| Identification |
|---|
| HMDB Protein ID
| CDBP01630 |
| Secondary Accession Numbers
| Not Available |
| Name
| Geranylgeranyl transferase type-1 subunit beta |
| Description
| Not Available |
| Synonyms
|
- GGTase-I-beta
- Geranylgeranyl transferase type I subunit beta
- Type I protein geranyl-geranyltransferase subunit beta
|
| Gene Name
| PGGT1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in CAAX-protein geranylgeranyltransferase acti |
| Specific Function
| Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. Acts on the Rac1, Rac2, Rap1A and Rap1B proteins. The beta subunit is responsible for peptide-binding.
|
| GO Classification
|
| Biological Process |
| positive regulation of cell proliferation |
| response to cytokine stimulus |
| protein geranylgeranylation |
| positive regulation of cell cycle |
| Cellular Component |
| CAAX-protein geranylgeranyltransferase complex |
| Function |
| catalytic activity |
| Molecular Function |
| isoprenoid binding |
| metal ion binding |
| peptide binding |
| zinc ion binding |
| drug binding |
| CAAX-protein geranylgeranyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5q22.3 |
| SNPs
| PGGT1B |
| Gene Sequence
|
>1134 bp
ATGGCGGCCACTGAGGATGAGAGGCTAGCAGGGAGCGGTGAGGGAGAGCGGCTGGATTTC
TTACGGGATCGGCACGTGCGATTTTTCCAGCGCTGCCTCCAGGTTTTGCCGGAGCGCTAT
TCTTCACTCGAGACAAGCAGGTTGACAATTGCATTTTTTGCACTCTCCGGGCTGGATATG
TTGGATTCCTTAGATGTGGTGAACAAAGATGATATAATAGAGTGGATTTATTCCCTGCAG
GTCCTTCCCACAGAAGACAGATCAAATCTAAATCGCTGTGGTTTCCGAGGCTCTTCATAC
CTGGGTATTCCGTTCAATCCATCAAAGGCTCCTGGAACAGCTCATCCTTATGATAGTGGC
CACATTGCAATGACCTACACTGGCCTCTCATGCTTAGTTATTCTTGGAGACGACTTAAGC
CGAGTAAATAAAGAAGCTTGCTTAGCGGGCTTGAGAGCCCTTCAGCTGGAAGATGGGAGT
TTTTGTGCAGTACCTGAAGGCAGTGAAAATGACATGCGATTTGTGTACTGTGCTTCCTGT
ATTTGCTATATGCTCAACAACTGGTCAGGCATGGATATGAAAAAAGCCATCACCTATATT
AGAAGGAGTATGTCCTATGACAATGGACTGGCACAGGGAGCTGGACTTGAATCTCATGGA
GGATCAACTTTTTGTGGCATTGCCTCACTATGTCTGATGGGTAAACTAGAAGAAGTTTTT
TCAGAAAAAGAATTGAACAGGATAAAGAGGTGGTGTATAATGAGGCAACAAAATGGTTAT
CATGGAAGACCTAATAAGCCTGTAGACACCTGTTATTCTTTTTGGGTGGGAGCAACTCTG
AAGCTTCTAAAAATTTTCCAATACACTAACTTTGAGAAAAATAGAAATTACATCTTATCA
ACTCAAGATCGCCTTGTAGGGGGATTTGCCAAGTGGCCAGACAGTCATCCAGATGCTTTG
CATGCATACTTTGGGATCTGTGGCCTGTCACTAATGGAGGAAAGTGGAATTTGTAAAGTT
CATCCTGCTCTGAATGTAAGCACACGGACTTCTGAACGCCTTCTAGATCTCCATCAAAGC
TGGAAAACCAAGGACTCTAAACAATGCTCAGAGAATGTACATATCTCCACATGA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 42367.81 |
| Theoretical pI
| 6.822 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Geranylgeranyl transferase type-1 subunit beta
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDM
LDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSG
HIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASC
ICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVF
SEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILS
TQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQS
WKTKDSKQCSENVHIST
|
| External Links |
|---|
| GenBank ID Protein
| 167860116 |
| UniProtKB/Swiss-Prot ID
| P53609 |
| UniProtKB/Swiss-Prot Entry Name
| PGTB1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005023.3 |
| GeneCard ID
| PGGT1B |
| GenAtlas ID
| Not Available |
| HGNC ID
| HGNC:8895 |
| References |
|---|
| General References
| Not Available |