Identification |
HMDB Protein ID
| CDBP00586 |
Secondary Accession Numbers
| Not Available |
Name
| Tyrosine--tRNA ligase, mitochondrial |
Description
| Not Available |
Synonyms
|
- TyrRS
- Tyrosine--tRNA ligase
- Tyrosyl-tRNA synthetase
|
Gene Name
| YARS2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in nucleotide binding |
Specific Function
| Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).
|
GO Classification
|
Biological Process |
mitochondrial tyrosyl-tRNA aminoacylation |
Cellular Component |
mitochondrial matrix |
Component |
cell part |
intracellular part |
cytoplasm |
Function |
binding |
nucleotide binding |
catalytic activity |
nucleoside binding |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
atp binding |
ligase activity |
tyrosine-trna ligase activity |
ligase activity, forming carbon-oxygen bonds |
ligase activity, forming aminoacyl-trna and related compounds |
aminoacyl-trna ligase activity |
Molecular Function |
ATP binding |
tyrosine-tRNA ligase activity |
tyrosine binding |
tRNA binding |
Process |
biosynthetic process |
rna metabolic process |
ncrna metabolic process |
trna metabolic process |
trna aminoacylation |
trna aminoacylation for protein translation |
macromolecule biosynthetic process |
cellular macromolecule biosynthetic process |
translation |
metabolic process |
macromolecule metabolic process |
cellular macromolecule metabolic process |
tyrosyl-trna aminoacylation |
|
Cellular Location
|
- Mitochondrion matrix
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Aminoacyl-tRNA biosynthesis | Not Available | ![Map00970](https://www.genome.jp/kegg/misc/thumbnail/map00970.gif) |
|
Gene Properties |
Chromosome Location
| 12 |
Locus
| 12p11.21 |
SNPs
| YARS2 |
Gene Sequence
|
>1434 bp
ATGGCGGCGCCCATCTTGCGGTCCTTTTCCTGGGGCCGGTGGTCTGGTACCCTAAATCTC
TCAGTATTGTTGCCCTTGGGGCTGCGTAAGGCCCACTCGGGCGCTCAGGGGTTACTGGCA
GCGCAGAAGGCTCGAGGTCTGTTCAAGGACTTCTTCCCGGAGACGGGGACGAAAATAGAG
CTCCCAGAGCTCTTCGACCGTGGCACGGCGAGTTTTCCCCAAACCATTTACTGTGGCTTC
GACCCCACGGCAGACTCGCTTCATGTGGGTCATCTACTTGCGCTGCTGGGCCTGTTTCAT
TTGCAGCGAGCGGGCCACAACGTGATCGCGCTGGTGGGAGGCGCCACGGCGCGCCTGGGA
GACCCGAGCGGCCGTACCAAGGAACGCGAGGCGCTGGAGACAGAGCGCGTGCGAGCCAAC
GCGCGAGCTCTGCGCCTAGGGCTTGAGGCCCTGGCGGCTAATCACCAGCAGCTTTTCACT
GATGGGCGCTCCTGGGGCAGCTTCACTGTGCTGGACAACTCGGCCTGGTACCAGAAGCAG
CACCTGGTGGACTTCCTGGCGGCAGTGGGGGGTCACTTCCGCATGGGGACGCTGCTGAGC
CGGCAGAGCGTGCAGCTGCGGCTCAAGAGCCCCGAGGGCATGAGCTTGGCCGAGTTCTTT
TACCAGGTGCTCCAGGCCTATGACTTCTATTACCTCTTCCAGCGTTATGGATGCAGGGTC
CAGCTGGGCGGATCTGATCAACTAGGCAACATCATGTCCGGATATGAGTTCATCAACAAG
TTGACTGGAGAAGATGTATTTGGAATCACCGTTCCTCTAATTACAAGTACAACTGGAGCA
AAGCTGGGAAAGTCTGCTGGCAACGCTGTTTGGCTAAACAGAGATAAGACATCTCCATTT
GAATTGTATCAATTCTTTGTCAGGCAACCGGACGATTCAGTGGAAAGGTACCTGAAGCTG
TTCACTTTCCTGCCCCTTCCAGAGATTGATCATATCATGCAGCTGCATGTCAAAGAGCCA
GAAAGGCGGGGTCCTCAGAAACGACTGGCAGCAGAAGTAACAAAGCTTGTTCATGGACGA
GAAGGATTGGATTCTGCTAAAAGGTGTACACAAGCCCTTTATCACAGTAGCATAGATGCA
CTGGAGGTCATGTCTGATCAGGAGTTAAAAGAGTTGTTTAAAGAAGCTCCATTTTCTGAA
TTTTTTCTCGATCCTGGAACAAGTGTCCTAGATACTTGCCGCAAAGCAAATGCCATTCCA
GATGGTCCCCGAGGGTATCGAATGATAACAGAAGGCGGAGTCAGCATAAATCACCAACAA
GTAACAAATCCTGAGAGTGTTTTAATTGTTGGACAACATATTCTCAAGAATGGACTTTCC
TTACTTAAAATAGGAAAAAGAAATTTCTACATTATAAAATGGCTTCAGTTGTGA
|
Protein Properties |
Number of Residues
| 477 |
Molecular Weight
| 53198.56 |
Theoretical pI
| 8.976 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Tyrosyl-tRNA synthetase, mitochondrial
MAAPILRSFSWGRWSGTLNLSVLLPLGLRKAHSGAQGLLAAQKARGLFKDFFPETGTKIE
LPELFDRGTASFPQTIYCGFDPTADSLHVGHLLALLGLFHLQRAGHNVIALVGGATARLG
DPSGRTKEREALETERVRANARALRLGLEALAANHQQLFTDGRSWGSFTVLDNSAWYQKQ
HLVDFLAAVGGHFRMGTLLSRQSVQLRLKSPEGMSLAEFFYQVLQAYDFYYLFQRYGCRV
QLGGSDQLGNIMSGYEFINKLTGEDVFGITVPLITSTTGAKLGKSAGNAVWLNRDKTSPF
ELYQFFVRQPDDSVERYLKLFTFLPLPEIDHIMQLHVKEPERRGPQKRLAAEVTKLVHGR
EGLDSAKRCTQALYHSSIDALEVMSDQELKELFKEAPFSEFFLDPGTSVLDTCRKANAIP
DGPRGYRMITEGGVSINHQQVTNPESVLIVGQHILKNGLSLLKIGKRNFYIIKWLQL
|
External Links |
GenBank ID Protein
| 94681057 |
UniProtKB/Swiss-Prot ID
| Q9Y2Z4 |
UniProtKB/Swiss-Prot Entry Name
| SYYM_HUMAN |
PDB IDs
|
|
GenBank Gene ID
| NM_001040436.1 |
GeneCard ID
| YARS2 |
GenAtlas ID
| YARS2 |
HGNC ID
| HGNC:24249 |
References |
General References
| Not Available |