| Identification |
|---|
| HMDB Protein ID
| CDBP03701 |
| Secondary Accession Numbers
| Not Available |
| Name
| Rab effector MyRIP |
| Description
| Not Available |
| Synonyms
|
- Exophilin-8
- Myosin-VIIa- and Rab-interacting protein
- SlaC2-c
- Slp homolog lacking C2 domains c
|
| Gene Name
| MYRIP |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in Rab GTPase binding |
| Specific Function
| Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and the motor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments |
| GO Classification
|
| Function |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
| enzyme regulator activity |
| rab gtpase binding |
| nucleoside-triphosphatase regulator activity |
| gtpase regulator activity |
| small gtpase regulator activity |
| ion binding |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p22.1 |
| SNPs
| MYRIP |
| Gene Sequence
|
>2580 bp
ATGGGGAGGAAGCTGGACCTGTCTGGTTTGACTGATGATGAAACAGAGCATGTTCTTCAG
GTGGTTCAAAGAGACTTCAATCTTCGCAAAAAAGAAGAAGAACGACTAAGTGAGCTGAAG
CAGAAGCTGGATGAGGAAGGCAGCAAGTGCAGCATCCTCTCGAAGCACCAGCAGTTTGTG
GAGCACTGCTGCATGCGCTGCTGCTCGCCCTTCACCTTCCTCGTCAACACCAAGCGCCAG
TGTGGAGATTGCAAATTCAATGTCTGCAAGAGCTGCTGCTCCTACCAGAAGCACGAAAAG
GCCTGGGTCTGCTGCGTCTGCCAGCAAGCGAGGCTTCTGAGGGCCCAATCTCTGGAATGG
TTCTACAATAATGTGAAGAGCCGCTTCAAGCGCTTTGGCAGTGCCAAGGTTCTGAAGAAC
CTGTACAGGAAGCACCGGCTGGAGAGTGGCGCGTGCTTCGACATTCTAGGAGGAAGCCTT
TTTGAGTCAAACCTGGAGAATGAAGGAAGCATTTCTGGCAGTGATTCAACATTTTATAGG
CAGTCAGAAGGACATAGTGTGATGGACACCTTGGCTGTGGCCCTACGGGTGGCTGAAGAG
GCCATTGAGGAAGCAATTTCCAAAGCAGAGGCATATGGGGACAGCCTGGACAAGCAAAAT
GAGGCCAGTTACCTGCGGGACCACAAGGAGGAGCTAACTGAGGAACTGGCCACGACAATC
CTGCAGAAGATTATACGAAAACAGAAGAGCAAAAGTGAGCAGCAAGTGGAAGAAGAGCCA
GGATGGCCACATCCCCAGAGTTGCAGCACAAAGGTGGCAGATGAGGGGACCTCAGCATCC
CCTGGAGGCTACCGTGCTCCCGCTGCCCTCTGGAGGTCCCAGTCTGCCTTCTCAATCACT
GGAGAAGAAGCCCTGAAGACCCCTCCAGTGGAGGCTCCATCGAGGCAGCCAAGGGACCAA
GGCCAACACCCGAGAGCAGAGTCTGCTCTGCCCAGCTGGAAGAGTGTGGACAGGCTGGAT
GAAACAAACCTGGCCCCAGTTTTGCAGAGCCCCGACGGGAACTGGGTGGCCCTGAAGGAT
GGCGCTCCACCCCCCACCCGACTACTGGCCAAACCTAAGAGCGGGACGTTTCAGGCCCTG
GAGGTGGCCTCCAGTGTGGCATCTGCCTACGATGAGATGGGCTCCGATAGCGAGGAAGAC
TTTGACTGGAGTGAGGCCTTGAGCAAGCTGTGTCCCAGGTCCCGGGCCCTGCCCAGGAAC
CCCCAGCCTCAGCCCACACAGGCCCAGAGCTCTGACCAAGGCCCCATAGCTGCCTCCCCA
TCCTCTGCACTCTCCCCCAACCCTGAGGCCATGTGCTCTGACTCGGAGACCTCCTCCGCA
GGCTCTTCCCGAGAAGTTGGGCACCAGGCCAGACTGTCCTGGTTGCAGAGGAAGGCCCCC
AGGAACCCTGCAGCTGAGAAGATGCGCTTGCATGGAGAGCTGGACGTGAACTTCAACCCC
CAGTTGGCCAGCAGGGAGACCTCGGACAGCAGCGAGCCGGAGGAGGCCCCCCACACCACA
GACCGGCGGGCCAGGAGGTGGAGAAGAGCCCGACTGGGCTCAGAAGAGCCAAGCAAAGAA
CCATCTTCCCCCAGCGCCCAGCTCCGGGATCTAGACACACATCAGGTGTCGGATGATTTA
TCAGAGACAGACATCAGCAATGAGGCTCGGGATCCCCAGACTCTCACAGACACCACAGAG
GAGAAACGGAGAAACAGGCTGTACGAGTTAGCAATGAAAATGAGTGAAAAGGAGACTTCT
TCAGGGGAGGATCAGGAGTCTGAGCCCAAGACAGAATCTGAGAACCAGAAGGAAAGTCTG
TCCTCTGAAGACAACAGCCAGAGTGTCCAGGAAGAGCTGAAGAAGAAGTTTTCTGCTGTT
TCTCTCTGCAACATCTCCACAGAAGTCCTGAAAGTCATCAATGCCACAGAGGAGTTGATA
GCAGGATCTACAGGGCCCTGGGAGTCCCCACAAGTCCCTCCTGACAGACAGAAGGGGATG
TTTCCTCGTGGGACAGACCAAGTGAGACTGGATGAGCAGCTGACTTCCCTGGAAGAAAAT
GTATACCTGGCAGCAGGCACTGTGTATGGACTGGAGACCCAGCTGACTGAGCTAGAAGAT
GCCGCCCGCTGCATCCACAGCGGCACTGATGAGACCCATCTGGCGGATCTGGAGGACCAG
GTGGCCACGGCTGCAGCCCAAGTCCACCATGCTGAACTCCAGATTTCAGATATTGAGAGC
CGGATTTCAGCCCTGACCATTGCAGGATTAAACATAGCACCATGTGTGCGCTTCACAAGA
AGACGGGATCAGAAGCAAAGGACCCAGGTACAAACCATAGATACATCAAGGCAGCAAAGG
AGGAAACTGCCTGCTCCACCGGTGAAAGCTGAAAAAATTGAGACATCTTCAGTGACTACC
ATTAAAACATTTAACCACAACTTCATTCTCCAAGGCTCCTCAACAAACAGGACTAAGGAA
AGGAAAGGCACCACCAAGGATTTGATGGAGCCTGCTCTGGAGTCAGCTGTGATGTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 859 |
| Molecular Weight
| 95705.3 |
| Theoretical pI
| 5.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Rab effector MyRIP
MGRKLDLSGLTDDETEHVLQVVQRDFNLRKKEEERLSELKQKLDEEGSKCSILSKHQQFV
EHCCMRCCSPFTFLVNTKRQCGDCKFNVCKSCCSYQKHEKAWVCCVCQQARLLRAQSLEW
FYNNVKSRFKRFGSAKVLKNLYRKHRLESGACFDILGGSLFESNLENEGSISGSDSTFYR
QSEGHSVMDTLAVALRVAEEAIEEAISKAEAYGDSLDKQNEASYLRDHKEELTEELATTI
LQKIIRKQKSKSEQQVEEEPGWPHPQSCSTKVADEGTSASPGGYRAPAALWRSQSAFSIT
GEEALKTPPVEAPSRQPRDQGQHPRAESALPSWKSVDRLDETNLAPVLQSPDGNWVALKD
GAPPPTRLLAKPKSGTFQALEVASSVASAYDEMGSDSEEDFDWSEALSKLCPRSRALPRN
PQPQPTQAQSSDQGPIAASPSSALSPNPEAMCSDSETSSAGSSREVGHQARLSWLQRKAP
RNPAAEKMRLHGELDVNFNPQLASRETSDSSEPEEAPHTTDRRARRWRRARLGSEEPSKE
PSSPSAQLRDLDTHQVSDDLSETDISNEARDPQTLTDTTEEKRRNRLYELAMKMSEKETS
SGEDQESEPKTESENQKESLSSEDNSQSVQEELKKKFSAVSLCNISTEVLKVINATEELI
AGSTGPWESPQVPPDRQKGMFPRGTDQVRLDEQLTSLEENVYLAAGTVYGLETQLTELED
AARCIHSGTDETHLADLEDQVATAAAQVHHAELQISDIESRISALTIAGLNIAPCVRFTR
RRDQKQRTQVQTIDTSRQQRRKLPAPPVKAEKIETSSVTTIKTFNHNFILQGSSTNRTKE
RKGTTKDLMEPALESAVMY
|
| External Links |
|---|
| GenBank ID Protein
| 22779206 |
| UniProtKB/Swiss-Prot ID
| Q8NFW9 |
| UniProtKB/Swiss-Prot Entry Name
| MYRIP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB083783 |
| GeneCard ID
| MYRIP |
| GenAtlas ID
| MYRIP |
| HGNC ID
| HGNC:19156 |
| References |
|---|
| General References
| Not Available |