Identification
HMDB Protein ID CDBP00615
Secondary Accession Numbers Not Available
Name Ubiquitin-conjugating enzyme E2 C
Description Not Available
Synonyms
  1. UbcH10
  2. Ubiquitin carrier protein C
  3. Ubiquitin-protein ligase C
Gene Name UBE2C
Protein Type Enzyme
Biological Properties
General Function Involved in ubiquitin-protein ligase activity
Specific Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit.
GO Classification
Biological Process
anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
mitotic cell cycle spindle assembly checkpoint
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
protein K48-linked ubiquitination
protein K11-linked ubiquitination
cyclin catabolic process
free ubiquitin chain polymerization
positive regulation of exit from mitosis
spindle organization
phosphatidylinositol-mediated signaling
exit from mitosis
mitosis
cell division
activation of anaphase-promoting complex activity
Cellular Component
cytosol
nucleoplasm
anaphase-promoting complex
Function
binding
catalytic activity
small conjugating protein ligase activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
ubiquitin-protein ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
protein modification by small protein conjugation or removal
protein modification by small protein conjugation
protein ubiquitination
macromolecule modification
protein modification process
metabolic process
regulation of protein metabolic process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 20
Locus 20q13.12
SNPs UBE2C
Gene Sequence
>540 bp
ATGGCTTCCCAAAACCGCGACCCAGCCGCCACTAGCGTCGCCGCCGCCCGTAAAGGAGCT
GAGCCGAGCGGGGGCGCCGCCCGGGGTCCGGTGGGCAAAAGGCTACAGCAGGAGCTGATG
ACCCTCATGATGTCTGGCGATAAAGGGATTTCTGCCTTCCCTGAATCAGACAACCTTTTC
AAATGGGTAGGGACCATCCATGGAGCAGCTGGAACAGTATATGAAGACCTGAGGTATAAG
CTCTCGCTAGAGTTCCCCAGTGGCTACCCTTACAATGCGCCCACAGTGAAGTTCCTCACG
CCCTGCTATCACCCCAACGTGGACACCCAGGGTAACATATGCCTGGACATCCTGAAGGAA
AAGTGGTCTGCCCTGTATGATGTCAGGACCATTCTGCTCTCCATCCAGAGCCTTCTAGGA
GAACCCAACATTGATAGTCCCTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA
GCTTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCACCAGCCAGGAGCCCTGA
Protein Properties
Number of Residues 179
Molecular Weight 19652.13
Theoretical pI 7.371
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ubiquitin-conjugating enzyme E2 C
MASQNRDPAATSVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF
KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKE
KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVTSQEP
GenBank ID Protein 5902146
UniProtKB/Swiss-Prot ID O00762
UniProtKB/Swiss-Prot Entry Name UBE2C_HUMAN
PDB IDs
GenBank Gene ID NM_007019.2
GeneCard ID UBE2C
GenAtlas ID UBE2C
HGNC ID HGNC:15937
References
General References Not Available