Identification |
HMDB Protein ID
| CDBP05519 |
Secondary Accession Numbers
| Not Available |
Name
| Speckle targeted PIP5K1A-regulated poly(A) polymerase |
Description
| Not Available |
Synonyms
|
- Star-PAP
- RNA-binding motif protein 21
- U6 snRNA-specific terminal uridylyltransferase 1
- RNA-binding protein 21
- U6-TUTase
|
Gene Name
| TUT1 |
Protein Type
| Enzyme |
Biological Properties |
General Function
| Not Available |
Specific Function
| Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.
|
GO Classification
|
Biological Process |
mRNA cleavage |
snRNA processing |
mRNA polyadenylation |
Cellular Component |
nucleolus |
nuclear speck |
Molecular Function |
metal ion binding |
ATP binding |
RNA uridylyltransferase activity |
zinc ion binding |
polynucleotide adenylyltransferase activity |
mRNA 3'-UTR binding |
|
Cellular Location
|
Not Available
|
Pathways
|
Not Available
|
Gene Properties |
Chromosome Location
| 11 |
Locus
| 11q12.2 |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| Not Available |
Molecular Weight
| 98434.355 |
Theoretical pI
| 6.436 |
Pfam Domain Function
|
Not Available |
Signals
|
Not Available
|
Transmembrane Regions
|
Not Available
|
Protein Sequence
|
>gi|226371750|ref|NP_073741.2| speckle targeted PIP5K1A-regulated poly(A) polymerase [Homo sapiens]
MSLPIGSAEVASERVELWRSGFRWWQRCLCFCRYRRVAMAAVDSDVESLPRGGFRCCLCH
VTTANRPSLD
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q9H6E5 |
UniProtKB/Swiss-Prot Entry Name
| Not Available |
PDB IDs
|
|
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| HGNC:26184 |
References |
General References
| Not Available |