Identification |
HMDB Protein ID
| CDBP01013 |
Secondary Accession Numbers
| Not Available |
Name
| UDP-N-acetylhexosamine pyrophosphorylase |
Description
| Not Available |
Synonyms
|
- AGX
- AGX-1
- AGX-2
- Antigen X
- Sperm-associated antigen 2
- UDP-N-acetylgalactosamine pyrophosphorylase
- UDP-N-acetylglucosamine pyrophosphorylase
|
Gene Name
| UAP1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotidyltransferase activity |
Specific Function
| Converts UDP and GlcNAc-1-P into UDP-GlcNAc, and UDP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.
|
GO Classification
|
Biological Process |
post-translational protein modification |
protein N-linked glycosylation via asparagine |
UDP-N-acetylglucosamine biosynthetic process |
dolichol-linked oligosaccharide biosynthetic process |
Cellular Component |
cytosol |
plasma membrane |
nucleus |
Function |
catalytic activity |
transferase activity |
transferase activity, transferring phosphorus-containing groups |
nucleotidyltransferase activity |
Molecular Function |
UDP-N-acetylglucosamine diphosphorylase activity |
Process |
metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | UDP-N-acetyl-alpha-D-glucosamine biosynthesis | Not Available | Not Available | Amino sugar and nucleotide sugar metabolism | Not Available | ![Map00520](https://www.genome.jp/kegg/misc/thumbnail/map00520.gif) | Amino Sugar Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000008/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000008/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000008/thumb?image_type=simple) | ![Map00520](https://www.genome.jp/kegg/misc/thumbnail/map00520.gif) | Sialuria or French Type Sialuria | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000123/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000123/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000123/thumb?image_type=simple) | Not Available | Salla Disease/Infantile Sialic Acid Storage Disease | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000124/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000124/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000124/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 1 |
Locus
| 1q23.3 |
SNPs
| UAP1 |
Gene Sequence
|
>1518 bp
ATGAACATTAATGACCTCAAACTCACGTTGTCCAAAGCTGGGCAAGAGCACCTACTACGT
TTCTGGAATGAGCTTGAAGAAGCCCAACAGGTAGAACTTTATGCAGAGCTCCAGGCCATG
AACTTTGAGGAGCTGAACTTCTTTTTCCAAAAGGCCATTGAAGGTTTTAACCAGTCTTCT
CACCAAAAGAATGTGGATGCACGAATGGAACCTGTGCCTCGAGAGGTATTAGGCAGTGCT
ACAAGGGATCAAGATCAGCTCCAGGCCTGGGAAAGTGAAGGACTTTTCCAGATTTCTCAG
AATAAAGTAGCAGTTCTTCTTCTAGCTGGTGGGCAGGGGACAAGACTCGGCGTTGCATAT
CCTAAGGGGATGTATGATGTTGGTTTGCCATCCCGTAAGACACTTTTTCAGATTCAAGCA
GAGCGTATCCTGAAGCTACAGCAGGTTGCTGAAAAATATTATGGCAACAAATGCATTATT
CCATGGTATATAATGACCAGTGGCAGAACAATGGAATCTACAAAGGAGTTCTTCACCAAG
CACAAGTACTTTGGTTTAAAAAAAGAGAATGTAATCTTTTTTCAGCAAGGAATGCTCCCC
GCCATGAGTTTTGATGGGAAAATTATTTTGGAAGAGAAGAACAAAGTTTCTATGGCTCCA
GATGGGAATGGTGGTCTTTATCGGGCACTTGCAGCCCAGAATATTGTGGAGGATATGGAG
CAAAGAGGCATTTGGAGCATTCATGTCTATTGTGTTGACAACATATTAGTAAAAGTGGCA
GACCCACGGTTCATTGGATTTTGCATTCAGAAAGGAGCAGACTGTGGAGCAAAGGTGGTA
GAGAAAACGAACCCTACAGAACCAGTTGGAGTGGTTTGCCGAGTGGATGGAGTTTACCAG
GTGGTAGAATATAGTGAGATTTCCCTGGCAACAGCTCAAAAACGAAGCTCAGACGGACGA
CTGCTGTTCAATGCGGGGAACATTGCCAACCATTTCTTCACTGTACCATTTCTGAGAGAT
GTTGTCAATGTTTATGAACCTCAGTTGCAGCACCATGTGGCTCAAAAGAAGATTCCTTAT
GTGGATACCCAAGGACAGTTAATTAAGCCAGACAAACCCAATGGAATAAAGATGGAAAAA
TTTGTCTTTGACATCTTCCAGTTTGCAAAGAAGTTTGTGGTATATGAAGTATTGCGAGAA
GATGAGTTTTCCCCACTAAAGAATGCTGATAGTCAGAATGGGAAAGACAACCCTACTACT
GCAAGGCATGCTTTGATGTCCCTTCATCATTGCTGGGTCCTCAATGCAGGGGGCCATTTC
ATAGATGAAAATGGCTCTCGCCTTCCAGCAATTCCCCGCTTGAAGGATGCCAATGATGTA
CCAATCCAATGTGAAATCTCTCCTCTTATCTCCTATGCTGGAGAAGGATTAGAAAGTTAT
GTGGCAGATAAAGAATTCCATGCACCTCTAATCATCGATGAGAATGGAGTTCATGAGCTG
GTGAAAAATGGTATTTGA
|
Protein Properties |
Number of Residues
| 522 |
Molecular Weight
| 57027.91 |
Theoretical pI
| 6.375 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>UDP-N-acetylhexosamine pyrophosphorylase
MNINDLKLTLSKAGQEHLLRFWNELEEAQQVELYAELQAMNFEELNFFFQKAIEGFNQSS
HQKNVDARMEPVPREVLGSATRDQDQLQAWESEGLFQISQNKVAVLLLAGGQGTRLGVAY
PKGMYDVGLPSRKTLFQIQAERILKLQQVAEKYYGNKCIIPWYIMTSGRTMESTKEFFTK
HKYFGLKKENVIFFQQGMLPAMSFDGKIILEEKNKVSMAPDGNGGLYRALAAQNIVEDME
QRGIWSIHVYCVDNILVKVADPRFIGFCIQKGADCGAKVVEKTNPTEPVGVVCRVDGVYQ
VVEYSEISLATAQKRSSDGRLLFNAGNIANHFFTVPFLRDVVNVYEPQLQHHVAQKKIPY
VDTQGQLIKPDKPNGIKMEKFVFDIFQFAKKFVVYEVLREDEFSPLKNADSQNGKDNPTT
ARHALMSLHHCWVLNAGGHFIDENGSRLPAIPRSATNGKSETITADVNHNLKDANDVPIQ
CEISPLISYAGEGLESYVADKEFHAPLIIDENGVHELVKNGI
|
External Links |
GenBank ID Protein
| 156627575 |
UniProtKB/Swiss-Prot ID
| Q16222 |
UniProtKB/Swiss-Prot Entry Name
| UAP1_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| NM_003115 |
GeneCard ID
| UAP1 |
GenAtlas ID
| UAP1 |
HGNC ID
| HGNC:12457 |
References |
General References
| Not Available |