Cannabis Compound Database: Showing Protein Uridine 5'-monophosphate synthase (CDBP00982)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP00982

Secondary Accession Numbers

Not Available

Name

Uridine 5'-monophosphate synthase

Description

Not Available

Synonyms

OMPdecase
OPRTase
Orotate phosphoribosyltransferase
Orotidine 5'-phosphate decarboxylase
UMP synthase

Gene Name

UMPS

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Not Available

GO Classification

Biological Process
pyrimidine nucleobase metabolic process
UMP biosynthetic process
'de novo' pyrimidine nucleobase biosynthetic process
'de novo' UMP biosynthetic process
Cellular Component
cytosol
nucleus
Function
transferase activity
lyase activity
carbon-carbon lyase activity
transferase activity, transferring pentosyl groups
carboxy-lyase activity
orotate phosphoribosyltransferase activity
orotidine-5'-phosphate decarboxylase activity
transferase activity, transferring glycosyl groups
catalytic activity
Molecular Function
orotate phosphoribosyltransferase activity
orotidine-5'-phosphate decarboxylase activity
Process
nucleotide metabolic process
cellular aromatic compound metabolic process
nucleoside metabolic process
cellular metabolic process
nucleobase metabolic process
pyrimidine base metabolic process
pyrimidine base biosynthetic process
'de novo' pyrimidine base biosynthetic process
pyrimidine nucleoside monophosphate biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
'de novo' ump biosynthetic process
metabolic process
nitrogen compound metabolic process
ump biosynthetic process
cellular nitrogen compound metabolic process
pyrimidine nucleotide metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
pyrimidine nucleotide biosynthetic process
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
UMP biosynthesis via de novo pathway	Not Available	Not Available
Drug metabolism - other enzymes	Not Available

Gene Properties

Chromosome Location

Locus

3q13

SNPs

UMPS

Gene Sequence

>1443 bp
ATGGCGGTCGCTCGTGCAGCTTTGGGGCCATTGGTGACGGGTCTGTACGACGTGCAGGCT
TTCAAGTTTGGGGACTTCGTGCTGAAGAGCGGGCTTTCCTCCCCCATCTACATCGATCTG
CGGGGCATCGTGTCTCGACCGCGTCTTCTGAGTCAGGTTGCAGATATTTTATTCCAAACT
GCCCAAAATGCAGGCATCAGTTTTGACACCGTGTGTGGAGTGCCTTATACAGCTTTGCCA
TTGGCTACAGTTATCTGTTCAACCAATCAAATTCCAATGCTTATTAGAAGGAAAGAAACA
AAGGATTATGGAACTAAGCGTCTTGTAGAAGGAACTATTAATCCAGGAGAAACCTGTTTA
ATCATTGAAGATGTTGTCACCAGTGGATCTAGTGTTTTGGAAACTGTTGAGGTTCTTCAG
AAGGAGGGCTTGAAGGTCACTGATGCCATAGTGCTGTTGGACAGAGAGCAGGGAGGCAAG
GACAAGTTGCAGGCGCACGGGATCCGCCTCCACTCAGTGTGTACATTGTCCAAAATGCTG
GAGATTCTCGAGCAGCAGAAAAAAGTTGATGCTGAGACAGTTGGGAGAGTGAAGAGGTTT
ATTCAGGAGAATGTCTTTGTGGCAGCGAATCATAATGGTTCTCCCCTTTCTATAAAGGAA
GCACCCAAAGAACTCAGCTTCGGTGCACGTGCAGAGCTGCCCAGGATCCACCCAGTTGCA
TCGAAGCTTCTCAGGCTTATGCAAAAGAAGGAGACCAATCTGTGTCTATCTGCTGATGTT
TCACTGGCCAGAGAGCTGTTGCAGCTAGCAGATGCTTTAGGACCTAGTATCTGCATGCTG
AAGACTCATGTAGATATTTTGAATGATTTTACTCTGGATGTGATGAAGGAGTTGATAACT
CTGGCAAAATGCCATGAGTTCTTGATATTTGAAGACCGGAAGTTTGCAGATATAGGAAAC
ACAGTGAAAAAGCAGTATGAAGGAGGTATCTTTAAAATAGCTTCCTGGGCAGATCTAGTA
AATGCTCACGTGGTGCCAGGCTCAGGAGTTGTGAAAGGCCTGCAAGAAGTGGGCCTGCCT
TTGCATCGGGGGTGCCTCCTTATTGCGGAAATGAGCTCCACCGGCTCCCTGGCCACTGGG
GACTACACTAGAGCAGCGGTTAGAATGGCTGAGGAGCACTCTGAATTTGTTGTTGGTTTT
ATTTCTGGCTCCCGAGTAAGCATGAAACCAGAATTTCTTCACTTGACTCCAGGAGTTCAG
TTGGAAGCAGGAGGAGATAATCTTGGCCAACAGTACAATAGCCCACAAGAAGTTATTGGC
AAACGAGGTTCCGATATCATCATTGTAGGTCGTGGCATAATCTCAGCAGCTGATCGTCTG
GAAGCAGCAGAGATGTACAGAAAAGCTGCTTGGGAAGCGTATTTGAGTAGACTTGGTGTT
TGA

Protein Properties

Number of Residues

480

Molecular Weight

52221.075

Theoretical pI

7.237

Pfam Domain Function

Pribosyltran (PF00156 )
OMPdecase (PF00215 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Uridine 5'-monophosphate synthase
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV

External Links

GenBank ID Protein

340168

UniProtKB/Swiss-Prot ID

P11172

UniProtKB/Swiss-Prot Entry Name

PYR5_HUMAN

PDB IDs

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Not Available