Cannabis Compound Database: Showing Compound Card for Guanosine triphosphate (CDB005097)

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Record Information

Version

1.0

Created at

2020-04-17 19:09:01 UTC

Updated at

2020-12-07 19:11:34 UTC

CannabisDB ID

CDB005097

Secondary Accession Numbers

Not Available

Cannabis Compound Identification

Common Name

Guanosine triphosphate

Description

Guanosine triphosphate, also known as 5'-GTP or H4GTP, belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. Thus, a GTP-bound tubulin serves as a cap at the tip of microtubule to protect from depolymerization; and, once the GTP is hydrolyzed, the microtubule begins to depolymerize and shrink rapidly. Guanosine triphosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Guanosine triphosphate exists in all living species, ranging from bacteria to humans. In humans, guanosine triphosphate is involved in intracellular signalling through adenosine receptor A2B and adenosine. Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. Outside of the human body, Guanosine triphosphate has been detected, but not quantified in, several different foods, such as mandarin orange (clementine, tangerine), coconuts, new zealand spinachs, sweet marjorams, and pepper (capsicum). This could make guanosine triphosphate a potential biomarker for the consumption of these foods. Cyclic guanosine triphosphate (cGTP) helps cyclic adenosine monophosphate (cAMP) activate cyclic nucleotide-gated ion channels in the olfactory system. It also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. It is used as a source of energy for protein synthesis and gluconeogenesis. For instance, a GTP molecule is generated by one of the enzymes in the citric acid cycle. GTP is also used as an energy source for the translocation of the ribosome towards the 3' end of the mRNA.During microtubule polymerization, each heterodimer formed by an alpha and a beta tubulin molecule carries two GTP molecules, and the GTP is hydrolyzed to GDP when the tubulin dimers are added to the plus end of the growing microtubule. The importing of these proteins plays an important role in several pathways regulated within the mitochondria organelle, such as converting oxaloacetate to phosphoenolpyruvate (PEP) in gluconeogenesis. GTP is involved in energy transfer within the cell. Guanosine triphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.

Structure

MOL SDF PDB SMILES InChI

Synonyms

Value	Source
5'-GTP	ChEBI
Guanosine 5'-triphosphate	ChEBI
Guanosine 5'-triphosphoric acid	ChEBI
GUANOSINE-5'-triphosphATE	ChEBI
H4GTP	ChEBI
GUANOSINE-5'-triphosphoric acid	Generator
Guanosine triphosphoric acid	Generator
GTG	HMDB
GTP	HMDB
Guanosine 5'-(tetrahydrogen triphosphate)	HMDB
Guanosine 5'-triphosphorate	HMDB
Guanosine mono(tetrahydrogen triphosphate) (ester)	HMDB
Triphosphate, guanosine	HMDB

Chemical Formula

C₁₀H₁₆N₅O₁₄P₃

Average Molecular Weight

523.18

Monoisotopic Molecular Weight

522.9907

IUPAC Name

({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

Traditional Name

triphosphate, guanosine

CAS Registry Number

86-01-1

SMILES

NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1

InChI Identifier

InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1

InChI Key

XKMLYUALXHKNFT-UUOKFMHZSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Purine nucleotides

Sub Class

Purine ribonucleotides

Direct Parent

Purine ribonucleoside triphosphates

Alternative Parents

Substituents

Purine ribonucleoside triphosphate
Purine ribonucleoside monophosphate
Pentose phosphate
Pentose-5-phosphate
Glycosyl compound
N-glycosyl compound
Monosaccharide phosphate
Imidazopyrimidine
Purine
Monoalkyl phosphate
Hydroxypyrimidine
Alkyl phosphate
Pyrimidine
Monosaccharide
Phosphoric acid ester
N-substituted imidazole
Organic phosphoric acid derivative
Heteroaromatic compound
Azole
Imidazole
Tetrahydrofuran
Secondary alcohol
1,2-diol
Oxacycle
Organoheterocyclic compound
Azacycle
Organopnictogen compound
Organic oxide
Hydrocarbon derivative
Alcohol
Organic oxygen compound
Organic nitrogen compound
Organonitrogen compound
Organooxygen compound
Aromatic heteropolycyclic compound

Molecular Framework

Aromatic heteropolycyclic compounds

External Descriptors

guanosine 5'-phosphate (CHEBI:15996 )
purine ribonucleoside 5'-triphosphate (CHEBI:15996 )
Ribonucleotides (C00044 )

Ontology

Physiological effect

Health effect:

Health condition:

Nervous system disorders:

Stroke

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Organ and components:

Testicle

Tissue and substructures:

Placenta

Biofluid and excreta:

Subcellular:

Cell and elements:

Extracellular

Element:

Platelet

Cell:

Nerve cell

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Properties

Property	Value	Reference
Melting Point	Not Available	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
logP	Not Available	Not Available

Predicted Properties

Property	Value	Source
logP	-0.63	ALOGPS
logP	-3.7	ChemAxon
logS	-1.7	ALOGPS
pKa (Strongest Acidic)	0.9	ChemAxon
pKa (Strongest Basic)	-1.9	ChemAxon
Physiological Charge	-3	ChemAxon
Hydrogen Acceptor Count	14	ChemAxon
Hydrogen Donor Count	8	ChemAxon
Polar Surface Area	294.81 Å²	ChemAxon
Rotatable Bond Count	8	ChemAxon
Refractivity	97.24 m³·mol⁻¹	ChemAxon
Polarizability	39.81 Å³	ChemAxon
Number of Rings	3	ChemAxon
Bioavailability	No	ChemAxon
Rule of Five	No	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	Yes	ChemAxon

Spectra

EI-MS/GC-MS

Type	Description	Splash Key	View
Predicted GC-MS	Guanosine triphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positive	splash10-056v-8895330000-0a8a2d408be3cbe00023	Spectrum
Predicted GC-MS	Guanosine triphosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positive	splash10-0zos-8469026000-e08a35d5d35a9e63303c	Spectrum

MS/MS

Type	Description	Splash Key	View
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-006t-0000970000-ed775d45b7d4c3b969df	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-0002-0000920000-eea0cfe4824f5aee7e4a	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-0006-0900000000-895098906ea44c18ea43	2012-07-24	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0a4i-1910300000-cbc290b8c193beb6665f	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 20V, Negative	splash10-05fr-0910760000-0149aa219d4b60fa61f4	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0a4i-1910300000-8315c93064efa4da6b1b	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 30V, Negative	splash10-0a4i-1910300000-2664d57dfe06bffb291e	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 10V, Negative	splash10-00di-0100090000-b5bdb718aeaf9666be2a	2021-09-20	View Spectrum
MS/MS	LC-MS/MS Spectrum - 40V, Negative	splash10-0a6r-4910000000-13c0865e4dfdc30cae73	2021-09-20	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0911220000-75ec8e10f63e3aae4b1f	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900000000-2b6055d302734ab3eecf	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0900000000-936551c9f8ce17b0cbfd	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-0fk9-0730090000-511cdeecbbfb6b7c8615	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0zir-4930000000-cc969f818e5f659cd09c	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9300000000-dff84bbb768f44c2c74b	2016-09-12	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-0udi-0900020000-66587b5a3e1149d9032f	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-0udi-0900010000-2351199532a3a6242774	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-0udi-0901000000-7daab2908ef3ebe15a5a	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-00di-0000190000-a7b3d2c63ee2ad144d4d	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0fi0-9742370000-3cb9d3e33126e947b5dd	2021-09-24	View Spectrum
Predicted MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-004i-9200100000-29fc63b8efb32dd43b52	2021-09-24	View Spectrum

NMR

Type	Description	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 100 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 1000 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 200 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 300 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 500 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 600 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 700 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 800 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹³C NMR Spectrum (1D, 900 MHz, D₂O, predicted)	Spectrum
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	Spectrum
2D NMR	[¹H, ¹³C]-HSQC NMR Spectrum (2D, 600 MHz, H₂O, experimental)	Spectrum

Pathways

Name	SMPDB/Pathwhiz	KEGG
Citric Acid Cycle
Gluconeogenesis
Pterine Biosynthesis
Transcription/Translation	Not Available	Not Available
Purine Metabolism

Protein Targets

Enzymes

Protein Name	Gene Name	Locus	Uniprot ID	Details
Phospholipase D1	PLD1	3q26	Q13393	details
Ectonucleoside triphosphate diphosphohydrolase 1	ENTPD1	10q24	P49961	details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Ectonucleoside triphosphate diphosphohydrolase 3	ENTPD3	3p21.3	O75355	details
Uridine-cytidine kinase 1	UCK1	9q34.13	Q9HA47	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase A	NME1	17q21.3	P15531	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Fucose-1-phosphate guanylyltransferase	FPGT	1p31.1	O14772	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
GMP synthase [glutamine-hydrolyzing]	GMPS	3q24	P49915	details
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]	NUDT2	9p13	P50583	details
Adenylate kinase isoenzyme 5	AK5	1p31	Q9Y6K8	details
CTP synthase 1	CTPS1	1p34.1	P17812	details
Glutamate dehydrogenase 1, mitochondrial	GLUD1	10q23.3	P00367	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
DNA-directed RNA polymerase III subunit RPC4	POLR3D		P05423	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC7	POLR3G		O15318	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA-directed RNA polymerase I subunit RPA49	POLR1E	9p13.2	Q9GZS1	details
DNA-directed RNA polymerase III subunit RPC8	POLR3H		Q9Y535	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Ectonucleoside triphosphate diphosphohydrolase 4	ENTPD4	8p21.3	Q9Y227	details
Adenylosuccinate synthetase isozyme 2	ADSS	1q44	P30520	details
Adenylosuccinate synthetase isozyme 1	ADSSL1	14q32.33	Q8N142	details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial	SUCLG1	2p11.2	P53597	details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PCK2	14q11.2	Q16822	details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial	SUCLG2	3p14.1	Q96I99	details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	PCK1	20q13.31	P35558	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
GTP cyclohydrolase 1	GCH1	14q22.1-q22.2	P30793	details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	13q12.2-q13.3	Q9P2R7	details
Guanylate cyclase soluble subunit beta-1	GUCY1B3	4q31.3-q33	Q02153	details
Retinal guanylyl cyclase 1	GUCY2D	17p13.1	Q02846	details
Guanylate cyclase soluble subunit alpha-3	GUCY1A3	4q31.1-q31.2	Q02108	details
Guanylate cyclase soluble subunit alpha-2	GUCY1A2	11q21-q22	P33402	details
Retinal guanylyl cyclase 2	GUCY2F	Xq22	P51841	details
Guanylate cyclase soluble subunit beta-2	GUCY1B2		O75343	details
Serine/threonine-protein kinase PAK 7	PAK7	20p12	Q9P286	details
Serine/threonine-protein kinase PAK 6	PAK6	15q14	Q9NQU5	details
Serine/threonine-protein kinase PAK 4	PAK4	19q13.2	O96013	details
Serine/threonine-protein kinase Nek9	NEK9	14q24.3	Q8TD19	details
Citron Rho-interacting kinase	CIT	12q24	O14578	details
Serine/threonine-protein kinase PAK 3	PAK3		O75914	details
Rho-associated protein kinase 1	ROCK1	18q11.1	Q13464	details
Serine/threonine-protein kinase PAK 2	PAK2	3q29	Q13177	details
Ectonucleoside triphosphate diphosphohydrolase 2	ENTPD2		Q9Y5L3	details
Rho-associated protein kinase 2	ROCK2	2p24	O75116	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	AGAP2	12q14.1	Q99490	details
Rho guanine nucleotide exchange factor 1	ARHGEF1	19q13.13	Q92888	details
Rap1 GTPase-GDP dissociation stimulator 1	RAP1GDS1	4q23-q25	P52306	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	20q13.3	P63092	details
Vinexin	SORBS3	8p21.3	O60504	details
GTPase HRas	HRAS	11p15.5	P01112	details
GTP cyclohydrolase 1 feedback regulatory protein	GCHFR	15q15	P30047	details
Guanine nucleotide-binding protein G(q) subunit alpha	GNAQ	9q21	P50148	details
Guanine nucleotide-binding protein subunit alpha-11	GNA11	19p13.3	P29992	details
Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	3p21	P11488	details
Uridine-cytidine kinase 2	UCK2	1q23	Q9BZX2	details
Protein ALEX	GNAS	20q13.3	P84996	details
Lysophosphatidic acid receptor 2	LPAR2	19p12	Q9HBW0	details
Mannose-1-phosphate guanyltransferase beta	GMPPB	3p21.31	Q9Y5P6	details
Mannose-1-phosphate guanyltransferase alpha	GMPPA	2q35	Q96IJ6	details
Adenylate cyclase type 10	ADCY10	1q24	Q96PN6	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	PLCE1	10q23	Q9P212	details
Uridine-cytidine kinase-like 1	UCKL1	20q13.33	Q9NWZ5	details
Ectonucleoside triphosphate diphosphohydrolase 7	ENTPD7		Q9NQZ7	details
Ectonucleoside triphosphate diphosphohydrolase 8	ENTPD8	9q34.3	Q5MY95	details
Rho GTPase-activating protein 32	ARHGAP32	11q24.3	A7KAX9	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
ADP-ribosylation factor GTPase-activating protein 1	ARFGAP1	20q13.33	Q8N6T3	details
ADP-ribosylation factor GTPase-activating protein 2	ARFGAP2	11p11.2-p11.12	Q8N6H7	details
ADP-ribosylation factor GTPase-activating protein 3	ARFGAP3	22q13.2	Q9NP61	details
Eukaryotic peptide chain release factor subunit 1	ETF1	5q31.1	P62495	details
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A	GSPT1	16p13.1	P15170	details
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B	GSPT2		Q8IYD1	details
GTPase-activating protein and VPS9 domain-containing protein 1	GAPVD1	9q33.3	Q14C86	details
GTPase IMAP family member 1	GIMAP1	7q36.1	Q8WWP7	details
GTPase IMAP family member 2	GIMAP2	7q36.1	Q9UG22	details
GTPase IMAP family member 4	GIMAP4	7q36.1	Q9NUV9	details
GTPase IMAP family member 5	GIMAP5	7q36.1	Q96F15	details
GTPase IMAP family member 6	GIMAP6		Q6P9H5	details
GTPase IMAP family member 7	GIMAP7	7q36.1	Q8NHV1	details
GTPase IMAP family member 8	GIMAP8	7q36.1	Q8ND71	details
tRNA modification GTPase GTPBP3, mitochondrial	GTPBP3	19p13.11	Q969Y2	details
Probable E3 ubiquitin-protein ligase HERC1	HERC1	15q22	Q15751	details
Protein-cysteine N-palmitoyltransferase HHAT	HHAT	1q32	Q5VTY9	details
Interferon-inducible GTPase 5	IRGC	19q13.31	Q6NXR0	details
Ras GTPase-activating-like protein IQGAP1	IQGAP1	15q26.1	P46940	details
Leucine-rich repeat serine/threonine-protein kinase 1	LRRK1	15q26.3	Q38SD2	details
Large subunit GTPase 1 homolog	LSG1	3q29	Q9H089	details
MAP kinase-activating death domain protein	MADD	11p11.2	Q8WXG6	details
Ran guanine nucleotide release factor	RANGRF	17p13.1	Q9HD47	details
Serine/threonine-protein kinase MRCK alpha	CDC42BPA	1q42.11	Q5VT25	details
Serine/threonine-protein kinase MRCK beta	CDC42BPB	14q32.3	Q9Y5S2	details
Serine/threonine-protein kinase MRCK gamma	CDC42BPG	11q13.1	Q6DT37	details
Mitochondrial GTPase 1	MTG1	10q26.3	Q9BT17	details
2'-5'-oligoadenylate synthase 3	OAS3	12q24.2	Q9Y6K5	details
Obg-like ATPase 1	OLA1	2q31.1	Q9NTK5	details
Phosphatidylinositol 4-kinase type 2-beta	PI4K2B	4p15.2	Q8TCG2	details
Serine/threonine-protein kinase PAK 1	PAK1	11q13-q14	Q13153	details
Rab GTPase-binding effector protein 1	RABEP1	17p13.2	Q15276	details
Rab GTPase-binding effector protein 2	RABEP2	16p11.2	Q9H5N1	details
Ran-specific GTPase-activating protein	RANBP1	22q11.21	P43487	details
GTPase ERas	ERAS		Q7Z444	details
GTPase KRas	KRAS	12p12.1	P01116	details
GTPase NRas	NRAS	1p13.2	P01111	details
Rab3 GTPase-activating protein catalytic subunit	RAB3GAP1	2q21.3	Q15042	details
Rab3 GTPase-activating protein non-catalytic subunit	RAB3GAP2	1q41	Q9H2M9	details
E3 SUMO-protein ligase RanBP2	RANBP2	2q12.3	P49792	details
GTPase RhebL1	RHEBL1	12q13.12	Q8TAI7	details
Rho GTPase-activating protein 21	ARHGAP21	10p12.1\|10p12.3	Q5T5U3	details
Putative E3 ubiquitin-protein ligase SH3RF1	SH3RF1	4q32.3	Q7Z6J0	details
Putative nucleoside diphosphate kinase	NME2P1	12q24.31	O60361	details
Rho-related GTP-binding protein RhoU	RHOU	1q42.11-q42.3	Q7L0Q8	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerases I and III subunit RPAC2	POLR1D	13q12.2	Q9Y2S0	details
DNA-directed RNA polymerase	DKFZp686D10173		Q7Z3R8	details
DNA-directed RNA polymerase III subunit RPC7-like	POLR3GL		Q9BT43	details
POLR1C protein	POLR1C	6p21.1	Q96HT3	details
Leucine-rich repeat serine/threonine-protein kinase 2	LRRK2	12q12	Q5S007	details
Mitochondrial Rho GTPase 1	RHOT1	17q11.2	Q8IXI2	details
Ninein	NIN	14q22.1	Q8N4C6	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	AGAP1	2q37	Q9UPQ3	details
Protein RCC2	RCC2	1p36.13	Q9P258	details
Protein very KIND	KNDC1	10q26.3	Q76NI1	details
Hydroxylysine kinase	AGPHD1	15q25.1	A2RU49	details
Cyclic GMP-AMP synthase	MB21D1	6q13	Q8N884	details
Nucleoside diphosphate kinase homolog 5	NME5		P56597	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerase I subunit RPA43	TWISTNB	7p21.1	Q3B726	details
DNA-directed RNA polymerases I, II, and III subunit RPABC1	POLR2E	19p13.3	P19388	details
DNA-directed RNA polymerases I, II, and III subunit RPABC2	POLR2F	22q13.1	P61218	details
DNA-directed RNA polymerases I, II, and III subunit RPABC3	POLR2H	3q28	P52434	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerases I and III subunit RPAC1	POLR1C	6p21.1	O15160	details
DNA-directed RNA polymerase II subunit RPB11-a	POLR2J	7q22.1	P52435	details
DNA-directed RNA polymerase II subunit RPB11-b1	POLR2J2	7q22.1	Q9GZM3	details
DNA-directed RNA polymerase II subunit RPB3	POLR2C	16q13-q21	P19387	details
DNA-directed RNA polymerase II subunit RPB4	POLR2D	2q21	O15514	details
DNA-directed RNA polymerase II subunit RPB7	POLR2G	11q13.1	P62487	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
DNA-directed RNA polymerase III subunit RPC3	POLR3C		Q9BUI4	details
DNA-directed RNA polymerase III subunit RPC5	POLR3E		Q9NVU0	details
DNA-directed RNA polymerase III subunit RPC6	POLR3F		Q9H1D9	details
Probable tRNA(His) guanylyltransferase	THG1L	5q33.3	Q9NWX6	details

Transporters

Protein Name	Gene Name	Locus	Uniprot ID	Details
Importin subunit alpha-1	KPNA1	3q21	P52294	details
Importin subunit alpha-2	KPNA2	17q24.2	P52292	details
Importin subunit alpha-3	KPNA3	13q14.3	O00505	details
Importin subunit alpha-4	KPNA4	3q25.33	O00629	details
Importin subunit alpha-6	KPNA5	6q22.1	O15131	details
Importin subunit alpha-7	KPNA6	1p35.1	O60684	details
Importin subunit beta-1	KPNB1	17q21.32	Q14974	details
Importin-11	IPO11	5q12.1	Q9UI26	details
Importin-13	IPO13	1p34.1	O94829	details
Importin-4	IPO4	14q12	Q8TEX9	details
Importin-5	IPO5	13q32.2	O00410	details
Importin-7	IPO7	11p15.4	O95373	details
Importin-8	IPO8	12p11.21	O15397	details
Importin-9	IPO9	1q32.1	Q96P70	details
Ran-binding protein 17	RANBP17	5q34	Q9H2T7	details
Transportin-1	TNPO1	5q13.2	Q92973	details
Transportin-2	TNPO2	19p13.2	O14787	details
Exportin-1	XPO1	2p16	O14980	details
Exportin-2	CSE1L	20q13	P55060	details
Exportin-7	XPO7	8p21	Q9UIA9	details
Exportin-T	XPOT	12q14.2	O43592	details

Metal Bindings

Protein Name	Gene Name	Locus	Uniprot ID	Details
Soluble calcium-activated nucleotidase 1	CANT1	17q25.3	Q8WVQ1	details
Nucleoside diphosphate kinase, mitochondrial	NME4	16p13.3	O00746	details
Nucleoside diphosphate kinase 7	NME7	1q24	Q9Y5B8	details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
Nucleoside diphosphate kinase 3	NME3	16q13.3	Q13232	details
Nucleoside diphosphate kinase 6	NME6	3p21	O75414	details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Inosine triphosphate pyrophosphatase	ITPA	20p	Q9BY32	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
Pyruvate kinase isozymes M1/M2	PKM	15q22	P14618	details
Pyruvate kinase isozymes R/L	PKLR	1q21	P30613	details
Adenylosuccinate synthetase isozyme 2	ADSS	1q44	P30520	details
Adenylosuccinate synthetase isozyme 1	ADSSL1	14q32.33	Q8N142	details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial	PCK2	14q11.2	Q16822	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial	SUCLA2	13q12.2-q13.3	Q9P2R7	details
Guanylate cyclase soluble subunit beta-1	GUCY1B3	4q31.3-q33	Q02153	details
Guanylate cyclase soluble subunit alpha-3	GUCY1A3	4q31.1-q31.2	Q02108	details
Guanylate cyclase soluble subunit alpha-2	GUCY1A2	11q21-q22	P33402	details
Guanylate cyclase soluble subunit beta-2	GUCY1B2		O75343	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2	AGAP2	12q14.1	Q99490	details
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2	ASAP2	2p25\|2p24	O43150	details
Molybdenum cofactor biosynthesis protein 1	MOCS1	6p21.3	Q9NZB8	details
Early endosome antigen 1	EEA1	12q22	Q15075	details
Adenylate cyclase type 10	ADCY10	1q24	Q96PN6	details
Acyl-coenzyme A synthetase ACSM1, mitochondrial	ACSM1	16p12.3	Q08AH1	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	PLCE1	10q23	Q9P212	details
RAS guanyl-releasing protein 1	RASGRP1	15q14	O95267	details
RAS guanyl-releasing protein 2	RASGRP2	11q13	Q7LDG7	details
Regulating synaptic membrane exocytosis protein 1	RIMS1	6q12-q13	Q86UR5	details
Synaptotagmin-like protein 3	SYTL3	6q25.3	Q4VX76	details
Acyl-coenzyme A synthetase ACSM6, mitochondrial	ACSM6	10q23.33	Q6P461	details
ADP-ribosylation factor GTPase-activating protein 1	ARFGAP1	20q13.33	Q8N6T3	details
ADP-ribosylation factor GTPase-activating protein 2	ARFGAP2	11p11.2-p11.12	Q8N6H7	details
ADP-ribosylation factor GTPase-activating protein 3	ARFGAP3	22q13.2	Q9NP61	details
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1	ACAP1	17p13.1	Q15027	details
Coatomer subunit alpha	COPA	1q23-q25	P53621	details
Dedicator of cytokinesis protein 2	DOCK2	5q35.1	Q92608	details
EH domain-containing protein 2	EHD2	19q13.3	Q9NZN4	details
FYVE, RhoGEF and PH domain-containing protein 1	FGD1		P98174	details
FYVE, RhoGEF and PH domain-containing protein 2	FGD2	6p21.2	Q7Z6J4	details
FYVE, RhoGEF and PH domain-containing protein 3	FGD3		Q5JSP0	details
FYVE, RhoGEF and PH domain-containing protein 4	FGD4	12p11.21	Q96M96	details
FYVE, RhoGEF and PH domain-containing protein 5	FGD5	3p25.1	Q6ZNL6	details
FYVE, RhoGEF and PH domain-containing protein 6	FGD6	12q22	Q6ZV73	details
GTP-binding protein 5	GTPBP5	20q13.33	Q9H4K7	details
GTP-binding protein 10	GTPBP10	7q21.13	A4D1E9	details
Melanophilin	MLPH	2q37.3	Q9BV36	details
Rab effector MyRIP	MYRIP	3p22.1	Q8NFW9	details
Rab5 GDP/GTP exchange factor	RABGEF1	7q11.21	Q9UJ41	details
Ras and EF-hand domain-containing protein	RASEF	9q21.32	Q8IZ41	details
RNA-binding protein 4	RBM4	11q13	Q9BWF3	details
Rabenosyn-5	ZFYVE20	3p25.1	Q9H1K0	details
E3 SUMO-protein ligase RanBP2	RANBP2	2q12.3	P49792	details
Rab11 family-interacting protein 4	RAB11FIP4	17q11.2	Q86YS3	details
Regulating synaptic membrane exocytosis protein 2	RIMS2	8q22.3	Q9UQ26	details
Rab effector Noc2	RPH3AL	17p13.3	Q9UNE2	details
RUN and FYVE domain-containing protein 1	RUFY1	5q35.3	Q96T51	details
Putative E3 ubiquitin-protein ligase SH3RF1	SH3RF1	4q32.3	Q7Z6J0	details
Synaptotagmin-like protein 2	SYTL2	11q14	Q9HCH5	details
Synaptotagmin-like protein 5	SYTL5		Q8TDW5	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
Mitochondrial Rho GTPase 1	RHOT1	17q11.2	Q8IXI2	details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	AGAP1	2q37	Q9UPQ3	details
Ras guanyl-releasing protein 3	RASGRP3	2p25.1-p24.1	Q8IV61	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details

Receptors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	ENPP1	6q22-q23	P22413	details
Adenylate cyclase type 7	ADCY7	16q12.1	P51828	details
Adenylate cyclase type 4	ADCY4	14q12	Q8NFM4	details
Adenylate cyclase type 6	ADCY6	12q12-q13	O43306	details
Adenylate cyclase type 5	ADCY5	3q21.1	O95622	details
Adenylate cyclase type 8	ADCY8	8q24	P40145	details
Adenylate cyclase type 9	ADCY9	16p13.3	O60503	details
Adenylate cyclase type 3	ADCY3	2p23.3	O60266	details
Adenylate cyclase type 1	ADCY1	7p13-p12	Q08828	details
Adenylate cyclase type 2	ADCY2	5p15.3	Q08462	details
Atrial natriuretic peptide receptor 2	NPR2	9p21-p12	P20594	details
Guanylate cyclase soluble subunit beta-1	GUCY1B3	4q31.3-q33	Q02153	details
Retinal guanylyl cyclase 1	GUCY2D	17p13.1	Q02846	details
Guanylate cyclase soluble subunit alpha-3	GUCY1A3	4q31.1-q31.2	Q02108	details
Atrial natriuretic peptide receptor 1	NPR1	1q21-q22	P16066	details
Heat-stable enterotoxin receptor	GUCY2C	12p12	P25092	details
Retinal guanylyl cyclase 2	GUCY2F	Xq22	P51841	details
Ectonucleoside triphosphate diphosphohydrolase 2	ENTPD2		Q9Y5L3	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2	GNG2	14q21	P59768	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	20q13.3	P63092	details
Guanine nucleotide-binding protein G(q) subunit alpha	GNAQ	9q21	P50148	details
Guanine nucleotide-binding protein subunit alpha-11	GNA11	19p13.3	P29992	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11	GNG11	7q21	P61952	details
Guanine nucleotide-binding protein G(t) subunit alpha-1	GNAT1	3p21	P11488	details
Lysophosphatidic acid receptor 2	LPAR2	19p12	Q9HBW0	details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	PLCE1	10q23	Q9P212	details
Dynamin-1	DNM1	9q34	Q05193	details
Dynamin-2	DNM2	19p13.2	P50570	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10	GNG10	9q31.3	P50151	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12	GNG12	1p31.3	Q9UBI6	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13	GNG13	16p13.3	Q9P2W3	details
Guanine nucleotide-binding protein G(T) subunit gamma-T1	GNGT1	7q21.3	P63211	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3	GNG3	11p11	P63215	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4	GNG4	1q42.3	P50150	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5	GNG5	1p22	P63218	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7	GNG7	19p13.3	O60262	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8	GNG8	19q13.32	Q9UK08	details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2	GNGT2	17q21	O14610	details
Plexin-B1	PLXNB1	3p21.31	O43157	details
Rab GTPase-binding effector protein 1	RABEP1	17p13.2	Q15276	details
Rab GTPase-binding effector protein 2	RABEP2	16p11.2	Q9H5N1	details
Signal recognition particle receptor subunit alpha	SRPR	11q24.2	P08240	details
T-lymphoma invasion and metastasis-inducing protein 1	TIAM1	21q22.1\|21q22.11	Q13009	details
T-lymphoma invasion and metastasis-inducing protein 2	TIAM2	6q25.2	Q8IVF5	details
Exportin-2	CSE1L	20q13	P55060	details
Guanine nucleotide-binding protein G(i) subunit alpha-1	GNAI1	7q21	P63096	details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas	GNAS	20q13.3	Q5JWF2	details
Guanine nucleotide-binding protein subunit alpha-14	GNA14	9q21	O95837	details
Guanine nucleotide-binding protein G(k) subunit alpha	GNAI3	1p13	P08754	details
Guanine nucleotide-binding protein G(i) subunit alpha-2	GNAI2	3p21	P04899	details
Guanine nucleotide-binding protein G(t) subunit alpha-2	GNAT2	1p13.1	P19087	details
Guanine nucleotide-binding protein G(o) subunit alpha	GNAO1	16q13	P09471	details
Guanine nucleotide-binding protein subunit alpha-13	GNA13	17q24.3	Q14344	details
Guanine nucleotide binding protein (G protein), alpha 14	GNA14	9q21	B1ALW3	details
Guanine nucleotide-binding protein subunit alpha-12	GNA12	7p22.2	Q03113	details
Growth factor receptor-bound protein 2	GRB2	17q24-q25	P62993	details
Guanine nucleotide binding protein (G protein), q polypeptide	GNAQ	9q21	B1AM21	details
Guanine nucleotide-binding protein G(z) subunit alpha	GNAZ	22q11.22	P19086	details
Guanine nucleotide-binding protein G(olf) subunit alpha	GNAL	18p11.22-p11.21	P38405	details
Guanine nucleotide-binding protein subunit alpha-15	GNA15	19p13.3	P30679	details

Transcriptional Factors

Protein Name	Gene Name	Locus	Uniprot ID	Details
Nucleoside diphosphate kinase B	NME2	17q21.3	P22392	details
DNA-directed RNA polymerase III subunit RPC4	POLR3D		P05423	details
DNA-directed RNA polymerase II subunit RPB2	POLR2B	4q12	P30876	details
DNA-directed RNA polymerase II subunit RPB1	POLR2A	17p13.1	P24928	details
DNA-directed RNA polymerase, mitochondrial	POLRMT	19p13.3	O00411	details
DNA-directed RNA polymerase I subunit RPA2	POLR1B	2q13	Q9H9Y6	details
DNA-directed RNA polymerase III subunit RPC7	POLR3G		O15318	details
DNA-directed RNA polymerase III subunit RPC2	POLR3B	12q23.3	Q9NW08	details
DNA-directed RNA polymerase I subunit RPA49	POLR1E	9p13.2	Q9GZS1	details
DNA-directed RNA polymerase III subunit RPC8	POLR3H		Q9Y535	details
DNA-directed RNA polymerase III subunit RPC10	POLR3K		Q9Y2Y1	details
mRNA-capping enzyme	RNGTT	6q16	O60942	details
Dynamin-2	DNM2	19p13.2	P50570	details
GTP-binding protein REM 2	REM2	14q11.2	Q8IYK8	details
Sex-determining region Y protein	SRY		Q05066	details
DNA-directed RNA polymerase III subunit RPC1	POLR3A	10q22-q23	O14802	details
DNA-directed RNA polymerase I subunit RPA1	POLR1A	2p11.2	O95602	details
Zinc ribbon domain containing 1	ZNRD1	6p21.3	Q2L6J2	details
DNA-directed RNA polymerases I and III subunit RPAC2	POLR1D	13q12.2	Q9Y2S0	details
DNA-directed RNA polymerase	DKFZp686D10173		Q7Z3R8	details
DNA-directed RNA polymerase III subunit RPC7-like	POLR3GL		Q9BT43	details
POLR1C protein	POLR1C	6p21.1	Q96HT3	details
DNA-directed RNA polymerase I subunit RPA12	ZNRD1		Q9P1U0	details
DNA-directed RNA polymerase I subunit RPA43	TWISTNB	7p21.1	Q3B726	details
DNA-directed RNA polymerases I, II, and III subunit RPABC1	POLR2E	19p13.3	P19388	details
DNA-directed RNA polymerases I, II, and III subunit RPABC2	POLR2F	22q13.1	P61218	details
DNA-directed RNA polymerases I, II, and III subunit RPABC3	POLR2H	3q28	P52434	details
DNA-directed RNA polymerases I, II, and III subunit RPABC4	POLR2K	8q22.2	P53803	details
DNA-directed RNA polymerases I, II, and III subunit RPABC5	POLR2L	11p15	P62875	details
DNA-directed RNA polymerases I and III subunit RPAC1	POLR1C	6p21.1	O15160	details
DNA-directed RNA polymerase II subunit RPB11-a	POLR2J	7q22.1	P52435	details
DNA-directed RNA polymerase II subunit RPB11-b1	POLR2J2	7q22.1	Q9GZM3	details
DNA-directed RNA polymerase II subunit RPB3	POLR2C	16q13-q21	P19387	details
DNA-directed RNA polymerase II subunit RPB4	POLR2D	2q21	O15514	details
DNA-directed RNA polymerase II subunit RPB7	POLR2G	11q13.1	P62487	details
DNA-directed RNA polymerase II subunit RPB9	POLR2I	19q12	P36954	details
DNA-directed RNA polymerase III subunit RPC3	POLR3C		Q9BUI4	details
DNA-directed RNA polymerase III subunit RPC5	POLR3E		Q9NVU0	details
DNA-directed RNA polymerase III subunit RPC6	POLR3F		Q9H1D9	details

Concentrations Data

Not Available

External Links

HMDB ID

HMDB0001273

DrugBank ID

DB04137

Phenol Explorer Compound ID

Not Available

FoodDB ID

KNApSAcK ID

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

Guanosine triphosphate

METLIN ID

6128

PubChem Compound

6830

PDB ID

Not Available

ChEBI ID

15996

References

General References

Not Available

Only showing the first 10 proteins. There are 370 proteins in total.

Show All

Enzymes

Enzyme Details

1. Phospholipase D1

General function:: Involved in protein binding
Specific function:: Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Gene Name:: PLD1
Uniprot ID:: Q13393
Molecular weight:: 124183.135

Enzyme Details

2. Ectonucleoside triphosphate diphosphohydrolase 1

General function:: Involved in hydrolase activity
Specific function:: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:: ENTPD1
Uniprot ID:: P49961
Molecular weight:: 58706.0

Enzyme Details

3. Soluble calcium-activated nucleotidase 1

General function:: Involved in calcium ion binding
Specific function:: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:: CANT1
Uniprot ID:: Q8WVQ1
Molecular weight:: 44839.24

Enzyme Details

4. Ectonucleoside triphosphate diphosphohydrolase 3

General function:: Involved in hydrolase activity
Specific function:: Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:: ENTPD3
Uniprot ID:: O75355
Molecular weight:: 59104.76

Enzyme Details

5. Uridine-cytidine kinase 1

General function:: Involved in ATP binding
Specific function:: Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:: UCK1
Uniprot ID:: Q9HA47
Molecular weight:: 22760.43

Enzyme Details

6. Nucleoside diphosphate kinase, mitochondrial

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:: NME4
Uniprot ID:: O00746
Molecular weight:: 20658.45

Enzyme Details

7. Nucleoside diphosphate kinase A

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:: NME1
Uniprot ID:: P15531
Molecular weight:: 17148.635

Enzyme Details

8. Nucleoside diphosphate kinase 7

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:: NME7
Uniprot ID:: Q9Y5B8
Molecular weight:: 42491.365

Enzyme Details

9. Nucleoside diphosphate kinase B

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:: NME2
Uniprot ID:: P22392
Molecular weight:: 30136.92

Enzyme Details

10. Nucleoside diphosphate kinase 3

General function:: Involved in nucleoside diphosphate kinase activity
Specific function:: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:: NME3
Uniprot ID:: Q13232
Molecular weight:: 19014.85

Transporters

Enzyme Details

1. Importin subunit alpha-1

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS
Gene Name:: KPNA1
Uniprot ID:: P52294
Molecular weight:: 60221.2

Enzyme Details

2. Importin subunit alpha-2

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Gene Name:: KPNA2
Uniprot ID:: P52292
Molecular weight:: 57861.4

Enzyme Details

3. Importin subunit alpha-3

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9
Gene Name:: KPNA3
Uniprot ID:: O00505
Molecular weight:: 57810.4

Enzyme Details

4. Importin subunit alpha-4

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS
Gene Name:: KPNA4
Uniprot ID:: O00629
Molecular weight:: 57886.3

Enzyme Details

5. Importin subunit alpha-6

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS
Gene Name:: KPNA5
Uniprot ID:: O15131
Molecular weight:: 60348.4

Enzyme Details

6. Importin subunit alpha-7

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Gene Name:: KPNA6
Uniprot ID:: O60684
Molecular weight:: 60028.9

Enzyme Details

7. Importin subunit beta-1

General function:: Involved in binding
Specific function:: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus
Gene Name:: KPNB1
Uniprot ID:: Q14974
Molecular weight:: 97169.2

Enzyme Details

8. Importin-11

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12
Gene Name:: IPO11
Uniprot ID:: Q9UI26
Molecular weight:: 112534.4

Enzyme Details

9. Importin-13

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13
Gene Name:: IPO13
Uniprot ID:: O94829
Molecular weight:: 108194.1

Enzyme Details

10. Importin-4

General function:: Involved in binding
Specific function:: Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS
Gene Name:: IPO4
Uniprot ID:: Q8TEX9
Molecular weight:: 118713.8

Only showing the first 10 proteins. There are 370 proteins in total.

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Showing Compound Card for Guanosine triphosphate (CDB005097)

Structure for CDB005097 (Guanosine triphosphate)

Enzymes

Transporters