTCGAATGTCACCAGTTAAACAATTGAACCCT
ATAAATTTAACTGAGCGTGGCTGTGTGACTAAGATATATGGAAGAGCTTTCGTTGCTGGT
GTTTTGCCATTTAAAGTAGCAAAAGATATGGCAGCGGCAGCAGTTAGATGCATCAGAAAG
GAGATCCGGGATTTGTATGTTAACATCCAGCCTGTTCAAGAACCTAAAGACCAAGCATTT
GGCAATGGAAATGGAATAATAATTATTGCTGAGACCTCCACTGGCTGTTTGTTTGCTGGA
TCATCGCTTGGTAAACGAGGTGTAAATGCAGACAAAGTTGGAATTGAAGCTGCCGAAATG
CTATTAGCAAATCTTAGACATGGTGGTACTGTGGATGAGTATCTGCAAGACCAGCTGATT
GTTTTCATGGCATTAGCCAATGGAGTTTCCAGAATAAAAACAGGACCAGTTACACTCCAT
ACGCAAACCGCGATACATTTTGCTGAACAAATAGCAAAGGCTAAATTTATTGTGAAGAAA
TCAGAAGATGAAGAAGACGCCGCTAAAGATACTTATATTATTGAATGCCAAGGAATTGGG
ATGACAAATCCAAATCTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 366 |
| Molecular Weight
| 40709.05 |
| Theoretical pI
| 8.342 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>RNA 3'-terminal phosphate cyclase
MAGPRVEVDGSIMEGGGQILRVSTALSCLLGLPLRVQKIRAGRSTPGLRPQHLSGLEMIR
DLCDGQLEGAEIGSTEITFTPEKIKGGIHTADTKTAGSVCLLMQVSMPCVLFAASPSELH
LKGGTNAEMAPQIDYTVMVFKPIVEKFGFIFNCDIKTRGYYPKGGGEVIVRMSPVKQLNP
INLTERGCVTKIYGRAFVAGVLPFKVAKDMAAAAVRCIRKEIRDLYVNIQPVQEPKDQAF
GNGNGIIIIAETSTGCLFAGSSLGKRGVNADKVGIEAAEMLLANLRHGGTVDEYLQDQLI
VFMALANGVSRIKTGPVTLHTQTAIHFAEQIAKAKFIVKKSEDEEDAAKDTYIIECQGIG
MTNPNL
|
| External Links |
|---|
| GenBank ID Protein
| 55665043 |
| UniProtKB/Swiss-Prot ID
| O00442 |
| UniProtKB/Swiss-Prot Entry Name
| RTC1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL445928 |
| GeneCard ID
| RTCD1 |
| GenAtlas ID
| RTCD1 |
| HGNC ID
| HGNC:17981 |
| References |
|---|
| General References
| Not Available |