Showing Protein E3 ubiquitin-protein ligase MARCH5 (CDBP04422)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP04422
Secondary Accession Numbers Not Available
Name E3 ubiquitin-protein ligase MARCH5
Description Not Available
Synonyms
  1. MARCH-V
  2. MITOL
  3. Membrane-associated RING finger protein 5
  4. Membrane-associated RING-CH protein V
  5. Mitochondrial ubiquitin ligase
  6. RING finger protein 153
Gene Name MARCH5
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1
GO Classification
Function
zinc ion binding
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
Cellular Location
  1. Endoplasmic reticulum membrane
  2. Multi-pass membrane protein
  3. Mitochondrion outer membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 10q23.32-q23.33
SNPs MARCH5
Gene Sequence 
>837 bp
ATGCCGGACCAAGCCCTACAGCAGATGCTGGACAGAAGTTGCTGGGTTTGTTTTGCTACT
GATGAAGATGATAGAACAGCTGAATGGGTGAGACCATGCAGGTGCAGAGGATCTACAAAA
TGGGTTCACCAGGCCTGTCTACAACGCTGGGTGGATGAAAAGCAAAGAGGAAACAGTACA
GCCAGAGTGGCATGTCCTCAGTGCAATGCTGAATACCTAATAGTTTTTCCAAAATTGGGT
CCAGTGGTTTACGTCTTGGATCTTGCAGATAGACTGATCTCAAAAGCCTGTCCATTTGCT
GCAGCAGGAATAATGGTCGGCTCTATCTATTGGACAGCTGTGACTTATGGAGCAGTGACA
GTGATGCAGGTTGTAGGTCATAAAGAAGGTCTGGATGTTATGGAGAGAGCTGATCCTTTA
TTCCTTTTAATTGGACTTCCTACTATTCCTGTCATGCTGATATTAGGCAAGATGATTCGC
TGGGAGGACTATGTGCTTAGACTGTGGCGCAAATACTCGAATAAACTACAAATTTTAAAT
AGTATATTTCCAGGGATAGGTTGTCCTGTTCCTCGAATTCCAGCTGAGGCCAATCCTTTA
GCAGATCATGTCTCTGCTACTCGAATCTTGTGTGGAGCCCTTGTCTTTCCTACTATTGCT
ACAATAGTTGGTAAATTGATGTTCAGTAGTGTTAACTCTAATTTACAAAGGACAATCTTG
GGTGGAATTGCGTTTGTTGCCATAAAAGGAGCATTTAAAGTTTACTTCAAACAGCAGCAA
TATTTACGACAGGCACACCGCAAAATTCTGAATTATCCAGAACAAGAAGAAGCATAA
Protein Properties
Number of Residues 278
Molecular Weight 31231.4
Theoretical pI 8.83
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["99-119", "139-159", "209-229", "238-258"]
Protein Sequence 
>E3 ubiquitin-protein ligase MARCH5
MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNST
ARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVT
VMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILN
SIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTIL
GGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
GenBank ID Protein 110796914
UniProtKB/Swiss-Prot ID Q9NX47
UniProtKB/Swiss-Prot Entry Name MARH5_HUMAN
PDB IDs Not Available
GenBank Gene ID AB191202
GeneCard ID MARCH5
GenAtlas ID MARCH5
HGNC ID HGNC:26025
References
General References Not Available