| Identification |
|---|
| HMDB Protein ID
| CDBP03681 |
| Secondary Accession Numbers
| Not Available |
| Name
| Importin-8 |
| Description
| Not Available |
| Synonyms
|
- Imp8
- Ran-binding protein 8
- RanBP8
|
| Gene Name
| IPO8 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Seems to function in nuclear protein import, either by acting as autonomous nuclear transport receptor or as an adapter- like protein in association with the importin-beta subunit KPNB1. Acting autonomously, is thought to serve itself as receptor for nuclear localization signals (NLS) and to promote translocation of import substrates through the nuclear pore complex (NPC) by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro mediates the nuclear import of SRP19 |
| GO Classification
|
| Function |
| transporter activity |
| substrate-specific transporter activity |
| binding |
| protein transporter activity |
| Process |
| establishment of localization |
| transport |
| protein transport |
| intracellular protein transport |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p11.21 |
| SNPs
| IPO8 |
| Gene Sequence
|
>3114 bp
ATGGACCTCAACCGGATCATCCAGGCGCTGAAGGGCACCATCGACCCGAAGTTGCGGATT
GCAGCCGAGAACGAGCTCAACCAGTCCTACAAGATTATCAATTTTGCCCCCAGTTTACTT
CGGATTATAGTCTCTGACCATGTGGAATTCCCAGTACGACAGGCAGCTGCCATTTACCTG
AAGAACATGGTGACACAATACTGGCCAGATCGAGAACCTCCACCAGGAGAAGCAATATTT
CCATTCAACATTCACGAAAACGATCGCCAGCAAATACGTGATAACATTGTGGAAGGAATA
ATTCGGTCTCCAGATTTAGTGAGAGTCCAATTAACAATGTGTCTCCGTGCCATCATAAAA
CATGATTTTCCTGGTCACTGGCCAGGAGTGGTCGACAAGATAGACTATTACTTGCAATCA
CAGAGCAGTGCAAGCTGGCTTGGCAGTTTATTATGCCTGTATCAACTGGTGAAGACATAT
GAATATAAGAAAGCAGAAGAGAGAGAACCTCTTATAATAGCAATGCAGATATTCCTGCCT
CGTATTCAGCAACAAATTGTTCAGCTCCTTCCTGATTCCTCCTATTATTCTGTATTACTG
CAGAAACAAATTCTGAAAATCTTTTATGCACTTGTTCAGTATGCATTGCCTCTTCAGCTA
GTGAATAACCAAACCATGACAACATGGATGGAGATCTTCCGAACTATTATCGACAGGACC
GTTCCTCCTGAGACTCTGCACATTGATGAGGATGATAGACCAGAACTGGTATGGTGGAAG
TGTAAGAAGTGGGCACTGCATATTGTAGCTCGGCTCTTTGAACGATATGGAAGCCCAGGA
AATGTCACAAAAGAATACTTTGAATTTTCTGAATTCTTTTTGAAAACCTATGCAGTGGGC
ATTCAGCAGGTGCTACTAAAAATTTTAGATCAATATAGACAGAAAGAATATGTAGCTCCC
CGTGTTCTTCAGCAAGCATTCAACTATCTCAACCAAGGGGTGGTTCATTCTATAACCTGG
AAGCAGATGAAGCCACACATACAGAATATCTCTGAAGATGTGATTTTTTCTGTGATGTGT
TATAAAGATGAGGATGAAGAGCTGTGGCAAGAAGATCCATATGAGTATATAAGGATGAAA
TTTGATATTTTTGAAGATTATGCTTCTCCCACCACAGCAGCCCAGACTCTCTTATATACT
GCTGCAAAGAAAAGAAAAGAGGTGTTGCCAAAAATGATGGCATTCTGTTATCAAATCCTG
ACAGACCCGAACTTTGACCCTAGGAAGAAAGATGGAGCCCTGCATGTGATTGGTTCCCTA
GCTGAGATTTTACTGAAGAAGAGTTTATTCAAGGACCAAATGGAGCTGTTTCTACAAAAT
CATGTATTTCCATTATTATTGTCTAACCTGGGATATCTTCGAGCTAGATCTTGCTGGGTA
CTTCATGCATTTAGTTCTTTGAAGTTCCATAATGAGCTCAATCTAAGAAATGCCGTTGAA
TTAGCGAAGAAGAGCCTGATTGAAGATAAAGAGATGCCTGTCAAAGTTGAAGCTGCCCTT
GCTCTTCAGTCTTTAATTTCTAACCAGATACAAGCTAAGGAATATATGAAGCCACATGTG
AGGCCTATTATGCAGGAACTGTTGCACATTGTTAGAGAGACAGAAAATGATGATGTTACT
AATGTCATCCAGAAGATGATATGTGAATACAGTCAAGAGGTAGCCTCAATTGCTGTTGAT
ATGACCCAACACTTGGCTGAGATATTTGGCAAAGTTCTTCAAAGTGATGAATATGAAGAA
GTTGAAGACAAAACAGTAATGGCTATGGGAATTTTACATACCATTGATACTATCTTAACA
GTTGTAGAAGATCATAAAGAGATTACCCAGCAGTTAGAGAATATCTGTCTACGGATCATT
GATCTTGTTCTGCAGAAACATGTAATTGAATTCTATGAAGAAATTCTTTCCCTGGCATAC
AGTTTAACCTGCCACAGTATTTCCCCTCAAATGTGGCAGCTTCTAGGTATACTATATGAA
GTGTTTCAGCAGGATTGCTTTGAATACTTTACAGACATGATGCCTCTCCTGCATAATTAT
GTGACAATAGATACAGATACCTTACTATCAAATGCAAAACATTTAGAAATTCTTTTTACA
ATGTGTAGGAAGGTACTATGTGGAGATGCAGGAGAAGATGCAGAGTGTCATGCAGCTAAA
CTTCTGGAAGTCATCATTCTTCAGTGCAAAGGAAGGGGAATTGATCAGTGCATTCCACTC
TTCGTTCAACTTGTTTTGGAGAGATTAACTCGAGGGGTCAAAACTAGTGAGCTTCGTACT
ATGTGTCTTCAGGTTGCAATTGCTGCCTTGTACTACAACCCTGATTTGCTGCTACATACT
TTAGAACGAATTCAGTTGCCTCACAACCCTGGACCTATCACTGTACAGTTTATAAATCAA
TGGATGAATGATACAGATTGTTTTCTTGGGCATCATGACCGGAAGATGTGTATAATAGGA
CTGAGTATCCTTTTGGAATTGCAAAATCGACCTCCTGCAGTAGATGCTGTGGTGGGACAG
ATTGTTCCCTCAATTCTTTTCCTTTTCCTTGGCCTAAAGCAGGTCTGTGCTACTAGACAA
CTGGTAAACCGGGAAGATCGTTCAAAAGCAGAGAAAGCTGATATGGAAGAAAATGAGGAG
ATTTCAAGTGATGAAGAGGAGACAAATGTAACTGCTCAAGCAATGCAGTCAAATAATGGA
AGAGGTGAAGATGAGGAGGAGGAAGATGATGACTGGGATGAAGAAGTATTGGAAGAAACC
GCGCTTGAGGGGTTCAGTACTCCACTTGACCTTGACAATAGTGTGGATGAATATCAGTTT
TTTACACAAGCTCTGATAACTGTGCAGAGTCGAGATGCAGCCTGGTACCAGCTGCTGATG
GCACCACTCAGCGAGGATCAGAGGACAGCACTGCAGGAGGTGTACACACTGGCAGAGCAC
CGACGGACGGTGGCAGAGGCAAAGAAGAAGATTGAACAACAGGGAGGCTTCACCTTTGAA
AACAAAGGAGTCCTCTCCGCATTTAATTTTGGGACTGTGCCCAGCAACAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1037 |
| Molecular Weight
| 119937.0 |
| Theoretical pI
| 4.8 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Importin-8
MDLNRIIQALKGTIDPKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYL
KNMVTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIK
HDFPGHWPGVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLP
RIQQQIVQLLPDSSYYSVLLQKQILKIFYALVQYALPLQLVNNQTMTTWMEIFRTIIDRT
VPPETLHIDEDDRPELVWWKCKKWALHIVARLFERYGSPGNVTKEYFEFSEFFLKTYAVG
IQQVLLKILDQYRQKEYVAPRVLQQAFNYLNQGVVHSITWKQMKPHIQNISEDVIFSVMC
YKDEDEELWQEDPYEYIRMKFDIFEDYASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQIL
TDPNFDPRKKDGALHVIGSLAEILLKKSLFKDQMELFLQNHVFPLLLSNLGYLRARSCWV
LHAFSSLKFHNELNLRNAVELAKKSLIEDKEMPVKVEAALALQSLISNQIQAKEYMKPHV
RPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMTQHLAEIFGKVLQSDEYEE
VEDKTVMAMGILHTIDTILTVVEDHKEITQQLENICLRIIDLVLQKHVIEFYEEILSLAY
SLTCHSISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTDTLLSNAKHLEILFT
MCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSELRT
MCLQVAIAALYYNPDLLLHTLERIQLPHNPGPITVQFINQWMNDTDCFLGHHDRKMCIIG
LSILLELQNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDRSKAEKADMEENEE
ISSDEEETNVTAQAMQSNNGRGEDEEEEDDDWDEEVLEETALEGFSTPLDLDNSVDEYQF
FTQALITVQSRDAAWYQLLMAPLSEDQRTALQEVYTLAEHRRTVAEAKKKIEQQGGFTFE
NKGVLSAFNFGTVPSNN
|
| External Links |
|---|
| GenBank ID Protein
| 53759103 |
| UniProtKB/Swiss-Prot ID
| O15397 |
| UniProtKB/Swiss-Prot Entry Name
| IPO8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_006390.3 |
| GeneCard ID
| IPO8 |
| GenAtlas ID
| IPO8 |
| HGNC ID
| HGNC:9853 |
| References |
|---|
| General References
| Not Available |