| Identification |
|---|
| HMDB Protein ID
| CDBP04421 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase TRIM33 |
| Description
| Not Available |
| Synonyms
|
- Ectodermin homolog
- Protein Rfg7
- RET-fused gene 7 protein
- TIF1-gamma
- Transcription intermediary factor 1-gamma
- Tripartite motif-containing protein 33
|
| Gene Name
| TRIM33 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade) |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| binding |
| transition metal ion binding |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p13.1 |
| SNPs
| TRIM33 |
| Gene Sequence
|
>3384 bp
ATGGCGGAAAACAAAGGCGGCGGCGAGGCTGAGAGCGGCGGCGGGGGCAGCGGCAGCGCG
CCGGTAACTGCCGGGGCCGCCGGGCCCGCCGCGCAGGAGGCGGAGCCGCCTCTCACCGCG
GTGCTGGTGGAGGAGGAGGAGGAGGAAGGCGGCAGGGCCGGCGCTGAGGGCGGCGCGGCC
GGGCCCGACGACGGGGGGGTGGCCGCGGCCTCCTCGGGCTCGGCCCAGGCTGCTTCATCT
CCTGCGGCCTCAGTGGGCACTGGAGTTGCCGGGGGCGCAGTATCGACGCCGGCTCCAGCT
CCAGCCTCGGCTCCCGCTCCGGGTCCCTCGGCAGGGCCGCCTCCTGGACCGCCAGCCTCG
CTCCTGGACACCTGCGCCGTGTGTCAGCAGAGCTTGCAGAGCCGGCGTGAGGCGGAGCCC
AAGCTGCTGCCCTGTCTTCACTCCTTCTGCCTGCGCTGCCTGCCCGAGCCGGAGCGCCAG
CTCAGCGTGCCCATCCCGGGGGGCAGCAACGGCGACATCCAGCAAGTTGGTGTAATACGG
TGCCCAGTATGCCGCCAAGAATGCAGACAGATAGACCTTGTGGATAATTATTTTGTGAAA
GACACATCTGAAGCTCCTAGCAGTTCTGATGAAAAATCAGAACAGGTATGTACTAGTTGT
GAAGACAATGCAAGTGCAGTTGGCTTTTGTGTAGAATGTGGAGAGTGGCTATGTAAGACA
TGTATCGAAGCACATCAAAGAGTAAAATTTACTAAAGATCACTTGATCAGGAAGAAAGAA
GATGTCTCAGAGTCTGTTGGAGCATCTGGTCAACGCCCTGTTTTCTGCCCTGTACACAAA
CAAGAACAGTTGAAACTTTTCTGTGAAACATGTGATAGATTGACATGTAGAGACTGTCAG
CTATTGGAACACAAAGAACATAGGTATCAGTTTTTGGAAGAAGCTTTTCAAAATCAGAAG
GGTGCAATTGAGAATCTACTGGCGAAACTTCTTGAGAAGAAGAATTATGTTCATTTTGCA
GCTACTCAGGTGCAGAATAGGATAAAAGAAGTAAATGAGACTAACAAACGAGTAGAACAG
GAAATTAAAGTGGCCATTTTCACCCTTATCAATGAAATTAATAAGAAAGGAAAATCTCTC
TTACAACAGCTAGAGAATGTTACAAAGGAAAGACAGATGAAGTTACTACAGCAGCAGAAT
GACATCACAGGCCTTTCCCGGCAGGTGAAGCATGTTATGAACTTCACAAATTGGGCAATT
GCAAGTGGCAGCAGCACAGCACTACTATACAGCAAGCGACTGATTACTTTCCAGTTGCGT
CATATTTTGAAAGCACGGTGTGATCCTGTCCCTGCTGCTAATGGAGCAATACGTTTCCAT
TGTGATCCCACCTTCTGGGCAAAGAATGTAGTCAATTTAGGTAATCTAGTAATAGAGAGT
AAACCAGCTCCTGGTTATACTCCTAATGTTGTAGTTGGGCAAGTTCCTCCAGGGACAAAC
CACATTAGTAAAACCCCTGGACAGATTAACTTAGCACAGCTTCGACTCCAGCACATGCAA
CAACAAGTATATGCACAGAAACATCAGCAGTTGCAACAGATGAGGATGCAGCAACCACCA
GCACCTGTACCAACTACAACAACAACAACACAACAGCATCCTAGACAAGCAGCCCCTCAG
ATGTTACAACAACAGCCTCCTCGATTGATCAGTGTGCAAACAATGCAAAGAGGCAACATG
AACTGTGGAGCTTTTCAAGCCCATCAGATGAGACTGGCTCAGAATGCTGCCAGAATACCA
GGGATACCCAGGCACAGCGGCCCTCAATATTCCATGATGCAGCCACACCTCCAAAGACAA
CACTCAAACCCAGGGCATGCTGGACCCTTTCCCGTAGTATCGGTACACAACACCACAATC
AACCCAACGAGCCCTACTACAGCAACTATGGCAAATGCAAACCGAGGTCCCACCAGCCCA
TCTGTTACAGCAATAGAGCTAATCCCCTCAGTTACCAATCCAGAAAACCTTCCATCGCTG
CCAGATATTCCACCCATACAGTTGGAAGATGCTGGCTCAAGTAGTTTAGATAATCTACTA
AGTAGATACATCTCAGGCAGTCACCTACCCCCACAGCCTACAAGCACCATGAATCCTTCT
CCAGGTCCCTCTGCCCTTTCTCCGGGATCATCAGGTTTATCCAATTCTCACACACCTGTG
AGACCCCCAAGTACTTCTAGTACTGGCAGTCGAGGCAGCTGTGGGTCATCAGGAAGAACT
GCTGAGAAGACAAGTCTTAGTTTCAAATCTGATCAGGTGAAGGTCAAGCAAGAACCTGGG
ACTGAAGATGAAATATGTAGCTTTTCAGGAGGTGTAAAACAAGAAAAAACAGAGGATGGC
AGGAGGAGTGCTTGCATGTTGAGCAGTCCTGAGAGTAGCTTGACACCACCTCTCTCAACC
AACCTGCATCTAGAAAGTGAATTGGATGCATTGGCAAGCCTGGAAAACCATGTGAAAATT
GAACCTGCAGATATGAATGAAAGCTGCAAACAGTCAGGGCTCAGCAGCCTTGTTAATGGA
AAGTCCCCAATTCGAAGCCTCATGCACAGGTCGGCAAGGATTGGAGGAGATGGCAACAAT
AAAGATGATGACCCAAATGAAGACTGGTGTGCTGTCTGCCAAAACGGAGGAGATCTCTTG
TGCTGCGAAAAATGTCCAAAGGTCTTTCATCTAACTTGTCATGTTCCAACACTACTTAGC
TTTCCAAGTGGGGACTGGATATGCACATTTTGTAGAGATATTGGAAAGCCAGAAGTTGAA
TATGATTGTGATAATTTGCAACATAGTAAGAAGGGGAAAACTGCGCAGGGGTTAAGCCCC
GTGGACCAAAGGAAATGTGAACGTCTTCTGCTTTACCTCTATTGCCATGAATTAAGTATT
GAATTCCAGGAGCCTGTTCCTGCTTCGATACCAAACTACTATAAAATTATAAAGAAACCA
ATGGATTTATCCACCGTGAAAAAGAAGCTTCAGAAAAAACATTCCCAACACTACCAAATC
CCGGATGACTTTGTGGCCGATGTCCGTTTGATCTTCAAGAACTGTGAAAGGTTTAATGAA
ATGATGAAAGTTGTTCAAGTTTATGCAGACACACAAGAGATTAATTTGAAGGCTGATTCA
GAAGTAGCTCAGGCAGGGAAAGCAGTTGCATTGTACTTTGAAGATAAACTCACAGAGATC
TACTCAGACAGGACCTTCGCACCTTTGCCAGAGTTTGAGCAGGAAGAGGATGATGGTGAG
GTAACTGAGGACTCTGATGAAGACTTTATACAGCCCCGCAGAAAACGCCTAAAGTCAGAT
GAGAGACCAGTACATATAAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1127 |
| Molecular Weight
| 122520.2 |
| Theoretical pI
| 6.65 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase TRIM33
MAENKGGGEAESGGGGSGSAPVTAGAAGPAAQEAEPPLTAVLVEEEEEEGGRAGAEGGAA
GPDDGGVAAASSGSAQAASSPAASVGTGVAGGAVSTPAPAPASAPAPGPSAGPPPGPPAS
LLDTCAVCQQSLQSRREAEPKLLPCLHSFCLRCLPEPERQLSVPIPGGSNGDIQQVGVIR
CPVCRQECRQIDLVDNYFVKDTSEAPSSSDEKSEQVCTSCEDNASAVGFCVECGEWLCKT
CIEAHQRVKFTKDHLIRKKEDVSESVGASGQRPVFCPVHKQEQLKLFCETCDRLTCRDCQ
LLEHKEHRYQFLEEAFQNQKGAIENLLAKLLEKKNYVHFAATQVQNRIKEVNETNKRVEQ
EIKVAIFTLINEINKKGKSLLQQLENVTKERQMKLLQQQNDITGLSRQVKHVMNFTNWAI
ASGSSTALLYSKRLITFQLRHILKARCDPVPAANGAIRFHCDPTFWAKNVVNLGNLVIES
KPAPGYTPNVVVGQVPPGTNHISKTPGQINLAQLRLQHMQQQVYAQKHQQLQQMRMQQPP
APVPTTTTTTQQHPRQAAPQMLQQQPPRLISVQTMQRGNMNCGAFQAHQMRLAQNAARIP
GIPRHSGPQYSMMQPHLQRQHSNPGHAGPFPVVSVHNTTINPTSPTTATMANANRGPTSP
SVTAIELIPSVTNPENLPSLPDIPPIQLEDAGSSSLDNLLSRYISGSHLPPQPTSTMNPS
PGPSALSPGSSGLSNSHTPVRPPSTSSTGSRGSCGSSGRTAEKTSLSFKSDQVKVKQEPG
TEDEICSFSGGVKQEKTEDGRRSACMLSSPESSLTPPLSTNLHLESELDALASLENHVKT
EPADMNESCKQSGLSSLVNGKSPIRSLMHRSARIGGDGNNKDDDPNEDWCAVCQNGGDLL
CCEKCPKVFHLTCHVPTLLSFPSGDWICTFCRDIGKPEVEYDCDNLQHSKKGKTAQGLSP
VDQRKCERLLLYLYCHELSIEFQEPVPASIPNYYKIIKKPMDLSTVKKKLQKKHSQHYQI
PDDFVADVRLIFKNCERFNEMMKVVQVYADTQEINLKADSEVAQAGKAVALYFEDKLTEI
YSDRTFAPLPEFEQEEDDGEVTEDSDEDFIQPRRKRLKSDERPVHIK
|
| External Links |
|---|
| GenBank ID Protein
| 74027249 |
| UniProtKB/Swiss-Prot ID
| Q9UPN9 |
| UniProtKB/Swiss-Prot Entry Name
| TRI33_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015906.3 |
| GeneCard ID
| TRIM33 |
| GenAtlas ID
| TRIM33 |
| HGNC ID
| HGNC:16290 |
| References |
|---|
| General References
| Not Available |