| Identification |
|---|
| HMDB Protein ID
| CDBP04459 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin-conjugating enzyme E2 Q2 |
| Description
| Not Available |
| Synonyms
|
- Ubiquitin carrier protein Q2
- Ubiquitin-protein ligase Q2
|
| Gene Name
| UBE2Q2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination.
|
| GO Classification
|
| Biological Process |
| protein K48-linked ubiquitination |
| Cellular Component |
| cytoplasm |
| Function |
| catalytic activity |
| small conjugating protein ligase activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| Molecular Function |
| ubiquitin-protein ligase activity |
| ATP binding |
| acid-amino acid ligase activity |
| Process |
| metabolic process |
| regulation of protein metabolic process |
| macromolecule metabolic process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein ubiquitination | Not Available | Not Available | | Ubiquitin mediated proteolysis | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q24.2 |
| SNPs
| UBE2Q2 |
| Gene Sequence
|
>1128 bp
ATGTCCGTGTCAGGGCTCAAGGCCGAGCTGAAGTTCCTGGCGTCCATCTTCGACAAGAAC
CACGAGCGATTCCGCATCGTCAGTTGGAAGCTGGACGAGCTGCACTGCCAGTTCCTGGTG
CCGCAGCAGGGCAGCCCGCACTCGCTGCCGCCGCCACTCACGCTCCACTGCAACATCACG
GAATCCTATCCATCTTCTTCACCGATATGGTTTGTGGATTCTGAAGACCCAAATCTGACA
TCAGTTCTGGAACGTCTAGAAGATACTAAGAACAACAATTTGCTTCGTCAGCAATTGAAG
TGGTTGATATGTGAACTCTGCAGTTTATATAACCTTCCTAAGCACCTGGATGTTGAGATG
CTAGATCAACCACTACCCACGGGTCAGAATGGGACAACAGAAGAAGTGACTTCAGAAGAA
GAGGAAGAAGAAGAAGAGATGGCTGAAGATATAGAAGACTTAGATCACTATGAGATGAAG
GAAGAAGAGCCTATTAGTGGGAAAAAGTCAGAGGATGAAGGAATTGAAAAAGAAAATTTG
GCAATATTAGAGAAAATTAGGAAGACTCAAAGGCAAGACCATTTAAATGGTGCAGTGTCT
GGGTCAGTGCAAGCTTCAGATAGACTTATGAAAGAGCTCAGGGACATATACAGATCACAG
AGTTATAAAACAGGGATTTATTCAGTGGAACTCATAAATGACAGTTTATATGACTGGCAT
GTTAAACTGCAGAAGGTTGACCCTGATAGTCCTTTGCACAGTGATCTTCAGATCTTAAAA
GAAAAAGAAGGCATAGAATATATTTTGCTTAACTTCTCTTTTAAGGATAACTTTCCATTT
GATCCTCCATTTGTTCGAGTGGTGTTACCTGTTCTCTCAGGAGGGTATGTATTGGGTGGA
GGAGCATTATGTATGGAACTTCTCACAAAACAGGGCTGGAGCAGTGCCTACTCAATAGAA
TCGGTCATCATGCAAATAAATGCCACCTTAGTCAAAGGCAAAGCCAGAGTGCAGTTTGGA
GCAAATAAGAATCAATATAATCTAGCAAGAGCCCAACAATCCTATAATTCCATTGTACAG
ATACATGAGAAAAATGGCTGGTACACCCCTCCAAAGGAAGATGGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 375 |
| Molecular Weight
| 40955.82 |
| Theoretical pI
| 4.785 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 Q2
MSVSGLKAELKFLASIFDKNHERFRIVSWKLDELHCQFLVPQQGSPHSLPPPLTLHCNIT
ESYPSSSPIWFVDSEDPNLTSVLERLEDTKNNNLLRQQLKWLICELCSLYNLPKHLDVEM
LDQPLPTGQNGTTEEVTSEEEEEEEEMAEDIEDLDHYEMKEEEPISGKKSEDEGIEKENL
AILEKIRKTQRQDHLNGAVSGSVQASDRLMKELRDIYRSQSYKTGIYSVELINDSLYDWH
VKLQKVDPDSPLHSDLQILKEKEGIEYILLNFSFKDNFPFDPPFVRVVLPVLSGGYVLGG
GALCMELLTKQGWSSAYSIESVIMQINATLVKGKARVQFGANKNQYNLARAQQSYNSIVQ
IHEKNGWYTPPKEDG
|
| External Links |
|---|
| GenBank ID Protein
| 50949459 |
| UniProtKB/Swiss-Prot ID
| Q8WVN8 |
| UniProtKB/Swiss-Prot Entry Name
| UB2Q2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AL832429 |
| GeneCard ID
| UBE2Q2 |
| GenAtlas ID
| UBE2Q2 |
| HGNC ID
| HGNC:19248 |
| References |
|---|
| General References
| Not Available |