Cannabis Compound Database: Showing Protein Ubiquitin-like modifier-activating enzyme 6 (CDBP04426)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 compounds

Identification

HMDB Protein ID

CDBP04426

Secondary Accession Numbers

Not Available

Name

Ubiquitin-like modifier-activating enzyme 6

Description

Not Available

Synonyms

E1-L2
MOP-4
Monocyte protein 4
Ubiquitin-activating enzyme 6
Ubiquitin-activating enzyme E1-like protein 2

Gene Name

UBA6

Protein Type

Enzyme

Biological Properties

General Function

Involved in catalytic activity

Specific Function

Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin- E1 thioester and free AMP. Specific for ubiquitin, does not activate ubiquitin-like peptides. Differs from UBE1 in its specificity for substrate E2 charging. Does not charge cell cycle E2s, such as CDC34. Essential for embryonic development. Required for UBD/FAT10 conjugation. Isoform 2 may play a key role in ubiquitin system and may influence spermatogenesis and male fertility

GO Classification

Function
binding
catalytic activity
nucleoside binding
purine nucleoside binding
adenyl nucleotide binding
adenyl ribonucleotide binding
atp binding
small protein activating enzyme activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process

Cellular Location

Not Available

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:4

Locus

4q13.2

SNPs

UBA6

Gene Sequence

>3159 bp
ATGGAAGGATCCGAGCCTGTGGCCGCCCATCAGGGGGAAGAGGCGTCCTGTTCTTCCTGG
GGGACTGGCAGCACAAATAAAAATTTGCCCATTATGTCAACAGCATCTGTGGAAATCGAT
GATGCATTGTATAGTCGACAGAGGTACGTTCTTGGAGACACAGCAATGCAGAAGATGGCC
AAGTCCCATGTTTTCTTAAGTGGGATGGGTGGTCTTGGTTTGGAAATTGCAAAGAATCTT
GTTCTTGCAGGGATTAAGGCAGTTACAATTCATGATACAGAAAAATGCCAAGCATGGGAT
CTAGGAACCAACTTCTTTCTCAGTGAAGATGATGTTGTTAATAAGAGAAACAGGGCTGAA
GCTGTACTTAAACATATTGCAGAACTAAATCCATACGTTCATGTCACATCATCTTCTGTT
CCTTTCAATGAGACCACAGATCTCTCCTTTTTAGATAAATACCAGTGTGTAGTATTGACT
GAGATGAAACTTCCATTGCAGAAGAAGATCAATGACTTTTGCCGTTCTCAGTGCCCTCCA
ATTAAGTTTATCAGTGCAGATGTACATGGAATTTGGTCAAGGTTATTTTGTGATTTCGGT
GATGAATTTGAAGTTTTAGATACAACAGGAGAAGAACCAAAAGAAATTTTCATTTCAAAC
ATAACGCAAGCAAATCCTGGCATTGTTACTTGCCTTGAAAATCATCCTCACAAACTGGAG
ACAGGACAATTCCTAACATTTCGAGAAATTAATGGAATGACAGGTTTAAATGGATCTATA
CAACAAATAACGGTGATATCGCCATTTTCTTTTAGTATTGGTGACACCACAGAACTGGAA
CCATATTTACATGGAGGCATAGCTGTCCAAGTTAAGACTCCTAAAACAGTTTTTTTTGAA
TCACTGGAGAGGCAGTTAAAACATCCAAAGTGCCTTATTGTGGATTTTAGCAACCCTGAG
GCACCTTTAGAGATTCACACAGCTATGCTTGCCTTGGACCAGTTTCAGGAGAAATACAGT
CGCAAGCCAAATGTTGGATGCCAACAAGATTCAGAAGAACTGTTGAAACTAGCAACATCT
ATAAGTGAAACCTTGGAAGAGAAGCCTGATGTAAATGCTGACATTGTGCATTGGCTCTCT
TGGACTGCCCAAGGCTTTTTATCTCCACTTGCTGCAGCAGTAGGAGGTGTTGCCAGCCAA
GAAGTATTGAAAGCTGTAACAGGAAAATTTTCTCCTTTGTGCCAGTGGTTATATCTTGAA
GCAGCAGATATTGTTGAATCACTAGGCAAACCTGAATGTGAAGAATTTCTCCCACGAGGA
GATAGATATGATGCCTTAAGAGCTTGCATTGGAGACACTTTGTGTCAGAAACTGCAAAAT
TTAAACATCTTCTTAGTAGGGTGTGGAGCCATAGGCTGTGAAATGTTGAAAAATTTTGCT
TTACTTGGTGTTGGCACAAGCAAAGAGAAAGGAATGATTACAGTTACAGATCCTGACTTG
ATAGAGAAATCCAACTTAAATAGACAGTTCCTATTTCGTCCTCATCACATACAGAAACCT
AAAAGCTACACTGCTGCTGATGCTACTCTGAAAATAAATTCTCAAATAAAGATAGATGCA
CACCTGAACAAAGTATGTCCAACCACTGAGACCATTTACAATGATGAGTTCTATACTAAA
CAAGATGTAATTATTACAGCATTAGATAATGTGGAAGCCAGGAGATACGTAGACAGTCGT
TGCTTAGCAAATCTAAGGCCTCTTTTAGATTCTGGAACAATGGGCACTAAGGGACACACT
GAAGTTATTGTACCGCATTTGACTGAGTCTTACAATAGTCATCGGGATCCCCCAGAAGAG
GAAATACCATTTTGTACTCTAAAATCCTTTCCAGCTGCTATTGAACATACCATACAGTGG
GCAAGAGATAAGTTTGAAAGTTCCTTTTCCCACAAACCTTCATTGTTTAACAAATTTTGG
CAAACCTATTCATCTGCAGAAGAAGTCTTACAGAAGATACAGAGTGGACACAGTTTAGAA
GGCTGTTTTCAAGTTATAAAGTTACTTAGCAGAAGACCTAGAAATTGGTCCCAGTGTGTA
GAATTAGCAAGATTAAAGTTTGAAAAATATTTTAACCATAAGGCTCTTCAGCTTCTTCAC
TGTTTCCCTCTGGACATACGATTAAAAGATGGCAGTTTATTTTGGCAGTCACCAAAGAGG
CCACCCTCTCCAATAAAATTTGATTTAAATGAGCCTTTGCACCTCAGTTTCCTTCAGAAT
GCTGCAAAACTATATGCTACAGTATATTGTATTCCATTTGCAGAAGAGGACTTATCAGCA
GATGCCCTCTTGAATATTCTTTCAGAAGTAAAGATTCAGGAATTCAAGCCTTCCAATAAG
GTTGTTCAAACAGATGAAACTGCAAGGAAACCAGACCATGTTCCTATTAGCAGTGAAGAT
GAGAGGAATGCAATTTTCCAACTAGAAAAGGCTATTTTATCTAATGAAGCCACCAAAAGT
GACCTTCAGATGGCAGTGCTTTCATTTGAAAAAGATGATGATCATAATGGACACATAGAT
TTCATCACAGCTGCATCAAATCTTCGTGCCAAAATGTACAGCATTGAACCAGCTGACCGT
TTCAAAACAAAGCGCATAGCTGGTAAAATTATACCTGCTATAGCAACAACCACTGCTACA
GTTTCTGGCTTGGTTGCCTTGGAGATGATCAAAGTAACTGGTGGCTATCCATTTGAAGTT
TACAAAAATTGTTTTCTTAACTTAGCCATTCCAATTGTAGTATTTACAGAGACAACTGAA
GTAAGGAAAACTAAAATCAGAAATGGAATATCATTTACAATTTGGGATCGATGGACCGTA
CATGGAAAAGAAGATTTCACCCTCTTGGATTTCATAAATGCAGTCAAAGAGAAGTATGGA
ATTGAGCCAACAATGGTGGTACAGGGAGTCAAAATGCTTTATGTTCCTGTAATGCCTGGT
CATGCAAAAAGATTGAAGTTAACAATGCATAAACTTGTAAAACCTACTACTGAAAAGAAA
TATGTGGATCTTACTGTGTCATTTGCTCCAGACATTGATGGAGATGAAGATTTGCCGGGA
CCTCCAGTAAGATACTACTTCAGTCATGACACTGATTAA

Protein Properties

Number of Residues

1052

Molecular Weight

117968.9

Theoretical pI

6.05

Pfam Domain Function

ThiF (PF00899 )
UBA_e1_C (PF09358 )
UBA_e1_thiolCys (PF10585 )
UBACT (PF02134 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Ubiquitin-like modifier-activating enzyme 6
MEGSEPVAAHQGEEASCSSWGTGSTNKNLPIMSTASVEIDDALYSRQRYVLGDTAMQKMA
KSHVFLSGMGGLGLEIAKNLVLAGIKAVTIHDTEKCQAWDLGTNFFLSEDDVVNKRNRAE
AVLKHIAELNPYVHVTSSSVPFNETTDLSFLDKYQCVVLTEMKLPLQKKINDFCRSQCPP
IKFISADVHGIWSRLFCDFGDEFEVLDTTGEEPKEIFISNITQANPGIVTCLENHPHKLE
TGQFLTFREINGMTGLNGSIQQITVISPFSFSIGDTTELEPYLHGGIAVQVKTPKTVFFE
SLERQLKHPKCLIVDFSNPEAPLEIHTAMLALDQFQEKYSRKPNVGCQQDSEELLKLATS
ISETLEEKPDVNADIVHWLSWTAQGFLSPLAAAVGGVASQEVLKAVTGKFSPLCQWLYLE
AADIVESLGKPECEEFLPRGDRYDALRACIGDTLCQKLQNLNIFLVGCGAIGCEMLKNFA
LLGVGTSKEKGMITVTDPDLIEKSNLNRQFLFRPHHIQKPKSYTAADATLKINSQIKIDA
HLNKVCPTTETIYNDEFYTKQDVIITALDNVEARRYVDSRCLANLRPLLDSGTMGTKGHT
EVIVPHLTESYNSHRDPPEEEIPFCTLKSFPAAIEHTIQWARDKFESSFSHKPSLFNKFW
QTYSSAEEVLQKIQSGHSLEGCFQVIKLLSRRPRNWSQCVELARLKFEKYFNHKALQLLH
CFPLDIRLKDGSLFWQSPKRPPSPIKFDLNEPLHLSFLQNAAKLYATVYCIPFAEEDLSA
DALLNILSEVKIQEFKPSNKVVQTDETARKPDHVPISSEDERNAIFQLEKAILSNEATKS
DLQMAVLSFEKDDDHNGHIDFITAASNLRAKMYSIEPADRFKTKRIAGKIIPAIATTTAT
VSGLVALEMIKVTGGYPFEAYKNCFLNLAIPIVVFTETTEVRKTKIRNGISFTIWDRWTV
HGKEDFTLLDFINAVKEKYGIEPTMVVQGVKMLYVPVMPGHAKRLKLTMHKLVKPTTEKK
YVDLTVSFAPDIDGDEDLPGPPVRYYFSHDTD

External Links

GenBank ID Protein

11990422

UniProtKB/Swiss-Prot ID

A0AVT1

UniProtKB/Swiss-Prot Entry Name

UBA6_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AB014773

GeneCard ID