| Identification |
|---|
| HMDB Protein ID
| CDBP00587 |
| Secondary Accession Numbers
| Not Available |
| Name
| Ubiquitin-conjugating enzyme E2 E1 |
| Description
| Not Available |
| Synonyms
|
- UbcH6
- Ubiquitin carrier protein E1
- Ubiquitin-protein ligase E1
|
| Gene Name
| UBE2E1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in acid-amino acid ligase activity |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.
|
| GO Classification
|
| Biological Process |
| ISG15-protein conjugation |
| cytokine-mediated signaling pathway |
| anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process |
| mitotic cell cycle spindle assembly checkpoint |
| negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
| positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle |
| protein K48-linked ubiquitination |
| histone H2B ubiquitination |
| histone monoubiquitination |
| Cellular Component |
| cytosol |
| nucleoplasm |
| ubiquitin ligase complex |
| Function |
| catalytic activity |
| small conjugating protein ligase activity |
| ligase activity |
| ligase activity, forming carbon-nitrogen bonds |
| acid-amino acid ligase activity |
| Molecular Function |
| ubiquitin-protein ligase activity |
| ATP binding |
| ISG15 ligase activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| post-translational protein modification |
| macromolecule modification |
| protein modification process |
| metabolic process |
| regulation of protein metabolic process |
| macromolecule metabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein ubiquitination | Not Available | Not Available | | Ubiquitin mediated proteolysis | Not Available |  | | Protein processing in endoplasmic reticulum | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| 3p24.2 |
| SNPs
| UBE2E1 |
| Gene Sequence
|
>582 bp
ATGTCGGATGACGATTCGAGGGCCAGCACCAGCTCCTCCTCATCTTCGTCTTCCAACCAG
CAAACCGAGAAAGAAACAAACACCCCCAAGAAGAAGGAGAGTAAAGTCAGCATGAGCAAA
AACTCCAAACTCCTCTCCACCAGCGCCAAGAGAATTCAGAAGGAGCTGGCGGACATCACT
TTAGACCCTCCACCTAATTGCAGTGCTGGTCCCAAAGGCGATAACATCTATGAATGGAGA
TCAACCATTCTAGGGCCTCCAGGATCCGTGTATGAGGGTGGTGTATTCTTTCTCGATATC
ACTTTTACACCAGAATATCCCTTCAAGCCTCCAAAGGTTACATTTCGGACAAGAATCTAT
CATTGTAATATTAACAGTCAAGGTGTTATTTGCTTGGACATATTGAAAGATAATTGGAGT
CCAGCACTAACCATTTCTAAAGTCCTCCTTTCTATCTGCTCACTTCTTACAGACTGTAAT
CCTGCCGACCCCTTGGTGGGAAGTATTGCCACTCAGTATATGACCAACAGAGCAGAACAT
GACAGAATGGCCAGACAGTGGACCAAGAGATACGCTACATAA
|
| Protein Properties |
|---|
| Number of Residues
| 193 |
| Molecular Weight
| 21403.93 |
| Theoretical pI
| 8.524 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 E1
MSDDDSRASTSSSSSSSSNQQTEKETNTPKKKESKVSMSKNSKLLSTSAKRIQKELADIT
LDPPPNCSAGPKGDNIYEWRSTILGPPGSVYEGGVFFLDITFTPEYPFKPPKVTFRTRIY
HCNINSQGVICLDILKDNWSPALTISKVLLSICSLLTDCNPADPLVGSIATQYMTNRAEH
DRMARQWTKRYAT
|
| External Links |
|---|
| GenBank ID Protein
| 189054583 |
| UniProtKB/Swiss-Prot ID
| P51965 |
| UniProtKB/Swiss-Prot Entry Name
| UB2E1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK314854 |
| GeneCard ID
| UBE2E1 |
| GenAtlas ID
| UBE2E1 |
| HGNC ID
| HGNC:12477 |
| References |
|---|
| General References
| Not Available |