Identification
HMDB Protein ID CDBP04426
Secondary Accession Numbers Not Available
Name Ubiquitin-like modifier-activating enzyme 6
Description Not Available
Synonyms
  1. E1-L2
  2. MOP-4
  3. Monocyte protein 4
  4. Ubiquitin-activating enzyme 6
  5. Ubiquitin-activating enzyme E1-like protein 2
Gene Name UBA6
Protein Type Enzyme
Biological Properties
General Function Involved in catalytic activity
Specific Function Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility
GO Classification
Function
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
small protein activating enzyme activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
Cellular Location Not Available
Pathways
Gene Properties
Chromosome Location Chromosome:4
Locus 4q13.2
SNPs UBA6
Gene Sequence
>3159 bp
ATGGAAGGATCCGAGCCTGTGGCCGCCCATCAGGGGGAAGAGGCGTCCTGTTCTTCCTGG
GGGACTGGCAGCACAAATAAAAATTTGCCCATTATGTCAACAGCATCTGTGGAAATCGAT
GATGCATTGTATAGTCGACAGAGGTACGTTCTTGGAGACACAGCAATGCAGAAGATGGCC
AAGTCCCATGTTTTCTTAAGTGGGATGGGTGGTCTTGGTTTGGAAATTGCAAAGAATCTT
GTTCTTGCAGGGATTAAGGCAGTTACAATTCATGATACAGAAAAATGCCAAGCATGGGAT
CTAGGAACCAACTTCTTTCTCAGTGAAGATGATGTTGTTAATAAGAGAAACAGGGCTGAA
GCTGTACTTAAACATATTGCAGAACTAAATCCATACGTTCATGTCACATCATCTTCTGTT
CCTTTCAATGAGACCACAGATCTCTCCTTTTTAGATAAATACCAGTGTGTAGTATTGACT
GAGATGAAACTTCCATTGCAGAAGAAGATCAATGACTTTTGCCGTTCTCAGTGCCCTCCA
ATTAAGTTTATCAGTGCAGATGTACATGGAATTTGGTCAAGGTTATTTTGTGATTTCGGT
GATGAATTTGAAGTTTTAGATACAACAGGAGAAGAACCAAAAGAAATTTTCATTTCAAAC
ATAACGCAAGCAAATCCTGGCATTGTTACTTGCCTTGAAAATCATCCTCACAAACTGGAG
ACAGGACAATTCCTAACATTTCGAGAAATTAATGGAATGACAGGTTTAAATGGATCTATA
CAACAAATAACGGTGATATCGCCATTTTCTTTTAGTATTGGTGACACCACAGAACTGGAA
CCATATTTACATGGAGGCATAGCTGTCCAAGTTAAGACTCCTAAAACAGTTTTTTTTGAA
TCACTGGAGAGGCAGTTAAAACATCCAAAGTGCCTTATTGTGGATTTTAGCAACCCTGAG
GCACCTTTAGAGATTCACACAGCTATGCTTGCCTTGGACCAGTTTCAGGAGAAATACAGT
CGCAAGCCAAATGTTGGATGCCAACAAGATTCAGAAGAACTGTTGAAACTAGCAACATCT
ATAAGTGAAACCTTGGAAGAGAAGCCTGATGTAAATGCTGACATTGTGCATTGGCTCTCT
TGGACTGCCCAAGGCTTTTTATCTCCACTTGCTGCAGCAGTAGGAGGTGTTGCCAGCCAA
GAAGTATTGAAAGCTGTAACAGGAAAATTTTCTCCTTTGTGCCAGTGGTTATATCTTGAA
GCAGCAGATATTGTTGAATCACTAGGCAAACCTGAATGTGAAGAATTTCTCCCACGAGGA
GATAGATATGATGCCTTAAGAGCTTGCATTGGAGACACTTTGTGTCAGAAACTGCAAAAT
TTAAACATCTTCTTAGTAGGGTGTGGAGCCATAGGCTGTGAAATGTTGAAAAATTTTGCT
TTACTTGGTGTTGGCACAAGCAAAGAGAAAGGAATGATTACAGTTACAGATCCTGACTTG
ATAGAGAAATCCAACTTAAATAGACAGTTCCTATTTCGTCCTCATCACATACAGAAACCT
AAAAGCTACACTGCTGCTGATGCTACTCTGAAAATAAATTCTCAAATAAAGATAGATGCA
CACCTGAACAAAGTATGTCCAACCACTGAGACCATTTACAATGATGAGTTCTATACTAAA
CAAGATGTAATTATTACAGCATTAGATAATGTGGAAGCCAGGAGATACGTAGACAGTCGT
TGCTTAGCAAATCTAAGGCCTCTTTTAGATTCTGGAACAATGGGCACTAAGGGACACACT
GAAGTTATTGTACCGCATTTGACTGAGTCTTACAATAGTCATCGGGATCCCCCAGAAGAG
GAAATACCATTTTGTACTCTAAAATCCTTTCCAGCTGCTATTGAACATACCATACAGTGG
GCAAGAGATAAGTTTGAAAGTTCCTTTTCCCACAAACCTTCATTGTTTAACAAATTTTGG
CAAACCTATTCATCTGCAGAAGAAGTCTTACAGAAGATACAGAGTGGACACAGTTTAGAA
GGCTGTTTTCAAGTTATAAAGTTACTTAGCAGAAGACCTAGAAATTGGTCCCAGTGTGTA
GAATTAGCAAGATTAAAGTTTGAAAAATATTTTAACCATAAGGCTCTTCAGCTTCTTCAC
TGTTTCCCTCTGGACATACGATTAAAAGATGGCAGTTTATTTTGGCAGTCACCAAAGAGG
CCACCCTCTCCAATAAAATTTGATTTAAATGAGCCTTTGCACCTCAGTTTCCTTCAGAAT
GCTGCAAAACTATATGCTACAGTATATTGTATTCCATTTGCAGAAGAGGACTTATCAGCA
GATGCCCTCTTGAATATTCTTTCAGAAGTAAAGATTCAGGAATTCAAGCCTTCCAATAAG
GTTGTTCAAACAGATGAAACTGCAAGGAAACCAGACCATGTTCCTATTAGCAGTGAAGAT
GAGAGGAATGCAATTTTCCAACTAGAAAAGGCTATTTTATCTAATGAAGCCACCAAAAGT
GACCTTCAGATGGCAGTGCTTTCATTTGAAAAAGATGATGATCATAATGGACACATAGAT
TTCATCACAGCTGCATCAAATCTTCGTGCCAAAATGTACAGCATTGAACCAGCTGACCGT
TTCAAAACAAAGCGCATAGCTGGTAAAATTATACCTGCTATAGCAACAACCACTGCTACA
GTTTCTGGCTTGGTTGCCTTGGAGATGATCAAAGTAACTGGTGGCTATCCATTTGAAGTT
TACAAAAATTGTTTTCTTAACTTAGCCATTCCAATTGTAGTATTTACAGAGACAACTGAA
GTAAGGAAAACTAAAATCAGAAATGGAATATCATTTACAATTTGGGATCGATGGACCGTA
CATGGAAAAGAAGATTTCACCCTCTTGGATTTCATAAATGCAGTCAAAGAGAAGTATGGA
ATTGAGCCAACAATGGTGGTACAGGGAGTCAAAATGCTTTATGTTCCTGTAATGCCTGGT
CATGCAAAAAGATTGAAGTTAACAATGCATAAACTTGTAAAACCTACTACTGAAAAGAAA
TATGTGGATCTTACTGTGTCATTTGCTCCAGACATTGATGGAGATGAAGATTTGCCGGGA
CCTCCAGTAAGATACTACTTCAGTCATGACACTGATTAA
Protein Properties
Number of Residues 1052
Molecular Weight 117968.9
Theoretical pI 6.05
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Ubiquitin-like modifier-activating enzyme 6
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA
KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE
AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP
IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE
TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE
SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS
ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE
AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA
LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA
HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT
EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW
QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH
CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA
DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS
DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV
HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK
YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD
GenBank ID Protein 11990422
UniProtKB/Swiss-Prot ID A0AVT1
UniProtKB/Swiss-Prot Entry Name UBA6_HUMAN
PDB IDs Not Available
GenBank Gene ID AB014773
GeneCard ID UBA6
GenAtlas ID UBA6
HGNC ID HGNC:25581
References
General References Not Available