Showing Protein E3 ubiquitin-protein ligase MARCH1 (CDBP04424)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 3 compounds
Identification
HMDB Protein ID CDBP04424
Secondary Accession Numbers Not Available
Name E3 ubiquitin-protein ligase MARCH1
Description Not Available
Synonyms
  1. MARCH-I
  2. Membrane-associated RING finger protein 1
  3. Membrane-associated RING-CH protein I
  4. RING finger protein 171
Gene Name MARCH1
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase that mediates ubiquitination of TFRC, CD86, FAS and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. By constitutively ubiquitinating MHC class II proteins in immature dendritic cells, downregulates their cell surface localization thus sequestering them in the intracellular endosomal system
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location
  1. Cell membrane
  2. Late endosome membrane
  3. Golgi apparatus
  4. Lysosome membrane
  5. Multi-pass membrane protein
  6. Multi-pass membrane protein
  7. Multi-pass membrane protein
  8. Multi-pass membrane protein
  9. Multi-pass membrane protein
  10. Multi-pass membrane protein
  11. trans-Golgi network membrane
  12. Cytoplasmic vesicle membrane
  13. Early endosome membrane
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q32.2
SNPs MARCH1
Gene Sequence 
>870 bp
ATGCTGGGCTGGTGTGAAGCGATAGCCCGTAACCCTCACAGAATTCCAAACAACACGCGA
ACACCCGAGATCTCAGGGGATTTGGCTGACGCCTCACAAACCTCCACATTGAATGAAAAA
TCCCCAGGGCGATCTGCAAGTCGATCAAGTAACATTTCAAAAGCAAGCAGCCCAACAACA
GGGACAGCTCCCAGGAGCCAGTCAAGGTTGTCTGTCTGTCCATCCACTCAGGACATCTGC
AGAATCTGTCACTGCGAAGGGGATGAAGAGAGCCCCCTCATCACACCCTGTCGCTGCACT
GGGACACTGCGCTTTGTCCACCAGTCCTGCCTCCACCAGTGGATAAAGAGCTCAGATACA
CGCTGCTGTGAGCTCTGCAAGTATGACTTCATAATGGAGACCAAGCTCAAACCCCTCCGG
AAGTGGGAGAAACTACAGATGACCACAAGTGAAAGGAGGAAAATATTCTGCTCTGTCACA
TTCCACGTAATCGCGATCACCTGTGTGGTTTGGTCTTTGTATGTATTGATAGACCGGACA
GCGGAGGAAATCAAGCAAGGCAATGACAATGGTGTCCTTGAATGGCCATTTTGGACAAAA
CTGGTTGTGGTAGCCATTGGCTTCACAGGAGGTCTTGTCTTCATGTACGTACAGTGTAAA
GTCTATGTTCAGTTGTGGCGCAGGCTGAAGGCCTACAACCGTGTGATCTTTGTACAAAAT
TGCCCAGACACTGCCAAAAAACTGGAGAAGAACTTCTCATGTAATGTAAACACAGACATC
AAAGATGCTGTGGTAGTGCCTGTACCACAAACAGGTGCAAATTCACTGCCATCTGCAGAG
GGTGGCCCCCCTGAAGTTGTATCAGTCTGA
Protein Properties
Number of Residues 289
Molecular Weight 32307.9
Theoretical pI 8.44
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["155-175", "197-217"]
Protein Sequence 
>E3 ubiquitin-protein ligase MARCH1
MLGWCEAIARNPHRIPNNTRTPEISGDLADASQTSTLNEKSPGRSASRSSNISKASSPTT
GTAPRSQSRLSVCPSTQDICRICHCEGDEESPLITPCRCTGTLRFVHQSCLHQWIKSSDT
RCCELCKYDFIMETKLKPLRKWEKLQMTTSERRKIFCSVTFHVIAITCVVWSLYVLIDRT
AEEIKQGNDNGVLEWPFWTKLVVVAIGFTGGLVFMYVQCKVYVQLWRRLKAYNRVIFVQN
CPDTAKKLEKNFSCNVNTDIKDAVVVPVPQTGANSLPSAEGGPPEVVSV
GenBank ID Protein 261823980
UniProtKB/Swiss-Prot ID Q8TCQ1
UniProtKB/Swiss-Prot Entry Name MARH1_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001166373.1
GeneCard ID MARCH1
GenAtlas ID MARCH1
HGNC ID HGNC:26077
References
General References Not Available