| Identification |
|---|
| HMDB Protein ID
| CDBP02400 |
| Secondary Accession Numbers
| Not Available |
| Name
| Acetoacetyl-CoA synthetase |
| Description
| Not Available |
| Synonyms
|
- Acyl-CoA synthetase family member 1
- Protein sur-5 homolog
|
| Gene Name
| AACS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acetoacetate-CoA ligase activity |
| Specific Function
| Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).
|
| GO Classification
|
| Biological Process |
| response to oleic acid |
| response to purine-containing compound |
| response to starvation |
| white fat cell differentiation |
| adipose tissue development |
| cellular response to cholesterol |
| cellular response to glucose stimulus |
| cellular response to testosterone stimulus |
| fatty acid metabolic process |
| liver development |
| positive regulation of insulin secretion |
| response to drug |
| response to ethanol |
| response to nutrient |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| ligase activity |
| ligase activity, forming carbon-sulfur bonds |
| acid-thiol ligase activity |
| acetoacetate-coa ligase activity |
| Molecular Function |
| acetoacetate-CoA ligase activity |
| ATP binding |
| butyrate-CoA ligase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
|
| Cellular Location
|
- Cytoplasm
- cytosol
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Butanoate metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 12 |
| Locus
| 12q24.31 |
| SNPs
| AACS |
| Gene Sequence
|
>2019 bp
ATGTCCAAGGAGGAGCGCCCCGGTCGGGAGGAGATCCTGGAGTGCCAGGTGATGTGGGAG
CCTGACAGTAAGAAGAACACGCAGATGGACCGCTTCCGGGCGGCTGTGGGCGCCGCCTGC
GGCCTGGCGCTGGAGAGTTATGATGACTTGTACCATTGGTCCGTTGAGTCATATTCAGAC
TTCTGGGCAGAGTTCTGGAAATTCAGTGGAATTGTCTTCTCACGTGTGTATGATGAGGTT
GTGGACACATCGAAAGGAATCGCAGATGTCCCCGAGTGGTTCAAAGGCAGTCGGCTCAAC
TATGCAGAAAACCTCCTGCGGCACAAAGAGAATGACAGAGTTGCCCTTTACATTGCAAGG
GAAGGCAAAGAGGAAATTGTGAAGGTGACTTTTGAAGAGCTGAGGCAAGAAGTGGCTTTG
TTTGCAGCAGCAATGAGGAAAATGGGTGTGAAGAAAGGAGATCGGGTTGTTGGTTATTTA
CCCAACAGTGAGCACGCTGTCGAGGCGATGCTGGCTGCGGCAAGCATTGGTGCCATCTGG
AGCTCCACGTCCCCGGACTTCGGTGTGAATGGTGTGCTGGACCGGTTTTCTCAAATTCAG
CCAAAGCTCATCTTCTCTGTGGAGGCTGTTGTCTATAATGGCAAAGAGCACAACCACATG
GAAAAGCTGCAGCAGGTGGTTAAAGGCCTACCAGACTTGAAGAAAGTGGTGGTGATTCCT
TATGTGTCCTCCAGAGAGAACATAGACCTTTCAAAGATTCCAAACAGTGTGTTTCTGGAT
GACTTTCTTGCCACCGGCACCAGTGAGCAGGCCCCGCAGCTGGAGTTCGAGCAGCTGCCC
TTCAGCCACCCACTGTTCATCATGTTCTCATCGGGCACCACGGGCGCACCCAAGTGCATG
GTGCATTCCGCTGGGGGCACCCTCATCCAGCATCTGAAGGAGCACCTGCTGCACGGCAAC
ATGACCAGCAGTGACATCCTCCTGTGCTACACCACGGTCGGCTGGATGATGTGGAACTGG
ATGGTGTCCCTTCTGGCCACAGGAGCGGCCATGGTCTTGTACGATGGCTCCCCCCTGGTG
CCCACGCCCAATGTGCTCTGGGACCTGGTTGACAGGATAGGCATCACTGTCCTGGTAACT
GGGGCCAAGTGGCTGTCAGTGCTGGAAGAGAAGGCCATGAAGCCGGTGGAAACCCACAGT
CTCCAGATGCTCCACACGATCCTGTCCACTGGCTCCCCACTGAAAGCCCAGAGCTACGAG
TATGTCTACAGGTGCATCAAGAGCAGCATCCTCCTGGGCTCCATCTCAGGAGGCACCGAC
ATCATCTCCTGCTTCATGGGCCACAATTTTTCTCTTCCTGTGTATAAAGGGGAGATTCAG
GCCCGGAACCTGGGCATGGCCGTGGAAGCGTGGAACGAGGAAGGAAAGGCGGTCTGGGGA
GAGAGCGGCGAGCTGGTGTGTACTAAGCCGATCCCTTGCCAGCCCACACACTTCTGGAAC
GATGAGAACGGCAACAAGTACAGGAAGGCGTATTTCTCCAAATTCCCAGGTATCTGGGCT
CATGGCGACTACTGCAGAATCAACCCCAAGACCGGGGGCATCGTCATGCTTGGCCGGAGT
GACGGCACCCTCAACCCCAACGGGGTGCGGTTCGGCAGCTCGGAAATCTATAACATTGTG
GAATCCTTCGAGGAGGTGGAGGACAGCCTGTGTGTCCCCCAGTATAACAAGTACAGGGAG
GAGAGGGTGATCCTCTTCCTGAAGATGGCCTCCGGGCACGCCTTCCAGCCTGACTTGGTT
AAGAGGATCCGTGACGCCATCCGCATGGGCTTGTCTGCGCGACACGTGCCCAGCCTCATC
CTGGAAACCAAGGGCATCCCGTATACGCTCAACGGCAAGAAAGTGGAAGTTGCCGTCAAA
CAGATCATCGCTGGAAAAGCCGTGGAGCAAGGAGGTGCTTTCTCGAACCCCGAGACCCTG
GATCTGTACCGGGACATCCCTGAGCTGCAGGGCTTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 672 |
| Molecular Weight
| 75143.645 |
| Theoretical pI
| 6.244 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Acetoacetyl-CoA synthetase
MSKEERPGREEILECQVMWEPDSKKNTQMDRFRAAVGAACGLALESYDDLYHWSVESYSD
FWAEFWKFSGIVFSRVYDEVVDTSKGIADVPEWFKGSRLNYAENLLRHKENDRVALYIAR
EGKEEIVKVTFEELRQEVALFAAAMRKMGVKKGDRVVGYLPNSEHAVEAMLAAASIGAIW
SSTSPDFGVNGVLDRFSQIQPKLIFSVEAVVYNGKEHNHMEKLQQVVKGLPDLKKVVVIP
YVSSRENIDLSKIPNSVFLDDFLATGTSEQAPQLEFEQLPFSHPLFIMFSSGTTGAPKCM
VHSAGGTLIQHLKEHLLHGNMTSSDILLCYTTVGWMMWNWMVSLLATGAAMVLYDGSPLV
PTPNVLWDLVDRIGITVLVTGAKWLSVLEEKAMKPVETHSLQMLHTILSTGSPLKAQSYE
YVYRCIKSSILLGSISGGTDIISCFMGHNFSLPVYKGEIQARNLGMAVEAWNEEGKAVWG
ESGELVCTKPIPCQPTHFWNDENGNKYRKAYFSKFPGIWAHGDYCRINPKTGGIVMLGRS
DGTLNPNGVRFGSSEIYNIVESFEEVEDSLCVPQYNKYREERVILFLKMASGHAFQPDLV
KRIRDAIRMGLSARHVPSLILETKGIPYTLNGKKVEVAVKQIIAGKAVEQGGAFSNPETL
DLYRDIPELQGF
|
| External Links |
|---|
| GenBank ID Protein
| 48290356 |
| UniProtKB/Swiss-Prot ID
| Q86V21 |
| UniProtKB/Swiss-Prot Entry Name
| AACS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB054121 |
| GeneCard ID
| AACS |
| GenAtlas ID
| AACS |
| HGNC ID
| HGNC:21298 |
| References |
|---|
| General References
| Not Available |