| Identification |
|---|
| HMDB Protein ID
| CDBP04449 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase TRIM11 |
| Description
| Not Available |
| Synonyms
|
- Protein BIA1
- RING finger protein 92
- Tripartite motif-containing protein 11
|
| Gene Name
| TRIM11 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase that promotes the degradation of insoluble ubiquitinated proteins, including insoluble PAX6, poly-Gln repeat expanded HTT and poly-Ala repeat expanded ARX. Mediates PAX6 ubiquitination leading to proteasomal degradation, thereby modulating cortical neurogenesis. May also inhibit PAX6 transcriptional activity, possibly in part by preventing the binding of PAX6 to its consensus sequences. May contribute to the regulation of the intracellular level of HN (humanin) or HN-containing proteins through the proteasomal degradation pathway. Mediates MED15 ubiquitination leading to proteasomal degradation. May contribute to the innate restriction of retroviruses. Upon overexpression, reduces HIV-1 and murine leukemia virus infectivity, by suppressing viral gene expression. Antiviral activity depends on a functional E3 ubiquitin-protein ligase domain. May regulate TRIM5 turnover via the proteasome pathway, thus counteracting the TRIM5-mediated cross-species restriction of retroviral infection at early stages of the retroviral life cycle |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q42.13 |
| SNPs
| TRIM11 |
| Gene Sequence
|
>1407 bp
ATGGCCGCCCCCGACCTGTCCACCAACCTCCAGGAGGAGGCCACCTGCGCCATCTGCCTC
GACTACTTCACGGATCCGGTGATGACCGACTGCGGCCACAACTTCTGCCGCGAGTGCATC
CGGCGCTGCTGGGGCCAGCCCGAGGGCCCGTACGCGTGCCCCGAGTGCCGCGAGCTGTCC
CCGCAGAGGAACCTGCGGCCCAACCGCCCGCTTGCTAAGATGGCCGAGATGGCGCGGCGC
CTGCACCCGCCGTCGCCGGTCCCGCAGGGCGTGTGCCCCGCGCACCGCGAGCCACTGGCC
GCCTTCTGTGGCGACGAGCTGCGCCTCCTGTGTGCGGCCTGCGAGCGCTCTGGGGAGCAC
TGGGCGCACCGCGTGCGGCCGCTGCAGGACGCGGCCGAAGACCTCAAGGCGAAGCTGGAG
AAGTCACTGGAGCATCTCCGGAAGCAGATGCAGGATGCGTTGCTGTTCCAAGCCCAGGCG
GATGAGACCTGCGTCTTGTGGCAGAAGATGGTGGAGAGCCAGCGGCAGAACGTGCTGGGT
GAGTTCGAGCGTCTTCGCCGTTTGCTGGCAGAGGAGGAGCAGCAGCTGCTGCAGAGGCTG
GAGGAGGAGGAGCTGGAGGTGCTGCCCCGGCTGCGGGAGGGCGCAGCCCACCTAGGCCAG
CAGAGCGCCCACCTAGCTGAGCTCATCGCCGAGCTCGAGGGCCGCTGCCAGCTGCCTGCT
CTGGGGCTGCTGCAGGACATCAAGGACGCCCTGCGCAGGGTCCAGGATGTGAAGCTGCAG
CCCCCAGAAGTTGTGCCTATGGAGCTGAGGACCGTGTGCAGGGTCCCGGGACTGGTAGAG
ACACTGCGGAGGTTTCGAGGGGACGTGACCTTGGACCCGGACACCGCCAACCCTGAGCTG
ATCCTGTCTGAAGACAGGCGGAGCGTGCAGCGGGGGGACCTACGGCAGGCCCTGCCGGAC
AGCCCAGAGCGCTTTGACCCCGGCCCCTGCGTGCTGGGCCAGGAGCGCTTCACCTCAGGC
CGCCACTACTGGGAGGTGGAGGTTGGGGACCGCACCAGCTGGGCCCTGGGGGTGTGCAGG
GAGAACGTGAACAGGAAGGAGAAGGGCGAGCTGTCCGCGGGCAACGGCTTCTGGATCCTG
GTCTTCCTGGGGAGCTATTACAATTCCTCGGAACGGGCCTTGGCTCCACTCCGGGACCCA
CCCAGGCGCGTGGGGATCTTTCTGGACTACGAGGCTGGACATCTCTCTTTCTACAGTGCC
ACCGATGGGTCACTGCTATTCATCTTTCCCGAGATCCCCTTCTCGGGGACGCTGCGGCCC
CTCTTCTCACCCCTGTCCAGCAGCCCGACCCCGATGACTATCTGCCGGCCGAAAGGTGGG
TCCGGGGACACCCTGGCTCCCCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 468 |
| Molecular Weight
| 52773.6 |
| Theoretical pI
| 5.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase TRIM11
MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
PQRNLRPNRPLAKMAEMARRLHPPSPVPQGVCPAHREPLAAFCGDELRLLCAACERSGEH
WAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVLG
EFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLPA
LGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPEL
ILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVCR
ENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPLRDPPRRVGIFLDYEAGHLSFYSA
TDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
|
| External Links |
|---|
| GenBank ID Protein
| 21630277 |
| UniProtKB/Swiss-Prot ID
| Q96F44 |
| UniProtKB/Swiss-Prot Entry Name
| TRI11_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_145214.2 |
| GeneCard ID
| TRIM11 |
| GenAtlas ID
| TRIM11 |
| HGNC ID
| HGNC:16281 |
| References |
|---|
| General References
| Not Available |