Identification
HMDB Protein ID CDBP03682
Secondary Accession Numbers Not Available
Name Importin-9
Description Not Available
Synonyms
  1. Imp9
  2. Ran-binding protein 9
  3. RanBP9
Gene Name IPO9
Protein Type Transporter
Biological Properties
General Function Involved in binding
Specific Function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates the nuclear import of H2B histone, RPS7 and RPL18A. Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains. May also import H2A, H3, H4 histones, RPL4 and RPL6
GO Classification
Function
protein transporter activity
transporter activity
substrate-specific transporter activity
binding
Process
establishment of localization
transport
protein transport
intracellular protein transport
Cellular Location
  1. Nucleus
  2. Cytoplasm
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1q32.1
SNPs IPO9
Gene Sequence
>3126 bp
ATGGCGGCGGCGGCGGCAGCTGGTGCGGCCTCCGGGCTGCCGGGTCCAGTGGCACAAGGA
TTAAAGGAAGCGTTAGTGGATACGCTCACCGGGATCCTATCCCCAGTACAGGAGGTGCGG
GCGGCTGCTGAAGAACAGATTAAGGTGCTGGAGGTGACGGAGGAATTTGGTGTTCACTTG
GCAGAACTGACTGTAGATCCCCAGGGGGCACTGGCAATCCGTCAGCTGGCATCAGTCATC
TTGAAACAATATGTGGAGACTCACTGGTGTGCCCAATCAGAGAAATTTAGGCCTCCTGAA
ACTACAGAAAGGGCAAAAATTGTTATCCGGGAGCTATTGCCTAATGGGTTGAGAGAATCG
ATAAGCAAAGTGCGCTCCAGTGTGGCCTATGCAGTGTCAGCCATTGCCCACTGGGACTGG
CCTGAAGCTTGGCCCCAACTCTTCAACCTGCTCATGGAGATGTTGGTGAGCGGAGACTTA
AATGCCGTCCATGGAGCCATGCGTGTGCTGACAGAATTCACTCGTGAAGTAACAGACACA
CAGATGCCACTTGTTGCTCCTGTCATTCTCCCAGAGATGTATAAGATCTTCACCATGGCT
GAGGTGTATGGTATTCGAACCCGTTCCCGAGCCGTGGAGATTTTTACCACTTGTGCCCAT
ATGATCTGTAACATGGAGGAGCTGGAAAAGGGTGCAGCCAAAGTCCTGATCTTTCCCGTG
GTACAGCAGTTCACAGAGGCCTTTGTTCAGGCCCTCCAGATACCAGATGGCCCCACATCT
GACAGTGGGTTTAAGATGGAGGTCCTAAAGGCAGTGACAGCCCTAGTGAAAAACTTCCCA
AAGCACATGGTGTCCTCCATGCAGCAGATTCTGCCTATTGTTTGGAACACCCTAACCGAG
AGTGCAGCTTTTTATGTGAGGACAGAAGTAAATTACACAGAAGAAGTAGAAGATCCTGTG
GATTCTGATGGTGAAGTCCTGGGCTTTGAAAATCTCGTCTTTAGCATTTTTGAATTTGTC
CATGCTCTACTAGAAAATAGCAAATTCAAAAGCACTGTTAAGAAAGCCTTGCCTGAATTG
ATTTATTATATTATCCTGTACATGCAAATCACTGAGGAGCAGATTAAAGTATGGACAGCC
AACCCCCAACAATTTGTAGAAGATGAAGATGATGATACATTCTCCTATACTGTTAGAATA
GCAGCTCAAGACTTGTTGCTGGCTGTGGCCACAGATTTCCAGAATGAAAGTGCAGCAGCC
CTGGCTGCTGCAGCCACTCGACATTTACAAGAAGCTGAGCAAACCAAAAACAGTGGCACT
GAGCACTGGTGGAAGATCCATGAGGCATGCATGCTTGCCCTAGGCTCAGTGAAGGCCATC
ATCACTGACAGTGTGAAAAATGGCAGGATTCATTTTGACATGCATGGGTTCCTGACCAAT
GTCATCCTTGCAGACCTCAACCTCTCAGTGTCTCCTTTCCTCTTGGGCCGGGCACTTTGG
GCTGCCAGTCGGTTCACTGTTGCTATGTCCCCTGAACTGATCCAGCAGTTCCTACAGGCA
ACAGTTAGTGGTCTTCACGAGACACAGCCCCCATCAGTTCGAATTTCTGCAGTGAGAGCC
ATCTGGGGTTATTGTGACCAACTGAAAGTCTCAGAGAGTACCCACGTGCTCCAGCCCTTC
CTCCCCAGCATCCTTGATGGCTTAATTCACCTAGCAGCCCAGTTCAGCTCAGAGGTCCTC
AACCTGGTGATGGAGACCCTGTGCATCGTTTGTACAGTAGACCCCGAATTCACAGCAAGC
ATGGAAAGCAAAATCTGCCCCTTCACCATCGCCATTTTCCTAAAGTACAGTAATGATCCC
GTCGTCGCCTCACTGGCTCAGGACATCTTCAAGGAGCTGTCCCAGATTGAAGCCTGTCAG
GGCCCAATGCAAATGAGGCTGATTCCCACTCTGGTCAGCATAATGCAGGCCCCAGCAGAC
AAGATTCCTGCAGGGCTTTGTGCGACAGCCATTGATATCCTGACAACAGTAGTACGAAAT
ACAAAGCCTCCCCTTTCCCAGCTTCTCATCTGCCAAGCTTTCCCTGCTGTGGCACAGTGT
ACCCTTCACACAGATGACAATGCCACCATGCAGAATGGCGGAGAGTGCTTGCGGGCCTAT
GTGTCAGTGACCCTGGAACAAGTAGCCCAGTGGCATGATGAGCAGGGCCACAATGGACTG
TGGTATGTGATGCAAGTGGTGAGCCAGCTCCTGGACCCCCGCACCTCAGAGTTCACTGCG
GCCTTTGTGGGCCGCCTTGTTTCCACCCTCATCTCCAAGGCAGGGCGGGAACTCGGGGAG
AATCTAGACCAGATTCTTCGTGCCATCCTCAGTAAGATGCAGCAGGCAGAGACGCTCAGT
GTCATGCAGTCCCTGATCATGGTGTTCGCTCATCTGGTGCACACTCAGCTAGAACCTCTC
TTGGAGTTCCTGTGTAGCCTCCCAGGACCTACTGGCAAACCTGCTCTAGAGTTTGTGATG
GCTGAGTGGACAAGCCGACAGCACCTGTTCTATGGACAGTATGAAGGCAAAGTCAGCTCT
GTGGCACTCTGTAAGCTGCTCCAGCATGGCATCAATGCAGATGACAAACGGCTACAGGAT
ATCCGTGTGAAGGGAGAGGAGATCTACAGCATGGATGAGGGCATCCGCACCCGCTCTAAG
TCAGCCAAAAACCCAGAACGCTGGACAAACATTCCTTTGCTGGTCAAGATCCTAAAGCTG
ATCATCAACGAGCTCTCCAACGTCATGGAGGCTAATGCCGCTCGCCAGGCCACTCCTGCA
GAGTGGAGTCAAGATGACTCCAATGATATGTGGGAGGACCAGGAGGAGGAAGAGGAGGAG
GAGGAGGATGGTTTAGCTGGCCAACTTTTATCTGACATTCTTGCTACAAGTAAATATGAG
GAGGATTACTACGAGGATGATGAGGAAGATGACCCTGATGCCCTGAAGGATCCTCTCTAT
CAGATTGATCTGCAGGCATATCTCACAGATTTCCTCTGCCAGTTTGCTCAGCAGCCCTGC
TACATAATGTTTTCAGGCCACCTTAATGACAATGAGAGGCGAGTTCTACAGACCATCGGC
ATCTAA
Protein Properties
Number of Residues 1041
Molecular Weight 115961.8
Theoretical pI 4.44
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence
>Importin-9
MAAAAAAGAASGLPGPVAQGLKEALVDTLTGILSPVQEVRAAAEEQIKVLEVTEEFGVHL
AELTVDPQGALAIRQLASVILKQYVETHWCAQSEKFRPPETTERAKIVIRELLPNGLRES
ISKVRSSVAYAVSAIAHWDWPEAWPQLFNLLMEMLVSGDLNAVHGAMRVLTEFTREVTDT
QMPLVAPVILPEMYKIFTMAEVYGIRTRSRAVEIFTTCAHMICNMEELEKGAAKVLIFPV
VQQFTEAFVQALQIPDGPTSDSGFKMEVLKAVTALVKNFPKHMVSSMQQILPIVWNTLTE
SAAFYVRTEVNYTEEVEDPVDSDGEVLGFENLVFSIFEFVHALLENSKFKSTVKKALPEL
IYYIILYMQITEEQIKVWTANPQQFVEDEDDDTFSYTVRIAAQDLLLAVATDFQNESAAA
LAAAATRHLQEAEQTKNSGTEHWWKIHEACMLALGSVKAIITDSVKNGRIHFDMHGFLTN
VILADLNLSVSPFLLGRALWAASRFTVAMSPELIQQFLQATVSGLHETQPPSVRISAVRA
IWGYCDQLKVSESTHVLQPFLPSILDGLIHLAAQFSSEVLNLVMETLCIVCTVDPEFTAS
MESKICPFTIAIFLKYSNDPVVASLAQDIFKELSQIEACQGPMQMRLIPTLVSIMQAPAD
KIPAGLCATAIDILTTVVRNTKPPLSQLLICQAFPAVAQCTLHTDDNATMQNGGECLRAY
VSVTLEQVAQWHDEQGHNGLWYVMQVVSQLLDPRTSEFTAAFVGRLVSTLISKAGRELGE
NLDQILRAILSKMQQAETLSVMQSLIMVFAHLVHTQLEPLLEFLCSLPGPTGKPALEFVM
AEWTSRQHLFYGQYEGKVSSVALCKLLQHGINADDKRLQDIRVKGEEIYSMDEGIRTRSK
SAKNPERWTNIPLLVKILKLIINELSNVMEANAARQATPAEWSQDDSNDMWEDQEEEEEE
EEDGLAGQLLSDILATSKYEEDYYEDDEEDDPDALKDPLYQIDLQAYLTDFLCQFAQQPC
YIMFSGHLNDNERRVLQTIGI
GenBank ID Protein 21361659
UniProtKB/Swiss-Prot ID Q96P70
UniProtKB/Swiss-Prot Entry Name IPO9_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_018085.4
GeneCard ID IPO9
GenAtlas ID IPO9
HGNC ID HGNC:19425
References
General References Not Available