Identification |
HMDB Protein ID
| CDBP00035 |
Secondary Accession Numbers
| Not Available |
Name
| Acetyl-coenzyme A synthetase, cytoplasmic |
Description
| Not Available |
Synonyms
|
- ACS
- AceCS
- Acetate--CoA ligase
- Acetyl-CoA synthetase
- Acyl-CoA synthetase short-chain family member 2
- Acyl-activating enzyme
|
Gene Name
| ACSS2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in acetate-CoA ligase activity |
Specific Function
| Activates acetate so that it can be used for lipid synthesis or for energy generation.
|
GO Classification
|
Biological Process |
xenobiotic metabolic process |
acetyl-CoA biosynthetic process from acetate |
ethanol oxidation |
lipid biosynthetic process |
Cellular Component |
cytosol |
nucleus |
Function |
purine nucleoside binding |
adenyl nucleotide binding |
adenyl ribonucleotide binding |
ligase activity |
ligase activity, forming carbon-sulfur bonds |
coa-ligase activity |
amp binding |
acetate-coa ligase activity |
binding |
catalytic activity |
nucleoside binding |
Molecular Function |
ATP binding |
acetate-CoA ligase activity |
AMP binding |
Process |
metabolic process |
|
Cellular Location
|
- Cytoplasm
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | Glycolysis / Gluconeogenesis | Not Available | ![Map00010](https://www.genome.jp/kegg/misc/thumbnail/map00010.gif) | Ethanol Degradation | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000021/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000021/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000021/thumb?image_type=simple) | Not Available | Disulfiram Action Pathway | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000431/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000431/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000431/thumb?image_type=simple) | Not Available | Pyruvate Metabolism | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000054/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000054/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000054/thumb?image_type=simple) | ![Map00620](https://www.genome.jp/kegg/misc/thumbnail/map00620.gif) | Leigh Syndrome | ![Thumb](https://smpdb.ca/super_pathway_visualizations/PW000115/thumb) ![Thumb?image type=greyscale](https://smpdb.ca/super_pathway_visualizations/PW000115/thumb?image_type=greyscale) ![Thumb?image type=simple](https://smpdb.ca/super_pathway_visualizations/PW000115/thumb?image_type=simple) | Not Available |
|
Gene Properties |
Chromosome Location
| 20 |
Locus
| 20q11.22 |
SNPs
| ACSS2 |
Gene Sequence
|
>2106 bp
ATGGGGCTTCCTGAGGAGCGGGTCCGGAGCGGCAGCGGGAGCCGGGGCCAGGAGGAAGCT
GGAGCCGGAGGCCGGGCGCGGAGTTGGTCTCCGCCGCCCGAGGTCAGCCGCTCCGCGCAC
GTCCCCTCGCTGCAGCGCTACCGCGAGCTGCACCGGCGCTCCGTGGAGGAGCCGCGGGAA
TTCTGGGGAGACATTGCCAAGGAATTTTACTGGAAGACTCCATGCCCTGGCCCATTCCTT
CGGTACAACTTTGATGTGACTAAAGGGAAAATCTTCATTGAGTGGATGAAAGGAGCAACT
ACCAACATCTGCTACAATGTACTGGATCGAAATGTCCATGAGAAAAAGCTTGGAGATAAA
GTTGCTTTTTACTGGGAGGGCAATGAGCCAGGGGAGACCACTCAGATCACATACCATCAG
CTTCTGGTCCAAGTGTGTCAGTTCAGCAATGTTCTCCGAAAACAGGGCATTCAGAAGGGG
GACCGAGTGGCCATCTACATGCCTATGATCCCAGAGCTTGTGGTGGCCATGCTGGCATGT
GCCCGCATTGGGGCTTTGCACTCCATTGTGTTTGCAGGCTTCTCTTCAGAGTCTCTATGT
GAACGGATCTTGGATTCCAGCTGCAGTCTTCTCATCACTACAGATGCCTTCTACAGGGGG
GAAAAGCTTGTGAACCTGAAGGAGCTGGCTGACGAGGCCCTGCAGAAGTGTCAGGAGAAG
GGTTTCCCAGTAAGATGCTGCATTGTGGTCAAGCACCTGGGGCGGGCAGAGCTCGGCATG
GGTGACTCCACCAGCCAGTCCCCCCCAATTAAGAGGTCATGCCCAGATGTGCAGATCTCA
TGGAACCAAGGGATTGACTTGTGGTGGCATGAGCTCATGCAAGAGGCAGGGGATGAGTGT
GAGCCCGAGTGGTGTGATGCCGAGGACCCACTCTTCATCCTGTACACCAGTGGCTCCACA
GGCAAACCCAAGGGTGTGGTTCACACAGTTGGGGGCTACATGCTCTATGTAGCCACAACC
TTCAAGTATGTGTTTGACTTCCATGCAGAGGATGTGTTCTGGTGCACGGCAGACATTGGT
TGGATCACTGGTCATTCCTACGTCACCTATGGGCCACTGGCCAATGGTGCCACCAGTGTT
TTGTTTGAGGGGATTCCCACATATCCGGACGTGAACCGCCTGTGGAGCATTGTGGACAAA
TACAAGGTGACCAAGTTCTACACAGCACCCACAGCCATCCGTCTGCTCATGAAGTTTGGA
GATGAGCCTGTCACCAAGCATAGCCGGGCATCCTTGCAGGTGTTAGGCACAGTGGGTGAA
CCCATCAACCCTGAGGCCTGGCTATGGTACCACCGGGTGGTAGGTGCCCAGCGCTGCCCC
ATCGTGGACACCTTCTGGCAAACAGAGACAGGTGGCCACATGTTGACTCCCCTTCCTGGT
GCCACACCCATGAAACCCGGTTCTGCTACTTTCCCATTCTTTGGTGTAGCTCCTGCAATC
CTGAATGAGTCCGGGGAAGAGTTGGAAGGTGAAGCTGAAGGTTATCTGGTGTTCAAGCAG
CCCTGGCCAGGGATCATGCGCACAGTCTATGGGAACCACGAACGCTTTGAGACAACCTAC
TTTAAGAAGTTTCCTGGATACTATGTTACAGGAGATGGCTGCCAGCGGGACCAGGATGGC
TATTACTGGATCACTGGCAGGATTGATGACATGCTCAATGTATCTGGACACCTGCTGAGT
ACAGCAGAGGTGGAGTCAGCACTTGTGGAACATGAGGCTGTTGCAGAGGCAGCTGTGGTG
GGCCACCCTCATCCTGTGAAGGGTGAATGCCTCTACTGCTTTGTCACCTTGTGTGATGGC
CACACCTTCAGCCCCAAGCTCACCGAGGAGCTCAAGAAGCAGATTAGAGAAAAGATTGGC
CCCATTGCCACACCAGACTACATCCAGAATGCACCTGGCTTGCCTAAAACCCGCTCAGGG
AAAATCATGAGGCGAGTGCTTCGGAAGATTGCTCAGAATGACCATGACCTCGGGGACATG
TCTACTGTGGCTGACCCATCTGTCATCAGTCACCTCTTCAGCCACCGCTGCCTGACCATC
CAGTGA
|
Protein Properties |
Number of Residues
| 701 |
Molecular Weight
| 78579.11 |
Theoretical pI
| 6.461 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Acetyl-coenzyme A synthetase, cytoplasmic
MGLPEERVRSGSGSRGQEEAGAGGRARSWSPPPEVSRSAHVPSLQRYRELHRRSVEEPRE
FWGDIAKEFYWKTPCPGPFLRYNFDVTKGKIFIEWMKGATTNICYNVLDRNVHEKKLGDK
VAFYWEGNEPGETTQITYHQLLVQVCQFSNVLRKQGIQKGDRVAIYMPMIPELVVAMLAC
ARIGALHSIVFAGFSSESLCERILDSSCSLLITTDAFYRGEKLVNLKELADEALQKCQEK
GFPVRCCIVVKHLGRAELGMGDSTSQSPPIKRSCPDVQISWNQGIDLWWHELMQEAGDEC
EPEWCDAEDPLFILYTSGSTGKPKGVVHTVGGYMLYVATTFKYVFDFHAEDVFWCTADIG
WITGHSYVTYGPLANGATSVLFEGIPTYPDVNRLWSIVDKYKVTKFYTAPTAIRLLMKFG
DEPVTKHSRASLQVLGTVGEPINPEAWLWYHRVVGAQRCPIVDTFWQTETGGHMLTPLPG
ATPMKPGSATFPFFGVAPAILNESGEELEGEAEGYLVFKQPWPGIMRTVYGNHERFETTY
FKKFPGYYVTGDGCQRDQDGYYWITGRIDDMLNVSGHLLSTAEVESALVEHEAVAEAAVV
GHPHPVKGECLYCFVTLCDGHTFSPKLTEELKKQIREKIGPIATPDYIQNAPGLPKTRSG
KIMRRVLRKIAQNDHDLGDMSTVADPSVISHLFSHRCLTIQ
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9NR19 |
UniProtKB/Swiss-Prot Entry Name
| ACSA_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AF263614 |
GeneCard ID
| ACSS2 |
GenAtlas ID
| ACSS2 |
HGNC ID
| HGNC:15814 |
References |
General References
| Not Available |