Cannabis Compound Database: Showing Protein Ubiquitin-conjugating enzyme E2 D4 (CDBP05125)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP05125

Secondary Accession Numbers

Not Available

Name

Ubiquitin-conjugating enzyme E2 D4

Description

Not Available

Synonyms

HBUCE1
Ubiquitin carrier protein D4
Ubiquitin-protein ligase D4

Gene Name

UBE2D4

Protein Type

Enzyme

Biological Properties

General Function

Involved in acid-amino acid ligase activity

Specific Function

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, but may prefer 'Lys-11' and 'Lys-48'-linked polyubiquitination.

GO Classification

Biological Process
protein K48-linked ubiquitination
protein K11-linked ubiquitination
protein K27-linked ubiquitination
protein K29-linked ubiquitination
protein K6-linked ubiquitination
protein K63-linked ubiquitination
Function
small conjugating protein ligase activity
ligase activity
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
catalytic activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process

Cellular Location

Not Available

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein ubiquitination	Not Available	Not Available
Ubiquitin mediated proteolysis	Not Available
Protein processing in endoplasmic reticulum	Not Available

Gene Properties

Chromosome Location

Locus

7p13

SNPs

UBE2D4

Gene Sequence

>444 bp
ATGGCGCTAAAGCGGATCCAGAAGGAATTAACCGACTTGCAGAGGGATCCTCCTGCCCAG
TGTTCTGCAGGACCTGTCGGTGATGACTTGTTCCACTGGCAGGCCACCATCATGGGCCCG
AATGACAGTCCTTACCAAGGAGGTGTTTTCTTCCTGACCATCCACTTTCCTACAGATTAC
CCGTTCAAGCCCCCAAAGGTTGCTTTCACAACCAAAATTTATCACCCTAATATCAACAGC
AATGGCAGCATCTGCCTTGATATCCTGCGGTCTCAGTGGTCTCCAGCGTTGACTGTGTCA
AAAGTTCTCTTGTCCATCTGCTCGCTGCTCTGCGACCCCAACCCCGATGACCCCCTGGTG
CCAGAGATAGCACACACCTACAAGGCCGACAGAGAGAAGTACAACAGACTAGCAAGAGAG
TGGACACAAAAATATGCTATGTAA

Protein Properties

Number of Residues

147

Molecular Weight

16648.92

Theoretical pI

7.365

Pfam Domain Function

UQ_con (PF00179 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Ubiquitin-conjugating enzyme E2 D4
MALKRIQKELTDLQRDPPAQCSAGPVGDDLFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV
PEIAHTYKADREKYNRLAREWTQKYAM

External Links

GenBank ID Protein

4868140

UniProtKB/Swiss-Prot ID

Q9Y2X8

UniProtKB/Swiss-Prot Entry Name

UB2D4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF125044

GeneCard ID