Cannabis Compound Database: Showing Protein E3 ubiquitin-protein ligase LRSAM1 (CDBP04458)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP04458

Secondary Accession Numbers

Not Available

Name

E3 ubiquitin-protein ligase LRSAM1

Description

Not Available

Synonyms

Leucine-rich repeat and sterile alpha motif-containing protein 1
Tsg101-associated ligase
hTAL

Gene Name

LRSAM1

Protein Type

Enzyme

Biological Properties

General Function

Involved in hormone activity

Specific Function

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) and exocytic (HIV-1 viral proteins) cargos

GO Classification

Component
extracellular region
Function
hormone activity
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
protein binding
receptor binding

Cellular Location

Cytoplasm

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:9

Locus

9q33.3

SNPs

LRSAM1

Gene Sequence

>2172 bp
ATGCCGCTCTTCTTCCGGAAGCGGAAACCCAGTGAGGAGGCTCGGAAACGCCTGGAGTAC
CAGATGTGTTTGGCAAAAGAAGCTGGGGCAGATGACATTCTCGACATCTCTAAATGTGAG
CTCTCAGAGATTCCATTTGGAGCTTTTGCAACATGCAAAGTTCTGCAGAAGAAGGTGCTG
ATCGTCCACACGAATCACCTCACTTCCCTGCTTCCCAAATCCTGCAGCCTCCTGAGTCTG
GCAACCATCAAGGTTCTAGATCTCCACGATAATCAGCTGACAGCCCTTCCTGACGATCTG
GGGCAGCTGACTGCCCTCCAGGTCTTAAACGTGGAAAGGAATCAACTGATGCAGCTCCCA
CGTTCCATTGGGAACCTGACCCAGCTCCAGACTCTCAATGTTAAAGACAACAAGCTGAAG
GAGCTTCCAGACACCGTGGGGGAGCTTCGAAGCCTGCGTACCCTCAACATCAGTGGAAAC
GAGATCCAGAGATTGCCGCAGATGCTGGCTCACGTTCGAACCCTGGAGATGCTGAGCCTT
GACGCCTCGGCCATGGTCTACCCGCCGCGGGAGGTGTGTGGTGCCGGCACTGCGGCCATC
TTGCAGTTCCTCTGCAAAGAGTCAGGGCTGGAATACTACCCCCCTTCTCAGTACTTGCTG
CCAATTCTGGAGCAAGATGGAATCGAGAACTCTCGGGACAGCCCTGATGGGCCCACGGAC
AGATTCTCAAGGGAGGAGTTAGAGTGGCAGAACAGGTTCTCAGACTATGAGAAGAGGAAG
GAACAGAAGATGCTGGAGAAACTCGAGTTTGAACGGCGCCTGGAACTGGGGCAGCGGGAG
CACACCCAGCTCCTTCAGCAGAGCAGCAGCCAGAAGGATGAGATCCTTCAGACGGTCAAG
GAGGAGCAGTCCCGGCTGGAGCAGGGCCTGAGTGAGCACCAGCGCCACCTCAACGCAGAG
CGGCAGCGGCTGCAGGAGCAGCTGAAGCAGACGGAACAGAACATTTCCAGCCGGATCCAG
AAGCTGCTGCAGGACAATCAGAGACAAAAGAAAAGCTCCGAGATTTTGAAATCGCTGGAA
AATGAAAGAATAAGAATGGAACAGTTGATGTCCATAACCCAGGAGGAGACTGAGAGCCTG
CGGCGACGTGACGTTGCCTCCGCCATGCAGCAGATGCTGACTGAGAGCTGTAAGAACCGG
CTCATCCAGATGGCCTACGAATCTCAGAGGCAGAACTTGGTCCAGCAGGCCTGTTCCAGC
ATGGCCGAAATGGATGAACGATTCCAGCAGATTCTGTCGTGGCAGCAAATGGATCAGAAC
AAAGCCATCAGCCAGATCCTGCAGGAGAGCGCGATGCAGAAGGCTGCGTTCGAGGCACTC
CAGGTGAAGAAAGACCTGATGCATCGGCAGATCAGGAGCCAGATTAAGTTAATAGAAACT
GAGTTATTGCAGCTGACACAGCTGGAGTTAAAGAGGAAGTCCCTGGACACAGAGTCACTC
CAGGAGATGATCTCGGAGCAGCGCTGGGCCCTCAGCTCCCTGCTCCAGCAGCTGCTCAAA
GAGAAGCAGCAGCGAGAGGAAGAGCTCCGGGAAATCCTGACGGAGTTAGAAGCCAAAAGT
GAAACCAGGCAGGAAAATTACTGGCTGATTCAGTATCAACGGCTTTTGAACCAGAAGCCC
TTGTCCTTGAAGCTGCAAGAAGAGGGGATGGAGCGCCAGCTGGTGGCCCTCCTGGAGGAG
CTGTCGGCTGAGCACTACCTGCCCATCTTTGCGCACCACCGCCTCTCACTGGACCTGCTG
AGCCAAATGAGCCCAGGGGACCTGGCCAAGGTGGGCGTCTCAGAAGCTGGCCTGCAGCAC
GAGATCCTCCGGAGAGTCCAGGAACTGCTGGATGCAGCCAGGATCCAGCCAGAGCTGAAA
CCACCAATGGGTGAGGTCGTCACCCCTACGGCCCCCCAGGAGCCTCCTGAGTCTGTGAGG
CCATCCGCTCCCCCTGCAGAGCTGGAGGTGCAGGCCTCAGAGTGTGTCGTGTGCCTGGAA
CGGGAGGCCCAGATGATCTTCCTCAACTGTGGCCACGTCTGCTGCTGCCAGCAGTGCTGC
CAGCCACTGCGCACCTGCCCGCTGTGCCGCCAGGACATCGCCCAGCGCCTCCGCATCTAC
CACAGCAGCTGA

Protein Properties

Number of Residues

723

Molecular Weight

83593.1

Theoretical pI

5.75

Pfam Domain Function

SAM_2 (PF07647 )
LRR_1 (PF00560 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>E3 ubiquitin-protein ligase LRSAM1
MPLFFRKRKPSEEARKRLEYQMCLAKEAGADDILDISKCELSEIPFGAFATCKVLQKKVL
IVHTNHLTSLLPKSCSLLSLATIKVLDLHDNQLTALPDDLGQLTALQVLNVERNQLMQLP
RSIGNLTQLQTLNVKDNKLKELPDTVGELRSLRTLNISGNEIQRLPQMLAHVRTLEMLSL
DASAMVYPPREVCGAGTAAILQFLCKESGLEYYPPSQYLLPILEQDGIENSRDSPDGPTD
RFSREELEWQNRFSDYEKRKEQKMLEKLEFERRLELGQREHTQLLQQSSSQKDEILQTVK
EEQSRLEQGLSEHQRHLNAERQRLQEQLKQTEQNISSRIQKLLQDNQRQKKSSEILKSLE
NERIRMEQLMSITQEETESLRRRDVASAMQQMLTESCKNRLIQMAYESQRQNLVQQACSS
MAEMDERFQQILSWQQMDQNKAISQILQESAMQKAAFEALQVKKDLMHRQIRSQIKLIET
ELLQLTQLELKRKSLDTESLQEMISEQRWALSSLLQQLLKEKQQREEELREILTELEAKS
ETRQENYWLIQYQRLLNQKPLSLKLQEEGMERQLVALLEELSAEHYLPIFAHHRLSLDLL
SQMSPGDLAKVGVSEAGLQHEILRRVQELLDAARIQPELKPPMGEVVTPTAPQEPPESVR
PSAPPAELEVQASECVVCLEREAQMIFLNCGHVCCCQQCCQPLRTCPLCRQDIAQRLRIY
HSS

External Links

GenBank ID Protein

53729361

UniProtKB/Swiss-Prot ID

Q6UWE0

UniProtKB/Swiss-Prot Entry Name

LRSM1_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001005373.2

GeneCard ID