| Identification |
|---|
| HMDB Protein ID
| CDBP04410 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase AMFR |
| Description
| Not Available |
| Synonyms
|
- AMF receptor, isoform 2
- Autocrine motility factor receptor, isoform 2
- RING finger protein 45
- gp78
|
| Gene Name
| AMFR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| E3 ubiquitin-protein ligase which can target both itself and other proteins including CD3D and APOB for proteasomal degradation. Mediates polyubiquitination of CYP3A4. Specific receptor for the autocrine motility factor. Mediates tumor invasion and metastasis. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulun that are retrotranslocated in the cytosol. Promotes ubiquitination of misfolded proteins such as mutant CFTR; proposed to mediate sequential ubiquitination by recognizing already ubiquitin-conjugated substrates and to cooperate with E3 ubiquitin-protein ligase RNF5 |
| GO Classification
|
| Function |
| zinc ion binding |
| protein binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q21 |
| SNPs
| AMFR |
| Gene Sequence
|
>1932 bp
ATGCCGCTGCTCTTCCTCGAGCGCTTCCCCTGGCCCAGCCTCCGCACCTACACGGGCCTC
AGCGGCCTGGCCCTGCTGGGCACCATCATCAGCGCCTACCGCGCGCTCAGCCAGCCCGAG
GCCGGCCCCGGCGAGCCGGACCAGCTAACGGCCTCGCTGCAGCCTGAGCCGCCGGCGCCC
GCCCGGCCGAGCGCCGGGGGACCCCGGGCCCGCGATGTGGCCCAGTACCTGCTCTCAGAC
AGCCTCTTCGTGTGGGTTCTAGTAAATACCGCTTGCTGTGTTTTGATGTTGGTGGCTAAG
CTCATCCAGTGTATTGTGTTTGGCCCTCTTCGAGTGAGTGAGAGACAGCATCTCAAAGAC
AAATTTTGGAATTTTATTTTCTACAAGTTCATTTTCATCTTTGGTGTGCTGAATGTCCAG
ACAGTGGAAGAGGTGGTCATGTGGTGCCTCTGGTTTGCCGGACTTGTCTTTCTGCACCTG
ATGGTTCAGCTCTGCAAGGATCGATTTGAATATCTTTCCTTCTCGCCCACCACGCCGATG
AGCAGCCACGGTCGAGTCCTGTCCCTGTTGGTTGCCATGCTGCTTTCCTGCTGTGGACTG
GCGGCCGTCTGCTCCATCACCGGCTACACCCACGGAATGCACACCTTGGCTTTCATGGCT
GCAGAGTCTCTTCTTGTGACAGTGAGGACTGCTCATGTGATTTTACGATACGTAATTCAC
CTCTGGGACCTCAACCACGAAGGGACGTGGGAAGGAAAGGGGACGTATGTCTATTACACA
GACTTTGTCATGGAGCTCACTCTCCTGTCCCTGGACCTCATGCACCATATTCACATGTTG
TTATTTGGCAACATCTGGTTATCCATGGCCAGCCTGGTCATCTTTATGCAGCTGCGTTAC
CTGTTTCATGAGGTGCAACGTCGAATTCGTCGGCACAAGAACTATCTACGTGTGGTTGGA
AACATGGAGGCCAGGTTTGCAGTTGCAACTCCAGAGGAGCTGGCTGTCAACAATGACGAC
TGTGCCATCTGTTGGGACTCCATGCAGGCTGCGCGGAAACTGCCCTGTGGACATCTTTTC
CACAACTCCTGTCTTCGTTCCTGGCTAGAACAAGACACCTCCTGTCCAACATGCAGAATG
TCTCTTAATATTGCCGACAATAATCGTGTCAGGGAAGAACATCAAGGAGAGAACTTGGAT
GAGAATTTGGTTCCTGTAGCAGCAGCCGAAGGGAGACCTCGCTTAAACCAACACAATCAC
TTCTTCCATTTCGATGGGTCTCGGATTGCGAGCTGGCTGCCGAGTTTTTCGGTTGAAGTG
ATGCACACCACCAACATTCTTGGCATTACGCAGGCCAGCAACTCCCAGCTCAATGCAATG
GCTCATCAGATTCAAGAGATGTTTCCCCAGGTTCCATACCATCTGGTACTGCAGGACCTC
CAGCTGACACGCTCAGTTGAAATAACAACAGACAATATTTTAGAAGGACGGATTCAAGTA
CCTTTTCCTACACAGCGGTCAGATAGCATCAGACCTGCATTGAACAGTCCTGTGGAAAGG
CCAAGCAGTGACCAGGAAGAGGGAGAAACTTCTGCTCAGACCGAGCGTGTGCCACTGGAC
CTCAGTCCTCGCCTGGAGGAGACGCTGGACTTCGGCGAGGTGGAAGTGGAGCCCAGTGAG
GTGGAAGACTTCGAGGCTCGTGGGAGCCGCTTCTCCAAGTCTGCTGATGAGAGACAGCGC
ATGCTGGTGCAGCGTAAGGACGAACTCCTCCAGCAAGCTCGCAAACGTTTCTTGAACAAA
AGTTCTGAAGATGATGCGGCCTCAGAGAGCTTCCTCCCCTTGGAAGGTGCGTCCTCTGAC
CCCGTGACCCTGCGTCGAAGGATGCTGGCTGCCGCCGCGGAACGGAGGCTTCAGAAGCAG
CAGACCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 643 |
| Molecular Weight
| 72995.1 |
| Theoretical pI
| 6.36 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["82-102", "122-142", "145-165", "186-206", "215-235", "276-296", "429-449"]
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase AMFR
MPLLFLERFPWPSLRTYTGLSGLALLGTIISAYRALSQPEAGPGEPDQLTASLQPEPPAP
ARPSAGGPRARDVAQYLLSDSLFVWVLVNTACCVLMLVAKLIQCIVFGPLRVSERQHLKD
KFWNFIFYKFIFIFGVLNVQTVEEVVMWCLWFAGLVFLHLMVQLCKDRFEYLSFSPTTPM
SSHGRVLSLLVAMLLSCCGLAAVCSITGYTHGMHTLAFMAAESLLVTVRTAHVILRYVIH
LWDLNHEGTWEGKGTYVYYTDFVMELTLLSLDLMHHIHMLLFGNIWLSMASLVIFMQLRY
LFHEVQRRIRRHKNYLRVVGNMEARFAVATPEELAVNNDDCAICWDSMQAARKLPCGHLF
HNSCLRSWLEQDTSCPTCRMSLNIADNNRVREEHQGENLDENLVPVAAAEGRPRLNQHNH
FFHFDGSRIASWLPSFSVEVMHTTNILGITQASNSQLNAMAHQIQEMFPQVPYHLVLQDL
QLTRSVEITTDNILEGRIQVPFPTQRSDSIRPALNSPVERPSSDQEEGETSAQTERVPLD
LSPRLEETLDFGEVEVEPSEVEDFEARGSRFSKSADERQRMLVQRKDELLQQARKRFLNK
SSEDDAASESFLPSEGASSDPVTLRRRMLAAAAERRLQKQQTS
|
| External Links |
|---|
| GenBank ID Protein
| 5931955 |
| UniProtKB/Swiss-Prot ID
| Q9UKV5 |
| UniProtKB/Swiss-Prot Entry Name
| AMFR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF124145 |
| GeneCard ID
| AMFR |
| GenAtlas ID
| AMFR |
| HGNC ID
| HGNC:463 |
| References |
|---|
| General References
| Not Available |