| Identification |
|---|
| HMDB Protein ID
| CDBP00535 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin/ISG15-conjugating enzyme E2 L6 |
| Description
| Not Available |
| Synonyms
|
- RIG-B
- Retinoic acid-induced gene B protein
- UbcH8
- Ubiquitin carrier protein L6
- Ubiquitin-protein ligase L6
|
| Gene Name
| UBE2L6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3.
|
| GO Classification
|
| Biological Process |
| innate immune response |
| cytokine-mediated signaling pathway |
| ISG15-protein conjugation |
| modification-dependent protein catabolic process |
| negative regulation of type I interferon production |
| Cellular Component |
| cytosol |
| Function |
| catalytic activity |
| small conjugating protein ligase activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| Molecular Function |
| ubiquitin-protein ligase activity |
| ISG15 ligase activity |
| Process |
| regulation of macromolecule metabolic process |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| regulation of protein metabolic process |
| macromolecule metabolic process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein ubiquitination | Not Available | Not Available | | Ubiquitin mediated proteolysis | Not Available |  | | Parkinson's disease | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11q12 |
| SNPs
| UBE2L6 |
| Gene Sequence
|
>462 bp
ATGATGGCGAGCATGCGAGTGGTGAAGGAGCTGGAGGATCTTCAGAAGAAGCCTCCCCCA
TACCTGCGGAACCTGTCCAGCGATGATGCCAATGTCCTGGTGTGGCACGCTCTCCTCCTA
CCCGACCAACCTCCCTACCACCTGAAAGCCTTCAACCTGCGCATCAGCTTCCCGCCGGAG
TATCCGTTCAAGCCTCCCATGATCAAATTCACAACCAAGATCTACCACCCCAACGTGGAC
GAGAACGGACAGATTTGCCTGCCCATCATCAGCAGTGAGAACTGGAAGCCTTGCACCAAG
ACTTGCCAAGTCCTGGAGGCCCTCAATGTGCTGGTGAATAGACCGAATATCAGGGAGCCC
CTGCGGATGGACCTCGCTGACCTGCTGACACAGAATCCGGAGCTGTTCAGAAAGAATGCC
GAAGAGTTCACCCTCCGATTCGGAGTGGACCGGCCCTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 153 |
| Molecular Weight
| 17768.52 |
| Theoretical pI
| 7.884 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin/ISG15-conjugating enzyme E2 L6
MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPE
YPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREP
LRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS
|
| External Links |
|---|
| GenBank ID Protein
| 4759282 |
| UniProtKB/Swiss-Prot ID
| O14933 |
| UniProtKB/Swiss-Prot Entry Name
| UB2L6_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_004223.3 |
| GeneCard ID
| UBE2L6 |
| GenAtlas ID
| UBE2L6 |
| HGNC ID
| HGNC:12490 |
| References |
|---|
| General References
| Not Available |