| Identification |
|---|
| HMDB Protein ID
| CDBP04992 |
| Secondary Accession Numbers
| Not Available |
| Name
| Long-chain-fatty-acid--CoA ligase ACSBG2 |
| Description
| Not Available |
| Synonyms
|
- Acyl-CoA synthetase bubblegum family member 2
- Bubblegum-related protein
- PRTD-NY3
|
| Gene Name
| ACSBG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Has increased ability to activate oleic and linoleic acid. May play a role in spermatogenesis.
|
| GO Classification
|
| Biological Process |
| spermatogenesis |
| cell differentiation |
| multicellular organismal development |
| Cellular Component |
| mitochondrion |
| membrane |
| Function |
| catalytic activity |
| Molecular Function |
| acyl-CoA hydrolase activity |
| ATP binding |
| long-chain fatty acid-CoA ligase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | PPAR signaling pathway | Not Available |  | | Adipocytokine signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| 19p13.3 |
| SNPs
| ACSBG2 |
| Gene Sequence
|
>2001 bp
ATGACTGGAACCCCAAAGACTCAAGAAGGAGCTAAAGATCTTGAAGTAGACATGAATAAA
ACAGAAGTTACTCCCAGGCTGTGGACCACCTGTCGAGATGGAGAAGTCCTTCTGAGGCTA
TCCAAACACGGACCAGGCCATGAGACCCCGATGACCATCCCTGAATTTTTTCGAGAGTCA
GTCAACCGATTTGGAACTTATCCAGCCCTCGCATCCAAGAATGGCAAAAAGTGGGAAATT
CTGAATTTCAACCAGTACTATGAGGCTTGTCGGAAGGCTGCAAAATCCTTGATCAAGCTG
GGTTTGGAGCGTTTCCACGGAGTTGGTATCCTGGGGTTTAACTCTGCAGAGTGGTTTATC
ACTGCTGTTGGTGCCATCCTAGCCGGGGGTCTTTGTGTTGGTATTTATGCCACCAACTCT
GCCGAGGCTTGTCAATATGTCATCACTCATGCCAAAGTGAACATCTTGCTGGTTGAGAAT
GATCAACAGTTACAGAAAATCCTTTCGATTCCACAGAGCAGCCTAGAGCCCCTAAAAGCG
ATCATCCAGTACAGACTGCCAATGAAGAAGAACAACAACTTGTACTCTTGGGATGATTTC
ATGGAACTTGGCAGAAGTATCCCTGACACCCAACTGGAGCAGGTCATCGAGAGCCAGAAG
GCGAATCAATGCGCAGTGCTCATCTACACTTCAGGGACCACAGGCATACCCAAGGGAGTG
ATGCTCAGTCATGACAACATCACGTGGATTGCAGGAGCAGTGACAAAGGACTTTAAACTG
ACAGACAAGCATGAGACGGTGGTTAGCTACCTCCCACTCAGCCATATTGCAGCACAGATG
ATGGACATCTGGGTACCCATAAAGATTGGGGCGCTCACATACTTTGCTCAAGCAGATGCT
CTCAAGGGCACCTTGGTAAGTACTCTAAAGGAGGTAAAACCTACTGTCTTCATTGGAGTG
CCTCAAATTTGGGAGAAGATACATGAGATGGTGAAGAAAAATAGTGCCAAGTCCATGGGC
TTGAAGAAGAAGGCATTCGTGTGGGCAAGAAACATTGGCTTCAAGGTCAACTCAAAAAAG
ATGTTGGGGAAATATAATACTCCCGTGAGCTACCGCATGGCTAAGACTCTCGTGTTCAGC
AAAGTCAAGACATCCCTTGGCTTGGATCACTGTCACTCTTTTATCAGTGGGACTGCGCCC
CTCAACCAAGAGACTGCCGAGTTCTTTCTAAGCTTGGACATACCTATAGGCGAGTTGTAT
GGGTTGAGTGAGAGCTCGGGACCCCACACGATATCCAACCAGAATAACTACAGGCTTCTA
AGCTGTGGCAAGATCTTGACTGGGTGTAAGAATATGCTGTTCCAGCAGAACAAGGATGGC
ATTGGGGAGATCTGCCTCTGGGGTAGGCACATCTTCATGGGCTATCTGGAAAGTGAGACT
GAAACTACAGAGGCCATCGATGATGAAGGCTGGCTACACTCTGGGGATCTGGGCCAGCTG
GACGGTCTGGGTTTCCTCTATGTCACCGGCCACATCAAAGAAATCCTTATCACTGCTGGT
GGTGAAAATGTGCCCCCCATTCCTGTTGAGACCTTGGTTAAGAAGAAGATCCCCATCATC
AGTAACGCCATGTTAGTAGGAGATAAACTGAAGTTTCTGAGCATGTTGCTGACGCTGAAG
TGTGAGATGAATCAGATGAGCGGAGAACCTCTGGACAAGCTGAACTTCGAGGCCATCAAC
TTCTGTCGGGGTCTGGGCAGCCAGGCATCCACCGTGACTGAGATGGTGAAGCAGCAAGAC
CCCCTGGTCTACAAGGCCATCCAGCAAGGCATCAATGCTGTGAACCAGGAAGCCATGAAC
AATGCACAGAGGATTGAAAAGTGGGTCATCTTGGAGAAGGACTTTTCCATCTATGGTGGA
GAGCTAGGTCCAATGATGAAACTTAAGAGACATTTTGTAGCCCAGAAATACAAAAAACAA
ATTGATCACATGTACCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 666 |
| Molecular Weight
| 74353.835 |
| Theoretical pI
| 8.461 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Long-chain-fatty-acid--CoA ligase ACSBG2
MTGTPKTQEGAKDLEVDMNKTEVTPRLWTTCRDGEVLLRLSKHGPGHETPMTIPEFFRES
VNRFGTYPALASKNGKKWEILNFNQYYEACRKAAKSLIKLGLERFHGVGILGFNSAEWFI
TAVGAILAGGLCVGIYATNSAEVCQYVITHAKVNILLVENDQQLQKILSIPQSSLEPLKA
IIQYRLPMKKNNNLYSWDDFMELGRSIPDTQLEQVIESQKANQCAVLIYTSGTTGIPKGV
MLSHDNITWIAGAVTKDFKLTDKHETVVSYLPLSHIAAQMMDIWVPIKIGALTYFAQADA
LKGTLVSTLKEVKPTVFIGVPQIWEKIHEMVKKNSAKSMGLKKKAFVWARNIGFKVNSKK
MLGKYNTPVSYRMAKTLVFSKVKTSLGLDHCHSFISGTAPLNQETAEFFLSLDIPIGELY
GLSESSGPHTISNQNNYRLLSCGKILTGCKNMLFQQNKDGIGEICLWGRHIFMGYLESET
ETTEAIDDEGWLHSGDLGQLDGLGFLYVTGHIKEILITAGGENVPPIPVETLVKKKIPII
SNAMLVGDKLKFLSMLLTLKCEMNQMSGEPLDKLNFEAINFCRGLGSQASTVTEIVKQQD
PLVYKAIQQGINAVNQEAMNNAQRIEKWVILEKDFSIYGGELGPMMKLKRHFVAQKYKKQ
IDHMYH
|
| External Links |
|---|
| GenBank ID Protein
| 32968194 |
| UniProtKB/Swiss-Prot ID
| Q5FVE4 |
| UniProtKB/Swiss-Prot Entry Name
| ACBG2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ577571 |
| GeneCard ID
| ACSBG2 |
| GenAtlas ID
| ACSBG2 |
| HGNC ID
| HGNC:24174 |
| References |
|---|
| General References
| Not Available |