Record Information
Version1.0
Created at2020-04-17 19:09:01 UTC
Updated at2020-12-07 19:11:34 UTC
CannabisDB IDCDB005097
Secondary Accession NumbersNot Available
Cannabis Compound Identification
Common NameGuanosine triphosphate
DescriptionGuanosine triphosphate, also known as 5'-GTP or H4GTP, belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety. Thus, a GTP-bound tubulin serves as a cap at the tip of microtubule to protect from depolymerization; and, once the GTP is hydrolyzed, the microtubule begins to depolymerize and shrink rapidly. Guanosine triphosphate is an extremely weak basic (essentially neutral) compound (based on its pKa). Guanosine triphosphate exists in all living species, ranging from bacteria to humans. In humans, guanosine triphosphate is involved in intracellular signalling through adenosine receptor A2B and adenosine. Guanosine-5'-triphosphate (GTP) is a purine nucleoside triphosphate. Outside of the human body, Guanosine triphosphate has been detected, but not quantified in, several different foods, such as mandarin orange (clementine, tangerine), coconuts, new zealand spinachs, sweet marjorams, and pepper (capsicum). This could make guanosine triphosphate a potential biomarker for the consumption of these foods. Cyclic guanosine triphosphate (cGTP) helps cyclic adenosine monophosphate (cAMP) activate cyclic nucleotide-gated ion channels in the olfactory system. It also has the role of a source of energy or an activator of substrates in metabolic reactions, like that of ATP, but more specific. It is used as a source of energy for protein synthesis and gluconeogenesis. For instance, a GTP molecule is generated by one of the enzymes in the citric acid cycle. GTP is also used as an energy source for the translocation of the ribosome towards the 3' end of the mRNA.During microtubule polymerization, each heterodimer formed by an alpha and a beta tubulin molecule carries two GTP molecules, and the GTP is hydrolyzed to GDP when the tubulin dimers are added to the plus end of the growing microtubule. The importing of these proteins plays an important role in several pathways regulated within the mitochondria organelle, such as converting oxaloacetate to phosphoenolpyruvate (PEP) in gluconeogenesis. GTP is involved in energy transfer within the cell. Guanosine triphosphate is expected to be in Cannabis as all living plants are known to produce and metabolize it.
Structure
Thumb
Synonyms
ValueSource
5'-GTPChEBI
Guanosine 5'-triphosphateChEBI
Guanosine 5'-triphosphoric acidChEBI
GUANOSINE-5'-triphosphATEChEBI
H4GTPChEBI
GUANOSINE-5'-triphosphoric acidGenerator
Guanosine triphosphoric acidGenerator
GTGHMDB
GTPHMDB
Guanosine 5'-(tetrahydrogen triphosphate)HMDB
Guanosine 5'-triphosphorateHMDB
Guanosine mono(tetrahydrogen triphosphate) (ester)HMDB
Triphosphate, guanosineHMDB
Chemical FormulaC10H16N5O14P3
Average Molecular Weight523.18
Monoisotopic Molecular Weight522.9907
IUPAC Name({[({[(2R,3S,4R,5R)-5-(2-amino-6-oxo-6,9-dihydro-1H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid
Traditional Nametriphosphate, guanosine
CAS Registry Number86-01-1
SMILES
NC1=NC2=C(N=CN2[C@@H]2O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]2O)C(=O)N1
InChI Identifier
InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChI KeyXKMLYUALXHKNFT-UUOKFMHZSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as purine ribonucleoside triphosphates. These are purine ribobucleotides with a triphosphate group linked to the ribose moiety.
KingdomOrganic compounds
Super ClassNucleosides, nucleotides, and analogues
ClassPurine nucleotides
Sub ClassPurine ribonucleotides
Direct ParentPurine ribonucleoside triphosphates
Alternative Parents
Substituents
  • Purine ribonucleoside triphosphate
  • Purine ribonucleoside monophosphate
  • Pentose phosphate
  • Pentose-5-phosphate
  • Glycosyl compound
  • N-glycosyl compound
  • Monosaccharide phosphate
  • Imidazopyrimidine
  • Purine
  • Monoalkyl phosphate
  • Hydroxypyrimidine
  • Alkyl phosphate
  • Pyrimidine
  • Monosaccharide
  • Phosphoric acid ester
  • N-substituted imidazole
  • Organic phosphoric acid derivative
  • Heteroaromatic compound
  • Azole
  • Imidazole
  • Tetrahydrofuran
  • Secondary alcohol
  • 1,2-diol
  • Oxacycle
  • Organoheterocyclic compound
  • Azacycle
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Alcohol
  • Organic oxygen compound
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effect

Health effect:

Disposition

Route of exposure:

Source:

Biological location:

Role

Industrial application:

Physical Properties
StateSolid
Experimental Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
logPNot AvailableNot Available
Predicted Properties
PropertyValueSource
logP-0.63ALOGPS
logP-3.7ChemAxon
logS-1.7ALOGPS
pKa (Strongest Acidic)0.9ChemAxon
pKa (Strongest Basic)-1.9ChemAxon
Physiological Charge-3ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count8ChemAxon
Polar Surface Area294.81 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity97.24 m³·mol⁻¹ChemAxon
Polarizability39.81 ųChemAxon
Number of Rings3ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleYesChemAxon
Spectra
EI-MS/GC-MS
TypeDescriptionSplash KeyView
Predicted GC-MSGuanosine triphosphate, non-derivatized, Predicted GC-MS Spectrum - 70eV, Positivesplash10-056v-8895330000-0a8a2d408be3cbe00023Spectrum
Predicted GC-MSGuanosine triphosphate, 2 TMS, Predicted GC-MS Spectrum - 70eV, Positivesplash10-0zos-8469026000-e08a35d5d35a9e63303cSpectrum
MS/MS
TypeDescriptionSplash KeyView
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)splash10-006t-0000970000-ed775d45b7d4c3b969dfSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)splash10-0002-0000920000-eea0cfe4824f5aee7e4aSpectrum
MS/MSLC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)splash10-0006-0900000000-895098906ea44c18ea43Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0udi-0911220000-75ec8e10f63e3aae4b1fSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0udi-0900000000-2b6055d302734ab3eecfSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0udi-0900000000-936551c9f8ce17b0cbfdSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0fk9-0730090000-511cdeecbbfb6b7c8615Spectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0zir-4930000000-cc969f818e5f659cd09cSpectrum
Predicted MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-004i-9300000000-dff84bbb768f44c2c74bSpectrum
NMR
TypeDescriptionView
1D NMR1H NMR SpectrumSpectrum
2D NMR[1H,13C] 2D NMR SpectrumSpectrum
Pathways
Pathways
Protein Targets
Enzymes
Protein NameGene NameLocusUniprot IDDetails
Phospholipase D1PLD13q26Q13393 details
Ectonucleoside triphosphate diphosphohydrolase 1ENTPD110q24P49961 details
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Ectonucleoside triphosphate diphosphohydrolase 3ENTPD33p21.3O75355 details
Uridine-cytidine kinase 1UCK19q34.13Q9HA47 details
Nucleoside diphosphate kinase, mitochondrialNME416p13.3O00746 details
Nucleoside diphosphate kinase ANME117q21.3P15531 details
Nucleoside diphosphate kinase 7NME71q24Q9Y5B8 details
Nucleoside diphosphate kinase BNME217q21.3P22392 details
Nucleoside diphosphate kinase 3NME316q13.3Q13232 details
Nucleoside diphosphate kinase 6NME63p21O75414 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Fucose-1-phosphate guanylyltransferaseFPGT1p31.1O14772 details
Inosine triphosphate pyrophosphataseITPA20pQ9BY32 details
GMP synthase [glutamine-hydrolyzing]GMPS3q24P49915 details
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]NUDT29p13P50583 details
Adenylate kinase isoenzyme 5AK51p31Q9Y6K8 details
CTP synthase 1CTPS11p34.1P17812 details
Glutamate dehydrogenase 1, mitochondrialGLUD110q23.3P00367 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
DNA-directed RNA polymerase III subunit RPC4POLR3DP05423 details
DNA-directed RNA polymerase II subunit RPB2POLR2B4q12P30876 details
DNA-directed RNA polymerase II subunit RPB1POLR2A17p13.1P24928 details
DNA-directed RNA polymerase, mitochondrialPOLRMT19p13.3O00411 details
DNA-directed RNA polymerase I subunit RPA2POLR1B2q13Q9H9Y6 details
DNA-directed RNA polymerase III subunit RPC7POLR3GO15318 details
DNA-directed RNA polymerase III subunit RPC2POLR3B12q23.3Q9NW08 details
DNA-directed RNA polymerase I subunit RPA49POLR1E9p13.2Q9GZS1 details
DNA-directed RNA polymerase III subunit RPC8POLR3HQ9Y535 details
DNA-directed RNA polymerase III subunit RPC10POLR3KQ9Y2Y1 details
Pyruvate kinase isozymes M1/M2PKM15q22P14618 details
Pyruvate kinase isozymes R/LPKLR1q21P30613 details
Ectonucleoside triphosphate diphosphohydrolase 4ENTPD48p21.3Q9Y227 details
Adenylosuccinate synthetase isozyme 2ADSS1q44P30520 details
Adenylosuccinate synthetase isozyme 1ADSSL114q32.33Q8N142 details
Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrialSUCLG12p11.2P53597 details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialPCK214q11.2Q16822 details
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrialSUCLG23p14.1Q96I99 details
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]PCK120q13.31P35558 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
GTP cyclohydrolase 1GCH114q22.1-q22.2P30793 details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialSUCLA213q12.2-q13.3Q9P2R7 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Retinal guanylyl cyclase 1GUCY2D17p13.1Q02846 details
Guanylate cyclase soluble subunit alpha-3GUCY1A34q31.1-q31.2Q02108 details
Guanylate cyclase soluble subunit alpha-2GUCY1A211q21-q22P33402 details
Retinal guanylyl cyclase 2GUCY2FXq22P51841 details
Guanylate cyclase soluble subunit beta-2GUCY1B2O75343 details
Serine/threonine-protein kinase PAK 7PAK720p12Q9P286 details
Serine/threonine-protein kinase PAK 6PAK615q14Q9NQU5 details
Serine/threonine-protein kinase PAK 4PAK419q13.2O96013 details
Serine/threonine-protein kinase Nek9NEK914q24.3Q8TD19 details
Citron Rho-interacting kinaseCIT12q24O14578 details
Serine/threonine-protein kinase PAK 3PAK3O75914 details
Rho-associated protein kinase 1ROCK118q11.1Q13464 details
Serine/threonine-protein kinase PAK 2PAK23q29Q13177 details
Ectonucleoside triphosphate diphosphohydrolase 2ENTPD2Q9Y5L3 details
Rho-associated protein kinase 2ROCK22p24O75116 details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2AGAP212q14.1Q99490 details
Rho guanine nucleotide exchange factor 1ARHGEF119q13.13Q92888 details
Rap1 GTPase-GDP dissociation stimulator 1RAP1GDS14q23-q25P52306 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGNAS20q13.3P63092 details
VinexinSORBS38p21.3O60504 details
GTPase HRasHRAS11p15.5P01112 details
GTP cyclohydrolase 1 feedback regulatory proteinGCHFR15q15P30047 details
Guanine nucleotide-binding protein G(q) subunit alphaGNAQ9q21P50148 details
Guanine nucleotide-binding protein subunit alpha-11GNA1119p13.3P29992 details
Guanine nucleotide-binding protein G(t) subunit alpha-1GNAT13p21P11488 details
Uridine-cytidine kinase 2UCK21q23Q9BZX2 details
Protein ALEXGNAS20q13.3P84996 details
Lysophosphatidic acid receptor 2LPAR219p12Q9HBW0 details
Mannose-1-phosphate guanyltransferase betaGMPPB3p21.31Q9Y5P6 details
Mannose-1-phosphate guanyltransferase alphaGMPPA2q35Q96IJ6 details
Adenylate cyclase type 10ADCY101q24Q96PN6 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1PLCE110q23Q9P212 details
Uridine-cytidine kinase-like 1UCKL120q13.33Q9NWZ5 details
Ectonucleoside triphosphate diphosphohydrolase 7ENTPD7Q9NQZ7 details
Ectonucleoside triphosphate diphosphohydrolase 8ENTPD89q34.3Q5MY95 details
Rho GTPase-activating protein 32ARHGAP3211q24.3A7KAX9 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
ADP-ribosylation factor GTPase-activating protein 1ARFGAP120q13.33Q8N6T3 details
ADP-ribosylation factor GTPase-activating protein 2ARFGAP211p11.2-p11.12Q8N6H7 details
ADP-ribosylation factor GTPase-activating protein 3ARFGAP322q13.2Q9NP61 details
Eukaryotic peptide chain release factor subunit 1ETF15q31.1P62495 details
Eukaryotic peptide chain release factor GTP-binding subunit ERF3AGSPT116p13.1P15170 details
Eukaryotic peptide chain release factor GTP-binding subunit ERF3BGSPT2Q8IYD1 details
GTPase-activating protein and VPS9 domain-containing protein 1GAPVD19q33.3Q14C86 details
GTPase IMAP family member 1GIMAP17q36.1Q8WWP7 details
GTPase IMAP family member 2GIMAP27q36.1Q9UG22 details
GTPase IMAP family member 4GIMAP47q36.1Q9NUV9 details
GTPase IMAP family member 5GIMAP57q36.1Q96F15 details
GTPase IMAP family member 6GIMAP6Q6P9H5 details
GTPase IMAP family member 7GIMAP77q36.1Q8NHV1 details
GTPase IMAP family member 8GIMAP87q36.1Q8ND71 details
tRNA modification GTPase GTPBP3, mitochondrialGTPBP319p13.11Q969Y2 details
Probable E3 ubiquitin-protein ligase HERC1HERC115q22Q15751 details
Protein-cysteine N-palmitoyltransferase HHATHHAT1q32Q5VTY9 details
Interferon-inducible GTPase 5IRGC19q13.31Q6NXR0 details
Ras GTPase-activating-like protein IQGAP1IQGAP115q26.1P46940 details
Leucine-rich repeat serine/threonine-protein kinase 1LRRK115q26.3Q38SD2 details
Large subunit GTPase 1 homologLSG13q29Q9H089 details
MAP kinase-activating death domain proteinMADD11p11.2Q8WXG6 details
Ran guanine nucleotide release factorRANGRF17p13.1Q9HD47 details
Serine/threonine-protein kinase MRCK alphaCDC42BPA1q42.11Q5VT25 details
Serine/threonine-protein kinase MRCK betaCDC42BPB14q32.3Q9Y5S2 details
Serine/threonine-protein kinase MRCK gammaCDC42BPG11q13.1Q6DT37 details
Mitochondrial GTPase 1MTG110q26.3Q9BT17 details
2'-5'-oligoadenylate synthase 3OAS312q24.2Q9Y6K5 details
Obg-like ATPase 1OLA12q31.1Q9NTK5 details
Phosphatidylinositol 4-kinase type 2-betaPI4K2B4p15.2Q8TCG2 details
Serine/threonine-protein kinase PAK 1PAK111q13-q14Q13153 details
Rab GTPase-binding effector protein 1RABEP117p13.2Q15276 details
Rab GTPase-binding effector protein 2RABEP216p11.2Q9H5N1 details
Ran-specific GTPase-activating proteinRANBP122q11.21P43487 details
GTPase ERasERASQ7Z444 details
GTPase KRasKRAS12p12.1P01116 details
GTPase NRasNRAS1p13.2P01111 details
Rab3 GTPase-activating protein catalytic subunitRAB3GAP12q21.3Q15042 details
Rab3 GTPase-activating protein non-catalytic subunitRAB3GAP21q41Q9H2M9 details
E3 SUMO-protein ligase RanBP2RANBP22q12.3P49792 details
GTPase RhebL1RHEBL112q13.12Q8TAI7 details
Rho GTPase-activating protein 21ARHGAP2110p12.1|10p12.3Q5T5U3 details
Putative E3 ubiquitin-protein ligase SH3RF1SH3RF14q32.3Q7Z6J0 details
Putative nucleoside diphosphate kinaseNME2P112q24.31O60361 details
Rho-related GTP-binding protein RhoURHOU1q42.11-q42.3Q7L0Q8 details
DNA-directed RNA polymerase III subunit RPC1POLR3A10q22-q23O14802 details
DNA-directed RNA polymerase I subunit RPA1POLR1A2p11.2O95602 details
Zinc ribbon domain containing 1ZNRD16p21.3Q2L6J2 details
DNA-directed RNA polymerases I and III subunit RPAC2POLR1D13q12.2Q9Y2S0 details
DNA-directed RNA polymeraseDKFZp686D10173Q7Z3R8 details
DNA-directed RNA polymerase III subunit RPC7-likePOLR3GLQ9BT43 details
POLR1C proteinPOLR1C6p21.1Q96HT3 details
Leucine-rich repeat serine/threonine-protein kinase 2LRRK212q12Q5S007 details
Mitochondrial Rho GTPase 1RHOT117q11.2Q8IXI2 details
NineinNIN14q22.1Q8N4C6 details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1AGAP12q37Q9UPQ3 details
Protein RCC2RCC21p36.13Q9P258 details
Protein very KINDKNDC110q26.3Q76NI1 details
Hydroxylysine kinaseAGPHD115q25.1A2RU49 details
Cyclic GMP-AMP synthaseMB21D16q13Q8N884 details
Nucleoside diphosphate kinase homolog 5NME5P56597 details
DNA-directed RNA polymerase I subunit RPA12ZNRD1Q9P1U0 details
DNA-directed RNA polymerase I subunit RPA43TWISTNB7p21.1Q3B726 details
DNA-directed RNA polymerases I, II, and III subunit RPABC1POLR2E19p13.3P19388 details
DNA-directed RNA polymerases I, II, and III subunit RPABC2POLR2F22q13.1P61218 details
DNA-directed RNA polymerases I, II, and III subunit RPABC3POLR2H3q28P52434 details
DNA-directed RNA polymerases I, II, and III subunit RPABC4POLR2K8q22.2P53803 details
DNA-directed RNA polymerases I, II, and III subunit RPABC5POLR2L11p15P62875 details
DNA-directed RNA polymerases I and III subunit RPAC1POLR1C6p21.1O15160 details
DNA-directed RNA polymerase II subunit RPB11-aPOLR2J7q22.1P52435 details
DNA-directed RNA polymerase II subunit RPB11-b1POLR2J27q22.1Q9GZM3 details
DNA-directed RNA polymerase II subunit RPB3POLR2C16q13-q21P19387 details
DNA-directed RNA polymerase II subunit RPB4POLR2D2q21O15514 details
DNA-directed RNA polymerase II subunit RPB7POLR2G11q13.1P62487 details
DNA-directed RNA polymerase II subunit RPB9POLR2I19q12P36954 details
DNA-directed RNA polymerase III subunit RPC3POLR3CQ9BUI4 details
DNA-directed RNA polymerase III subunit RPC5POLR3EQ9NVU0 details
DNA-directed RNA polymerase III subunit RPC6POLR3FQ9H1D9 details
Probable tRNA(His) guanylyltransferaseTHG1L5q33.3Q9NWX6 details
Transporters
Protein NameGene NameLocusUniprot IDDetails
Importin subunit alpha-1KPNA13q21P52294 details
Importin subunit alpha-2KPNA217q24.2P52292 details
Importin subunit alpha-3KPNA313q14.3O00505 details
Importin subunit alpha-4KPNA43q25.33O00629 details
Importin subunit alpha-6KPNA56q22.1O15131 details
Importin subunit alpha-7KPNA61p35.1O60684 details
Importin subunit beta-1KPNB117q21.32Q14974 details
Importin-11IPO115q12.1Q9UI26 details
Importin-13IPO131p34.1O94829 details
Importin-4IPO414q12Q8TEX9 details
Importin-5IPO513q32.2O00410 details
Importin-7IPO711p15.4O95373 details
Importin-8IPO812p11.21O15397 details
Importin-9IPO91q32.1Q96P70 details
Ran-binding protein 17RANBP175q34Q9H2T7 details
Transportin-1TNPO15q13.2Q92973 details
Transportin-2TNPO219p13.2O14787 details
Exportin-1XPO12p16O14980 details
Exportin-2CSE1L20q13P55060 details
Exportin-7XPO78p21Q9UIA9 details
Exportin-TXPOT12q14.2O43592 details
Metal Bindings
Protein NameGene NameLocusUniprot IDDetails
Soluble calcium-activated nucleotidase 1CANT117q25.3Q8WVQ1 details
Nucleoside diphosphate kinase, mitochondrialNME416p13.3O00746 details
Nucleoside diphosphate kinase 7NME71q24Q9Y5B8 details
Nucleoside diphosphate kinase BNME217q21.3P22392 details
Nucleoside diphosphate kinase 3NME316q13.3Q13232 details
Nucleoside diphosphate kinase 6NME63p21O75414 details
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Inosine triphosphate pyrophosphataseITPA20pQ9BY32 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
DNA-directed RNA polymerase II subunit RPB2POLR2B4q12P30876 details
DNA-directed RNA polymerase II subunit RPB1POLR2A17p13.1P24928 details
DNA-directed RNA polymerase I subunit RPA2POLR1B2q13Q9H9Y6 details
DNA-directed RNA polymerase III subunit RPC2POLR3B12q23.3Q9NW08 details
DNA-directed RNA polymerase III subunit RPC10POLR3KQ9Y2Y1 details
Pyruvate kinase isozymes M1/M2PKM15q22P14618 details
Pyruvate kinase isozymes R/LPKLR1q21P30613 details
Adenylosuccinate synthetase isozyme 2ADSS1q44P30520 details
Adenylosuccinate synthetase isozyme 1ADSSL114q32.33Q8N142 details
Phosphoenolpyruvate carboxykinase [GTP], mitochondrialPCK214q11.2Q16822 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrialSUCLA213q12.2-q13.3Q9P2R7 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Guanylate cyclase soluble subunit alpha-3GUCY1A34q31.1-q31.2Q02108 details
Guanylate cyclase soluble subunit alpha-2GUCY1A211q21-q22P33402 details
Guanylate cyclase soluble subunit beta-2GUCY1B2O75343 details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2AGAP212q14.1Q99490 details
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2ASAP22p25|2p24O43150 details
Molybdenum cofactor biosynthesis protein 1MOCS16p21.3Q9NZB8 details
Early endosome antigen 1EEA112q22Q15075 details
Adenylate cyclase type 10ADCY101q24Q96PN6 details
Acyl-coenzyme A synthetase ACSM1, mitochondrialACSM116p12.3Q08AH1 details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1PLCE110q23Q9P212 details
RAS guanyl-releasing protein 1RASGRP115q14O95267 details
RAS guanyl-releasing protein 2RASGRP211q13Q7LDG7 details
Regulating synaptic membrane exocytosis protein 1RIMS16q12-q13Q86UR5 details
Synaptotagmin-like protein 3SYTL36q25.3Q4VX76 details
Acyl-coenzyme A synthetase ACSM6, mitochondrialACSM610q23.33Q6P461 details
ADP-ribosylation factor GTPase-activating protein 1ARFGAP120q13.33Q8N6T3 details
ADP-ribosylation factor GTPase-activating protein 2ARFGAP211p11.2-p11.12Q8N6H7 details
ADP-ribosylation factor GTPase-activating protein 3ARFGAP322q13.2Q9NP61 details
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1ACAP117p13.1Q15027 details
Coatomer subunit alphaCOPA1q23-q25P53621 details
Dedicator of cytokinesis protein 2DOCK25q35.1Q92608 details
EH domain-containing protein 2EHD219q13.3Q9NZN4 details
FYVE, RhoGEF and PH domain-containing protein 1FGD1P98174 details
FYVE, RhoGEF and PH domain-containing protein 2FGD26p21.2Q7Z6J4 details
FYVE, RhoGEF and PH domain-containing protein 3FGD3Q5JSP0 details
FYVE, RhoGEF and PH domain-containing protein 4FGD412p11.21Q96M96 details
FYVE, RhoGEF and PH domain-containing protein 5FGD53p25.1Q6ZNL6 details
FYVE, RhoGEF and PH domain-containing protein 6FGD612q22Q6ZV73 details
GTP-binding protein 5GTPBP520q13.33Q9H4K7 details
GTP-binding protein 10GTPBP107q21.13A4D1E9 details
MelanophilinMLPH2q37.3Q9BV36 details
Rab effector MyRIPMYRIP3p22.1Q8NFW9 details
Rab5 GDP/GTP exchange factorRABGEF17q11.21Q9UJ41 details
Ras and EF-hand domain-containing proteinRASEF9q21.32Q8IZ41 details
RNA-binding protein 4RBM411q13Q9BWF3 details
Rabenosyn-5ZFYVE203p25.1Q9H1K0 details
E3 SUMO-protein ligase RanBP2RANBP22q12.3P49792 details
Rab11 family-interacting protein 4RAB11FIP417q11.2Q86YS3 details
Regulating synaptic membrane exocytosis protein 2RIMS28q22.3Q9UQ26 details
Rab effector Noc2RPH3AL17p13.3Q9UNE2 details
RUN and FYVE domain-containing protein 1RUFY15q35.3Q96T51 details
Putative E3 ubiquitin-protein ligase SH3RF1SH3RF14q32.3Q7Z6J0 details
Synaptotagmin-like protein 2SYTL211q14Q9HCH5 details
Synaptotagmin-like protein 5SYTL5Q8TDW5 details
DNA-directed RNA polymerase III subunit RPC1POLR3A10q22-q23O14802 details
DNA-directed RNA polymerase I subunit RPA1POLR1A2p11.2O95602 details
Zinc ribbon domain containing 1ZNRD16p21.3Q2L6J2 details
Mitochondrial Rho GTPase 1RHOT117q11.2Q8IXI2 details
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1AGAP12q37Q9UPQ3 details
Ras guanyl-releasing protein 3RASGRP32p25.1-p24.1Q8IV61 details
DNA-directed RNA polymerase I subunit RPA12ZNRD1Q9P1U0 details
DNA-directed RNA polymerases I, II, and III subunit RPABC4POLR2K8q22.2P53803 details
DNA-directed RNA polymerases I, II, and III subunit RPABC5POLR2L11p15P62875 details
DNA-directed RNA polymerase II subunit RPB9POLR2I19q12P36954 details
Receptors
Protein NameGene NameLocusUniprot IDDetails
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1ENPP16q22-q23P22413 details
Adenylate cyclase type 7ADCY716q12.1P51828 details
Adenylate cyclase type 4ADCY414q12Q8NFM4 details
Adenylate cyclase type 6ADCY612q12-q13O43306 details
Adenylate cyclase type 5ADCY53q21.1O95622 details
Adenylate cyclase type 8ADCY88q24P40145 details
Adenylate cyclase type 9ADCY916p13.3O60503 details
Adenylate cyclase type 3ADCY32p23.3O60266 details
Adenylate cyclase type 1ADCY17p13-p12Q08828 details
Adenylate cyclase type 2ADCY25p15.3Q08462 details
Atrial natriuretic peptide receptor 2NPR29p21-p12P20594 details
Guanylate cyclase soluble subunit beta-1GUCY1B34q31.3-q33Q02153 details
Retinal guanylyl cyclase 1GUCY2D17p13.1Q02846 details
Guanylate cyclase soluble subunit alpha-3GUCY1A34q31.1-q31.2Q02108 details
Atrial natriuretic peptide receptor 1NPR11q21-q22P16066 details
Heat-stable enterotoxin receptorGUCY2C12p12P25092 details
Retinal guanylyl cyclase 2GUCY2FXq22P51841 details
Ectonucleoside triphosphate diphosphohydrolase 2ENTPD2Q9Y5L3 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2GNG214q21P59768 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms shortGNAS20q13.3P63092 details
Guanine nucleotide-binding protein G(q) subunit alphaGNAQ9q21P50148 details
Guanine nucleotide-binding protein subunit alpha-11GNA1119p13.3P29992 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-11GNG117q21P61952 details
Guanine nucleotide-binding protein G(t) subunit alpha-1GNAT13p21P11488 details
Lysophosphatidic acid receptor 2LPAR219p12Q9HBW0 details
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1PLCE110q23Q9P212 details
Dynamin-1DNM19q34Q05193 details
Dynamin-2DNM219p13.2P50570 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10GNG109q31.3P50151 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12GNG121p31.3Q9UBI6 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13GNG1316p13.3Q9P2W3 details
Guanine nucleotide-binding protein G(T) subunit gamma-T1GNGT17q21.3P63211 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3GNG311p11P63215 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4GNG41q42.3P50150 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5GNG51p22P63218 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7GNG719p13.3O60262 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8GNG819q13.32Q9UK08 details
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-T2GNGT217q21O14610 details
Plexin-B1PLXNB13p21.31O43157 details
Rab GTPase-binding effector protein 1RABEP117p13.2Q15276 details
Rab GTPase-binding effector protein 2RABEP216p11.2Q9H5N1 details
Signal recognition particle receptor subunit alphaSRPR11q24.2P08240 details
T-lymphoma invasion and metastasis-inducing protein 1TIAM121q22.1|21q22.11Q13009 details
T-lymphoma invasion and metastasis-inducing protein 2TIAM26q25.2Q8IVF5 details
Exportin-2CSE1L20q13P55060 details
Guanine nucleotide-binding protein G(i) subunit alpha-1GNAI17q21P63096 details
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasGNAS20q13.3Q5JWF2 details
Guanine nucleotide-binding protein subunit alpha-14GNA149q21O95837 details
Guanine nucleotide-binding protein G(k) subunit alphaGNAI31p13P08754 details
Guanine nucleotide-binding protein G(i) subunit alpha-2GNAI23p21P04899 details
Guanine nucleotide-binding protein G(t) subunit alpha-2GNAT21p13.1P19087 details
Guanine nucleotide-binding protein G(o) subunit alphaGNAO116q13P09471 details
Guanine nucleotide-binding protein subunit alpha-13GNA1317q24.3Q14344 details
Guanine nucleotide binding protein (G protein), alpha 14GNA149q21B1ALW3 details
Guanine nucleotide-binding protein subunit alpha-12GNA127p22.2Q03113 details
Growth factor receptor-bound protein 2GRB217q24-q25P62993 details
Guanine nucleotide binding protein (G protein), q polypeptideGNAQ9q21B1AM21 details
Guanine nucleotide-binding protein G(z) subunit alphaGNAZ22q11.22P19086 details
Guanine nucleotide-binding protein G(olf) subunit alphaGNAL18p11.22-p11.21P38405 details
Guanine nucleotide-binding protein subunit alpha-15GNA1519p13.3P30679 details
Transcriptional Factors
Protein NameGene NameLocusUniprot IDDetails
Nucleoside diphosphate kinase BNME217q21.3P22392 details
DNA-directed RNA polymerase III subunit RPC4POLR3DP05423 details
DNA-directed RNA polymerase II subunit RPB2POLR2B4q12P30876 details
DNA-directed RNA polymerase II subunit RPB1POLR2A17p13.1P24928 details
DNA-directed RNA polymerase, mitochondrialPOLRMT19p13.3O00411 details
DNA-directed RNA polymerase I subunit RPA2POLR1B2q13Q9H9Y6 details
DNA-directed RNA polymerase III subunit RPC7POLR3GO15318 details
DNA-directed RNA polymerase III subunit RPC2POLR3B12q23.3Q9NW08 details
DNA-directed RNA polymerase I subunit RPA49POLR1E9p13.2Q9GZS1 details
DNA-directed RNA polymerase III subunit RPC8POLR3HQ9Y535 details
DNA-directed RNA polymerase III subunit RPC10POLR3KQ9Y2Y1 details
mRNA-capping enzymeRNGTT6q16O60942 details
Dynamin-2DNM219p13.2P50570 details
GTP-binding protein REM 2REM214q11.2Q8IYK8 details
Sex-determining region Y proteinSRYQ05066 details
DNA-directed RNA polymerase III subunit RPC1POLR3A10q22-q23O14802 details
DNA-directed RNA polymerase I subunit RPA1POLR1A2p11.2O95602 details
Zinc ribbon domain containing 1ZNRD16p21.3Q2L6J2 details
DNA-directed RNA polymerases I and III subunit RPAC2POLR1D13q12.2Q9Y2S0 details
DNA-directed RNA polymeraseDKFZp686D10173Q7Z3R8 details
DNA-directed RNA polymerase III subunit RPC7-likePOLR3GLQ9BT43 details
POLR1C proteinPOLR1C6p21.1Q96HT3 details
DNA-directed RNA polymerase I subunit RPA12ZNRD1Q9P1U0 details
DNA-directed RNA polymerase I subunit RPA43TWISTNB7p21.1Q3B726 details
DNA-directed RNA polymerases I, II, and III subunit RPABC1POLR2E19p13.3P19388 details
DNA-directed RNA polymerases I, II, and III subunit RPABC2POLR2F22q13.1P61218 details
DNA-directed RNA polymerases I, II, and III subunit RPABC3POLR2H3q28P52434 details
DNA-directed RNA polymerases I, II, and III subunit RPABC4POLR2K8q22.2P53803 details
DNA-directed RNA polymerases I, II, and III subunit RPABC5POLR2L11p15P62875 details
DNA-directed RNA polymerases I and III subunit RPAC1POLR1C6p21.1O15160 details
DNA-directed RNA polymerase II subunit RPB11-aPOLR2J7q22.1P52435 details
DNA-directed RNA polymerase II subunit RPB11-b1POLR2J27q22.1Q9GZM3 details
DNA-directed RNA polymerase II subunit RPB3POLR2C16q13-q21P19387 details
DNA-directed RNA polymerase II subunit RPB4POLR2D2q21O15514 details
DNA-directed RNA polymerase II subunit RPB7POLR2G11q13.1P62487 details
DNA-directed RNA polymerase II subunit RPB9POLR2I19q12P36954 details
DNA-directed RNA polymerase III subunit RPC3POLR3CQ9BUI4 details
DNA-directed RNA polymerase III subunit RPC5POLR3EQ9NVU0 details
DNA-directed RNA polymerase III subunit RPC6POLR3FQ9H1D9 details
Concentrations Data
Not Available
HMDB IDHMDB0001273
DrugBank IDDB04137
Phenol Explorer Compound IDNot Available
FoodDB IDFDB022527
KNApSAcK IDC00007223
Chemspider ID6569
KEGG Compound IDC00044
BioCyc IDGTP
BiGG ID33641
Wikipedia LinkGuanosine triphosphate
METLIN ID6128
PubChem Compound6830
PDB IDNot Available
ChEBI ID15996
References
General ReferencesNot Available

Only showing the first 10 proteins. There are 370 proteins in total.

Enzymes

General function:
Involved in protein binding
Specific function:
Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (By similarity).
Gene Name:
PLD1
Uniprot ID:
Q13393
Molecular weight:
124183.135
General function:
Involved in hydrolase activity
Specific function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Gene Name:
ENTPD1
Uniprot ID:
P49961
Molecular weight:
58706.0
General function:
Involved in calcium ion binding
Specific function:
Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.
Gene Name:
CANT1
Uniprot ID:
Q8WVQ1
Molecular weight:
44839.24
General function:
Involved in hydrolase activity
Specific function:
Has a threefold preference for the hydrolysis of ATP over ADP.
Gene Name:
ENTPD3
Uniprot ID:
O75355
Molecular weight:
59104.76
General function:
Involved in ATP binding
Specific function:
Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4-thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)-benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5-methylcytidine, and N(4)-anisoylcytidine.
Gene Name:
UCK1
Uniprot ID:
Q9HA47
Molecular weight:
22760.43
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP (By similarity).
Gene Name:
NME4
Uniprot ID:
O00746
Molecular weight:
20658.45
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Possesses nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease activities. Involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. Required for neural development including neural patterning and cell fate determination.
Gene Name:
NME1
Uniprot ID:
P15531
Molecular weight:
17148.635
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate.
Gene Name:
NME7
Uniprot ID:
Q9Y5B8
Molecular weight:
42491.365
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. Negatively regulates Rho activity by interacting with AKAP13/LBC. Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752). Exhibits histidine protein kinase activity.
Gene Name:
NME2
Uniprot ID:
P22392
Molecular weight:
30136.92
General function:
Involved in nucleoside diphosphate kinase activity
Specific function:
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. Probably has a role in normal hematopoiesis by inhibition of granulocyte differentiation and induction of apoptosis.
Gene Name:
NME3
Uniprot ID:
Q13232
Molecular weight:
19014.85

Transporters

General function:
Involved in binding
Specific function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS
Gene Name:
KPNA1
Uniprot ID:
P52294
Molecular weight:
60221.2
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Gene Name:
KPNA2
Uniprot ID:
P52292
Molecular weight:
57861.4
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Recognizes NLSs of influenza A virus nucleoprotein probably through ARM repeats 7-9
Gene Name:
KPNA3
Uniprot ID:
O00505
Molecular weight:
57810.4
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a nonclassical NLS
Gene Name:
KPNA4
Uniprot ID:
O00629
Molecular weight:
57886.3
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1 homodimers and STAT1/STAT2 heterodimers by recognizing non- classical NLSs of STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS
Gene Name:
KPNA5
Uniprot ID:
O15131
Molecular weight:
60348.4
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus
Gene Name:
KPNA6
Uniprot ID:
O60684
Molecular weight:
60028.9
General function:
Involved in binding
Specific function:
Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re- exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports PRKCI into the nucleus
Gene Name:
KPNB1
Uniprot ID:
Q14974
Molecular weight:
97169.2
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBE2E3, and of RPL12
Gene Name:
IPO11
Uniprot ID:
Q9UI26
Molecular weight:
112534.4
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of UBC9, the RBM8A/MAGOH complex, PAX6 and probably other members of the paired homeobox family. Also mediates nuclear export of eIF-1A, and the cytoplasmic release of eIF-1A is triggered by the loading of import substrates onto IPO13
Gene Name:
IPO13
Uniprot ID:
O94829
Molecular weight:
108194.1
General function:
Involved in binding
Specific function:
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of RPS3A. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS
Gene Name:
IPO4
Uniprot ID:
Q8TEX9
Molecular weight:
118713.8

Only showing the first 10 proteins. There are 370 proteins in total.