Identification
HMDB Protein ID CDBP01630
Secondary Accession Numbers Not Available
Name Geranylgeranyl transferase type-1 subunit beta
Description Not Available
Synonyms
  1. GGTase-I-beta
  2. Geranylgeranyl transferase type I subunit beta
  3. Type I protein geranyl-geranyltransferase subunit beta
Gene Name PGGT1B
Protein Type Enzyme
Biological Properties
General Function Involved in CAAX-protein geranylgeranyltransferase acti
Specific Function Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.
GO Classification
Biological Process
positive regulation of cell proliferation
response to cytokine stimulus
protein geranylgeranylation
positive regulation of cell cycle
Cellular Component
CAAX-protein geranylgeranyltransferase complex
Function
catalytic activity
Molecular Function
isoprenoid binding
metal ion binding
peptide binding
zinc ion binding
drug binding
CAAX-protein geranylgeranyltransferase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 5
Locus 5q22.3
SNPs PGGT1B
Gene Sequence
>1134 bp
ATGGCGGCCACTGAGGATGAGAGGCTAGCAGGGAGCGGTGAGGGAGAGCGGCTGGATTTC
TTACGGGATCGGCACGTGCGATTTTTCCAGCGCTGCCTCCAGGTTTTGCCGGAGCGCTAT
TCTTCACTCGAGACAAGCAGGTTGACAATTGCATTTTTTGCACTCTCCGGGCTGGATATG
TTGGATTCCTTAGATGTGGTGAACAAAGATGATATAATAGAGTGGATTTATTCCCTGCAG
GTCCTTCCCACAGAAGACAGATCAAATCTAAATCGCTGTGGTTTCCGAGGCTCTTCATAC
CTGGGTATTCCGTTCAATCCATCAAAGGCTCCTGGAACAGCTCATCCTTATGATAGTGGC
CACATTGCAATGACCTACACTGGCCTCTCATGCTTAGTTATTCTTGGAGACGACTTAAGC
CGAGTAAATAAAGAAGCTTGCTTAGCGGGCTTGAGAGCCCTTCAGCTGGAAGATGGGAGT
TTTTGTGCAGTACCTGAAGGCAGTGAAAATGACATGCGATTTGTGTACTGTGCTTCCTGT
ATTTGCTATATGCTCAACAACTGGTCAGGCATGGATATGAAAAAAGCCATCACCTATATT
AGAAGGAGTATGTCCTATGACAATGGACTGGCACAGGGAGCTGGACTTGAATCTCATGGA
GGATCAACTTTTTGTGGCATTGCCTCACTATGTCTGATGGGTAAACTAGAAGAAGTTTTT
TCAGAAAAAGAATTGAACAGGATAAAGAGGTGGTGTATAATGAGGCAACAAAATGGTTAT
CATGGAAGACCTAATAAGCCTGTAGACACCTGTTATTCTTTTTGGGTGGGAGCAACTCTG
AAGCTTCTAAAAATTTTCCAATACACTAACTTTGAGAAAAATAGAAATTACATCTTATCA
ACTCAAGATCGCCTTGTAGGGGGATTTGCCAAGTGGCCAGACAGTCATCCAGATGCTTTG
CATGCATACTTTGGGATCTGTGGCCTGTCACTAATGGAGGAAAGTGGAATTTGTAAAGTT
CATCCTGCTCTGAATGTAAGCACACGGACTTCTGAACGCCTTCTAGATCTCCATCAAAGC
TGGAAAACCAAGGACTCTAAACAATGCTCAGAGAATGTACATATCTCCACATGA
Protein Properties
Number of Residues 377
Molecular Weight 42367.81
Theoretical pI 6.822
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Geranylgeranyl transferase type-1 subunit beta
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
GenBank ID Protein 167860116
UniProtKB/Swiss-Prot ID P53609
UniProtKB/Swiss-Prot Entry Name PGTB1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_005023.3
GeneCard ID PGGT1B
GenAtlas ID Not Available
HGNC ID HGNC:8895
References
General References Not Available