Identification
HMDB Protein ID CDBP02191
Secondary Accession Numbers Not Available
Name Phosphopantothenate--cysteine ligase
Description Not Available
Synonyms
  1. PPC synthetase
  2. Phosphopantothenoylcysteine synthetase
Gene Name PPCS
Protein Type Enzyme
Biological Properties
General Function Coenzyme transport and metabolism
Specific Function Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine.
GO Classification
Biological Process
pantothenate metabolic process
coenzyme A biosynthetic process
coenzyme biosynthetic process
Cellular Component
cytosol
Molecular Function
phosphopantothenate--cysteine ligase activity
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 1
Locus 1p34.2
SNPs PPCS
Gene Sequence
>417 bp
ATGTTTTACCTGGCTGCGGCTGTGTCAGATTTCTATGTTCCTGTCTCTGAAATGCCTGAA
CACAAGATCCAGTCATCTGGGGGCCCACTGCAGATAACAATGAAGATGGTGCCAAAACTG
CTTTCTCCTTTGGTTAAAGATTGGGCTCCCAAAGCATTTATAATTTCCTTTAAGTTGGAG
ACTGACCCCGCCATTGTAATTAATCGAGCTCGGAAGGCTTTGGAAATTTATCAGCATCAA
GTGGTGGTGGCTAATATCCTTGAGTCACGACAGTCCTTTGTGTTTATTGTAACCAAAGAC
TCGGAAACCAAGTTATTGCTATCAGAGGAAGAAATAGAAAAAGGCGTAGAGATAGAAGAG
AAGATAGTGGATAATCTTCAGTCTCGACACACAGCTTTTATAGGTGACAGAAACTGA
Protein Properties
Number of Residues 138
Molecular Weight 15645.035
Theoretical pI 5.889
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Phosphopantothenoylcysteine synthetase
MFYLAAAVSDFYVPVSEMPEHKIQSSGGPLQITMKMVPKLLSPLVKDWAPKAFIISFKLE
TDPAIVINRARKALEIYQHQVVVANILESRQSFVFIVTKDSETKLLLSEEEIEKGVEIEE
KIVDNLQSRHTAFIGDRN
GenBank ID Protein 55665120
UniProtKB/Swiss-Prot ID Q9HAB8
UniProtKB/Swiss-Prot Entry Name Q5VVM0_HUMAN
PDB IDs
GenBank Gene ID AL445669
GeneCard ID PPCS
GenAtlas ID PPCS
HGNC ID HGNC:25686
References
General References Not Available