| Identification |
|---|
| HMDB Protein ID
| CDBP00550 |
| Secondary Accession Numbers
| Not Available |
| Name
| Threonine--tRNA ligase, cytoplasmic |
| Description
| Not Available |
| Synonyms
|
- ThrRS
- Threonine--tRNA ligase
- Threonyl-tRNA synthetase
|
| Gene Name
| TARS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in nucleotide binding |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| threonyl-tRNA aminoacylation |
| Cellular Component |
| cytosol |
| actin cytoskeleton |
| cytoplasm |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| catalytic activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
| ligase activity |
| threonine-trna ligase activity |
| ligase activity, forming carbon-oxygen bonds |
| ligase activity, forming aminoacyl-trna and related compounds |
| aminoacyl-trna ligase activity |
| binding |
| nucleotide binding |
| Molecular Function |
| ATP binding |
| protein homodimerization activity |
| threonine-tRNA ligase activity |
| Process |
| trna metabolic process |
| trna aminoacylation |
| trna aminoacylation for protein translation |
| macromolecule biosynthetic process |
| cellular macromolecule biosynthetic process |
| translation |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| threonyl-trna aminoacylation |
| biosynthetic process |
| rna metabolic process |
| ncrna metabolic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycine and Serine Metabolism |    |  | | Aminoacyl-tRNA biosynthesis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| 5p13.2 |
| SNPs
| TARS |
| Gene Sequence
|
>2172 bp
ATGTTTGAGGAGAAGGCCAGCAGTCCTTCAGGGAAGATGGGAGGCGAGGAGAAGCCGATT
GGTGCTGGTGAAGAGAAGCAAAAGGAAGGAGGCAAAAAGAAGAACAAAGAAGGATCTGGA
GATGGAGGTCGAGCTGAGTTGAATCCTTGGCCTGAATATATTTACACACGTCTTGAGATG
TATAATATACTAAAAGCAGAACATGATTCCATTCTGGCAGAAAAGGCAGAAAAAGATAGC
AAGCCAATTAAAGTCACTTTGCCTGATGGTAAACAGGTTGATGCGGAATCTTGGAAAACT
ACACCATATCAAATTGCCTGTGGAATTAGTCAAGGCCTGGCCGACAACACCGTTATTGCT
AAAGTAAATAATGTTGTGTGGGACCTGGACCGCCCTCTGGAAGAAGATTGTACCTTGGAG
CTTCTCAAGTTTGAGGATGAGGAAGCTCAGGCAGTGTATTGGCACTCTAGTGCTCACATA
ATGGGTGAAGCCATGGAAAGAGTCTATGGTGGATGTTTATGCTACGGTCCGCCAATAGAA
AATGGATTCTATTATGACATGTACCTCGAAGAAGGGGGTGTGTCTAGCAATGATTTCTCT
TCTCTGGAGGCTTTGTGTAAGAAAATCATTAAAGAAAAACAAGCTTTTGAAAGACTGGAA
GTTAAGAAAGAAACTTTACTGGCAATGTTTAAGTACAACAAGTTCAAATGCCGGATATTG
AATGAAAAGGTGAATACTCCAACTACCACAGTCTATAGATGTGGCCCTTTGATAGATCTC
TGCCGGGGTCCTCATGTTAGACACACGGGCAAAATTAAGGCTTTAAAAATACACAAAAAT
TCCTCCACGTACTGGGAAGGCAAAGCAGATATGGAGACTCTCCAGAGAATTTATGGCATT
TCATTCCCAGATCCTAAAATGTTGAAAGAGTGGGAGAAGTTCCAAGAGGAAGCTAAAAAC
CGAGATCATAGGAAAATTGGCAGGGACCAAGAACTATATTTCTTTCATGAACTCAGCCCT
GGAAGTTGCTTTTTTCTGCCAAAAGGAGCCTACATTTATAATGCACTTATTGAATTCATT
AGGAGCGAATATAGGAAAAGAGGATTCCAGGAGGTAGTCACCCCAAACATCTTCAACAGC
CGACTCTGGATGACCTCGGGCCACTGGCAGCACTACAGCGAGAACATGTTCTCCTTTGAG
GTGGAGAAGGAGCTGTTTGCCCTGAAACCCATGAACTGCCCAGGACACTGCCTTATGTTT
GATCATCGGCCAAGGTCCTGGCGAGAACTGCCTCTGCGGCTAGCTGATTTTGGGGTACTT
CATAGGAACGAGCTGTCTGGAGCACTCACAGGACTCACCCGGGTACGAAGATTCCAACAG
GATGATGCTCACATATTCTGTGCCATGGAGCAGATTGAAGATGAAATAAAAGGTTGTTTG
GATTTTCTACGTACGGTATATAGCGTATTTGGATTTTCTTTTAAACTAAACCTTTCTACT
CGCCCGGAAAAATTCCTTGGAGATATCGAAGTATGGGATCAAGCTGAGAAACAACTTGAA
AACAGTCTGAATGAATTTGGTGAAAAGTGGGAGTTAAACTCTGGAGATGGAGCTTTCTAT
GGCCCAAAGATTGACATACAGATTAAAGATGCGATTGGGCGGTACCACCAGTGTGCAACC
ATCCAGCTGGATTTCCAGTTGCCCATCAGATTTAATCTTACTTATGTAAGCCATGATGGT
GATGATAAGAAAAGGCCAGTGATTGTTCATCGAGCCATCTTGGGATCAGTGGAAAGAATG
ATTGCTATCCTCACAGAAAACTATGGGGGCAAATGGCCCTTTTGGCTGTCCCCTCGCCAG
GTAATGGTAGTTCCAGTGGGACCAACCTGTGATGAATATGCCCAAAAGGTACGACAACAA
TTCCACGATGCCAAATTCATGGCAGACATTGATCTGGATCCAGGCTGTACATTGAATAAA
AAGATTCGAAATGCACAGTTAGCACAGTATAACTTCATTTTAGTTGTTGGTGAAAAAGAG
AAAATCAGTGGCACTGTTAATATCCGCACAAGAGACAATAAGGTCCACGGGGAACGCACC
ATTTCTGAAACTATCGAGCGGCTACAGCAGCTCAAAGAGTTCCGCAGCAAACAGGCAGAA
GAAGAATTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 723 |
| Molecular Weight
| 83434.5 |
| Theoretical pI
| 6.664 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Threonyl-tRNA synthetase, cytoplasmic
MFEEKASSPSGKMGGEEKPIGAGEEKQKEGGKKKNKEGSGDGGRAELNPWPEYIYTRLEM
YNILKAEHDSILAEKAEKDSKPIKVTLPDGKQVDAESWKTTPYQIACGISQGLADNTVIA
KVNNVVWDLDRPLEEDCTLELLKFEDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIE
NGFYYDMYLEEGGVSSNDFSSLEALCKKIIKEKQAFERLEVKKETLLAMFKYNKFKCRIL
NEKVNTPTTTVYRCGPLIDLCRGPHVRHTGKIKALKIHKNSSTYWEGKADMETLQRIYGI
SFPDPKMLKEWEKFQEEAKNRDHRKIGRDQELYFFHELSPGSCFFLPKGAYIYNALIEFI
RSEYRKRGFQEVVTPNIFNSRLWMTSGHWQHYSENMFSFEVEKELFALKPMNCPGHCLMF
DHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCAMEQIEDEIKGCL
DFLRTVYSVFGFSFKLNLSTRPEKFLGDIEVWDQAEKQLENSLNEFGEKWELNSGDGAFY
GPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTYVSHDGDDKKRPVIVHRAILGSVERM
IAILTENYGGKWPFWLSPRQVMVVPVGPTCDEYAQKVRQQFHDAKFMADIDLDPGCTLNK
KIRNAQLAQYNFILVVGEKEKISGTVNIRTRDNKVHGERTISETIERLQQLKEFRSKQAE
EEF
|
| External Links |
|---|
| GenBank ID Protein
| 158258124 |
| UniProtKB/Swiss-Prot ID
| P26639 |
| UniProtKB/Swiss-Prot Entry Name
| SYTC_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK292346 |
| GeneCard ID
| TARS |
| GenAtlas ID
| TARS |
| HGNC ID
| HGNC:11572 |
| References |
|---|
| General References
| Not Available |