Identification
HMDB Protein ID CDBP04423
Secondary Accession Numbers Not Available
Name Ubiquitin-conjugating enzyme E2 R2
Description Not Available
Synonyms
  1. Ubiquitin carrier protein R2
  2. Ubiquitin-conjugating enzyme E2-CDC34B
  3. Ubiquitin-protein ligase R2
Gene Name UBE2R2
Protein Type Enzyme
Biological Properties
General Function Involved in acid-amino acid ligase activity
Specific Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.
GO Classification
Biological Process
protein K48-linked ubiquitination
protein monoubiquitination
Function
ligase activity, forming carbon-nitrogen bonds
acid-amino acid ligase activity
catalytic activity
small conjugating protein ligase activity
ligase activity
Molecular Function
ubiquitin-protein ligase activity
ATP binding
Process
metabolic process
regulation of protein metabolic process
macromolecule metabolic process
biological regulation
regulation of biological process
regulation of metabolic process
regulation of macromolecule metabolic process
post-translational protein modification
macromolecule modification
protein modification process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location 9
Locus 9p13.3
SNPs UBE2R2
Gene Sequence
>717 bp
ATGGCCCAGCAGCAGATGACCAGCTCGCAGAAGGCCCTGATGCTCGAGCTGAAATCCCTG
CAGGAGGAACCGGTGGAGGGCTTCCGGATCACCCTGGTGGACGAGTCCGACCTCTACAAC
TGGGAGGTGGCCATCTTCGGACCCCCCAACACCCTCTACGAAGGCGGCTACTTCAAGGCG
CATATTAAATTTCCTATTGACTACCCCTATTCACCACCTACCTTCAGATTCTTGACCAAA
ATGTGGCACCCCAACATTTATGAGAATGGAGATGTATGCATTTCGATTCTTCATCCGCCT
GTAGATGACCCACAGAGTGGAGAACTGCCTTCTGAAAGGTGGAATCCTACTCAGAATGTG
AGGACTATCCTATTAAGTGTAATCTCACTGCTTAATGAGCCCAACACCTTCTCCCCAGCC
AATGTCGATGCTTCAGTTATGTTCAGGAAATGGAGAGACAGTAAAGGAAAAGACAAAGAA
TATGCTGAAATTATTAGGAAACAAGTTTCAGCCACTAAGGCCGAAGCAGAAAAGGATGGA
GTGAAGGTCCCCACAACCCTGGCGGAATACTGCATCAAAACTAAAGTGCCTTCCAATGAC
AACAGCTCAGATTTGCTTTACGACGACTTGTATGATGACGACATTGATGATGAAGATGAG
GAGGAGGAAGATGCCGACTGTTATGATGATGATGATTCTGGGAATGAGGAGTCGTGA
Protein Properties
Number of Residues 238
Molecular Weight 27165.725
Theoretical pI 4.418
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>Ubiquitin-conjugating enzyme E2 R2
MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKA
HIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNV
RTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVSATKAEAEKDG
VKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNEES
GenBank ID Protein 17645997
UniProtKB/Swiss-Prot ID Q712K3
UniProtKB/Swiss-Prot Entry Name UB2R2_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ240087
GeneCard ID UBE2R2
GenAtlas ID UBE2R2
HGNC ID HGNC:19907
References
General References Not Available