Identification
HMDB Protein ID CDBP04419
Secondary Accession Numbers Not Available
Name E3 ubiquitin-protein ligase MARCH2
Description Not Available
Synonyms
  1. MARCH-II
  2. Membrane-associated RING finger protein 2
  3. Membrane-associated RING-CH protein II
  4. RING finger protein 172
Gene Name MARCH2
Protein Type Enzyme
Biological Properties
General Function Involved in zinc ion binding
Specific Function E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin- conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May be involved in endosomal trafficking through interaction with STX6
GO Classification
Function
zinc ion binding
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
Cellular Location
  1. Endosome membrane
  2. Endoplasmic reticulum membrane
  3. Lysosome membrane
  4. Multi-pass membrane protein
  5. Multi-pass membrane protein
  6. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 19p13.2
SNPs MARCH2
Gene Sequence
>741 bp
ATGACGACGGGTGACTGCTGCCACCTCCCCGGCTCCCTGTGTGACTGCTCCGGCAGCCCT
GCCTTCTCCAAGGTCGTGGAGGCTACGGGCCTCGGACCGCCCCAGTATGTGGCACAGGTG
ACTTCAAGGGATGGCCGGCTCCTCTCCACCGTCATCCGTGCCTTGGACACACCGAGTGAT
GGTCCTTTCTGCCGGATCTGCCATGAGGGAGCGAACGGGGAGTGCTTGCTGTCCCCGTGT
GGCTGCACCGGCACGCTGGGTGCCGTGCATAAGAGCTGTCTGGAGAAGTGGCTTTCCTCA
TCTAACACCAGCTACTGCGAGCTGTGCCACACGGAGTTTGCAGTGGAGAAACGGCCTCGA
CCCCTCACAGAGTGGCTGAAGGACCCGGGGCCGCGGACGGAGAAGCGGACACTGTGCTGC
GACATGGTGTGTTTCCTGTTCATCACACCGCTGGCCGCCATCTCAGGCTGGTTGTGCCTG
CGCGGGGCCCAGGACCACCTCCGGCTCCACAGCCAGCTGGAGGCCGTGGGTCTCATTGCC
CTCACCATCGCCCTCTTCACCATCTATGTCCTCTGGACGCTGGTCTCCTTCCGCTACCAC
TGCCAGCTGTACTCCGAGTGGAGAAAGACCAACCAGAAAGTTCGCCTGAAGATCCGGGAG
GCGGACAGCCCCGAGGGCCCCCAGCATTCTCCACTGGCAGCTGGACTCCTGAAGAAGGTG
GCAGAGGAGACACCAGTATGA
Protein Properties
Number of Residues 246
Molecular Weight 26994.9
Theoretical pI 7.52
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["138-158", "175-195"]
Protein Sequence
>E3 ubiquitin-protein ligase MARCH2
MTTGDCCHLPGSLCDCSGSPAFSKVVEATGLGPPQYVAQVTSRDGRLLSTVIRALDTPSD
GPFCRICHEGANGECLLSPCGCTGTLGAVHKSCLEKWLSSSNTSYCELCHTEFAVEKRPR
PLTEWLKDPGPRTEKRTLCCDMVCFLFITPLAAISGWLCLRGAQDHLRLHSQLEAVGLIA
LTIALFTIYVLWTLVSFRYHCQLYSEWRKTNQKVRLKIREADSPEGPQHSPLAAGLLKKV
AEETPV
GenBank ID Protein 58652038
UniProtKB/Swiss-Prot ID Q9P0N8
UniProtKB/Swiss-Prot Entry Name MARH2_HUMAN
PDB IDs Not Available
GenBank Gene ID AB197929
GeneCard ID MARCH2
GenAtlas ID MARCH2
HGNC ID HGNC:28038
References
General References Not Available