Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 G1 (CDBP00548)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP00548

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 G1

Description

Not Available

Synonyms

E217K
UBC7
Ubiquitin carrier protein G1
Ubiquitin-protein ligase G1

Gene Name

UBE2G1

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. May be involved in degradation of muscle-specific proteins. Mediates polyubiquitination of CYP3A4.

GO Classification

Biological Process
protein K63-linked ubiquitination
protein K48-linked ubiquitination
ubiquitin-dependent protein catabolic process
Function
catalytic activity
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available
Protein processing in endoplasmic reticulum	Not Available
Parkinson's disease	Not Available

Gene Properties

Chromosome Location

Locus

17p13.2

SNPs

UBE2G1

Gene Sequence

>513 bp
ATGACGGAGCTGCAGTCGGCACTGCTACTGCGAAGACAGCTGGCAGAACTCAACAAAAAT
CCAGTGGAAGGCTTTTCTGCAGGTTTAATAGATGACAATGATCTCTACCGATGGGAAGTC
CTTATTATTGGCCCTCCAGATACACTTTATGAAGGTGGTGTTTTTAAGGCTCATCTTACT
TTCCCAAAAGATTATCCCCTCCGACCTCCTAAAATGAAATTCATTACAGAAATCTGGCAC
CCAAATGTTGATAAAAATGGTGATGTGTGCATTTCTATTCTTCATGAGCCTGGGGAAGAT
AAGTATGGTTATGAAAAGCCAGAGGAACGCTGGCTCCCTATCCACACTGTGGAAACCATC
ATGATTAGTGTCATTTCTATGCTGGCAGACCCTAATGGAGACTCACCTGCTAATGTTGAT
GCTGCGAAAGAATGGAGGGAAGATAGAAATGGAGAATTTAAAAGAAAAGTTGCCCGCTGT
GTAAGAAAAAGCCAAGAGACTGCTTTTGAGTGA

Protein Properties

Number of Residues

170

Molecular Weight

19509.035

Theoretical pI

5.301

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 G1
MTELQSALLLRRQLAELNKNPVEGFSAGLIDDNDLYRWEVLIIGPPDTLYEGGVFKAHLT
FPKDYPLRPPKMKFITEIWHPNVDKNGDVCISILHEPGEDKYGYEKPEERWLPIHTVETI
MISVISMLADPNGDSPANVDAAKEWREDRNGEFKRKVARCVRKSQETAFE

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P62253

UniProtKB/Swiss-Prot Entry Name

UB2G1_HUMAN

PDB IDs