| Identification |
|---|
| HMDB Protein ID
| CDBP04419 |
| Secondary Accession Numbers
| Not Available |
| Name
| E3 ubiquitin-protein ligase MARCH2 |
| Description
| Not Available |
| Synonyms
|
- MARCH-II
- Membrane-associated RING finger protein 2
- Membrane-associated RING-CH protein II
- RING finger protein 172
|
| Gene Name
| MARCH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6 |
| GO Classification
|
| Function |
| zinc ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
|
| Cellular Location
|
- Endosome membrane
- Endoplasmic reticulum membrane
- Lysosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.2 |
| SNPs
| MARCH2 |
| Gene Sequence
|
>741 bp
ATGACGACGGGTGACTGCTGCCACCTCCCCGGCTCCCTGTGTGACTGCTCCGGCAGCCCT
GCCTTCTCCAAGGTCGTGGAGGCTACGGGCCTCGGACCGCCCCAGTATGTGGCACAGGTG
ACTTCAAGGGATGGCCGGCTCCTCTCCACCGTCATCCGTGCCTTGGACACACCGAGTGAT
GGTCCTTTCTGCCGGATCTGCCATGAGGGAGCGAACGGGGAGTGCTTGCTGTCCCCGTGT
GGCTGCACCGGCACGCTGGGTGCCGTGCATAAGAGCTGTCTGGAGAAGTGGCTTTCCTCA
TCTAACACCAGCTACTGCGAGCTGTGCCACACGGAGTTTGCAGTGGAGAAACGGCCTCGA
CCCCTCACAGAGTGGCTGAAGGACCCGGGGCCGCGGACGGAGAAGCGGACACTGTGCTGC
GACATGGTGTGTTTCCTGTTCATCACACCGCTGGCCGCCATCTCAGGCTGGTTGTGCCTG
CGCGGGGCCCAGGACCACCTCCGGCTCCACAGCCAGCTGGAGGCCGTGGGTCTCATTGCC
CTCACCATCGCCCTCTTCACCATCTATGTCCTCTGGACGCTGGTCTCCTTCCGCTACCAC
TGCCAGCTGTACTCCGAGTGGAGAAAGACCAACCAGAAAGTTCGCCTGAAGATCCGGGAG
GCGGACAGCCCCGAGGGCCCCCAGCATTCTCCACTGGCAGCTGGACTCCTGAAGAAGGTG
GCAGAGGAGACACCAGTATGA
|
| Protein Properties |
|---|
| Number of Residues
| 246 |
| Molecular Weight
| 26994.9 |
| Theoretical pI
| 7.52 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>E3 ubiquitin-protein ligase MARCH2
MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSD
GPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPR
PLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIA
LTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKV
AEETPV
|
| External Links |
|---|
| GenBank ID Protein
| 58652038 |
| UniProtKB/Swiss-Prot ID
| Q9P0N8 |
| UniProtKB/Swiss-Prot Entry Name
| MARH2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB197929 |
| GeneCard ID
| MARCH2 |
| GenAtlas ID
| MARCH2 |
| HGNC ID
| HGNC:28038 |
| References |
|---|
| General References
| Not Available |