| Identification |
|---|
| HMDB Protein ID
| CDBP05117 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase RING2 |
| Description
| Not Available |
| Synonyms
|
- HIP2-interacting protein 3
- Huntingtin-interacting protein 2-interacting protein 3
- Protein DinG
- RING finger protein 1B
- RING finger protein 2
- RING finger protein BAP-1
- RING1b
|
| Gene Name
| RNF2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin- protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
|
| Cellular Location
|
- Nucleus
- Chromosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q25.3 |
| SNPs
| RNF2 |
| Gene Sequence
|
>1011 bp
ATGTCTCAGGCTGTGCAGACAAACGGAACTCAACCATTAAGCAAAACATGGGAACTCAGT
TTATATGAGTTACAACGAACACCTCAGGAGGCAATAACAGATGGCTTAGAAATTGTGGTT
TCACCTCGAAGTCTACACAGTGAATTAATGTGCCCAATTTGTTTGGATATGTTGAAGAAC
ACCATGACTACAAAGGAGTGTTTACATCGTTTTTGTGCAGACTGCATCATCACAGCCCTT
AGAAGTGGCAACAAAGAATGTCCTACCTGTCGGAAAAAACTAGTTTCCAAAAGATCACTA
AGGCCAGACCCAAACTTTGATGCACTCATCAGCAAAATTTATCCAAGTCGTGATGAGTAT
GAAGCTCATCAAGAGAGAGTATTAGCCAGGATCAACAAGCACAATAATCAGCAAGCACTC
AGTCACAGCATTGAGGAAGGACTGAAGATACAGGCCATGAACAGACTGCAGCGAGGCAAG
AAACAACAGATTGAAAATGGTAGTGGAGCAGAAGATAATGGTGACAGTTCACACTGCAGT
AATGCATCCACACATAGCAATCAGGAAGCAGGCCCTAGTAACAAACGGACCAAAACATCT
GATGATTCTGGGCTAGAGCTTGATAATAACAATGCAGCAATGGCAATTGATCCAGTAATG
GATGGTGCTAGTGAAATTGAATTAGTATTCAGGCCTCATCCCACACTTATGGAAAAAGAT
GACAGTGCACAGACGAGATACATAAAGACTTCTGGTAACGCCACTGTTGATCACTTATCC
AAGTATCTGGCTGTGAGGTTAGCTTTAGAAGAACTTCGAAGCAAAGGTGAATCAAACCAG
ATGAACCTTGATACAGCCAGTGAGAAGCAGTATACCATTTATATAGCAACAGCCAGTGGC
CAGTTCACTGTATTAAATGGCTCTTTTTCTTTGGAATTGGTCAGTGAGAAATACTGGAAA
GTGAACAAACCCATGGAACTTTATTACGCACCTACAAAGGAGCACAAATGA
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 37655.0 |
| Theoretical pI
| 6.84 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase RING2
MSQAVQTNGTQPLSKTWELSLYELQRTPQEAITDGLEIVVSPRSLHSELMCPICLDMLKN
TMTTKECLHRFCADCIITALRSGNKECPTCRKKLVSKRSLRPDPNFDALISKIYPSRDEY
EAHQERVLARINKHNNQQALSHSIEEGLKIQAMNRLQRGKKQQIENGSGAEDNGDSSHCS
NASTHSNQEAGPSNKRTKTSDDSGLELDNNNAAMAIDPVMDGASEIELVFRPHPTLMEKD
DSAQTRYIKTSGNATVDHLSKYLAVRLALEELRSKGESNQMNLDTASEKQYTIYIATASG
QFTVLNGSFSLELVSEKYWKVNKPMELYYAPTKEHK
|
| External Links |
|---|
| GenBank ID Protein
| 1785643 |
| UniProtKB/Swiss-Prot ID
| Q99496 |
| UniProtKB/Swiss-Prot Entry Name
| RING2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y10571 |
| GeneCard ID
| RNF2 |
| GenAtlas ID
| RNF2 |
| HGNC ID
| HGNC:10061 |
| References |
|---|
| General References
| Not Available |