| Identification |
|---|
| HMDB Protein ID
| CDBP01512 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protoheme IX farnesyltransferase, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- Heme O synthase
|
| Gene Name
| COX10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protoheme IX farnesyltransferase activity |
| Specific Function
| Converts protoheme IX and farnesyl diphosphate to heme O (By similarity).
|
| GO Classification
|
| Biological Process |
| cytochrome complex assembly |
| heme a biosynthetic process |
| heme O biosynthetic process |
| mitochondrial electron transport, cytochrome c to oxygen |
| mitochondrial fission |
| respiratory chain complex IV assembly |
| aerobic respiration |
| Cellular Component |
| mitochondrial membrane |
| mitochondrion |
| integral to membrane |
| Component |
| intrinsic to membrane |
| integral to membrane |
| mitochondrial membrane |
| membrane |
| cell part |
| membrane part |
| organelle membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring alkyl or aryl (other than methyl) groups |
| prenyltransferase activity |
| farnesyltranstransferase activity |
| protoheme ix farnesyltransferase activity |
| Molecular Function |
| farnesyltranstransferase activity |
| protoheme IX farnesyltransferase activity |
| Process |
| porphyrin biosynthetic process |
| heme o biosynthetic process |
| metabolic process |
| nitrogen compound metabolic process |
| tetrapyrrole metabolic process |
| porphyrin metabolic process |
| heme biosynthetic process |
|
| Cellular Location
|
- Mitochondrion membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Porphyrin Metabolism |    |  | | Oxidative phosphorylation | Not Available |  | | Porphyrin and chlorophyll metabolism | Not Available | | | Acute Intermittent Porphyria |    | Not Available | | Porphyria Variegata (PV) |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| COX10 |
| Gene Sequence
|
>1332 bp
ATGGCCGCATCTCCGCACACTCTCTCCTCACGCCTCCTGACAGGTTGCGTAGGAGGCTCT
GTCTGGTATCTTGAAAGAAGAACTATACAGGACTCCCCTCACAAGTTCTTACATCTTCTC
AGGAATGTCAATAAGCAGTGGATTACATTTCAGCACTTTAGCTTCCTCAAACGCATGTAT
GTCACACAGCTGAACAGAAGCCACAACCAGCAAGTAAGACCCAAGCCAGAACCAGTAGCA
TCTCCTTTCCTTGAAAAAACATCTTCAGGTCAAGCCAAAGCAGAAATATATGAGATGAGA
CCTCTCTCACCGCCCAGCCTATCTTTGTCCAGAAAGCCAAATGAAAAGGAATTGATAGAA
CTAGAGCCAGACTCAGTAATTGAAGACTCAATAGATGTAGGGAAAGAGACAAAAGAGGAA
AAGCGGTGGAAAGAGATGAAGCTGCAAGTGTATGATTTGCCAGGAATTTTGGCTCGACTA
TCCAAAATCAAACTCACAGCTCTGGTTGTAAGTACCACTGCAGCTGGATTTGCATTGGCT
CCGGGCCCTTTTGACTGGCCCTGTTTCCTGCTTACTTCTGTTGGGACAGGCCTTGCATCC
TGTGCTGCCAACTCCATCAATCAGTTTTTTGAGGTGCCATTTGACTCAAACATGAATAGG
ACAAAGAACAGACCGCTGGTTCGTGGACAGATCAGCCCATTGCTAGCTGTGTCCTTTGCC
ACTTGTTGTGCTGTTCCGGGAGTTGCCATTCTGACCTTGGGGGTGAATCCACTCACAGGA
GCCCTGGGGCTCTTCAACATTTTCCTGTATACCTGCTGCTACACACCACTGAAAAGGATC
AGCATTGCCAACACATGGGTCGGAGCTGTGGTTGGGGCCATCCCGCCTGTCATGGGCTGG
ACAGCGGCCACGGGCAGCCTCGATGCTGGCGCATTTCTCCTGGGAGGAATCCTCTACTCC
TGGCAGTTTCCTCATTTCAACGCCCTGAGCTGGGGCCTCCGTGAAGACTACTCCCGGGGC
GGCTACTGCATGATGTCGGTCACCCACCCGGGCCTGTGCCGGCGCGTGGCGCTGCGCCAC
TGCCTGGCCCTGCTCGTGCTGTCCGCAGCAGCCCCTGTGCTGGACATCACCACATGGACC
TTCCCCATCATGGCCCTTCCCATCAATGCGTACATCTCCTACCTCGGCTTCCGCTTCTAC
GTGGACGCAGACCGCAGGAGCTCGCGGAGACTGTTCTTCTGCAGCCTGTGGCACCTGCCG
CTGCTGCTGCTGCTCATGCTCACCTGCAAGCGGCCGAGCGGAGGCGGGGACGCAGGGCCC
CCTCCCAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 443 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protoheme IX farnesyltransferase, mitochondrial
MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMY
VTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIE
LEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALA
PGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFA
TCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGW
TAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRH
CLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLP
LLLLLMLTCKRPSGGGDAGPPPS
|
| External Links |
|---|
| GenBank ID Protein
| 17921982 |
| UniProtKB/Swiss-Prot ID
| Q12887 |
| UniProtKB/Swiss-Prot Entry Name
| COX10_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001303.3 |
| GeneCard ID
| COX10 |
| GenAtlas ID
| COX10 |
| HGNC ID
| HGNC:2260 |
| References |
|---|
| General References
| Not Available |