Identification |
HMDB Protein ID
| CDBP04407 |
Secondary Accession Numbers
| Not Available |
Name
| E3 ubiquitin-protein ligase MGRN1 |
Description
| Not Available |
Synonyms
|
- Mahogunin RING finger protein 1
- RING finger protein 156
|
Gene Name
| MGRN1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Involved in protein binding |
Specific Function
| E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to- lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination |
GO Classification
|
Function |
ion binding |
cation binding |
metal ion binding |
binding |
transition metal ion binding |
zinc ion binding |
protein binding |
|
Cellular Location
|
- Cell membrane
- cytosol
- Isoform 4:Cytoplasm
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| Chromosome:1 |
Locus
| 16p13.3 |
SNPs
| MGRN1 |
Gene Sequence
|
>1659 bp
ATGGGCTCCATTCTCAGCCGCCGCATCGCGGGGGTGGAGGACATCGACATCCAGGCGAAC
TCGGCCTATCGCTACCCTCCGAAGTCCGGAAACTACTTTGCTTCGCACTTTTTCATGGGA
GGAGAGAAATTCGACACCCCCCACCCTGAAGGTTACCTCTTTGGAGAGAACATGGATCTG
AACTTCCTGGGCAGCCGCCCGGTCCAGTTTCCCTACGTCACTCCTGCCCCCCACGAGCCC
GTGAAGACGCTGCGGAGCCTGGTGAACATCCGCAAAGACTCCCTGCGGCTGGTGAGGTAC
AAAGACGATGCCGACAGCCCCACCGAGGACGGCGACAAGCCCCGGGTGCTCTACAGCCTG
GAGTTCACCTTCGACGCCGATGCCCGCGTGGCCATCACCATCTACTGCCAGGCATCGGAG
GAGTTCCTGAACGGCAGGGCAGTATACAGCCCCAAGAGCCCCTCGCTACAGTCCGAGACC
GTCCACTACAAGAGAGGGGTGAGCCAGCAGTTCTCCCTGCCCTCCTTCAAGATTGACTTC
TCGGAATGGAAGGATGACGAGCTGAACTTTGACCTGGACCGGGGCGTGTTTCCAGTAGTC
ATCCAGGCTGTGGTGGACGAAGGAGATGTGGTGGAAGTGACTGGCCACGCCCACGTGCTC
TTGGCTGCCTTTGAAAAGCACATGGACGGCAGCTTCTCTGTGAAGCCTTTAAAGCAGAAG
CAAATTGTGGACCGGGTCAGCTACCTCCTGCAGGAGATCTATGGCATTGAGAACAAGAAC
AACCAGGAGACCAAGCCCTCGGACGACGAGAACAGCGACAACAGCAACGAGTGTGTGGTG
TGCCTGTCCGACCTGCGGGACACGCTGATCCTGCCCTGCCGCCACCTGTGCCTCTGTACC
TCCTGCGCCGACACGCTGCGCTACCAGGCCAACAACTGCCCCATCTGCCGGCTGCCTTTC
CGGGCCCTCCTGCAGATCCGGGCGGTGCGGAAGAAGCCAGGAGCCCTGTCCCCCGTGTCC
TTCAGCCCCGTCCTGGCCCAGAGCCTGGAGCATGATGAGCACTCTTGTCCCTTTAAAAAA
TCAAAGCCGCACCCCGCCTCCCTGGCCAGCAAGAAACCTAAAAGGGAAACAAACTCTGAC
AGCGTCCCACCTGGCTACGAGCCCATCTCGCTGCTCGAGGCGCTCAACGGCCTCCGGGCT
GTCTCCCCGGCCATCCCCTCGGCCCCTCTTTATGAAGAAATCACCTATTCAGGCATCTCG
GACGGCCTGTCCCAGGCCAGCTGTCCCCTCGCGGCTATCGACCACATCCTGGACAGCAGC
CGCCAGAAGGGCAGGCCGCAGAGCAAGGCCCCCGACAGCACCCTACGGTCCCCGTCTTCC
CCCATCCACGAAGAGGATGAGGAGAAGCTCTCCGAGGACGTGGACGCCCCTCCCCCACTG
GGTGGCGCAGAGCTGGCCCTGCGGGAAAGCAGCTCCCCTGAGAGTTTCATAACAGAAGAG
GTTGATGAGTCGTCGTCACCACAGCAAGGGACCCGAGCAGCTTCCATTGAGAATGTCCTG
CAGGACAGCAGCCCCGAGCACTGTGGCCGAGGCCCACCTGCTGACATCTACCTGCCAGCC
CTGGGGCCCGACTCCTGCTCTGTTGGTATAGACGAGTAA
|
Protein Properties |
Number of Residues
| 552 |
Molecular Weight
| 60752.2 |
Theoretical pI
| 4.77 |
Pfam Domain Function
|
Not Available |
Signals
|
|
Transmembrane Regions
|
|
Protein Sequence
|
>E3 ubiquitin-protein ligase MGRN1
MGSILSRRIAGVEDIDIQANSAYRYPPKSGNYFASHFFMGGEKFDTPHPEGYLFGENMDL
NFLGSRPVQFPYVTPAPHEPVKTLRSLVNIRKDSLRLVRYKDDADSPTEDGDKPRVLYSL
EFTFDADARVAITIYCQASEEFLNGRAVYSPKSPSLQSETVHYKRGVSQQFSLPSFKIDF
SEWKDDELNFDLDRGVFPVVIQAVVDEGDVVEVTGHAHVLLAAFEKHMDGSFSVKPLKQK
QIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTLILPCRHLCLCT
SCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEHSCPFKK
SKPHPASLASKKPKRETNSDSVPPGYEPISLLEALNGLRAVSPAIPSAPLYEEITYSGIS
DGLSQASCPLAAIDHILDSSRQKGRPQSKAPDSTLRSPSSPIHEEDEEKLSEDVDAPPPL
GGAELALRESSSPESFITEEVDESSSPQQGTRAASIENVLQDSSPEHCGRGPPADIYLPA
LGPDSCSVGIDE
|
External Links |
GenBank ID Protein
| 214010236 |
UniProtKB/Swiss-Prot ID
| O60291 |
UniProtKB/Swiss-Prot Entry Name
| MGRN1_HUMAN |
PDB IDs
|
Not Available |
GenBank Gene ID
| NM_001142290.1 |
GeneCard ID
| MGRN1 |
GenAtlas ID
| MGRN1 |
HGNC ID
| HGNC:20254 |
References |
General References
| Not Available |