| Identification |
|---|
| HMDB Protein ID
| CDBP00982 |
| Secondary Accession Numbers
| Not Available |
| Name
| Uridine 5'-monophosphate synthase |
| Description
| Not Available |
| Synonyms
|
- OMPdecase
- OPRTase
- Orotate phosphoribosyltransferase
- Orotidine 5'-phosphate decarboxylase
- UMP synthase
|
| Gene Name
| UMPS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| UMP biosynthetic process |
| 'de novo' pyrimidine nucleobase biosynthetic process |
| 'de novo' UMP biosynthetic process |
| pyrimidine nucleobase metabolic process |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| transferase activity |
| lyase activity |
| carbon-carbon lyase activity |
| transferase activity, transferring pentosyl groups |
| carboxy-lyase activity |
| orotate phosphoribosyltransferase activity |
| orotidine-5'-phosphate decarboxylase activity |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| orotate phosphoribosyltransferase activity |
| orotidine-5'-phosphate decarboxylase activity |
| Process |
| 'de novo' ump biosynthetic process |
| metabolic process |
| ump biosynthetic process |
| nitrogen compound metabolic process |
| pyrimidine nucleotide metabolic process |
| cellular nitrogen compound metabolic process |
| pyrimidine nucleotide biosynthetic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| cellular aromatic compound metabolic process |
| nucleoside metabolic process |
| cellular metabolic process |
| nucleobase metabolic process |
| pyrimidine base metabolic process |
| pyrimidine base biosynthetic process |
| 'de novo' pyrimidine base biosynthetic process |
| pyrimidine nucleoside monophosphate biosynthetic process |
| pyrimidine ribonucleoside monophosphate biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | UMP biosynthesis via de novo pathway | Not Available | Not Available | | Drug metabolism - other enzymes | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3q13 |
| SNPs
| UMPS |
| Gene Sequence
|
>1443 bp
ATGGCGGTCGCTCGTGCAGCTTTGGGGCCATTGGTGACGGGTCTGTACGACGTGCAGGCT
TTCAAGTTTGGGGACTTCGTGCTGAAGAGCGGGCTTTCCTCCCCCATCTACATCGATCTG
CGGGGCATCGTGTCTCGACCGCGTCTTCTGAGTCAGGTTGCAGATATTTTATTCCAAACT
GCCCAAAATGCAGGCATCAGTTTTGACACCGTGTGTGGAGTGCCTTATACAGCTTTGCCA
TTGGCTACAGTTATCTGTTCAACCAATCAAATTCCAATGCTTATTAGAAGGAAAGAAACA
AAGGATTATGGAACTAAGCGTCTTGTAGAAGGAACTATTAATCCAGGAGAAACCTGTTTA
ATCATTGAAGATGTTGTCACCAGTGGATCTAGTGTTTTGGAAACTGTTGAGGTTCTTCAG
AAGGAGGGCTTGAAGGTCACTGATGCCATAGTGCTGTTGGACAGAGAGCAGGGAGGCAAG
GACAAGTTGCAGGCGCACGGGATCCGCCTCCACTCAGTGTGTACATTGTCCAAAATGCTG
GAGATTCTCGAGCAGCAGAAAAAAGTTGATGCTGAGACAGTTGGGAGAGTGAAGAGGTTT
ATTCAGGAGAATGTCTTTGTGGCAGCGAATCATAATGGTTCTCCCCTTTCTATAAAGGAA
GCACCCAAAGAACTCAGCTTCGGTGCACGTGCAGAGCTGCCCAGGATCCACCCAGTTGCA
TCGAAGCTTCTCAGGCTTATGCAAAAGAAGGAGACCAATCTGTGTCTATCTGCTGATGTT
TCACTGGCCAGAGAGCTGTTGCAGCTAGCAGATGCTTTAGGACCTAGTATCTGCATGCTG
AAGACTCATGTAGATATTTTGAATGATTTTACTCTGGATGTGATGAAGGAGTTGATAACT
CTGGCAAAATGCCATGAGTTCTTGATATTTGAAGACCGGAAGTTTGCAGATATAGGAAAC
ACAGTGAAAAAGCAGTATGAAGGAGGTATCTTTAAAATAGCTTCCTGGGCAGATCTAGTA
AATGCTCACGTGGTGCCAGGCTCAGGAGTTGTGAAAGGCCTGCAAGAAGTGGGCCTGCCT
TTGCATCGGGGGTGCCTCCTTATTGCGGAAATGAGCTCCACCGGCTCCCTGGCCACTGGG
GACTACACTAGAGCAGCGGTTAGAATGGCTGAGGAGCACTCTGAATTTGTTGTTGGTTTT
ATTTCTGGCTCCCGAGTAAGCATGAAACCAGAATTTCTTCACTTGACTCCAGGAGTTCAG
TTGGAAGCAGGAGGAGATAATCTTGGCCAACAGTACAATAGCCCACAAGAAGTTATTGGC
AAACGAGGTTCCGATATCATCATTGTAGGTCGTGGCATAATCTCAGCAGCTGATCGTCTG
GAAGCAGCAGAGATGTACAGAAAAGCTGCTTGGGAAGCGTATTTGAGTAGACTTGGTGTT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 480 |
| Molecular Weight
| 52221.075 |
| Theoretical pI
| 7.237 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Uridine 5'-monophosphate synthase
MAVARAALGPLVTGLYDVQAFKFGDFVLKSGLSSPIYIDLRGIVSRPRLLSQVADILFQT
AQNAGISFDTVCGVPYTALPLATVICSTNQIPMLIRRKETKDYGTKRLVEGTINPGETCL
IIEDVVTSGSSVLETVEVLQKEGLKVTDAIVLLDREQGGKDKLQAHGIRLHSVCTLSKML
EILEQQKKVDAETVGRVKRFIQENVFVAANHNGSPLSIKEAPKELSFGARAELPRIHPVA
SKLLRLMQKKETNLCLSADVSLARELLQLADALGPSICMLKTHVDILNDFTLDVMKELIT
LAKCHEFLIFEDRKFADIGNTVKKQYEGGIFKIASWADLVNAHVVPGSGVVKGLQEVGLP
LHRGCLLIAEMSSTGSLATGDYTRAAVRMAEEHSEFVVGFISGSRVSMKPEFLHLTPGVQ
LEAGGDNLGQQYNSPQEVIGKRGSDIIIVGRGIISAADRLEAAEMYRKAAWEAYLSRLGV
|
| External Links |
|---|
| GenBank ID Protein
| 340168 |
| UniProtKB/Swiss-Prot ID
| P11172 |
| UniProtKB/Swiss-Prot Entry Name
| PYR5_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| J03626 |
| GeneCard ID
| UMPS |
| GenAtlas ID
| UMPS |
| HGNC ID
| HGNC:12563 |
| References |
|---|
| General References
| Not Available |