Identification |
HMDB Protein ID
| CDBP04423 |
Secondary Accession Numbers
| Not Available |
Name
| Ubiquitin-conjugating enzyme E2 R2 |
Description
| Not Available |
Synonyms
|
- Ubiquitin carrier protein R2
- Ubiquitin-conjugating enzyme E2-CDC34B
- Ubiquitin-protein ligase R2
|
Gene Name
| UBE2R2 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in acid-amino acid ligase activity |
Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes monoubiquitination and 'Lys-48'-linked polyubiquitination. May be involved in degradation of katenin.
|
GO Classification
|
Biological Process |
protein K48-linked ubiquitination |
protein monoubiquitination |
Function |
ligase activity, forming carbon-nitrogen bonds |
acid-amino acid ligase activity |
catalytic activity |
small conjugating protein ligase activity |
ligase activity |
Molecular Function |
ubiquitin-protein ligase activity |
ATP binding |
Process |
metabolic process |
regulation of protein metabolic process |
macromolecule metabolic process |
biological regulation |
regulation of biological process |
regulation of metabolic process |
regulation of macromolecule metabolic process |
post-translational protein modification |
macromolecule modification |
protein modification process |
|
Cellular Location
|
Not Available
|
Pathways
|
Name | SMPDB/Pathwhiz | KEGG | protein ubiquitination | Not Available | Not Available | Ubiquitin mediated proteolysis | Not Available | ![Map04120](https://www.genome.jp/kegg/misc/thumbnail/map04120.gif) | Herpes simplex infection | Not Available | ![Map05168](https://www.genome.jp/kegg/misc/thumbnail/map05168.gif) |
|
Gene Properties |
Chromosome Location
| 9 |
Locus
| 9p13.3 |
SNPs
| UBE2R2 |
Gene Sequence
|
>717 bp
ATGGCCCAGCAGCAGATGACCAGCTCGCAGAAGGCCCTGATGCTCGAGCTGAAATCCCTG
CAGGAGGAACCGGTGGAGGGCTTCCGGATCACCCTGGTGGACGAGTCCGACCTCTACAAC
TGGGAGGTGGCCATCTTCGGACCCCCCAACACCCTCTACGAAGGCGGCTACTTCAAGGCG
CATATTAAATTTCCTATTGACTACCCCTATTCACCACCTACCTTCAGATTCTTGACCAAA
ATGTGGCACCCCAACATTTATGAGAATGGAGATGTATGCATTTCGATTCTTCATCCGCCT
GTAGATGACCCACAGAGTGGAGAACTGCCTTCTGAAAGGTGGAATCCTACTCAGAATGTG
AGGACTATCCTATTAAGTGTAATCTCACTGCTTAATGAGCCCAACACCTTCTCCCCAGCC
AATGTCGATGCTTCAGTTATGTTCAGGAAATGGAGAGACAGTAAAGGAAAAGACAAAGAA
TATGCTGAAATTATTAGGAAACAAGTTTCAGCCACTAAGGCCGAAGCAGAAAAGGATGGA
GTGAAGGTCCCCACAACCCTGGCGGAATACTGCATCAAAACTAAAGTGCCTTCCAATGAC
AACAGCTCAGATTTGCTTTACGACGACTTGTATGATGACGACATTGATGATGAAGATGAG
GAGGAGGAAGATGCCGACTGTTATGATGATGATGATTCTGGGAATGAGGAGTCGTGA
|
Protein Properties |
Number of Residues
| 238 |
Molecular Weight
| 27165.725 |
Theoretical pI
| 4.418 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 R2
MAQQQMTSSQKALMLELKSLQEEPVEGFRITLVDESDLYNWEVAIFGPPNTLYEGGYFKA
HIKFPIDYPYSPPTFRFLTKMWHPNIYENGDVCISILHPPVDDPQSGELPSERWNPTQNV
RTILLSVISLLNEPNTFSPANVDASVMFRKWRDSKGKDKEYAEIIRKQVSATKAEAEKDG
VKVPTTLAEYCIKTKVPSNDNSSDLLYDDLYDDDIDDEDEEEEDADCYDDDDSGNEES
|
External Links |
GenBank ID Protein
| 17645997 |
UniProtKB/Swiss-Prot ID
| Q712K3 |
UniProtKB/Swiss-Prot Entry Name
| UB2R2_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| AJ240087 |
GeneCard ID
| UBE2R2 |
GenAtlas ID
| UBE2R2 |
HGNC ID
| HGNC:19907 |
References |
General References
| Not Available |