Identification
HMDB Protein ID CDBP04449
Secondary Accession Numbers Not Available
Name E3 ubiquitin-protein ligase TRIM11
Description Not Available
Synonyms
  1. Protein BIA1
  2. RING finger protein 92
  3. Tripartite motif-containing protein 11
Gene Name TRIM11
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle
GO Classification
Component
cell part
intracellular
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q42.13
SNPs TRIM11
Gene Sequence
>1407 bp
ATGGCCGCCCCCGACCTGTCCACCAACCTCCAGGAGGAGGCCACCTGCGCCATCTGCCTC
GACTACTTCACGGATCCGGTGATGACCGACTGCGGCCACAACTTCTGCCGCGAGTGCATC
CGGCGCTGCTGGGGCCAGCCCGAGGGCCCGTACGCGTGCCCCGAGTGCCGCGAGCTGTCC
CCGCAGAGGAACCTGCGGCCCAACCGCCCGCTTGCTAAGATGGCCGAGATGGCGCGGCGC
CTGCACCCGCCGTCGCCGGTCCCGCAGGGCGTGTGCCCCGCGCACCGCGAGCCACTGGCC
GCCTTCTGTGGCGACGAGCTGCGCCTCCTGTGTGCGGCCTGCGAGCGCTCTGGGGAGCAC
TGGGCGCACCGCGTGCGGCCGCTGCAGGACGCGGCCGAAGACCTCAAGGCGAAGCTGGAG
AAGTCACTGGAGCATCTCCGGAAGCAGATGCAGGATGCGTTGCTGTTCCAAGCCCAGGCG
GATGAGACCTGCGTCTTGTGGCAGAAGATGGTGGAGAGCCAGCGGCAGAACGTGCTGGGT
GAGTTCGAGCGTCTTCGCCGTTTGCTGGCAGAGGAGGAGCAGCAGCTGCTGCAGAGGCTG
GAGGAGGAGGAGCTGGAGGTGCTGCCCCGGCTGCGGGAGGGCGCAGCCCACCTAGGCCAG
CAGAGCGCCCACCTAGCTGAGCTCATCGCCGAGCTCGAGGGCCGCTGCCAGCTGCCTGCT
CTGGGGCTGCTGCAGGACATCAAGGACGCCCTGCGCAGGGTCCAGGATGTGAAGCTGCAG
CCCCCAGAAGTTGTGCCTATGGAGCTGAGGACCGTGTGCAGGGTCCCGGGACTGGTAGAG
ACACTGCGGAGGTTTCGAGGGGACGTGACCTTGGACCCGGACACCGCCAACCCTGAGCTG
ATCCTGTCTGAAGACAGGCGGAGCGTGCAGCGGGGGGACCTACGGCAGGCCCTGCCGGAC
AGCCCAGAGCGCTTTGACCCCGGCCCCTGCGTGCTGGGCCAGGAGCGCTTCACCTCAGGC
CGCCACTACTGGGAGGTGGAGGTTGGGGACCGCACCAGCTGGGCCCTGGGGGTGTGCAGG
GAGAACGTGAACAGGAAGGAGAAGGGCGAGCTGTCCGCGGGCAACGGCTTCTGGATCCTG
GTCTTCCTGGGGAGCTATTACAATTCCTCGGAACGGGCCTTGGCTCCACTCCGGGACCCA
CCCAGGCGCGTGGGGATCTTTCTGGACTACGAGGCTGGACATCTCTCTTTCTACAGTGCC
ACCGATGGGTCACTGCTATTCATCTTTCCCGAGATCCCCTTCTCGGGGACGCTGCGGCCC
CTCTTCTCACCCCTGTCCAGCAGCCCGACCCCGATGACTATCTGCCGGCCGAAAGGTGGG
TCCGGGGACACCCTGGCTCCCCAGTGA
Protein Properties
Number of Residues 468
Molecular Weight 52773.6
Theoretical pI 5.42
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>E3 ubiquitin-protein ligase TRIM11
MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
GenBank ID Protein 21630277
UniProtKB/Swiss-Prot ID Q96F44
UniProtKB/Swiss-Prot Entry Name TRI11_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_145214.2
GeneCard ID TRIM11
GenAtlas ID TRIM11
HGNC ID HGNC:16281
References
General References Not Available