| Identification |
|---|
| HMDB Protein ID
| CDBP03866 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase HERC2 |
| Description
| Not Available |
| Synonyms
|
- HECT domain and RCC1-like domain-containing protein 2
|
| Gene Name
| HERC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase that regulates ubiquitin- dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintainance of RNF168 levels. E3 ubiquitin- protein ligase that promotes the ubiquitination and proteosomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity |
| GO Classification
|
| Component |
| cell part |
| macromolecular complex |
| protein complex |
| intracellular |
| ubiquitin ligase complex |
| nuclear ubiquitin ligase complex |
| anaphase-promoting complex |
| Function |
| zinc ion binding |
| ligase activity |
| iron ion binding |
| protein binding |
| heme binding |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| ubiquitin-protein ligase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| small conjugating protein ligase activity |
| transition metal ion binding |
| Process |
| protein ubiquitination |
| regulation of mitotic cell cycle |
| regulation of mitosis |
| regulation of mitotic metaphase/anaphase transition |
| macromolecule modification |
| protein modification process |
| metabolic process |
| macromolecule metabolic process |
| biological regulation |
| regulation of biological process |
| regulation of cell cycle |
| protein modification by small protein conjugation or removal |
| protein modification by small protein conjugation |
| regulation of cellular process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q13 |
| SNPs
| HERC2 |
| Gene Sequence
|
>14505 bp
ATGCCCTCTGAATCTTTCTGTTTGGCTGCCCAGGCTCGCCTCGACTCCAAATGGTTGAAA
ACAGATATACAGCTTGCATTCACAAGAGATGGGCTCTGTGGTCTGTGGAATGAAATGGTT
AAAGATGGAGAAATTGTATACACTGGAACAGAATCAACCCAGAACGGAGAGCTCCCTCCT
AGAAAAGATGATAGTGTCGAACCAAGTGGAACAAAGAAAGAAGATCTGAATGACAAAGAG
AAAAAAGATGAAGAAGAAACTCCTGCACCTATATATAGGGCCAAGTCAATTCTGGACAGC
TGGGTATGGGGCAAGCAACCAGATGTGAATGAACTGAAGGAGTGTCTTTCTGTGCTGGTT
AAAGAGCAGCAGGCCCTGGCCGTCCAGTCAGCCACCACCACCCTCTCAGCCCTGCGACTC
AAGCAGAGGCTGGTGATCTTGGAGCGCTATTTCATTGCCTTGAATAGAACCGTTTTTCAG
GAGAATGTCAAAGTTAAGTGGAAAAGCAGCGGTATTTCTCTGCCTCCTGTGGACAAAAAA
AGTTCCCGGCCTGCGGGCAAAGGTGTGGAGGGGCTCGCCAGAGTGGGATCCCGAGCGGCG
CTGTCTTTTGCCTTTGCCTTCCTGCGCAGGGCCTGGCGATCAGGCGAGGATGCGGACCTC
TGCAGTGAGCTGTTGCAGGAGTCCCTGGACGCCCTGCGAGCACTTCCCGAGGCCTCGCTC
TTTGACGAGAGCACCGTGTCCTCTGTGTGGCTGGAGGTGGTGGAGAGAGCGACCAGGTTC
CTCAGGTCCGTCGTGACGGGGGATGTTCACGGAACGCCAGCCACCAAAGGGCCAGGAAGC
ATCCCCCTGCAGGACCAGCACTTGGCCCTGGCCATCCTGCTGGAGCTGGCTGTGCAGAGA
GGCACGCTGAGCCAAATGTTGTCTGCCATCCTGTTGTTGCTTCAGCTGTGGGACAGCGGG
GCACAGGAGACTGACAATGAGCGTTCCGCCCAGGGCACCAGCGCCCCACTTTTGCCCTTG
CTGCAAAGGTTCCAGAGCATCATTTGCAGGAAGGATGCACCCCACTCCGAGGGCGACATG
CACCTTTTGTCTGGCCCTCTGAGCCCCAATGAGAGTTTCCTGAGGTACCTCACCCTTCCA
CAAGACAACGAGCTTGCCATTGATCTGCGACAAACGGCGGTTGTTGTCATGGCCCATTTA
GACCGTCTGGCTACGCCCTGTATGCCTCCGCTGTGTAGCTCTCCGACATCTCATAAGGGA
TCATTGCAAGAGGTCATAGGTTGGGGGTTAATAGGATGGAAATACTATGCCAATGTGATT
GGTCCAATCCAGTGCGAAGGCCTGGCCAACCTGGGAGTCACACAGATTGCCTGTGCAGAG
AAGCGTTTCCTGATTCTGTCACGCAATGGCCGCGTGTACACACAGGCCTATAATAGTGAC
ACGCTGGCCCCACAGCTGGTCCAAGGCCTTGCCTCCAGAAACATTGTAAAAATTGCTGCC
CATTCTGATGGTCACCACTACCTAGCCTTGGCTGCTACTGGAGAGGTGTACTCCTGGGGC
TGTGGGGACGGCGGACGGCTGGGCCATGGGGACACTGTGCCTTTGGAGGAGCCTAAGGTG
ATCTCCGCCTTCTCTGGAAAGCAGGCCGGGAAGCACGTGGTGCACATCGCTTGCGGGAGC
ACTTACAGTGCGGCCATCACTGCCGAGGGGGAGCTGTACACCTGGGGCCGCGGGAACTAC
GGCCGGCTGGGCCATGGCTCCAGTGAGGACGAGGCCATTCCGATGCTGGTAGCCGGGCTT
AAAGGACTGAAGGTCATCGATGTGGCGTGTGGGAGTGGGGATGCTCAAACCCTGGCTGTC
ACTGAGAACGGGCAAGTGTGGTCTTGGGGAGATGGTGACTATGGGAAATTGGGCAGAGGT
GGTAGTGATGGCTGCAAAACCCCAAAGCTGATTGAAAAGCTTCAAGACTTGGATGTGGTC
AAAGTCCGCTGTGGAAGTCAGTTTTCCATTGCTTTGACGAAAGATGGCCAAGTTTATTCA
TGGGGAAAAGGTGACAACCAGAGACTTGGACATGGAACAGAGGAACATGTTCGTTATCCA
AAACTCTTAGAAGGCTTGCAAGGGAAGAAGGTGATTGATGTGGCTGCAGGCTCCACCCAC
TGCCTGGCTCTGACTGAGGACAGCGAGGTCCACAGCTGGGGGAGCAACGACCAGTGCCAG
CACTTTGACACCTTGCGCGTGACCAAGCCAGAACCTGCAGCATTGCCAGGACTGGACACC
AAACACATAGTGGGAATTGCCTGTGGGCCTGCCCAGAGCTTTGCTTGGTCATCATGTTCT
GAGTGGTCCATTGGCCTCCGTGTCCCTTTTGTGGTGGACATCTGCTCAATGACTTTTGAG
CAGCTGGATCTCCTGCTTCGGCAGGTGAGTGAGGGGATGGATGGTTCCGCGGACTGGCCC
CCGCCCCAGGAGAAAGAGTGTGTGGCCGTGGCAACGCTGAATCTTCTACGACTTCAGTTG
CATGCTGCCATTAGTCACCAGGTTGACCCGGAATTCCTTGGTTTAGGTCTGGGCAGCATC
CTCCTGAACAGCCTGAAGCAGACGGTGGTGACCCTGGCCAGCAGTGCGGGCGTGCTGAGC
ACCGTGCAGTCGGCCGCCCAGGCCGTGCTGCAGAGTGGCTGGTCCGTGCTGCTGCCCACC
GCGGAGGAGCGGGCCCGGGCACTCTCTGCTCTCCTGCCCTGCGCAGTTTCAGGCAATGAA
GTGAACATAAGTCCAGGTCGTCGATTCATGATTGATCTTCTGGTGGGCAGCTTGATGGCT
GATGGAGGGTTGGAGTCAGCCTTACACGCAGCCATTACTGCAGAGATCCAGGATATTGAA
GCCAAAAAAGAAGCACAGAAGGAAAAAGAAATTGATGAACAGGAAGCGAATGCCTCAACA
TTTCATAGAAGCAGGACTCCACTGGATAAAGACCTTATTAATACGGGGATCTGTGAGTCT
TCTGGCAAACAGTGTTTGCCTCTGGTTCAGCTCATACAACAGCTTCTTAGAAACATTGCT
TCTCAGACTGTAGCCAGATTGAAAGATGTTGCCCGTCGGATTTCATCATGTCTGGACTTT
GAGCAACACAGTCGTGAAAGATCTGCTTCATTGGATTTGTTACTGCGTTTTCAACGTTTG
CTTATTAGTAAACTTTATCCAGGAGAAAGTATTGGTCAGACCTCAGATATTTCTAGTCCA
GAGCTAATGGGTGTTGGTTCCTTGCTGAAGAAGTACACAGCCCTCCTGTGCACGCACATT
GGAGATATACTGCCTGTGGCCGCCAGCATTGCTTCTACCAGCTGGCGGCACTTCGCGGAG
GTGGCTTACATTGTGGAAGGGGACTTTACTGGTGTTCTCCTTCCAGAACTAGTAGTTTCT
ATAGTGCTTCTGCTCAGTAAAAATGCTGGTCTCATGCAAGAGGCTGGAGCTGTACCTCTG
CTGGGTGGCCTGTTGGAACATCTGGATCGGTTCAACCATCTGGCACCAGGAAAGGAACGG
GATGATCATGAAGAGTTAGCCTGGCCTGGCATAATGGAGTCATTTTTTACAGGTCAGAAC
TGTAGAAATAATGAGGAAGTGACACTTATACGCAAAGCTGATTTGGAGAACCATAATAAA
GATGGAGGCTTCTGGACTGTGATTGACGGGAAGGTGTATGATATAAAGGACTTCCAGACA
CAGTCGTTAACAGGAAATAGTATTCTTGCTCAGTTTGCAGGGGAAGACCCAGTGGTAGCT
TTGGAAGCTGCTTTGCAGTTTGAAGACACCCGGGAATCCATGCACGCGTTTTGTGTTGGC
CAGTATTTGGAGCCTGACCAAGAAATCGTCACCATACCAGATCTGGGGAGTCTCTCTTCA
CCTCTGATAGACACAGAGAGGAATCTGGGCCTGCTTCTCGGATTACACGCTTCGTATTTG
GCAATGAGCACACCGCTGTCTCCTGTCGAGATTGAATGTGCCAAATGGCTTCAGTCATCC
ATCTTCTCTGGAGGCCTGCAGACCAGCCAGATCCACTACAGCTACAACGAGGAGAAAGAC
GAGGACCACTGCAGCTCCCCAGGGGGCACACCTGCCAGCAAATCTCGACTCTGCTCCCAC
AGACGGGCCCTGGGGGACCATTCCCAGGCATTTCTGCAAGCCATTGCAGACAACAACATT
CAGGATCACAACGTGAAGGACTTTTTGTGTCAAATAGAAAGGTACTGTAGGCAGTGCCAT
TTGACCACACCGATCATGTTTCCCCCCGAGCATCCCGTGGAAGAGGTCGGTCGCTTGTTG
TTATGTTGCCTCTTAAAACATGAAGATTTAGGTCATGTGGCATTATCTTTAGTTCATGCA
GGTGCACTTGGTATTGAGCAAGTAAAGCACAGAACGTTGCCTAAGTCAGTGGTGGATGTT
TGTAGAGTTGTCTACCAAGCAAAATGTTCGCTCATTAAGACTCATCAAGAACAGGGCCGT
TCTTACAAGGAGGTCTGCGCTCCTGTCATCGAACGTTTGAGATTCCTCTTTAATGAATTG
AGACCTGCTGTTTGTAATGACCTCTCTATAATGTCTAAGTTTAAATTGTTAAGTTCTTTG
CCCCGTTGGAGGAGGATAGCTCAAAAGATAATTCGAGAACGAAGGAAAAAGAGAGTTCCT
AAGAAGCCAGAATCTACGGATGATGAAGAAAAAATTGGAAACGAAGAGAGTGATTTAGAA
GAAGCTTGCATTTTGCCTCATAGTCCAATAAATGTGGACAAGAGACCCATTGCAATTAAA
TCACCCAAGGACAAATGGCAGCCGCTGTTGAGTACTGTTACAGGTGTTCACAAATACAAG
TGGTTGAAGCAGAATGTGCAGGGTCTTTATCCGCAGTCTCCACTCCTCAGTACAATTGCT
GAATTTGCCCTTAAAGAAGAGCCAGTGGATGTGGAAAAAATGAGAAAGTGCCTACTAAAA
CAGTTGGAGAGAGCAGAGGTTCGCCTGGAAGGGATAGATACAATTTTAAAACTGGCGAGC
AAGAATTTCTTACTTCCATCTGTGCAGTATGCGATGTTTTGTGGATGGCAAAGACTTATT
CCTGAGGGAATCGATATAGGGGAACCTCTTACTGATTGTTTAAAGGATGTTGATTTGATC
CCGCCTTTTAATCGGATGCTGCTGGAAGTCACCTTTGGCAAGCTGTACGCTTGGGCTGTA
CAGAACATTCGAAATGTTTTGATGGATGCCAGTGCCAAATTTAAAGAGCTTGGTATCCAG
CCGGTTCCCCTGCAAACCATCACCAATGAGAACCCGTCAGGACCGAGCCTGGGGACCATC
CCGCAAGCCCGCTTCCTCCTGGTGATGCTCAGCATGCTCACCCTGCAGCACGGCGCAAAC
AACCTCGACCTTCTGCTCAATTCCGGCATGCTGGCCCTCACGCAGACGGCACTGCGCCTG
ATTGGCCCCAGTTGTGACAACGTTGAGGAAGATATGAATGCTTCTGCTCAAGGTGCTTCT
GCCACAGTTTTGGAAGAAACAAGGAAGGAAACGGCTCCTGTGCAGCTCCCTGTTTCAGGA
CCAGAACTGGCTGCCATGATGAAGATTGGAACAAGGGTCATGAGAGGTGTGGACTGGAAA
TGGGGCGATCAGGATGGGCCTCCTCCAGGCCTAGGCCGCGTGATTGGTGAGCTGGGAGAG
GACGGATGGATAAGAGTCCAGTGGGACACAGGCAGCACCAACTCCTACAGGATGGGGAAA
GAAGGAAAATACGACCTCAAGCTGGCAGAGCTGCCGGCTGCTGCACAGCCCTCAGCAGAG
GATTCGGACACAGAGGATGACTCTGAAGCCGAACAAACTGAAAGGAACATTCACCCCACT
GCAATGATGTTTACCAGCACTATTAACTTACTGCAGACTCTTTGTCTGTCTGCTGGAGTT
CATGCTGAGATCATGCAGAGCGAAGCCACCAAGACTTTATGCGGACTGCTGCGAATGTTA
GTGGAAAGCGGAACGACGGACAAGACATCTTCTCCAAACAGGCTGGTGTACAGGGAGCAA
CACCGGAGCTGGTGCACGCTGGGGTTTGTGCGGAGCATCGCTCTCACGCCGCAGGTATGC
GGCGCCCTCAGCTCCCCGCAGTGGATCACGCTGCTCATGAAGGTCGTGGAAGGGCACGCA
CCCTTCACTGCCACCTCGCTGCAGAGGCAGATCTTAGCTGTGCATTTGTTGCAAGCAGTC
CTTCCATCATGGGACAAGACCGAAAGGGCGAGGGACATGAAATGCCTCGTGGAGAAGCTG
TTTGACTTCTTGGGAAGCTTGCTCACTACCTGCTCCTCTGACGTGCCATTACTCAGAGAG
TCCACGCTGAGGCGGCGCAGGGTGCGCCCGCAGGCCTCGCTGACTGCCACCCACAGCAGC
ACACTGGCGGAGGAGGTGGTGGCACTGCTGCGCACGCTGCACTCCCTGACTCAGTGGAAT
GGGCTCATCAACAAGTACATCAACTCCCAGCTCCGCTCCATCACCCACAGCTTTGTGGGA
AGGCCTTCCGAAGGGGCCCAGTTAGAGGACTACTTCCCCGACTCCGAGAACCCTGAAGTG
GGGGGCCTCATGGCAGTCCTGGCTGTGATTGGAGGCATCGATGGTCGCCTGCGCCTGGGC
GGTCAAGTTATGCACGATGAGTTTGGAGAAGGCACTGTGACTCGCATCACCCCAAAGGGC
AAAATCACCGTGCAGTTCTCTGACATGCGGACGTGTCGCGTTTGCCCATTGAATCAGCTG
AAACCACTCCCTGCCGTGGCCTTTAATGTGAACAACCTGCCCTTCACAGAGCCCATGCTG
TCTGTCTGGGCTCAGTTGGTGAACCTCGCTGGAAGCAAGTTAGAAAAGCACAAAATAAAG
AAATCGACTAAACAGGCCTTTGCAGGACAAGTGGACCTGGACCTGCTGCGGTGCCAGCAG
TTGAAGCTATACATCCTGAAAGCAGGTCGGGCGCTGCTCTCCCACCAGGATAAACTGCGG
CAGATCCTGTCTCAGCCAGCTGTTCAGGAGACTGGAACTGTTCACACAGATGATGGAGCA
GTGGTATCACCTGACCTTGGGGACATGTCTCCTGAAGGGCCGCAGCCCCCCATGATCCTC
TTGCAGCAGCTGCTGGCCTCGGCCACCCAGCCGTCTCCTGTGAAGGCCATATTTGATAAA
CAGGAACTTGAGGCTGCTGCACTGGCCGTTTGCCAGTGCTTGGCTGTGGAGTCCACTCAC
CCTTCGAGCCCAGGATTTGAAGACTGCAGCTCCAGTGAGGCCACCACGCCTGTCGCCGTG
CAGCACATCCGCCCTGCCAGAGTGAAGAGGCGCAAGCAGTCGCCCGTTCCCGCTCTGCCG
ATCGTGGTGCAGCTCATGGAGATGGGATTTTCCAGAAGGAACATCGAGTTTGCCCTGAAG
TCTCTCACTGGTGCTTCCGGGAATGCATCCAGCTTGCCTGGTGTGGAAGCCTTGGTCGGG
TGGCTGCTGGACCACTCCGACATACAGGTCACGGAGCTCTCAGATGCAGACACGGTGTCC
GACGAGTATTCTGACGAGGAGGTGGTGGAGGACGTGGATGATGCCGCCTACTCCATGTCT
ACTGGTGCTGTTGTGACGGAGAGCCAGACGTACAAAAAACGAGCTGATTTCTTGAGTAAT
GATGATTATGCTGTATATGTGAGAGAGAATATTCAGGTGGGAATGATGGTTAGATGCTGC
CGAGCGTATGAAGAAGTGTGCGAAGGTGATGTTGGCAAAGTCATCAAGCTGGACAGAGAT
GGATTGCATGATCTCAATGTGCAGTGTGACTGGCAGCAGAAAGGGGGCACCTACTGGGTT
AGGTACATTCATGTGGAACTTATAGGCTATCCTCCACCAAGTTCTTCTTCTCACATCAAG
ATTGGTGATAAAGTGCGGGTCAAAGCCTCTGTCACCACACCAAAATACAAATGGGGATCT
GTGACTCATCAGAGTGTGGGGGTTGTGAAAGCTTTCAGTGCCAATGGAAAAGATATCATT
GTCGACTTTCCCCAGCAGTCTCACTGGACTGGGTTGCTATCAGAAATGGAGTTGGTACCC
AGTATTCATCCTGGGGTTACGTGTGATGGATGTCAGATGTTTCCTATCAATGGATCCAGA
TTCAAATGCAGAAACTGTGATGACTTTGATTTTTGTGAAACGTGTTTCAAGACCAAAAAA
CACAATACCAGGCATACATTTGGCAGAATAAATGAACCAGGTCAGTCTGCGGTATTTTGT
GGCCGTTCTGGAAAACAGCTGAAGCGTTGCCACAGCAGCCAGCCAGGCATGCTGCTGGAC
AGCTGGTCCCGCATGGTGAAGAGCCTGAATGTGTCGTCCTCCGTGAACCAGGCATCCCGT
CTCATTGACGGCAGCGAGCCCTGCTGGCAGTCATCGGGGTCGCAAGGAAAGCACTGGATT
CGTTTGGAGATTTTCCCAGATGTTCTTGTTCATAGATTAAAAATGATCGTAGATCCTGCT
GACAGTAGCTACATGCCGTCCCTGGTTGTAGTGTCAGGTGGAAATTCCCTGAATAACCTT
ATTGAACTAAAGACAATCAATATTAACCCTTCTGACACCACAGTGCCCCTTCTGAATGAC
TGCACAGAGTATCACAGGTATATTGAAATTGCTATAAAGCAGTGCAGGAGCTCAGGAATC
GATTGTAAAATCCATGGTCTCATCCTGCTGGGACGGATCCGTGCAGAAGAGGAAGATTTG
GCTGCAGTTCCTTTCTTAGCTTCGGATAATGAAGAGGAGGAGGATGAGAAAGGCAACAGC
GGAAGCCTCATTAGAAAGAAGGCTGCTGGGCTGGAATCAGCAGCTACGATAAGAACCAAG
GTGTTTGTGTGGGGCCTGAATGACAAGGACCAGCTGGGCGGGCTGAAAGGCTCCAAGATA
AAGGTTCCTTCGTTCTCTGAGACACTGTCAGCTTTGAATGTGGTACAGGTGGCTGGTGGA
TCTAAAAGTTTGTTTGCAGTGACTGTGGAAGGGAAGGTGTATGCCTGTGGAGAAGCCACG
AATGGCCGGCTGGGGCTGGGCATTTCCAGCGGGACGGTGCCCATCCCACGGCAGATCACA
GCTCTCAGCAGCTACGTGGTCAAGAAGGTGGCTGTTCACTCAGGTGGCCGGCACGCGACG
GCTTTAACTGTCGATGGAAAAGTGTTTTCGTGGGGCGAAGGTGACGATGGAAAACTTGGA
CACTTCAGCAGAATGAACTGTGACAAACCAAGGCTGATCGAGGCCCTGAAAACCAAGCGT
ATCCGGGATATCGCCTGTGGGAGCTCGCACAGCGCAGCCCTCACATCCAGCGGAGAACTG
TACACCTGGGGCCTCGGCGAGTACGGCCGGCTGGGACATGGGGATAATACGACACAGCTA
AAGCCCAAAATGGTGAAAGTCCTTCTCGGTCACAGAGTAATCCAGGTTGCATGTGGGAGT
AGAGACGCGCAGACCCTGGCTCTGACCGATGAAGGTTTGGTATTTTCCTGGGGTGATGGT
GACTTTGGAAAACTGGGCCGGGGCGGAAGTGAAGGCTGTAACATTCCCCAGAACATTGAG
AGACTAAATGGACAGGGGGTGTGCCAGATTGAGTGTGGAGCTCAGTTCTCCCTGGCGCTC
ACCAAGTCTGGAGTGGTGTGGACATGGGGAAAGGGGGATTACTTCAGATTGGGCCACGGC
TCTGACGTGCACGTGCGGAAACCACAGGTGGTGGAAGGGCTGAGAGGGAAGAAGATCGTG
CATGTGGCTGTCGGGGCCCTGCACTGCCTGGCGGTCACGGACTCGGGGCAGGTGTATGCT
TGGGGTGACAACGACCACGGCCAGCAGGGCAATGGCACGACCACGGTTAACAGGAAGCCC
ACACTCGTGCAAGGCTTAGAAGGCCAGAAGATCACACGCGTGGCTTGTGGGTCGTCCCAC
AGTGTGGCGTGGACAACTGTGGATGTGGCCACGCCCTCTGTCCACGAGCCCGTCCTCTTC
CAGACTGCAAGAGACCCTTTAGGTGCTTCCTATTTAGGCGTGCCTTCAGATGCTGATTCT
TCTGCTGCCAGTAATAAAATAAGTGGTGCAAGTAATTCTAAGCCAAATCGCCCTTCTCTT
GCCAAGATTCTCTTGTCATTGGATGGAAATCTGGCCAAACAGCAGGCCTTATCACATATT
CTTACAGCATTGCAAATCATGTATGCCAGAGATGCTGTTGTCGGGGCCCTGATGCCGGCC
GCCATGATCGCCCCGGTGGAGTGCCCCTCGTTCTCCTCGGCGGCCCCTTCCGACGCATCT
GCGATGGCTAGTCCCATGAATGGAGAAGAATGCATGCTGGCTGTTGATATCGAAGACAGA
CTGAGTCCAAATCCATGGCAAGAAAAGAGAGAGATTGTTTCCTCTGAGGACGCAGTGACC
CCCTCTGCAGTGACTCCGTCGGCCCCCTCAGCCTCCGCTCGGCCTTTTATCCCAGTGACG
GATGACCTGGGAGCCGCAAGCATCATTGCAGAAACCATGACCAAAACCAAAGAGGATGTT
GAAAGCCAAAATAAAGCAGCAGGTCCGGAGCCTCAGGCCTTGGATGAGTTCACCAGTCTG
CTGATTGCGGATGACACTCGTGTGGTGGTAGACCTGCTCAAGCTGTCAGTGTGCAGCCGG
GCCGGGGACAGGGGCAGGGATGTGCTCTCCGCGGTGCTTTCCGGCATGGGGACCGCCTAC
CCACAGGTGGCAGATATGCTGTTGGAGCTCTGTGTCACCGAGTTGGAGGATGTGGCCACA
GACTCGCAGAGCGGCCGCCTCTCTTCTCAGCCTGTGGTGGTGGAGAGTAGCCACCCTTAC
ACCGACGACACCTCCACCAGTGGCACAGTGAAGATACCAGGTGCAGAAGGACTCAGGGTA
GAATTTGACCGGCAGTGCTCCACAGAGAGGCGCCACGACCCTCTCACAGTCATGGACGGC
GTCAACAGGATCGTCTCCGTGCGGTCAGGCCGAGAGTGGTCCGACTGGTCCAGCGAGCTG
CGCATCCCAGGGGATGAGTTAAAGTGGAAGTTCATCAGCGATGGGTCTGTGAATGGCTGG
GGCTGGCGCTTCACCGTCTATCCCATCATGCCAGCTGCTGGCCCTAAAGAACTCCTCTCT
GACCGCTGCGTCCTCTCCTGTCCATCCATGGACTTGGTGACGTGTCTGTTAGACTTCCGA
CTCAACCTTGCCTCTAACAGAAGCATCGTCCCTCGCCTTGCGGCCTCGCTGGCAGCTTGT
GCACAGCTGAGTGCCCTAGCTGCCAGTCACAGAATGTGGGCCCTTCAGAGACTGAGGAAG
CTGCTTACAACTGAATTTGGGCAGTCAATTAACATAAATAGGCTGCTTGGAGAAAATGAT
GGGGAAACAAGAGCTTTGAGTTTTACAGGTAGTGCTCTTGCTGCTTTGGTGAAAGGTCTT
CCAGAAGCTTTGCAAAGGCAGTTTGAATATGAAGATCCTATTGTGAGGGGTGGCAAACAG
CTGCTCCACAGCCCATTCTTTAAGGTACTGGTAGCTCTTGCTTGTGACCTGGAGCTGGAC
ACTCTGCCTTGCTGTGCCGAGACGCACAAGTGGGCCTGGTTCCGGAGGTACTGCATGGCC
TCCCGTGTTGCTGTGGCCCTTGACAAAAGAACACCGTTGCCCCGTCTGTTTCTTGATGAG
GTGGCTAAGAAAATTCGTGAATTAATGGCAGACAGCGAAAACATGGATGTTCTGCATGAG
AGCCATGACATTTTTAAAAGAGAGCAAGACGAACAACTTGTGCAGTGGATGAACAGGCGA
CCAGATGACTGGACTCTCTCTGCTGGTGGCAGTGGAACAATTTATGGATGGGGACATAAT
CACAGGGGCCAGCTCGGGGGCATTGAAGGCGCAAAAGTCAAAGTTCCCACTCCCTGTGAA
GCCCTTGCAACTCTCAGACCCGTGCAGTTAATCGGAGGGGAACAGACCCTCTTTGCTGTG
ACGGCTGATGGGAAGCTGTATGCCACTGGGTATGGTGCAGGTGGCAGACTAGGCATTGGA
GGGACAGAGTCGGTGTCCACCCCAACATTGCTTGAATCCATTCAGCATGTGTTTATTAAG
AAAGTAGCTGTGAACTCTGGAGGAAAGCACTGCCTTGCCCTGTCTTCAGAAGGAGAAGTT
TACTCTTGGGGTGAGGCAGAAGATGGGAAGTTGGGGCATGGCAACAGAAGTCCGTGTGAC
CGCCCTCGTGTCATCGAGTCTCTGAGAGGAATTGAAGTGGTCGATGTTGCTGCTGGCGGA
GCCCACAGCGCCTGTGTCACAGCAGCCGGGGACCTCTACACATGGGGCAAAGGCCGCTAC
GGCCGGCTGGGGCACAGCGACAGTGAGGACCAGCTGAAGCCGAAGCTGGTGGAGGCGCTG
CAGGGCCACCGTGTGGTTGACATCGCCTGTGGCAGTGGAGATGCCCAGACCCTCTGCCTC
ACAGATGACGACACTGTCTGGTCCTGGGGGGACGGGGACTACGGCAAGCTCGGCCGGGGA
GGCAGCGATGGCTGTAAAGTGCCTATGAAGATTGATTCTCTTACTGGTCTTGGAGTAGTT
AAAGTGGAATGCGGATCCCAGTTTTCTGTTGCCCTTACCAAATCTGGAGCTGTTTATACC
TGGGGCAAAGGCGATTATCACAGGTTGGGCCATGGATCAGATGACCATGTTCGAAGGCCT
CGGCAGGTCCAAGGGTTGCAGGGGAAGAAAGTCATCGCCATCGCCACTGGCTCCCTGCAC
TGTGTGTGCTGCACAGAGGATGGTGAGGTTTATACATGGGGCGACAATGATGAGGGACAA
CTGGGAGACGGAACCACCAATGCCATCCAGAGGCCTCGGTTGGTAGCTGCCCTTCAGGGT
AAGAAGGTCAACCGTGTGGCCTGTGGCTCAGCACATACCCTCGCCTGGTCGACCAGCAAG
CCCGCCAGTGCTGGCAAACTCCCTGCACAGGTCCCCATGGAGTACAATCACCTGCAGGAG
ATCCCCATCATTGCGCTGAGGAACCGTCTGCTGCTGCTGCACCACCTCTCCGAGCTCTTC
TGCCCCTGCATCCCCATGTTCGACCTGGAAGGCTCGCTCGACGAAACTGGACTCGGGCCT
TCTGTTGGGTTCGACACTCTCCGAGGAATTCTGATATCCCAGGGAAAGGAGGCGGCTTTC
CGGAAAGTAGTACAAGCAACTATGGTACGCGATCGTCAGCATGGCCCCGTCGTGGAGCTG
AACCGCATCCAGGTCAAACGATCAAGGAGCAAAGGCGGGCTGGCCGGCCCCGACGGCACC
AAGTCTGTCTTTGGGCAGATGTGTGCTAAGATGAGCTCGTTTGGTCCCGACAGCCTCCTC
CTTCCTCACCGTGTCTGGAAAGTCAAGTTTGTGGGTGAATCTGTGGATGACTGTGGGGGC
GGCTACAGCGAGTCCATAGCTGAGATCTGTGAGGAGCTGCAGAACGGACTCACGCCCCTG
CTGATCGTGACACCCAACGGGAGGGATGAGTCTGGGGCCAACCGAGACTGCTACCTGCTC
AGCCCGGCCGCCAGAGCACCCGTGCACAGCAGCATGTTCCGCTTCCTGGGTGTGTTGCTG
GGCATTGCCATCCGAACCGGGAGTCCCCTGAGCCTCAACCTTGCCGAGCCTGTCTGGAAG
CAGCTGGCTGGGATGAGCCTCACCATCGCGGACCTCAGTGAGGTTGATAAGGATTTTATT
CCTGGACTCATGTACATCCGAGACAATGAAGCCACCTCAGAGGAGTTTGAAGCCATGAGC
CTGCCCTTCACAGTGCCAAGTGCCAGTGGCCAGGACATTCAGTTGAGCTCCAAGCACACA
CACATCACCCTGGACAACCGCGCGGAGTACGTGCGGCTGGCGATAAACTATAGACTCCAT
GAATTTGATGAGCAGGTGGCTGCTGTTCGGGAAGGAATGGCCCGCGTTGTGCCTGTTCCC
CTCCTCTCTCTGTTCACCGGCTACGAACTGGAGACGATGGTGTGTGGCAGCCCTGACATC
CCGCTGCACCTTCTCAAGTCGGTGGCCACCTATAAAGGCATCGAGCCTTCCGCATCGCTG
ATCCAGTGGTTCTGGGAGGTGATGGAGTCCTTCTCCAACACAGAGCGCTCTCTTTTCCTT
CGCTTCGTCTGGGGCCGGACGAGGCTGCCCAGGACCATCGCCGACTTCCGGGGCCGAGAC
TTCGTCATCCAGGTGTTGGATAAATACAACCCTCCAGACCACTTCCTCCCTGAGTCCTAC
ACCTGTTTCTTCTTGCTGAAGCTGCCCAGGTATTCCTGCAAGCAGGTGCTGGAGGAGAAG
CTCAAGTACGCCATCCACTTCTGCAAGTCCATAGACACAGATGACTACGCTCGCATCGCA
CTTACAGGAGAGCCAGCCGCCGACGACAGCAGCGACGATTCAGATAACGAGGATGTCGAC
TCCTTTGCTTCGGACTCTACACAAGATTATTTAACAGGACACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 4834 |
| Molecular Weight
| 527223.0 |
| Theoretical pI
| 6.22 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase HERC2
MPSESFCLAAQARLDSKWLKTDIQLAFTRDGLCGLWNEMVKDGEIVYTGTESTQNGELPP
RKDDSVEPSGTKKEDLNDKEKKDEEETPAPIYRAKSILDSWVWGKQPDVNELKECLSVLV
KEQQALAVQSATTTLSALRLKQRLVILERYFIALNRTVFQENVKVKWKSSGISLPPVDKK
SSRPAGKGVEGLARVGSRAALSFAFAFLRRAWRSGEDADLCSELLQESLDALRALPEASL
FDESTVSSVWLEVVERATRFLRSVVTGDVHGTPATKGPGSIPLQDQHLALAILLELAVQR
GTLSQMLSAILLLLQLWDSGAQETDNERSAQGTSAPLLPLLQRFQSIICRKDAPHSEGDM
HLLSGPLSPNESFLRYLTLPQDNELAIDLRQTAVVVMAHLDRLATPCMPPLCSSPTSHKG
SLQEVIGWGLIGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNSD
TLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKV
ISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL
KGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVV
KVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTH
CLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFAWSSCS
EWSIGLRVPFVVDICSMTFEQLDLLLRQVSEGMDGSADWPPPQEKECVAVATLNLLRLQL
HAAISHQVDPEFLGLGLGSILLNSLKQTVVTLASSAGVLSTVQSAAQAVLQSGWSVLLPT
AEERARALSALLPCAVSGNEVNISPGRRFMIDLLVGSLMADGGLESALHAAITAEIQDIE
AKKEAQKEKEIDEQEANASTFHRSRTPLDKDLINTGICESSGKQCLPLVQLIQQLLRNIA
SQTVARLKDVARRISSCLDFEQHSRERSASLDLLLRFQRLLISKLYPGESIGQTSDISSP
ELMGVGSLLKKYTALLCTHIGDILPVAASIASTSWRHFAEVAYIVEGDFTGVLLPELVVS
IVLLLSKNAGLMQEAGAVPLLGGLLEHLDRFNHLAPGKERDDHEELAWPGIMESFFTGQN
CRNNEEVTLIRKADLENHNKDGGFWTVIDGKVYDIKDFQTQSLTGNSILAQFAGEDPVVA
LEAALQFEDTRESMHAFCVGQYLEPDQEIVTIPDLGSLSSPLIDTERNLGLLLGLHASYL
AMSTPLSPVEIECAKWLQSSIFSGGLQTSQIHYSYNEEKDEDHCSSPGGTPASKSRLCSH
RRALGDHSQAFLQAIADNNIQDHNVKDFLCQIERYCRQCHLTTPIMFPPEHPVEEVGRLL
LCCLLKHEDLGHVALSLVHAGALGIEQVKHRTLPKSVVDVCRVVYQAKCSLIKTHQEQGR
SYKEVCAPVIERLRFLFNELRPAVCNDLSIMSKFKLLSSLPRWRRIAQKIIRERRKKRVP
KKPESTDDEEKIGNEESDLEEACILPHSPINVDKRPIAIKSPKDKWQPLLSTVTGVHKYK
WLKQNVQGLYPQSPLLSTIAEFALKEEPVDVEKMRKCLLKQLERAEVRLEGIDTILKLAS
KNFLLPSVQYAMFCGWQRLIPEGIDIGEPLTDCLKDVDLIPPFNRMLLEVTFGKLYAWAV
QNIRNVLMDASAKFKELGIQPVPLQTITNENPSGPSLGTIPQARFLLVMLSMLTLQHGAN
NLDLLLNSGMLALTQTALRLIGPSCDNVEEDMNASAQGASATVLEETRKETAPVQLPVSG
PELAAMMKIGTRVMRGVDWKWGDQDGPPPGLGRVIGELGEDGWIRVQWDTGSTNSYRMGK
EGKYDLKLAELPAAAQPSAEDSDTEDDSEAEQTERNIHPTAMMFTSTINLLQTLCLSAGV
HAEIMQSEATKTLCGLLRMLVESGTTDKTSSPNRLVYREQHRSWCTLGFVRSIALTPQVC
GALSSPQWITLLMKVVEGHAPFTATSLQRQILAVHLLQAVLPSWDKTERARDMKCLVEKL
FDFLGSLLTTCSSDVPLLRESTLRRRRVRPQASLTATHSSTLAEEVVALLRTLHSLTQWN
GLINKYINSQLRSITHSFVGRPSEGAQLEDYFPDSENPEVGGLMAVLAVIGGIDGRLRLG
GQVMHDEFGEGTVTRITPKGKITVQFSDMRTCRVCPLNQLKPLPAVAFNVNNLPFTEPML
SVWAQLVNLAGSKLEKHKIKKSTKQAFAGQVDLDLLRCQQLKLYILKAGRALLSHQDKLR
QILSQPAVQETGTVHTDDGAVVSPDLGDMSPEGPQPPMILLQQLLASATQPSPVKAIFDK
QELEAAALAVCQCLAVESTHPSSPGFEDCSSSEATTPVAVQHIRPARVKRRKQSPVPALP
IVVQLMEMGFSRRNIEFALKSLTGASGNASSLPGVEALVGWLLDHSDIQVTELSDADTVS
DEYSDEEVVEDVDDAAYSMSTGAVVTESQTYKKRADFLSNDDYAVYVRENIQVGMMVRCC
RAYEEVCEGDVGKVIKLDRDGLHDLNVQCDWQQKGGTYWVRYIHVELIGYPPPSSSSHIK
IGDKVRVKASVTTPKYKWGSVTHQSVGVVKAFSANGKDIIVDFPQQSHWTGLLSEMELVP
SIHPGVTCDGCQMFPINGSRFKCRNCDDFDFCETCFKTKKHNTRHTFGRINEPGQSAVFC
GRSGKQLKRCHSSQPGMLLDSWSRMVKSLNVSSSVNQASRLIDGSEPCWQSSGSQGKHWI
RLEIFPDVLVHRLKMIVDPADSSYMPSLVVVSGGNSLNNLIELKTININPSDTTVPLLND
CTEYHRYIEIAIKQCRSSGIDCKIHGLILLGRIRAEEEDLAAVPFLASDNEEEEDEKGNS
GSLIRKKAAGLESAATIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGG
SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT
ALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGEL
YTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG
DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHG
SDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKP
TLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADS
SAASNKISGASNSKPNRPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPA
AMIAPVECPSFSSAAPSDASAMASPMNGEECMLAVDIEDRLSPNPWQEKREIVSSEDAVT
PSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAGPEPQALDEFTSL
LIADDTRVVVDLLKLSVCSRAGDRGRDVLSAVLSGMGTAYPQVADMLLELCVTELEDVAT
DSQSGRLSSQPVVVESSHPYTDDTSTSGTVKIPGAEGLRVEFDRQCSTERRHDPLTVMDG
VNRIVSVRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLS
DRCVLSCPSMDLVTCLLDFRLNLASNRSIVPRLAASLAACAQLSALAASHRMWALQRLRK
LLTTEFGQSININRLLGENDGETRALSFTGSALAALVKGLPEALQRQFEYEDPIVRGGKQ
LLHSPFFKVLVALACDLELDTLPCCAETHKWAWFRRYCMASRVAVALDKRTPLPRLFLDE
VAKKIRELMADSENMDVLHESHDIFKREQDEQLVQWMNRRPDDWTLSAGGSGTIYGWGHN
HRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIG
GTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCD
RPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEAL
QGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVV
KVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLH
CVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTSK
PASAGKLPAQVPMEYNHLQEIPIIALRNRLLLLHHLSELFCPCIPMFDLEGSLDETGLGP
SVGFDTLRGILISQGKEAAFRKVVQATMVRDRQHGPVVELNRIQVKRSRSKGGLAGPDGT
KSVFGQMCAKMSSFGPDSLLLPHRVWKVKFVGESVDDCGGGYSESIAEICEELQNGLTPL
LIVTPNGRDESGANRDCYLLSPAARAPVHSSMFRFLGVLLGIAIRTGSPLSLNLAEPVWK
QLAGMSLTIADLSEVDKDFIPGLMYIRDNEATSEEFEAMSLPFTVPSASGQDIQLSSKHT
HITLDNRAEYVRLAINYRLHEFDEQVAAVREGMARVVPVPLLSLFTGYELETMVCGSPDI
PLHLLKSVATYKGIEPSASLIQWFWEVMESFSNTERSLFLRFVWGRTRLPRTIADFRGRD
FVIQVLDKYNPPDHFLPESYTCFFLLKLPRYSCKQVLEEKLKYAIHFCKSIDTDDYARIA
LTGEPAADDSSDDSDNEDVDSFASDSTQDYLTGH
|
| External Links |
|---|
| GenBank ID Protein
| 126032348 |
| UniProtKB/Swiss-Prot ID
| O95714 |
| UniProtKB/Swiss-Prot Entry Name
| HERC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004667.4 |
| GeneCard ID
| HERC2 |
| GenAtlas ID
| HERC2 |
| HGNC ID
| HGNC:4868 |
| References |
|---|
| General References
| Not Available |