Identification |
HMDB Protein ID
| CDBP02598 |
Secondary Accession Numbers
| Not Available |
Name
| Probable arginine--tRNA ligase, mitochondrial |
Description
| Not Available |
Synonyms
|
- ArgRS
- Arginine--tRNA ligase
- Arginyl-tRNA synthetase-like
- Arginyl-tRNA synthetase
|
Gene Name
| RARS2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotide binding |
Specific Function
| Not Available |
GO Classification
|
Biological Process |
tRNA aminoacylation for protein translation |
arginyl-tRNA aminoacylation |
Cellular Component |
mitochondrial matrix |
Component |
cell part |
intracellular part |
cytoplasm |
Function |
ligase activity |
arginine-trna ligase activity |
ligase activity, forming carbon-oxygen bonds |
ligase activity, forming aminoacyl-trna and related compounds |
aminoacyl-trna ligase activity |
binding |
nucleotide binding |
catalytic activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
Molecular Function |
ATP binding |
arginine-tRNA ligase activity |
Process |
macromolecule metabolic process |
cellular macromolecule metabolic process |
arginyl-trna aminoacylation |
biosynthetic process |
rna metabolic process |
ncrna metabolic process |
trna metabolic process |
trna aminoacylation |
trna aminoacylation for protein translation |
macromolecule biosynthetic process |
cellular macromolecule biosynthetic process |
translation |
metabolic process |
|
Cellular Location
|
- Mitochondrion matrix
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Arginine and Proline Metabolism | | | Aminoacyl-tRNA biosynthesis | Not Available | | Prolidase Deficiency (PD) | | Not Available | Arginine: Glycine Amidinotransferase Deficiency (AGAT Deficiency) | | Not Available | Hyperprolinemia Type II | | Not Available |
|
Gene Properties |
Chromosome Location
| 6 |
Locus
| 6q16.1 |
SNPs
| RARS2 |
Gene Sequence
|
>1737 bp
ATGGCGTGCGGCTTTCGCCGCGCTATTGCTTGCCAGCTTTCCAGAGTGTTGAATCTTCCA
CCAGAAAACTTGATCACATCAATATCTGCAGTTCCAATTTCCCAAAAAGAAGAAGTAGCT
GATTTTCAGCTTTCTGTGGATCCTTTATTGGAAAAAGACAATGACCATTCAAGACCAGAT
ATTCAAGTTCAAGCCAAGAGACTAGCAGAGAAGCTAAGATGTGATACAGTGGTGAGTGAA
ATCAGTACTGGTCAAAGGACTGTAAATTTCAAAATAAACAGAGAGCTCTTAACAAAGACA
GTGCTACAACAAGTAATTGAAGATGGCTCAAAATATGGATTAAAAAGTGAACTTTTCTCT
GGACTTCCCCAGAAGAAGATTGTGGTTGAATTCAGTTCACCTAATGTTGCCAAAAAATTT
CATGTTGGACATTTGCGTTCTACCGTCATAGGAAATTTTATAGCAAATCTCAAAGAAGCT
TTAGGACATCAAGTAATAAGAATAAATTACCTTGGCGATTGGGGCATGCAGTTTGGTCTT
CTGGGAACTGGCTTCCAGCTGTTTGGCTATGAGGAAAAACTGCAGTCCAATCCTCTACAG
CATCTCTTTGAAGTTTATGTACAAGTTAATAAAGAAGCAGCGGATGATAAAAGTGTAGCA
AAAGCAGCACAGGAGTTCTTCCAACGATTGGAACTGGGCGATGTGCAAGCACTTTCACTG
TGGCAAAAATTTCGGGACTTGAGCATTGAAGAGTACATTCGGGTTTACAAGCGTCTGGGA
GTATATTTTGATGAATATTCAGGAGAATCATTTTATCGTGAAAAATCTCAAGAGGTCTTA
AAGTTGCTGGAGAGTAAAGGACTCCTACTGAAAACAATAAAAGGAACGGCTGTAGTAGAT
CTCTCTGGGAATGGCGACCCCTCCTCAATTTGTACTGTAATGCGAAGTGATGGGACTTCT
CTCTATGCAACCAGAGATCTTGCAGCTGCTGTAGATCGAATGGACAAGTATAATTTTGAT
ACAATGATATATGTGACAGATAAAGGACAAAAAAAGCATTTTCAGCAAGTATTCCAAATG
CTGAAGATCATGGGATATGACTGGGCAGAAAGGTGCCAGCACGTGCCCTTTGGAGTAGTA
CAGGGAATGAAGACTCGAAGAGGAGATGTCACTTTCCTGGAAGATGTTTTAAATGAGATT
CAATTAAGGATGCTACAGAACATGGCTTCAATTAAGACAACTAAAGAACTCAAGAACCCA
CAAGAGACTGCAGAGAGGGTCGGGCTCGCAGCACTCATTATTCAGGACTTCAAAGGTTTA
CTCTTATCTGACTACAAGTTCAGCTGGGATCGTGTTTTCCAGAGTCGCGGGGACACAGGA
GTCTTCCTACAGTACACACACGCCCGCCTCCACAGTTTGGAAGAGACTTTTGGATGTGGG
TACCTGAATGACTTCAACACTGCTTGTTTACAAGAGCCACAGTCTGTTTCAATTCTTCAG
CATCTTCTCAGGTTCGACGAGGTGCTTTATAAATCATCTCAGGACTTTCAACCCAGGCAT
ATCGTCAGTTACCTTCTAACTTTAAGTCATCTTGCAGCTGTGGCACACAAAACACTACAA
ATAAAAGATAGTCCTCCTGAAGTGGCTGGGGCCAGACTTCATCTTTTCAAAGCTGTCCGT
TCTGTCCTAGCCAATGGAATGAAACTTCTTGGAATAACACCTGTATGTAGGATGTAA
|
Protein Properties |
Number of Residues
| 578 |
Molecular Weight
| 65504.855 |
Theoretical pI
| 8.212 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Probable arginyl-tRNA synthetase, mitochondrial
MACGFRRAIACQLSRVLNLPPENLITSISAVPISQKEEVADFQLSVDSLLEKDNDHSRPD
IQVQAKRLAEKLRCDTVVSEISTGQRTVNFKINRELLTKTVLQQVIEDGSKYGLKSELFS
GLPQKKIVVEFSSPNVAKKFHVGHLRSTIIGNFIANLKEALGHQVIRINYLGDWGMQFGL
LGTGFQLFGYEEKLQSNPLQHLFEVYVQVNKEAADDKSVAKAAQEFFQRLELGDVQALSL
WQKFRDLSIEEYIRVYKRLGVYFDEYSGESFYREKSQEVLKLLESKGLLLKTIKGTAVVD
LSGNGDPSSICTVMRSDGTSLYATRDLAAAIDRMDKYNFDTMIYVTDKGQKKHFQQVFQM
LKIMGYDWAERCQHVPFGVVQGMKTRRGDVTFLEDVLNEIQLRMLQNMASIKTTKELKNP
QETAERVGLAALIIQDFKGLLLSDYKFSWDRVFQSRGDTGVFLQYTHARLHSLEETFGCG
YLNDFNTACLQEPQSVSILQHLLRFDEVLYKSSQDFQPRHIVSYLLTLSHLAAVAHKTLQ
IKDSPPEVAGARLHLFKAVRSVLANGMKLLGITPVCRM
|
External Links |
GenBank ID Protein
| 10435519 |
UniProtKB/Swiss-Prot ID
| Q5T160 |
UniProtKB/Swiss-Prot Entry Name
| SYRM_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AK023550 |
GeneCard ID
| RARS2 |
GenAtlas ID
| RARS2 |
HGNC ID
| HGNC:21406 |
References |
General References
| Not Available |