| Identification |
|---|
| HMDB Protein ID
| CDBP04443 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MARCH7 |
| Description
| Not Available |
| Synonyms
|
- Axotrophin
- MARCH-VII
- Membrane-associated RING finger protein 7
- Membrane-associated RING-CH protein VII
- RING finger protein 177
|
| Gene Name
| MARCH7 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q24.2 |
| SNPs
| MARCH7 |
| Gene Sequence
|
>2115 bp
ATGGAGTCTAAACCTTCAAGGATTCCAAGAAGAATTTCTGTTCAACCTTCCAGCTCCTTA
AGTGCTAGGATGATGTCTGGAAGCAGAGGAAGTAGTTTAAATGATACCTATCACTCAAGA
GACTCTTCATTTAGATTGGATTCTGAATATCAGTCTACATCAGCATCAGCATCTGCGTCA
CCATTTCAATCTGCATGGTATAGTGAATCTGAGATAACTCAGGGAGCACGCTCAAGATCG
CAGAACCAGCAACGGGATCATGATTCAAAAAGACCTAAACTTTCCTGTACAAACTGTACT
ACCTCAGCTGGGAGAAATGTTGGAAATGGTTTAAACACATTATCAGATTCATCTTGGAGG
CATAGTCAAGTTCCTAGATCTTCATCAATGGTACTTGGATCATTTGGAACAGACTTAATG
AGAGAGAGGAGAGATTTGGAGAGAAGAACAGATTCCTCTATTAGTAATCTTATGGATTAT
AGTCACCGAAGTGGTGATTTCACAACTTCATCATATGTTCAAGACAGAGTTCCTTCATAT
TCACAAGGAGCAAGACCAAAAGAAAACTCAATGAGCACTTTACAGTTGAATACATCATCC
ACAAACCACCAATTGCCTTCTGAACATCAGACCATACTAAGTTCTAGGGACTCCAGAAAT
TCTTTAAGATCAAATTTTTCTTCAAGAGAATCAGAATCTTCCCGAAGCAATACGCAGCCT
GGATTTTCTTACAGTTCAAGTAGAGATGAAGCCCCAATCATAAGCAATTCAGAAAGGGTT
GTTTCATCTCAAAGACCATTTCAAGAATCTTCTGACAATGAAGGTAGGCGGACAACGAGG
AGATTGCTGTCACGCATAGCTTCTAGCATGTCATCTACTTTTTTTTCACGAAGATCTAGT
CAGGATTCCTTGAATACAAGATCATTGAATTCTGAAAATTCTTACGTTTCTCCAAGAATC
TTGACAGCTTCACAGTCCCGTAGTAATGTACCATCAGCTTCTGAAGTTCCCGATAATAGG
GCATCTGAAGCTTCTCAGGGATTTCGATTTCTTAGGCGAAGATGGGGTTTGTCATCTCTT
AGCCACAATCATAGCTCTGAGTCAGATTCAGAAAATTTTAACCAAGAATCTGAAGGTAGA
AATACAGGACCATGGTTATCTTCCTCACTTAGAAATAGATGCACACCTTTGTTCTCTAGA
AGGAGGCGAGAGGGAAGAGATGAATCTTCAAGGATACCTACCTCTGATACATCATCTAGA
TCTCATATTTTTAGAAGAGAATCAAATGAAGTGGTTCACCTTGAAGCACAGAATGATCCT
CTTGGAGCTGCTGCCAACAGACCACAAGCATCTGCAGCATCAAGCAGTGCCACAACAGGT
GGCTCTACATCAGATTCGGCTCAAGGTGGAAGAAATACAGGAATATCAGGGATTCTTCCT
GGTTCCTTATTCCGGTTTGCAGTCCCTCCAGCACTTGGGAGTAATTTGACCGACAATGTC
ATGATCACAGTAGATATTATTCCTTCAGGTTGGAATTCAGCTGATGGTAAAAGTGATAAA
ACTAAAAGTGCGCCTTCAAGAGATCCAGAAAGATTGCAGAAAATAAAAGAGAGCCTCCTT
TTAGAGGACTCAGAAGAAGAAGAAGGTGACTTATGTAGAATTTGTCAAATGGCAGCTGCA
TCATCATCTAATTTGCTGATAGAGCCATGCAAGTGCACAGGAAGTTTGCAGTATGTCCAC
CAAGACTGTATGAAAAAGTGGTTACAGGCCAAAATTAACTCTGGTTCTTCATTAGAAGCT
GTAACCACCTGTGAACTATGTAAAGAGAAGTTGGAGCTTAACCTGGAGGATTTTGATATT
CATGAACTACATAGAGCTCATGCAAATGAACAAGCTGAGTATGAGTTTATCAGCTCTGGT
CTCTACCTAGTGGTGTTATTGCACTTGTGCGAACAAAGCTTTTCTGATATGATGGGAAAT
ACAAATGAACCAAGCACACGTGTCCGATTTATTAACCTTGCAAGAACTCTTCAGGCACAT
ATGGAAGATCTCGAAACTTCAGAGGATGATTCCGAAGAAGACGGAGACCATAACAGGACA
TTTGATATTGCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 704 |
| Molecular Weight
| 78050.0 |
| Theoretical pI
| 6.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MARCH7
MESKPSRIPRRISVQPSSSLSARMMSGSRGSSLNDTYHSRDSSFRLDSEYQSTSASASAS
PFQSAWYSESEITQGARSRSQNQQRDHDSKRPKLSCTNCTTSAGRNVGNGLNTLSDSSWR
HSQVPRSSSMVLGSFGTDLMRERRDLERRTDSSISNLMDYSHRSGDFTTSSYVQDRVPSY
SQGARPKENSMSTLQLNTSSTNHQLPSEHQTILSSRDSRNSLRSNFSSRESESSRSNTQP
GFSYSSSRDEAPIISNSERVVSSQRPFQESSDNEGRRTTRRLLSRIASSMSSTFFSRRSS
QDSLNTRSLNSENSYVSPRILTASQSRSNVPSASEVPDNRASEASQGFRFLRRRWGLSSL
SHNHSSESDSENFNQESEGRNTGPWLSSSLRNRCTPLFSRRRREGRDESSRIPTSDTSSR
SHIFRRESNEVVHLEAQNDPLGAAANRPQASAASSSATTGGSTSDSAQGGRNTGISGILP
GSLFRFAVPPALGSNLTDNVMITVDIIPSGWNSADGKSDKTKSAPSRDPERLQKIKESLL
LEDSEEEEGDLCRICQMAAASSSNLLIEPCKCTGSLQYVHQDCMKKWLQAKINSGSSLEA
VTTCELCKEKLELNLEDFDIHELHRAHANEQAEYEFISSGLYLVVLLHLCEQSFSDMMGN
TNEPSTRVRFINLARTLQAHMEDLETSEDDSEEDGDHNRTFDIA
|
| External Links |
|---|
| GenBank ID Protein
| 62822392 |
| UniProtKB/Swiss-Prot ID
| Q9H992 |
| UniProtKB/Swiss-Prot Entry Name
| MARH7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC009961 |
| GeneCard ID
| MARCH7 |
| GenAtlas ID
| MARCH7 |
| HGNC ID
| HGNC:17393 |
| References |
|---|
| General References
| Not Available |