| Identification |
|---|
| HMDB Protein ID
| CDBP00707 |
| Secondary Accession Numbers
| Not Available |
| Name
| DNA-directed RNA polymerase III subunit RPC8 |
| Description
| Not Available |
| Synonyms
|
- DNA-directed RNA polymerase III subunit H
- RNA polymerase III subunit 22.9 kDa subunit
- RNA polymerase III subunit C8
- RPC22.9
|
| Gene Name
| POLR3H |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA-directed RNA polymerase activity |
| Specific Function
| DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).
|
| GO Classification
|
| Biological Process |
| termination of RNA polymerase III transcription |
| transcription elongation from RNA polymerase III promoter |
| defense response to virus |
| innate immune response |
| Cellular Component |
| centrosome |
| DNA-directed RNA polymerase III complex |
| Function |
| transferase activity, transferring phosphorus-containing groups |
| nucleotidyltransferase activity |
| nucleic acid binding |
| dna binding |
| rna polymerase activity |
| dna-directed rna polymerase activity |
| binding |
| catalytic activity |
| transferase activity |
| Molecular Function |
| DNA-directed RNA polymerase activity |
| DNA binding |
| Process |
| macromolecule biosynthetic process |
| cellular macromolecule biosynthetic process |
| metabolic process |
| biosynthetic process |
| transcription |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | RNA polymerase | Not Available |  | | Cytosolic DNA-sensing pathway | Not Available |  | | Epstein-Barr virus infection | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| POLR3H |
| Gene Sequence
|
>615 bp
ATGTTCGTCCTGGTGGAAATGGTGGACACCGTCCGGATCCCCCCTTGGCAGTTTGAGAGG
AAGCTCAACGACTCCATTGCCGAGGAGCTGAACAAGAAGTTGGCCAACAAGGTCGTGTAC
AACGTGGGACTCTGCATTTGTCTGTTTGATATCACCAAACTGGAGGATGCCTATGTATTC
CCTGGGGATGGCGCATCACACACCAAAGTCCATTTTCGCTGCGTGGTGTTTCATCCATTC
CTAGATGAGATTCTCATTGGGAAGATCAAAGGCTGCAGCCCAGAAGGAGTGCACGTCTCT
CTAGGCTTCTTCGATGACATTCTCATCCCCCCAGAGTCACTGCAGCAGCCAGCCAAGTTC
GACGAAGCGGAGCAGGTGTGGGTGTGGGAGTACGAGACGGAGGAAGGAGCACACGACCTC
TACATGGACACCGGCGAGGAGATCCGCTTCCGGGTGGTGGACGAGAGCTTTGTTGACACG
TCCCCCACAGGGCCCAGCTCAGCAGATGCCACCACTTCCAGTGAGGAGCTGCCAAAGAAG
GAGGCTCCGTACACGCTTGTGGGATCCATCAGTGAGCCAGGCCTGGGCCTTCTCTCCTGG
TGGACCAGCAACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 204 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>DNA-directed RNA polymerase III subunit RPC8
MFVLVEMVDTVRIPPWQFERKLNDSIAEELNKKLANKVVYNVGLCICLFDITKLEDAYVF
PGDGASHTKVHFRCVVFHPFLDEILIGKIKGCSPEGVHVSLGFFDDILIPPESLQQPAKF
DEAEQVWVWEYETEEGAHDLYMDTGEEIRFRVVDESFVDTSPTGPSSADATTSSEELPKK
EAPYTLVGSISEPGLGLLSWWTSN
|
| External Links |
|---|
| GenBank ID Protein
| 65301161 |
| UniProtKB/Swiss-Prot ID
| Q9Y535 |
| UniProtKB/Swiss-Prot Entry Name
| RPC8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001018050.2 |
| GeneCard ID
| POLR3H |
| GenAtlas ID
| POLR3H |
| HGNC ID
| HGNC:30349 |
| References |
|---|
| General References
| Not Available |