Showing Protein Poly(A) RNA polymerase, mitochondrial (CDBP05423)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 compounds
Identification
HMDB Protein ID CDBP05423
Secondary Accession Numbers Not Available
Name Poly(A) RNA polymerase, mitochondrial
Description Not Available
Synonyms
  1. PAP
  2. PAP-associated domain-containing protein 1
  3. Polynucleotide adenylyltransferase
  4. Terminal uridylyltransferase 1
  5. mtPAP
  6. TUTase 1
Gene Name MTPAP
Protein Type Enzyme
Biological Properties
General Function Not Available
Specific Function Polymerase that creates the 3' poly(A) tail of mitochondrial transcripts. Can use all four nucleotides, but has higher activity with ATP and UTP (in vitro). Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. Might be responsible for the creation of some UAA stop codons which are not encoded in mtDNA.
GO Classification
Biological Process
histone mRNA catabolic process
mRNA polyadenylation
transcription, DNA-dependent
cell death
Cellular Component
mitochondrion
plasma membrane
Golgi apparatus
nucleus
Molecular Function
magnesium ion binding
ATP binding
RNA binding
UTP binding
polynucleotide adenylyltransferase activity
manganese ion binding
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 10
Locus 10p11.23
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 66170.995
Theoretical pI 9.044
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>gi|190194365|ref|NP_060579.3| poly(A) RNA polymerase, mitochondrial precursor [Homo sapiens]
MAVPGVGLLTRLNLCARRRTRVQRPIVRLLSCPGTVAKDLRRDEQPSGSVETGFEDKIPK
RRFSEMQNER
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NVV4
UniProtKB/Swiss-Prot Entry Name Not Available
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID HGNC:25532
References
General References Not Available