| Identification |
|---|
| HMDB Protein ID
| CDBP04456 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin-protein ligase E3B |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| UBE3B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| catalytic activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q24.11 |
| SNPs
| UBE3B |
| Gene Sequence
|
>3207 bp
ATGTTCACCCTGTCTCAGACCTCGAGAGCATGGTTCATCGATAGAGCCCGTCAGGCACGA
GAAGAAAGGCTTGTGCAGAAGGAACGGGAGCGGGCAGCTGTTGTGATCCAGGCCCATGTC
CGGAGTTTTCTCTGTCGGAGTCGACTGCAGAGAGATATCAGGAGAGAGATTGATGACTTT
TTTAAAGCAGATGACCCTGAGTCCACTAAAAGAAGTGCACTTTGTATTTTCAAGATTGCC
AGGAAACTGCTGTTCCTATTCAGAATCAAAGAGGATAATGAGAGATTTGAGAAGTTGTGT
CGCAGCATCCTGAGCAGCATGGATGCTGAGAATGAGCCTAAGGTGTGGTATGTGTCCCTG
GCTTGTTCTAAGGACCTCACCCTCCTTTGGATTCAACAGATCAAGAACATTTTGTGGTAC
TGCTGTGATTTTCTCAAGCAGCTCAAGCCTGAAATCCTGCAGGACTCCCGACTCATCACC
CTGTACCTCACGATGCTTGTCACCTTCACAGACACTTCAACGTGGAAAATTCTTCGGGGA
AAAGGTGAAAGTCTTCGACCAGCGATGAACCACATTTGTGCAAATATAATGGGACATCTC
AACCAGCATGGATTTTATTCTGTGCTGCAGATATTGTTAACCCGTGGCCTGGCAAGACCC
CGTCCTTGTCTATCCAAAGGCACTTTAACAGCAGCTTTTTCTCTAGCGTTACGCCCTGTG
ATTGCTGCACAGTTCTCAGACAATCTGATTCGGCCGTTCCTCATCCACATCATGTCTGTG
CCTGCTCTGGTGACTCATCTCAGCACAGTGACCCCTGAGCGCCTCACTGTTTTAGAATCC
CATGACATGCTTCGTAAATTCATCATATTTTTAAGAGACCAAGATCGATGCCGTGATGTA
TGTGAAAGTTTAGAAGGATGCCATACGCTTTGTCTAATGGGCAACCTCCTACACTTGGGC
TCCCTCAGCCCCAGAGTGTTAGAGGAGGAGACAGATGGGTTCGTGAGTTTGCTCACCCAG
ACGCTGTGCTACTGTCGGAAGTATGTGTCTCAGAAGAAGTCCAACCTGACCCACTGGCAT
CCTGTCCTTGGCTGGTTCTCCCAATCTGTGGATTATGGCCTTAACGAGTCAATGCACTTG
ATCACCAAACAGCTGCAGTTCTTGTGGGGGGTGCCTCTGATCCGGATCTTCTTCTGTGAC
ATCCTGAGCAAGAAGCTACTGGAGAGCCAGGAGCCAGCCCACGCACAGCCAGCATCCCCT
CAGAATGTGCTCCCAGTGAAGAGTCTCCTAAAGCGTGCTTTTCAAAAGTCGGCATCAGTC
CGGAATATTCTCAGGCCTGTCGGGGGTAAACGGGTCGACTCTGCAGAAGTCCAGAAGGTT
TGCAACATCTGTGTCCTCTACCAGACCTCGCTGACAACTCTCACACAGATTCGGCTGCAG
ATACTCACAGGTCTCACTTACCTTGATGACCTGCTTCCCAAACTGTGGGCATTTATCTGT
GAGCTCGGGCCCCACGGAGGGTTAAAGCTCTTCTTGGAATGCCTGAACAATGACACTGAA
GAGTCCAAGCAACTCTTGGCCATGCTGATGCTGTTCTGTGACTGTTCGCGGCACCTCATC
ACAATCCTTGATGACATTGAAGTTTATGAAGAACAGATTTCATTCAAACTGGAAGAGCTG
GTCACTATCTCCTCTTTCCTGAATTCTTTTGTGTTTAAGATGATCTGGGATGGAATTGTA
GAGAACGCCAAGGGTGAGACCTTGGAGCTGTTCCAGTCTGTCCACGGGTGGCTTATGGTG
CTGTACGAGCGGGACTGCCGGCGGCGCTTCACCCCCGAGGACCACTGGCTGCGAAAGGAT
CTCAAACCTAGCGTGCTCTTCCAAGAACTCGACAGGGACAGAAAACGGGCACAGTTGATC
CTGCAGTACATCCCACATGTCATCCCTCACAAAAACAGAGTTCTACTGTTTCGAACCATG
GTTACCAAGGAGAAGGAGAAACTGGGGCTGGTGGAAACCAGCTCTGCCTCCCCGCATGTC
ACTCACATCACCATCCGCCGGTCCAGGATGCTGGAGGACGGCTACGAGCAGCTTAGGCAG
CTCTCCCAGCACGCCATGAAGGGGGTCATCCGTGTGAAGTTTGTCAATGACCTCGGGGTG
GACGAAGCAGGGATTGATCAAGACGGTGTTTTTAAGGAGTTCTTGGAAGAGATCATCAAG
AGAGTTTTTGACCCAGCACTCAATCTGTTCAAGACAACCAGTGGGGATGAGAGGCTGTAC
CCCTCACCCACATCCTACATCCATGAGAATTACCTGCAGCTCTTCGAGTTTGTGGGGAAG
ATGCTGGGGAAGGCTGTGTATGAGGGAATTGTGGTGGACGTGCCATTTGCATCCTTCTTC
CTGAGCCAACTGCTTGGGCACCACCACAGCGTCTTCTATAGCTCGGTGGATGAACTGCCT
TCTCTGGACTCCGAGTTCTATAAAAACCTCACCTCCATCAAGCGCTATGATGGGGACATC
ACTGACCTGGGCCTGACGCTGTCTTACGACGAGGACGTCATGGGTCAGCTTGTTTGCCAT
GAACTGATTCCTGGAGGGAAGACCATTCCTGTTACAAATGAAAATAAAATTAGCTACATC
CATCTGATGGCACATTTTCGAATGCACACTCAAATAAAAAACCAAACAGCTGCCCTCATT
AGCGGATTCCGTTCCATTATCAAACCCGAGTGGATCCGAATGTTCTCAACTCCTGAACTG
CAGCGTCTCATCTCTGGCGACAATGCTGAGATTGATCTGGAAGATTTAAAGAAGCACACA
GTCTACTACGGTGGTTTCCATGGAAGTCACAGAGTCATCATCTGGCTCTGGGATATTCTG
GCCTCCGACTTCACACCGGATGAGAGAGCTATGTTTCTGAAGTTCGTGACCAGCTGCTCC
AGACCCCCGCTCCTGGGATTCGCCTACCTCAAGCCTCCATTCTCCATCCGCTGCGTGGAG
GTGTCGGACGATCAGGACACCGGGGACACTCTGGGCAGCGTCCTCCGGGGCTTCTTCACC
ATCCGCAAGCGGGAGCCAGGCGGCCGCCTGCCCACCTCCTCCACCTGCTTCAACCTGCTC
AAGCTGCCCAACTACAGCAAGAAGAGCGTCCTCCGCGAGAAGCTGCGCTACGCCATCAGC
ATGAACACGGGCTTTGAACTCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1068 |
| Molecular Weight
| 123096.7 |
| Theoretical pI
| 8.27 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin-protein ligase E3B
MFTLSQTSRAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDDF
FKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWYVSL
ACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTWKILRG
KGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLALRPV
IAAQFSDNLIRPFLIHIMSVPALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQDRCRDV
CESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVSQKKSNLTHWH
PVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPAHAQPASP
QNVLPVKSLLKRAFQKSASVRNILRPVGGKRVDSAEVQKVCNICVLYQTSLTTLTQIRLQ
ILTGLTYLDDLLPKLWAFICELGPHGGLKLFLECLNNDTEESKQLLAMLMLFCDCSRHLI
TILDDIEVYEEQISFKLEELVTISSFLNSFVFKMIWDGIVENAKGETLELFQSVHGWLMV
LYERDCRRRFTPEDHWLRKDLKPSVLFQELDRDRKRAQLILQYIPHVIPHKNRVLLFRTM
VTKEKEKLGLVETSSASPHVTHITIRRSRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGV
DEAGIDQDGVFKEFLEEIIKRVFDPALNLFKTTSGDERLYPSPTSYIHENYLQLFEFVGK
MLGKAVYEGIVVDVPFASFFLSQLLGHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDI
TDLGLTLSYDEDVMGQLVCHELIPGGKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALI
SGFRSIIKPEWIRMFSTPELQRLISGDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDIL
ASDFTPDERAMFLKFVTSCSRPPLLGFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFT
IRKREPGGRLPTSSTCFNLLKLPNYSKKSVLREKLRYAISMNTGFELS
|
| External Links |
|---|
| GenBank ID Protein
| 35493959 |
| UniProtKB/Swiss-Prot ID
| Q7Z3V4 |
| UniProtKB/Swiss-Prot Entry Name
| UBE3B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_130466.2 |
| GeneCard ID
| UBE3B |
| GenAtlas ID
| UBE3B |
| HGNC ID
| HGNC:13478 |
| References |
|---|
| General References
| Not Available |