Identification
HMDB Protein ID CDBP01015
Secondary Accession Numbers Not Available
Name Poly(A) polymerase gamma
Description Not Available
Synonyms
  1. Neo-PAP
  2. Neo-poly(A) polymerase
  3. PAP-gamma
  4. Polynucleotide adenylyltransferase gamma
  5. SRP RNA 3'-adenylating enzyme
Gene Name PAPOLG
Protein Type Enzyme
Biological Properties
General Function Involved in nucleotidyltransferase activity
Specific Function Responsible for the post-transcriptional adenylation of the 3'-terminal of mRNA precursors and several small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA.
GO Classification
Biological Process
transcription, DNA-dependent
mRNA polyadenylation
Cellular Component
nucleus
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
binding
catalytic activity
transferase activity
transferase activity, transferring phosphorus-containing groups
nucleotidyltransferase activity
adenylyltransferase activity
nucleic acid binding
polynucleotide adenylyltransferase activity
rna binding
Molecular Function
ATP binding
RNA binding
polynucleotide adenylyltransferase activity
metal ion binding
Process
rna metabolic process
macromolecule biosynthetic process
cellular macromolecule biosynthetic process
metabolic process
macromolecule metabolic process
cellular macromolecule metabolic process
rna processing
biosynthetic process
rna polyadenylation
transcription
rna 3'-end processing
Cellular Location
  1. Nucleus
Pathways
Gene Properties
Chromosome Location 2
Locus 2p16.1
SNPs PAPOLG
Gene Sequence
>2211 bp
ATGAAAGAGATGTCTGCAAACACCGTGCTGGACAGCCAGCGTCAACAAAAGCATTATGGA
ATTACCTCCCCAATTAGTTTGGCATCTCCTAAAGAAATTGATCATATTTACACACAGAAA
TTAATTGACGCCATGAAACCATTTGGAGTGTTTGAAGATGAGGAAGAATTGAACCACAGG
CTGGTGGTTCTTGGTAAATTGAACAATTTAGTAAAAGAATGGATTTCTGATGTCAGCGAG
AGTAAGAACCTCCCACCTTCTGTTGTGGCTACTGTTGGTGGTAAAATTTTCACATTTGGA
TCCTATAGGCTTGGAGTACACACCAAAGGAGCTGACATTGATGCACTTTGTGTAGCTCCA
AGACATGTGGAAAGATCTGATTTTTTTCAGTCTTTTTTTGAAAAATTGAAACATCAAGAT
GGCATTAGAAACTTAAGAGCTGTAGAAGATGCCTTTGTACCTGTTATAAAATTTGAATTT
GATGGTATTGAAATTGATCTAGTCTTTGCAAGACTGGCAATACAAACCATATCAGATAAT
TTAGATCTAAGAGACGACTCTCGCCTGAGAAGCCTTGATATAAGGTGTATTCGCAGCTTA
AATGGTTGTAGAGTTACTGATGAAATTTTGCATTTAGTGCCAAATAAAGAAACTTTTAGA
CTCACCCTAAGAGCTGTCAAATTATGGGCAAAACGACGTGGTATTTATTCCAACATGCTA
GGATTCCTTGGTGGTGTCTCCTGGGCAATGCTAGTTGCAAGAACTTGCCAATTGTATCCA
AATGCAGCAGCATCTACTTTAGTTCATAAGTTCTTTTTAGTTTTTTCCAAGTGGGAATGG
CCAAATCCTGTGCTGCTGAAGCAACCAGAAGAAAGCAATTTGAATTTGCCTGTCTGGGAT
CCTCGGGTAAATCCATCAGATAGGTATCATCTCATGCCCATAATCACCCCTGCCTACCCA
CAACAGAATTCTACGTATAATGTGTCCACATCAACTCGAACAGTAATGGTAGAAGAATTT
AAACAAGGTCTTGCAGTCACAGATGAAATTCTTCAAGGAAAGTCAGATTGGTCCAAACTA
CTTGAGCCACCGAATTTCTTTCAAAAGTATAGACATTATATAGTATTGACTGCCAGCGCA
TCAACAGAAGAAAACCATCTAGAGTGGGTTGGATTAGTAGAATCTAAAATCCGTGTACTT
GTTGGAAACTTGGAACGGAATGAATTTATTACTCTTGCCCATGTGAATCCCCAGTCATTC
CCAGGGAATAAGGAACATCATAAAGACAACAATTACGTATCAATGTGGTTCCTTGGGATA
ATTTTTCGGAGAGTAGAAAATGCAGAAAGTGTCAACATAGACTTGACATATGATATACAG
TCATTTACTGATACAGTGTACAGACAGGCAAACAATATAAATATGCTAAAGGAGGGAATG
AAAATTGAAGCAACTCATGTAAAGAAAAAACAACTTCACCACTACCTTCCTGCAGAAATT
CTTCAAAAGAAGAAAAAGCAAAGTCTCTCTGATGTCAATCGAAGCTCGGGCGGACTTCAA
TCCAAAAGATTGTCTCTGGATAGCAGTTGTCTGGATAGCTCCAGAGACACTGATAATGGA
ACACCTTTTAATTCTCCAGCGTCCAAGTCTGATAGCCCTTCTGTAGGAGAAACAGAAAGG
AATAGTGCTGAGCCTGCTGCTGTAATTGTGGAGAAGCCACTGAGTGTACCACCAGCCCAA
GGACTTTCCATTCCAGTGATTGGCGCAAAAGTTGACTCTACAGTAAAAACTGTATCACCC
CCCACTGTGTGTACCATTCCTACCGTAGTAGGACGAAATGTCATTCCTAGAATCACAACA
CCTCACAACCCTGCCCAGGGACAACCGCATCTGAATGGAATGTCAAATATAACTAAGACT
GTTACACCTAAGAGATCCCATTCCCCATCCATAGATGGGACTCCTAAGAGGTTGAAAGAC
GTAGAAAAGTTTATTCGACTTGAATCAACATTTAAGGACCCCCGCACTGCTGAAGAAAGA
AAAAGAAAATCAGTGGATGCCATTGGAGGAGAATCTATGCCTATTCCAACTATTGATACA
TCACGCAAAAAGAGACTACCCAGTAAAGAACTACCAGATTCATCATCTCCAGTTCCAGCA
AACAACATCCGTGTCATCAAAAATTCCATTCGACTGACCCTTAATCGGTAA
Protein Properties
Number of Residues 736
Molecular Weight 82801.935
Theoretical pI 9.149
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Poly(A) polymerase gamma
MKEMSANTVLDSQRQQKHYGITSPISLASPKEIDHIYTQKLIDAMKPFGVFEDEEELNHR
LVVLGKLNNLVKEWISDVSESKNLPPSVVATVGGKIFTFGSYRLGVHTKGADIDALCVAP
RHVERSDFFQSFFEKLKHQDGIRNLRAVEDAFVPVIKFEFDGIEIDLVFARLAIQTISDN
LDLRDDSRLRSLDIRCIRSLNGCRVTDEILHLVPNKETFRLTLRAVKLWAKRRGIYSNML
GFLGGVSWAMLVARTCQLYPNAAASTLVHKFFLVFSKWEWPNPVLLKQPEESNLNLPVWD
PRVNPSDRYHLMPIITPAYPQQNSTYNVSTSTRTVMVEEFKQGLAVTDEILQGKSDWSKL
LEPPNFFQKYRHYIVLTASASTEENHLEWVGLVESKIRVLVGNLERNEFITLAHVNPQSF
PGNKEHHKDNNYVSMWFLGIIFRRVENAESVNIDLTYDIQSFTDTVYRQANNINMLKEGM
KIEATHVKKKQLHHYLPAEILQKKKKQSLSDVNRSSGGLQSKRLSLDSSCLDSSRDTDNG
TPFNSPASKSDSPSVGETERNSAEPAAVIVEKPLSVPPAQGLSIPVIGAKVDSTVKTVSP
PTVCTIPTVVGRNVIPRITTPHNPAQGQPHLNGMSNITKTVTPKRSHSPSIDGTPKRLKD
VEKFIRLESTFKDPRTAEERKRKSVDAIGGESMPIPTIDTSRKKRLPSKELPDSSSPVPA
NNIRVIKNSIRLTLNR
GenBank ID Protein 15080911
UniProtKB/Swiss-Prot ID Q9BWT3
UniProtKB/Swiss-Prot Entry Name PAPOG_HUMAN
PDB IDs Not Available
GenBank Gene ID AF312211
GeneCard ID PAPOLG
GenAtlas ID PAPOLG
HGNC ID HGNC:14982
References
General References Not Available