Identification |
HMDB Protein ID
| CDBP00596 |
Secondary Accession Numbers
| Not Available |
Name
| Serine--tRNA ligase, mitochondrial |
Description
| Not Available |
Synonyms
|
- SerRS
- SerRSmt
- Serine--tRNA ligase
- Seryl-tRNA(Ser/Sec) synthetase
- Seryl-tRNA synthetase
|
Gene Name
| SARS2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotide binding |
Specific Function
| Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).
|
GO Classification
|
Biological Process |
selenocysteinyl-tRNA(Sec) biosynthetic process |
seryl-tRNA aminoacylation |
Cellular Component |
mitochondrial matrix |
Component |
cell part |
intracellular part |
cytoplasm |
Function |
aminoacyl-trna ligase activity |
binding |
nucleotide binding |
catalytic activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
ligase activity |
serine-trna ligase activity |
ligase activity, forming carbon-oxygen bonds |
ligase activity, forming aminoacyl-trna and related compounds |
Molecular Function |
ATP binding |
serine-tRNA ligase activity |
Process |
rna metabolic process |
ncrna metabolic process |
trna metabolic process |
trna aminoacylation |
trna aminoacylation for protein translation |
macromolecule biosynthetic process |
cellular macromolecule biosynthetic process |
translation |
metabolic process |
macromolecule metabolic process |
cellular macromolecule metabolic process |
seryl-trna aminoacylation |
biosynthetic process |
|
Cellular Location
|
- Mitochondrion matrix
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | selenocysteinyl-tRNA(Sec) biosynthesis | Not Available | Not Available | Aminoacyl-tRNA biosynthesis | Not Available | ![Map00970](https://www.genome.jp/kegg/misc/thumbnail/map00970.gif) |
|
Gene Properties |
Chromosome Location
| 19 |
Locus
| 19q13.2 |
SNPs
| SARS2 |
Gene Sequence
|
>1557 bp
ATGGCTGCGTCCATGGCGCGGCGCTTGTGGCCTTTGCTGACTCGTCGGGGGTTCCGGCCC
CGGGGAGGCTGCATCTCCAACGATAGTCCAAGGAGAAGTTTCACTACAGAGAAACGAAAC
CGGAACCTCCTGTACGAGTATGCGCGCGAGGGCTACAGCGCACTCCCTCAGCTGGACATA
GAGCGGTTCTGCGCATGCCCAGAAGAGGCCGCACACGCCCTGGAGCTCCGCAAGGGGGAG
CTGCGCTCGGCGGACCTGCCCGCGATCATCTCGACATGGCAGGAGCTGAGGCAGCTGCAG
GAGCAGATCCGGAGCCTGGAGGAAGAGAAGGCAGCTGTGACTGAGGCAGTGCGGGCCCTG
CTGGCAAACCAGGACAGTGGTGAAGTGCAGCAGGACCCCAAGTACCAGGGTCTGCGGGCA
CGTGGCCGGGAGATCCGGAAGGAGCTTGTTCACCTGTACCCCAGGGAGGCCCAGCTTGAG
GAGCAGTTCTACCTGCAGGCGCTGAAGCTGCCCAACCAGACCCACCCAGACGTGCCCGTC
GGGGATGAGAGCCAGGCTCGAGTGCTCCACATGGTCGGAGACAAGCCAGTTTTCTCCTTC
CAACCTCGGGGCCACCTGGAAATTGGCGAGAAACTCGACATCATCCGTCAGAAGCGCCTG
TCCCACGTGTCTGGCCACCGGTCCTATTACCTGCGCGGGGCTGGAGCCCTCCTGCAGCAC
GGCCTGGTCAACTTCACATTCAACAAGCTTCTCCGCCGGGGCTTCACCCCCATGACGGTG
CCAGACCTTCTCCGCGGAGCAGTGTTTGAAGGCTGTGGGATGACACCAAATGCCAACCCA
TCCCAAATTTACAACATCGACCCTGCCCGCTTCAAAGATCTCAACCTGGCTGGAACAGCG
GAGGTGGGGCTTGCAGGCTACTTCATGGACCACACCGTGGCCTTCAGGGACCTGCCAGTC
AGGATGGTTTGCTCCAGCACCTGCTACCGGGCAGAGACAAACACGGGACAGGAACCCCGG
GGGCTGTATCGAGTACACCACTTCACCAAGGTGGAGATGTTTGGGGTGACAGGCCCTGGG
CTGGAGCAGAGCTCACAGCTGCTGGAGGAGTTCCTGTCCCTTCAGATGGAGATCTTGACA
GAGCTGGGCTTGCACTTCCGGGTCCTGGATATGCCCACCCAAGAACTGGGCCTCCCCGCC
TACCGCAAGTTTGACATTGAGGCCTGGATGCCAGGCCGAGGCCGCTTTGGAGAGGTCACC
AGTGCTTCCAACTGCACAGACTTCCAGAGCCGCCGCCTCCACATCATGTTCCAGACCGAG
GCTGGGGAGCTGCAGTTTGCCCACACGGTGAACGCCACCGCCTGTGCTGTCCCCCGCCTT
CTCATCGCGCTCCTGGAGAGTAACCAGCAGAAGGACGGCTCAGTGCTCGTGCCCCCTGCC
CTCCAGTCCTACCTCGGCACTGATCGGATCACAGCCCCTACCCACGTGCCTCTCCAGTAC
ATCGGCCCCAACCAGCCCCGGAAGCCTGGGCTGCCTGGCCAGCCTGCTGTAAGCTAA
|
Protein Properties |
Number of Residues
| 518 |
Molecular Weight
| 58029.805 |
Theoretical pI
| 7.355 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Seryl-tRNA synthetase, mitochondrial
MAASMARRLWPLLTRRGFRPRGGCISNDSPRRSFTTEKRNRNLLYEYAREGYSALPQLDI
ERFCACPEEAAHALELRKGELRSADLPAIISTWQELRQLQEQIRSLEEEKAAVTEAVRAL
LANQDSGEVQQDPKYQGLRARGREIRKELVHLYPREAQLEEQFYLQALKLPNQTHPDVPV
GDESQARVLHMVGDKPVFSFQPRGHLEIGEKLDIIRQKRLSHVSGHRSYYLRGAGALLQH
GLVNFTFNKLLRRGFTPMTVPDLLRGAVFEGCGMTPNANPSQIYNIDPARFKDLNLAGTA
EVGLAGYFMDHTVAFRDLPVRMVCSSTCYRAETNTGQEPRGLYRVHHFTKVEMFGVTGPG
LEQSSQLLEEFLSLQMEILTELGLHFRVLDMPTQELGLPAYRKFDIEAWMPGRGRFGEVT
SASNCTDFQSRRLHIMFQTEAGELQFAHTVNATACAVPRLLIALLESNQQKDGSVLVPPA
LQSYLGTDRITAPTHVPLQYIGPNQPRKPGLPGQPAVS
|
External Links |
GenBank ID Protein
| 9188535 |
UniProtKB/Swiss-Prot ID
| Q9NP81 |
UniProtKB/Swiss-Prot Entry Name
| SYSM_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AB029948 |
GeneCard ID
| SARS2 |
GenAtlas ID
| SARS2 |
HGNC ID
| HGNC:17697 |
References |
General References
| Not Available |