| Identification |
|---|
| HMDB Protein ID
| CDBP00874 |
| Secondary Accession Numbers
| Not Available |
| Name
| Geranylgeranyl pyrophosphate synthase |
| Description
| Not Available |
| Synonyms
|
- Dimethylallyltranstransferase
- Farnesyltranstransferase
- GGPP synthase
- GGPPSase
- Geranylgeranyl diphosphate synthase
- Geranyltranstransferase
- (2E,6E)-farnesyl diphosphate synthase
- Farnesyl diphosphate synthase
|
| Gene Name
| GGPS1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in isoprenoid biosynthetic process |
| Specific Function
| Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins.
|
| GO Classification
|
| Biological Process |
| farnesyl diphosphate biosynthetic process |
| geranyl diphosphate biosynthetic process |
| cholesterol biosynthetic process |
| geranylgeranyl diphosphate biosynthetic process |
| isoprenoid metabolic process |
| Cellular Component |
| cytosol |
| Molecular Function |
| farnesyltranstransferase activity |
| metal ion binding |
| dimethylallyltranstransferase activity |
| geranyltranstransferase activity |
| Process |
| metabolic process |
| primary metabolic process |
| lipid metabolic process |
| cellular lipid metabolic process |
| isoprenoid metabolic process |
| isoprenoid biosynthetic process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | geranyl diphosphate biosynthesis | Not Available | Not Available | | farnesyl diphosphate biosynthesis | Not Available | Not Available | | geranylgeranyl diphosphate biosynthesis | Not Available | Not Available | | Terpenoid backbone biosynthesis | Not Available |  | | Steroid Biosynthesis |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q43 |
| SNPs
| GGPS1 |
| Gene Sequence
|
>903 bp
ATGGAGAAGACTCAAGAAACAGTCCAAAGAATTCTTCTAGAACCCTATAAATACTTACTT
CAGTTACCAGGTAAACAAGTGAGAACCAAACTTTCACAGGCATTTAATCATTGGCTGAAA
GTTCCAGAGGACAAGCTACAGATTATTATTGAAGTGACAGAAATGTTGCATAATGCCAGT
TTACTCATCGATGATATTGAAGACAACTCAAAACTCCGACGTGGCTTTCCAGTGGCCCAC
AGCATCTATGGAATCCCATCTGTCATCAATTCTGCCAATTACGTGTATTTCCTTGGCTTG
GAGAAAGTCTTAACCCTTGATCACCCAGATGCAGTGAAGCTTTTTACCCGCCAGCTTTTG
GAACTCCATCAGGGACAAGGCCTAGATATTTACTGGAGGGATAATTACACTTGTCCCACT
GAAGAAGAATATAAAGCTATGGTGCTGCAGAAAACAGGTGGACTGTTTGGATTAGCAGTA
GGTCTCATGCAGTTGTTCTCTGATTACAAAGAAGATTTAAAACCGCTACTTAATACACTT
GGGCTCTTTTTCCAAATTAGGGATGATTATGCTAATCTACACTCCAAAGAATATAGTGAA
AACAAAAGTTTTTGTGAAGATCTGACAGAGGGAAAGTTCTCATTTCCTACTATTCATGCT
ATTTGGTCAAGGCCTGAAAGCACCCAGGTGCAGAATATCTTGCGCCAGAGAACAGAAAAC
ATAGATATAAAAAAATACTGTGTACATTATCTTGAGGATGTAGGTTCTTTTGAATACACT
CGTAATACCCTTAAAGAGCTTGAAGCTAAAGCCTATAAACAGATTGATGCACGTGGTGGG
AACCCTGAGCTAGTAGCCTTAGTAAAACACTTAAGTAAGATGTTCAAAGAAGAAAATGAA
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 300 |
| Molecular Weight
| 34870.625 |
| Theoretical pI
| 6.14 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Geranylgeranyl pyrophosphate synthase
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O95749 |
| UniProtKB/Swiss-Prot Entry Name
| GGPPS_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AB017971 |
| GeneCard ID
| GGPS1 |
| GenAtlas ID
| GGPS1 |
| HGNC ID
| HGNC:4249 |
| References |
|---|
| General References
| Not Available |