Identification
HMDB Protein ID CDBP05442
Secondary Accession Numbers Not Available
Name HERV-K_6q14.1 provirus ancestral Gag-Pol polyprotein
Description Not Available
Synonyms
  1. HERV-K(C6) Gag-Pol protein
  2. HERV-K109 Gag-Pol protein
Gene Name Not Available
Protein Type Metal Binding
Biological Properties
General Function Not Available
Specific Function The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution (By similarity). Early post-infection, the reverse transcriptase converts the viral RNA genome into double-stranded viral DNA. The RNase H domain of the reverse transcriptase performs two functions. It degrades the RNA template and specifically removes the RNA primer from the RNA/DNA hybrid. Following nuclear import, the integrase catalyzes the insertion of the linear, double-stranded viral DNA into the host cell chromosome. Endogenous Pol proteins may have kept, lost or modified their original function during evolution (By similarity).
GO Classification
Biological Process
viral reproduction
proteolysis
RNA-dependent DNA replication
dUTP metabolic process
Cellular Component
plasma membrane
viral capsid
Molecular Function
RNA-directed DNA polymerase activity
structural molecule activity
aspartic-type endopeptidase activity
metal ion binding
DNA-directed DNA polymerase activity
zinc ion binding
RNA binding
ribonuclease H activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight Not Available
Theoretical pI Not Available
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P63128
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References Not Available