Cannabis Compound Database: Showing Protein Poly(A) polymerase alpha (CDBP01012)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP01012

Secondary Accession Numbers

Not Available

Name

Poly(A) polymerase alpha

Description

Not Available

Synonyms

PAP-alpha
Polynucleotide adenylyltransferase alpha

Gene Name

PAPOLA

Protein Type

Enzyme

Biological Properties

General Function

Involved in nucleotidyltransferase activity

Specific Function

Polymerase that creates the 3'-poly(A) tail of mRNA's. Also required for the endoribonucleolytic cleavage reaction at some polyadenylation sites. May acquire specificity through interaction with a cleavage and polyadenylation specificity factor (CPSF) at its C-terminus.

GO Classification

Biological Process
mRNA splicing, via spliceosome
mRNA polyadenylation
termination of RNA polymerase II transcription
Cellular Component
cytoplasm
nucleoplasm
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
adenylyltransferase activity
nucleic acid binding
polynucleotide adenylyltransferase activity
rna binding
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
Molecular Function
manganese ion binding
magnesium ion binding
ATP binding
RNA binding
polynucleotide adenylyltransferase activity
Process
biosynthetic process
rna polyadenylation
transcription
rna 3'-end processing
rna metabolic process
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing

Cellular Location

Nucleus
Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
mRNA surveillance pathway	Not Available

Gene Properties

Chromosome Location

Locus

14q32.31

SNPs

PAPOLA

Gene Sequence

>2238 bp
ATGCCGTTTCCAGTTACAACACAGGGATCACAACAAACACAACCGCCACAGAAGCACTAT
GGCATTACTTCTCCTATCAGCTTAGCAGCCCCCAAGGAGACTGACTGCGTACTTACACAG
AAACTAATTGAGACATTGAAACCCTTTGGGGTTTTTGAAGAGGAAGAGGAACTGCAGCGC
AGGATTTTAATTTTGGGAAAACTAAATAACCTGGTAAAAGAGTGGATACGAGAAATCAGT
GAAAGCAAGAATCTTCCACAATCTGTAATTGAAAATGTTGGAGGAAAAATTTTTACATTT
GGATCTTACAGATTAGGAGTGCATACAAAAGGTGCTGATATTGATGCGTTGTGTGTTGCA
CCAAGACATGTTGATCGAAGTGACTTTTTCACCTCATTCTATGATAAGTTGAAATTACAG
GAAGAAGTAAAAGATTTAAGAGCTGTTGAAGAGGCATTCGTACCAGTTATTAAACTCTGT
TTTGATGGGATAGAGATTGATATTTTGTTTGCAAGATTAGCACTGCAGACAATTCCTGAA
GATTTGGATCTACGAGATGACAGTCTGCTAAAAAATTTAGATATAAGATGTATAAGAAGT
CTTAACGGTTGCAGGGTAACCGATGAAATTTTACATCTAGTACCAAACATTGACAACTTC
AGGTTAACTCTGAGAGCTATCAAACTATGGGCCAAACGCCACAACATCTATTCCAATATA
TTAGGTTTCCTCGGTGGTGTTTCCTGGGCTATGCTAGTAGCAAGAACTTGCCAGCTTTAT
CCAAATGCAATAGCATCAACTCTTGTACATAAATTTTTCTTGGTATTTTCTAAATGGGAA
TGGCCAAATCCAGTGCTATTGAAACAGCCTGAAGAATGCAATCTTAATTTGCCTGTATGG
GACCCAAGGGTAAACCCCAGTGATAGGTACCATCTTATGCCTATAATTACACCAGCATAC
CCACAACAGAACTCCACGTACAATGTGTCCGTTTCAACACGGATGGTCATGGTTGAGGAG
TTTAAACAAGGTCTTGCTATCACAGATGAAATTTTGCTGAGTAAGGCAGAGTGGTCCAAA
CTTTTTGAAGCTCCAAACTTCTTTCAAAAGTACAAGCATTATATTGTACTTCTAGCAAGT
GCACCAACAGAAAAACAACGCCTGGAATGGGTGGGCTTGGTGGAATCAAAAATCCGAATC
CTGGTTGGAAGCTTGGAGAAGAATGAATTTATTACACTGGCTCATGTGAATCCCCAGTCA
TTTCCAGCACCCAAAGAAAATCCCGACAAGGAAGAATTTCGCACGATGTGGGTGATTGGG
TTAGTGTTTAAAAAAACAGAAAACTCTGAAAACCTCAGTGTTGATCTCACCTATGATATT
CAGTCTTTCACAGATACAGTTTATAGGCAAGCAATAAACAGCAAGATGTTTGAGGTGGAT
ATGAAAATTGCTGCAATGCATGTAAAAAGAAAGCAACTCCATCAACTACTACCTAATCAT
GTGCTTCAGAAAAAGAAAAAGCATTCAACAGAAGGTGTCAAATTGACAGCTCTCAATGAC
AGCAGCCTCGACTTGTCTATGGACAGTGATAACAGCATGTCTGTGCCTTCACCTACTAGT
GCTACGAAGACCAGTCCATTGAACAGTTCTGGCAGCTCTCAGGGCAGAAACAGTCCTGCT
CCAGCTGTAACAGCAGCATCTGTGACCAACATACAGGCTACTGAAGTTTCTGTGCCACAA
GTAAATTCCAGTGAAAGCTCAGGGGGTACATCGAGTGAAAGCATTCCTCAAACTGCCACA
CAACCAGCCATTTCTCCACCACCAAAGCCTACGGTCTCCAGAGTTGTTTCTTCAACACGT
CTGGTAAACCCACCACCTAGATCTTCAGGAAATGCAGCAACTTCAGGAAATGCAGCAACA
AAAATACCTACTCCTATAGTAGGAGTCAAGAGGACATCCTCACCTCATAAAGAAGAGAGT
CCCAAGAAAACCAAAACAGAAGAGGATGAAACAAGTGAAGATGCTAACTGTCTTGCTTTG
AGTGGACATGATAAAACAGAAGCAAAGGAACAACTTGATACAGAGACAAGTACAACTCAA
TCAGAAACTATTCAGACAGCGGCTTCTCTGTTGGCCTCTCAGAAAACATCCAGTACAGAC
CTTTCTGATATCCCTGCTCTCCCTGCAAATCCTATTCCTGTTATCAAGAATTCAATAAAA
CTGAGATTGAATCGGTAA

Protein Properties

Number of Residues

745

Molecular Weight

32625.6

Theoretical pI

7.728

Pfam Domain Function

NTP_transf_2 (PF01909 )
PAP_central; (PF04928 )
PAP_RNA-bind (PF04926 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Poly(A) polymerase alpha
MPFPVTTQGSQQTQPPQKHYGITSPISLAAPKETDCVLTQKLIETLKPFGVFEEEEELQR
RILILGKLNNLVKEWIREISESKNLPQSVIENVGGKIFTFGSYRLGVHTKGADIDALCVA
PRHVDRSDFFTSFYDKLKLQEEVKDLRAVEEAFVPVIKLCFDGIEIDILFARLALQTIPE
DLDLRDDSLLKNLDIRCIRSLNGCRVTDEILHLVPNIDNFRLTLRAIKLWAKRHNIYSNI
LGFLGGVSWAMLVARTCQLYPNAIASTLVHKFFLVFSKWEWPNPVLLKQPEECNLNLPVW
DPRVNPSDRYHLMPIITPAYPQQNSTYNVSVSTRMVMVEEFKQGLAITDEILLSKAEWSK
LFEAPNFFQKYKHYIVLLASAPTEKQRLEWVGLVESKIRILVGSLEKNEFITLAHVNPQS
FPAPKENPDKEEFRTMWVIGLVFKKTENSENLSVDLTYDIQSFTDTVYRQAINSKMFEVD
MKIAAMHVKRKQLHQLLPNHVLQKKKKHSTEGVKLTALNDSSLDLSMDSDNSMSVPSPTS
ATKTSPLNSSGSSQGRNSPAPAVTAASVTNIQATEVSVPQVNSSESSGGTSSESIPQTAT
QPAISPPPKPTVSRVVSSTRLVNPPPRSSGNAATSGNAATKIPTPIVGVKRTSSPHKEES
PKKTKTEEDETSEDANCLALSGHDKTEAKEQLDTETSTTQSETIQTAASLLASQKTSSTD
LSDIPALPANPIPVIKNSIKLRLNR

External Links

GenBank ID Protein

32490557

UniProtKB/Swiss-Prot ID

P51003

UniProtKB/Swiss-Prot Entry Name

PAPOA_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_032632.3

GeneCard ID